(data stored in ACNUC7421 zone)

HOGENOM: STRPC_1_PE1002

ID   STRPC_1_PE1002                       STANDARD;      PRT;   709 AA.
AC   STRPC_1_PE1002; Q1JLM9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA topoisomerase; EC=5.99.1 2; (STRPC_1.PE1002).
GN   OrderedLocusNames=MGAS9429_Spy1003;
OS   STREPTOCOCCUS PYOGENES MGAS9429.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
OX   NCBI_TaxID=370551;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STRPC_1.PE1002.
CC       Streptococcus pyogenes MGAS9429 chromosome, complete genome.
CC       chromosome 1, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:Q1JLM9_STRPC
CC   -!- FUNCTION: The reaction catalyzed by topoisomerases leads to the
CC       conversion of one topological isomer of DNA to another (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-independent breakage of single-stranded
CC       DNA, followed by passage and rejoining.
CC   -!- SIMILARITY: Belongs to the prokaryotic type I/III topoisomerase
CC       family.
CC   -!- SIMILARITY: Contains 1 Toprim domain.
CC   -!- GENE_FAMILY: HOG000004018 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q1JLM9; -.
DR   EMBL; CP000259; ABF32190.1; -; Genomic_DNA.
DR   RefSeq; YP_596734.1; NC_008021.1.
DR   ProteinModelPortal; Q1JLM9; -.
DR   STRING; Q1JLM9; -.
DR   EnsemblBacteria; EBSTRT00000046162; EBSTRP00000044379; EBSTRG00000046154.
DR   GeneID; 4061348; -.
DR   GenomeReviews; CP000259_GR; MGAS9429_Spy1003.
DR   KEGG; spk:MGAS9429_Spy1003; -.
DR   eggNOG; COG0550; -.
DR   GeneTree; EBGT00050000027862; -.
DR   OMA; EEYWSID; -.
DR   ProtClustDB; PRK05582; -.
DR   BioCyc; SPYO370551:MGAS9429_SPY1003-MONOMER; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR000380; Topo_IA.
DR   InterPro; IPR003601; Topo_IA_2.
DR   InterPro; IPR023406; Topo_IA_AS.
DR   InterPro; IPR013497; Topo_IA_cen.
DR   InterPro; IPR013824; Topo_IA_cen_sub1.
DR   InterPro; IPR013825; Topo_IA_cen_sub2.
DR   InterPro; IPR023405; Topo_IA_core_domain.
DR   InterPro; IPR003602; Topo_IA_DNA-bd.
DR   InterPro; IPR013498; Topo_IA_Znf.
DR   InterPro; IPR005733; TopoI_bac-type.
DR   InterPro; IPR006171; Toprim_domain.
DR   Gene3D; G3DSA:1.10.460.10; Topo_IA_cen_sub1; 2.
DR   Gene3D; G3DSA:2.70.20.10; Topo_IA_cen_sub2; 2.
DR   PANTHER; PTHR11390; Topo_IA; 1.
DR   Pfam; PF01131; Topoisom_bac; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   Pfam; PF01396; zf-C4_Topoisom; 2.
DR   PRINTS; PR00417; PRTPISMRASEI.
DR   SMART; SM00437; TOP1Ac; 1.
DR   SMART; SM00436; TOP1Bc; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF56712; Topo_IA_core; 1.
DR   TIGRFAMs; TIGR01051; TopA_bact; 1.
DR   PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR   HOGENOMDNA; STRPC_1.PE1002; -.
KW   DNA topoisomerase I;
KW   ATP-binding; Complete proteome; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   709 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGTKTTTKPK TGTKKSTTKK KSIAKKNLVI VESPAKAKTI EKYLGRSYKV VASVGHIRDL
     KKSSMSINFD NNYEPQYINI RGKGPLINSL KKEAKAAKKV YLASDPDREG EAISWHLSHI
     LGLDPQDNNR VVFNEITKDA VKHAFVEPRQ IDMDLVDSQQ ARRVLDRIVG YSISPILWKK
     VKKGLSAGRV QSVALKLIID RENDIKAFVP KEYWSIDGLF KKGTKKFQAT FYGINGKKTK
     LDNNNDVKEV LAKLTNEDFL VSKVDKKERR RNAPLPYTTS SLQQDAANKI NFRTRKTMMV
     AQQLYEGIHL GENGTQGLIT YMRTDSTRIS PVAQNDAAQF IINRFGANYS KHGNRVKNTS
     GAQDAHEAIR PSSVNHTPDS IAKYLNKDQL KLYTLIWNRF VASQMTAAVF DTVKVNLEQN
     GVIFVANGSQ MKFDGYMAVY NDSDKNKMLP EMEEGENVKK VSTSPEQHFT QPPARYSEAT
     LIKTLEENGV GRPSTYAPTL EVIQRRYYVK LSAKRFEPTE LGEIVNKLIV EFFPDIVDVA
     FTAEMEGKLD QVEIGEEEWQ HVIDQFYQPF VKELNKAESE IEKIQIKDEP AGFDCDVCGH
     PMVIKLGRFG KFYACSNFPE CRNTKAITKE IGVTCPVCHK GQVIERKTKK NRIFYGCDQY
     PDCEFISWDL PIGRACPKSG DYLIEKKVRG GKQVMCSNET CDYKEEKIK
//

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