(data stored in ACNUC30630 zone)

HOGENOM: THERP_1_PE1006

ID   THERP_1_PE1006                       STANDARD;      PRT;   383 AA.
AC   THERP_1_PE1006; B9L0I8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase;
DE   EC=1.17.7 1;AltName: Full=1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DE   synthase; (THERP_1.PE1006).
GN   Name=ispG; OrderedLocusNames=trd_1058;
OS   THERMOMICROBIUM ROSEUM DSM 5159.
OC   Bacteria; Chloroflexi; Thermomicrobiales; Thermomicrobiaceae;
OC   Thermomicrobium.
OX   NCBI_TaxID=309801;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS THERP_1.PE1006.
CC       Thermomicrobium roseum DSM 5159, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:B9L0I8_THERP
CC   -!- FUNCTION: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate
CC       (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: (E)-4-hydroxy-3-methylbut-2-en-1-yl
CC       diphosphate + H(2)O + 2 oxidized ferredoxin = 2-C-methyl-D-
CC       erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate
CC       biosynthesis via DXP pathway; isopentenyl diphosphate from 1-
CC       deoxy-D-xylulose 5-phosphate: step 5/6.
CC   -!- SIMILARITY: Belongs to the ispG family.
CC   -!- GENE_FAMILY: HOG000261019 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B9L0I8; -.
DR   EMBL; CP001275; ACM05380.1; -; Genomic_DNA.
DR   RefSeq; YP_002522268.1; NC_011959.1.
DR   STRING; B9L0I8; -.
DR   GeneID; 7356191; -.
DR   GenomeReviews; CP001275_GR; trd_1058.
DR   KEGG; tro:trd_1058; -.
DR   OMA; PRKLEIV; -.
DR   ProtClustDB; CLSK2807831; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046429; F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00159; IspG; 1; -.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR016425; IspG_bac.
DR   InterPro; IPR004588; IspG_bac-typ.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 2.
DR   Pfam; PF04551; GcpE; 1.
DR   PIRSF; PIRSF004640; IspG; 1.
DR   SUPFAM; SSF51717; DHP_synth_like; 1.
DR   TIGRFAMs; TIGR00612; IspG_gcpE; 1.
DR   HOGENOMDNA; THERP_1.PE1006; -.
KW   4Fe-4S; Complete proteome; Iron; Iron-sulfur; Isoprene biosynthesis;
KW   Metal-binding; Oxidoreductase.
SQ   SEQUENCE   383 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAYQRRKTRP VWVGDVQIGG DAPIVVQSMT TTDTRDPEAT LRQIHELADV GCEIVRVAVP
     DRIAAAALAD IVPRSPIPVV ADIHFEHTLA LKALEAGVHK LRLNPGNIRK PEEVREVVQK
     AKERGVPIRI GVNFGSLPPM TREFVDEMAA RGATQTELIA EHMVRTALSH VKILEDLDFG
     DIVISLKAFE VPVMIEAYRR MAKLNDYPLH LGVTEAGTPK AGAIRSAIGI GTLLQEGIGD
     TIRVSLTTDP VEEVWVAYEI LKTLGLRERG ATLVACPTCG RVEVDLFRLA NEIDEYLRTV
     KEPIKVAVMG CVVNGPGEAR DSDVGVAAGR GKGVIFRKGK IVRRVEEHEI VPALKEEIEA
     ILAERRSGSA QARREISIPI IAD
//

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