(data stored in ACNUC7421 zone)

HOGENOM: STRPS_1_PE1002

ID   STRPS_1_PE1002                       STANDARD;      PRT;   418 AA.
AC   STRPS_1_PE1002; B2IPI0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Serine hydroxymethyltransferase; Short=SHMT; Short=Serine
DE   methylase; EC=2.1.2 1; (STRPS_1.PE1002).
GN   Name=glyA; OrderedLocusNames=SPCG_1002;
OS   STREPTOCOCCUS PNEUMONIAE CGSP14.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
OX   NCBI_TaxID=516950;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STRPS_1.PE1002.
CC       Streptococcus pneumoniae CGSP14, complete genome.
CC       chromosome 1, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:GLYA_STRPS
CC   -!- FUNCTION: Interconversion of serine and glycine (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine +
CC       H(2)O = tetrahydrofolate + L-serine.
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the SHMT family.
CC   -!- GENE_FAMILY: HOG000239404 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B2IPI0; -.
DR   EMBL; CP001033; ACB90254.1; -; Genomic_DNA.
DR   RefSeq; YP_001835719.1; NC_010582.1.
DR   ProteinModelPortal; B2IPI0; -.
DR   STRING; B2IPI0; -.
DR   EnsemblBacteria; EBSTRT00000018565; EBSTRP00000017879; EBSTRG00000018565.
DR   GeneID; 6217457; -.
DR   GenomeReviews; CP001033_GR; SPCG_1002.
DR   KEGG; spw:SPCG_1002; -.
DR   GeneTree; EBGT00050000027108; -.
DR   OMA; FPMYADR; -.
DR   ProtClustDB; PRK00011; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006544; P:glycine metabolic process; IEA:InterPro.
DR   GO; GO:0006563; P:L-serine metabolic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00051; SHMT; 1; -.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase_major_dom.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_major_sub2.
DR   InterPro; IPR001085; Ser_HO-MeTrfase.
DR   InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR   Gene3D; G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
DR   Gene3D; G3DSA:3.90.1150.10; PyrdxlP-dep_Trfase_major_sub2; 1.
DR   PANTHER; PTHR11680; Gly_HO-Metrfase; 1.
DR   Pfam; PF00464; SHMT; 1.
DR   PIRSF; PIRSF000412; SHMT; 1.
DR   SUPFAM; SSF53383; PyrdxlP-dep_Trfase_major; 1.
DR   PROSITE; PS00096; SHMT; 1.
DR   HOGENOMDNA; STRPS_1.PE1002; -.
KW   serine hydroxymethyltransferase;
KW   Complete proteome; Cytoplasm; One-carbon metabolism;
KW   Pyridoxal phosphate; Transferase.
SQ   SEQUENCE   418 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MIFDKDDFKA YDADLWNAIA KEEERQQNNI ELIASENVVS KAVMAAQGSI LTNKYAEGYP
     GRRYYGGTDV VDVVETLAIE RAKEIFGAKF ANVQPHSGSQ ANCAAYMSLI EPGDTVMGMD
     LASGGHLTHG APVSFSGQTY NFVSYSVDPE TELLDFDAIL KQAQEVKPKL IVAGASAYSQ
     IIDFSKFREI ADAVGAKLMV DMAHIAGLVA AGLHPSPVPY AHITTTTTHK TLRGPRGGLI
     LTNDEELAKK INSAIFPGIQ GGPLEHVVAA KAVSFKEVLD PAFKEYAANV IKNSKAMADV
     FLQDPDFRII SGGTENHLFL VDVTKVVENG KVAQNLLDEV NITLNKNSIP YESLSPFKTS
     GIRIGAAAIT ARGFGEEESR KVAELIIKTL KNSENEAVLE EVRSAVKELT DAFLLYED
//

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