(data stored in SCRATCH3701 zone)

HOGENOM6: STRMN_1_PE927

ID   STRMN_1_PE927                        STANDARD;      PRT;   825 AA.
AC   STRMN_1_PE927; C6SQG1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase A subunit; (STRMN_1.PE927).
GN   Name=gyrA; OrderedLocusNames=SmuNN2025_0927;
OS   STREPTOCOCCUS MUTANS NN2025.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
OX   NCBI_TaxID=511691;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STRMN_1.PE927.
CC       Streptococcus mutans NN2025, complete genome.
CC       chromosome 1, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:C6SQG1_STRMN
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C6SQG1; -.
DR   EMBL; AP010655; BAH87953.1; -; Genomic_DNA.
DR   RefSeq; YP_003484845.1; NC_013928.1.
DR   EnsemblBacteria; EBSTRT00000091253; EBSTRP00000085392; EBSTRG00000091929.
DR   GeneID; 8835810; -.
DR   GenomeReviews; AP010655_GR; SmuNN2025_0927.
DR   KEGG; smc:SmuNN2025_0927; -.
DR   GeneTree; EBGT00050000028052; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; STRMN_1.PE927; -.
DR   PRODOM; STRMN_1_PE927.
DR   SWISS-2DPAGE; STRMN_1_PE927.
KW   DNA gyrase A subunit;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   825 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRHFLMQDRN LVDVNLTSEM KTSFIDYAMS VIVARALPDV RDGLKPVHRR ILYGMNELGV
     TPDKPHKKSA RITGDVMGKY HPHGDSSIYE AMVRMAQWWS YRHMLVDGHG NFGSMDGDGA
     AAQRYTEARM SKIAMEMLRD INKNTVDFAD NYDGSEREPL VLPSRFPNLL VNGATGIAVG
     MATNIPPHNL GETIDAVKLA MDNPDVTTRD LMEVLPGPDF PTGALVMGKS GIHRAYDTGK
     GSIVLRARTE IEQTKSGRER IVVTEFPYMV NKTKVHEHIV RLAQEKRIEG ITAVRDESSR
     EGVRFIIEVR RDASANVILN NLFKLTSLQT NFSFNMLAIE KGVPKILSLR QILDNYIDHQ
     KEVIVRRTKF DKAKAESRAH ILEGLLIALD HLDEVITIIR NSETDTIAQA ELMSRFDLSE
     RQSQAILDMR LRRLTGLERD KIQSEYNDLL ALIADLADIL AKPERVITII KDELEDIKRK
     FADQRRTELM VGEVLSLEDE DLIEEEDVLI TLSNKGYIKR LGQDEFRTQK RGGRGVQGTG
     VNDDDFVREL VSTSTHDAML FFTNQGRVYR LKGYEIPEYG RTAKGLPIVN LLKLDDGETI
     QTIINVKSDD FHDKYLFFTT RQGVVKRTSV SAFGNIRQNG LKALSLRDND ELINVLLTNG
     QEDIIIGTHL GYSVRFQESA VRNMGRLATG VKGVNLRKND YVIGADHIAD NRNVLTITEK
     GYGKQTPASE YPTKGRGGKG IKTANITAKN GPLAGLVTVN DDEDIMIITD TGVIIRTSVA
     DISQTGRSAM GVKVMRLDEN AKIVTFALVK SEVIEGTSLN NNENE
//

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