(data stored in ACNUC7421 zone)

HOGENOM: THET1_1_PE1007

ID   THET1_1_PE1007                       STANDARD;      PRT;   736 AA.
AC   THET1_1_PE1007; D1CG75;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Phosphoribosylformylglycinamidine synthase 2; EC=6.3.5
DE   3;AltName: Full=Phosphoribosylformylglycinamidine synthase II;
DE   (THET1_1.PE1007).
GN   Name=purL; OrderedLocusNames=Tter_1015;
OS   THERMOBACULUM TERRENUM ATCC BAA-798.
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS THET1_1.PE1007.
CC       Thermobaculum terrenum ATCC BAA-798 chromosome 1, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:D1CG75_THET1
CC   -!- CATALYTIC ACTIVITY: ATP + N(2)-formyl-N(1)-(5-phospho-D-
CC       ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-
CC       (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 1/2.
CC   -!- SUBUNIT: Heterodimer of two subunits, purQ and purL (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the FGAMS family.
CC   -!- GENE_FAMILY: HOG000238227 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D1CG75; -.
DR   EMBL; CP001825; ACZ41931.1; -; Genomic_DNA.
DR   RefSeq; YP_003322753.1; NC_013525.1.
DR   ProteinModelPortal; D1CG75; -.
DR   GeneID; 8645502; -.
DR   GenomeReviews; CP001825_GR; Tter_1015.
DR   KEGG; ttr:Tter_1015; -.
DR   OMA; YGNSFGV; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00420; PurL_2; 1; -.
DR   InterPro; IPR000728; AIR_synth.
DR   InterPro; IPR010918; AIR_synth_C.
DR   InterPro; IPR010074; PRibForGlyAmidine_synth_II.
DR   InterPro; IPR016188; PurM_N-like.
DR   Pfam; PF00586; AIRS; 2.
DR   Pfam; PF02769; AIRS_C; 2.
DR   SUPFAM; SSF56042; AIR_synth_C; 2.
DR   SUPFAM; SSF55326; PurM_N-like; 2.
DR   TIGRFAMs; TIGR01736; FGAM_synth_II; 1.
DR   HOGENOMDNA; THET1_1.PE1007; -.
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
SQ   SEQUENCE   736 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNAAELREVA LTEEEYRTAV KLLGREPNRL ELGIIGAMWS EHCGYKNSRP LLRYFPTEGE
     KVVQGPGENA GAVAIDDNLA VVFKVESHNH PSAIEPYQGA ATGVGGIVRD IFTMGARPIA
     LLNSLRFGPL SEPENRRLLA GVVKGIGDYG NSIGIPTVGG EVWFHPSYNG NPLVNAMCIG
     VADINKIVRA QAGSPGNLLL LVGADTGRDG IHGATFASVD DPHASHKGVI QVGNPFMEKL
     LMEACLELLD SPYVVGMQDL GAAGLTSSSV ECAGRAGSGV EIDVSKVSRR ESGMTPYEVM
     LSESQERMLI VVRPEGLEEV KQVFEKWDLH SDVVGLVTSD GMLRVRDGDE IVGELPIRLL
     TEDVPKYVRE ATPSPEVINK ASIDVDSKFS GQVNFDPESD LIRLLSSPNI ASKHWIWEQY
     DHTIGTSTVR GPGSADAAVM RVRPHGQGVA ITMDCNPRYC YLDPYCGGMA AVIEAARNLA
     CVGAVPIGMT NCLNFGNPEK PEIYWQLREC ILGMSDACRR LQIPVVSGNV SLYNESNDKA
     IYPTPVVGLV GLIESASGSV SAGAKSGDAI YLLHTSQQVT LGASEWLAVV ANEESGHPPV
     CDLDKEISLH RLLVESIQDG VISAAHDVSD GGLLVALAEM AIIGGAGIDA SNWKPQINPL
     YLFGEGHGRA LVSVPTNKEE ELTELCGQYG VQFERIGVVG GDALIIGDVI KLPVGELIDL
     YDQAIPSMLG WDSKGH
//

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