(data stored in ACNUC7421 zone)

HOGENOM: STRPF_1_PE1011

ID   STRPF_1_PE1011                       STANDARD;      PRT;   189 AA.
AC   STRPF_1_PE1011; Q1J6M2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Thymidine kinase; EC=2.7.1 21; (STRPF_1.PE1011).
GN   Name=tdk2; Synonyms=tdk; OrderedLocusNames=MGAS10750_Spy1011;
OS   STREPTOCOCCUS PYOGENES MGAS10750.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
OX   NCBI_TaxID=370554;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STRPF_1.PE1011.
CC       Streptococcus pyogenes MGAS10750 chromosome, complete genome.
CC       chromosome 1, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:Q1J6M2_STRPF
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC   -!- GENE_FAMILY: HOG000076391 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q1J6M2; -.
DR   EMBL; CP000262; ABF37961.1; -; Genomic_DNA.
DR   RefSeq; YP_602505.1; NC_008024.1.
DR   ProteinModelPortal; Q1J6M2; -.
DR   STRING; Q1J6M2; -.
DR   EnsemblBacteria; EBSTRT00000042302; EBSTRP00000040697; EBSTRG00000042297.
DR   GeneID; 4067217; -.
DR   GenomeReviews; CP000262_GR; MGAS10750_Spy1011.
DR   KEGG; spi:MGAS10750_Spy1011; -.
DR   eggNOG; COG1435; -.
DR   GeneTree; EBGT00050000028198; -.
DR   OMA; FRYGAMN; -.
DR   ProtClustDB; PRK04296; -.
DR   BioCyc; SPYO370554:MGAS10750_SPY1011-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1; -.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   InterPro; IPR020634; Thymidine_kinase_subgr.
DR   PANTHER; PTHR11441; TK_cell; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
DR   HOGENOMDNA; STRPF_1.PE1011; -.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
SQ   SEQUENCE   189 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAQLYYKYGT MNSGKTIEIL KVAHNYEEQG KPVVIMTSAL DTRDGFGIVS SRIGMRREAI
     PISNDMDIFT FIAQLEEKPY CVLIDESQFL SKQNVYDLAR VVDELNVPVM AFGLKNDFQN
     NLFEGSKHLL LLADKIDEIK TICQYCSKKA TMVLRTENGK PVYEGDQIQI GGNETYIPVC
     RKHYFNPEI
//

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