(data stored in ACNUC7421 zone)

HOGENOM: STRPF_1_PE1006

ID   STRPF_1_PE1006                       STANDARD;      PRT;   334 AA.
AC   STRPF_1_PE1006; Q1J6M7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=GMP reductase; EC=1.7.1 7;AltName: Full=Guanosine
DE   5'-monophosphate oxidoreductase; Short=Guanosine monophosphate reductase;
DE   (STRPF_1.PE1006).
GN   Name=guaC; OrderedLocusNames=MGAS10750_Spy1006;
OS   STREPTOCOCCUS PYOGENES MGAS10750.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
OX   NCBI_TaxID=370554;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STRPF_1.PE1006.
CC       Streptococcus pyogenes MGAS10750 chromosome, complete genome.
CC       chromosome 1, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:GUAC_STRPF
CC   -!- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination
CC       of GMP to IMP. It functions in the conversion of nucleobase,
CC       nucleoside and nucleotide derivatives of G to A nucleotides, and
CC       in maintaining the intracellular balance of A and G nucleotides
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH(3) + NADP(+) =
CC       guanosine 5'-phosphate + NADPH.
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 2
CC       subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABF37956.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000165753 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q1J6M7; -.
DR   EMBL; CP000262; ABF37956.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_602500.1; NC_008024.1.
DR   ProteinModelPortal; Q1J6M7; -.
DR   SMR; Q1J6M7; 7-322.
DR   STRING; Q1J6M7; -.
DR   EnsemblBacteria; EBSTRT00000041494; EBSTRP00000039889; EBSTRG00000041489.
DR   GeneID; 4067212; -.
DR   GenomeReviews; CP000262_GR; guaC.
DR   KEGG; spi:MGAS10750_Spy1006; -.
DR   eggNOG; COG0516; -.
DR   GeneTree; EBGT00050000027666; -.
DR   ProtClustDB; PRK05458; -.
DR   BioCyc; SPYO370554:MGAS10750_SPY1006-MON; -.
DR   GO; GO:0003920; F:GMP reductase activity; IEA:EC.
DR   GO; GO:0006163; P:purine nucleotide metabolic process; IEA:InterPro.
DR   HAMAP; MF_01511; GMP_reduct_type2; 1; -.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005994; GMP_reduct2.
DR   InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR11911:SF30; PTHR11911:SF30; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   PIRSF; PIRSF036500; GMP_red_Firmic; 1.
DR   TIGRFAMs; TIGR01306; GMP_reduct_2; 1.
DR   PROSITE; PS00487; IMP_DH_GMP_RED; 1.
DR   HOGENOMDNA; STRPF_1.PE1006; -.
KW   guanosine 5'-monophosphate oxidoreductase;
KW   Complete proteome; NADP; Oxidoreductase.
SQ   SEQUENCE   334 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLKEEKLMFN DIPVFDYEDI QLIPNKCIIT SRSQADTSVT LGKYQFKLPV IPANMQTIID
     ETIAEQLAKE GYFYIMHRFD EDSRKPFIKR MHEQGLIASI SVGVKAYEYE FVTSLKEDTP
     EFITIDIAHG HANSVIDMIK HIKTELPETF VIAGNVGTPE AVRELENAGA DATKVGIGPG
     KVCITKVKTG FGTGGWQLAA LRWCAKAARK PIIADGGIRT HGDIAKSIRF GASMVMIGSL
     FAGHIESPGK TVEVNGETFK EYYGSASAYQ KGEHKNVEGK KILLPTKGHL SDTLTEMQQD
     LQSSISYAGG KDLDSLRHVD YVIVKNSIWN GDSI
//

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