(data stored in SCRATCH3701 zone)

HOGENOM6: STRP0_1_PE1283

ID   STRP0_1_PE1283                       STANDARD;      PRT;   841 AA.
AC   STRP0_1_PE1283; D6ZSC2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA topoisomerase (STRP0_1.PE1283) (ATP-hydrolyzing);
DE   EC=5.99.1 3; .
GN   Name=gyrA; OrderedLocusNames=HMPREF0837_11283;
OS   STREPTOCOCCUS PNEUMONIAE TCH8431/19A.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
OX   NCBI_TaxID=525381;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STRP0_1.PE1283.
CC       Streptococcus pneumoniae TCH8431/19A chromosome, complete genome.
CC       chromosome 1, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:D6ZSC2_STRP0
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D6ZSC2; -.
DR   EMBL; CP001993; ADI69511.1; -; Genomic_DNA.
DR   RefSeq; YP_003724725.1; NC_014251.1.
DR   EnsemblBacteria; EBSTRT00000098565; EBSTRP00000091489; EBSTRG00000098856.
DR   GeneID; 9344541; -.
DR   GenomeReviews; CP001993_GR; HMPREF0837_11283.
DR   KEGG; snc:HMPREF0837_11283; -.
DR   GeneTree; EBGT00050000028052; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; STRP0_1.PE1283; -.
DR   PRODOM; STRP0_1_PE1283.
DR   SWISS-2DPAGE; STRP0_1_PE1283.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   841 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGIYGIMLLL TNCEMRHLLM QDKNLVNVNL TKEMKASFID YAMSVIVARA LPDVRDGLKP
     VHRRILYGMN ELGVTPDKPH KKSARITGDV MGKYHPHGDS SIYEAMVRMA QWWSYRYMLV
     DGHGNFGSMD GDSAAAQRYT EARMSKIALE MLRDINKNTV DFVDNYDANE REPLVLPARF
     PNLLVNGATG IAVGMATNIP PHNLGETIDA VKLVMDNPEV TTKDLMEVLP GPDFPTGALV
     MGKSGIHKAY ETGKGSIVLR SRTEIETTKT GRERIVVTEF PYMVNKTKVH EHIVRLVQEK
     RIEGITAVRD ESNREGVRFV IEVKRDASAN VILNNLFKMT QMQTNFGFNM LAIQNGIPKI
     LSLRQILDAY IEHQKEVVVR RTRFDKEKAE ARAHILEGLL IALDHIDEVI RIIRASETDA
     EAQAELMSKF KLSERQSQAI LDMRLRRLTG LERDKIQSEY DDLLALIADL ADILAKPERV
     SQIIKDELDE VKRKFSDKRR TELMIGQVLS LEDEDLIEES DVLITLSNRG YIKRLDQDEF
     TAQKRGGRGV QGTGVKDDDF VRELVSTSTH DHLLFFTNKG RVYRLKGYEI PEYGRTAKGL
     PVVNLLKLDE DESIQTVINV ESDRSDDAYL FFTTRHGIVK RTSVKEFANI RQNGLKALNL
     KDEDELINVL LAEGDMDIII GTKFGYAVRF NQSAVRGMSR IATGVKGVNL REGDTVVGAS
     LITDQDEVLI ITEKGYGKRT VATEYPTKGR GGKGMQTAKI TEKNGLLAGL MTVQGDEDLM
     IITDTGVMIR TNLANISQTG RATMGVKVMR LDQDAQIVTF TTVAVAEKEE VGTENETEGE
     A
//

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