(data stored in ACNUC30630 zone)

HOGENOM: SUSOL1_1_PE810

ID   SUSOL1_1_PE810                       STANDARD;      PRT;   421 AA.
AC   SUSOL1_1_PE810; Q06128;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (SUSOL1_1.PE810).
GN   Name=trpE; OrderedLocusNames=SSO0893;
OS   SULFOLOBUS SOLFATARICUS P2.
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=273057;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SUSOL1_1.PE810.
CC       Sulfolobus solfataricus P2 chromosome, complete genome.
CC       1..88329 annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:TRPE_SULSO
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II.
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q06128; -.
DR   EMBL; M98048; AAA73379.1; -; Genomic_DNA.
DR   EMBL; Z50014; CAA90311.1; -; Genomic_DNA.
DR   EMBL; AE006641; AAK41175.1; -; Genomic_DNA.
DR   PIR; H90239; H90239.
DR   PIR; JC5323; JC5323.
DR   RefSeq; NP_342385.1; NC_002754.1.
DR   PDB; 1QDL; X-ray; 2.50 A; A=1-421.
DR   PDBsum; 1QDL; -.
DR   ProteinModelPortal; Q06128; -.
DR   SMR; Q06128; 1-421.
DR   DIP; DIP-6202N; -.
DR   IntAct; Q06128; 1.
DR   MINT; MINT-102245; -.
DR   GeneID; 1455142; -.
DR   GenomeReviews; AE006641_GR; SSO0893.
DR   KEGG; sso:SSO0893; -.
DR   NMPDR; fig|273057.1.peg.808; -.
DR   OMA; IRDYMAR; -.
DR   PhylomeDB; Q06128; -.
DR   ProtClustDB; PRK13574; -.
DR   BioCyc; MetaCyc:MONOMER-3603; -.
DR   BioCyc; SSOL273057:SSO0893-MON; -.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR010116; Anthranilate_synth_I_arc.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   TIGRFAMs; TIGR01820; TrpE-arch; 1.
DR   HOGENOMDNA; SUSOL1_1.PE810; -.
KW   anthranilate synthase component I;
KW   3D-structure; Amino-acid biosynthesis;
KW   Aromatic amino acid biosynthesis; Complete proteome; Lyase;
KW   Reference proteome; Tryptophan biosynthesis.
SQ   SEQUENCE   421 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEVHPISEFA SPFEVFKCIE RDFKVAGLLE SIGGPQYKAR YSVIAWSTNG YLKIHDDPVN
     ILNGYLKDLK LADIPGLFKG GMIGYISYDA VRFWEKIRDL KPAAEDWPYA EFFTPDNIII
     YDHNEGKVYV NADLSSVGGC GDIGEFKVSF YDESLNKNSY ERIVSESLEY IRSGYIFQVV
     LSRFYRYIFS GDPLRIYYNL RRINPSPYMF YLKFDEKYLI GSSPELLFRV QDNIVETYPI
     AGTRPRGADQ EEDLKLELEL MNSEKDKAEH LMLVDLARND LGKVCVPGTV KVPELMYVEK
     YSHVQHIVSK VIGTLKKKYN ALNVLSATFP AGTVSGAPKP MAMNIIETLE EYKRGPYAGA
     VGFISADGNA EFAIAIRTAF LNKELLRIHA GAGIVYDSNP ESEYFETEHK LKALKTAIGV
     R
//

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