(data stored in ACNUC30630 zone)

HOGENOM: THET8_1_PE1844

ID   THET8_1_PE1844                       STANDARD;      PRT;   462 AA.
AC   THET8_1_PE1844; P05378; Q5SH86;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (THET8_1.PE1844).
GN   Name=trpE; OrderedLocusNames=TTHA1844;
OS   THERMUS THERMOPHILUS HB8.
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS THET8_1.PE1844.
CC       Thermus thermophilus HB8, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:TRPE_THET8
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P05378; Q5SH86; -.
DR   EMBL; X07744; CAA30566.1; -; Genomic_DNA.
DR   EMBL; AP008226; BAD71667.1; -; Genomic_DNA.
DR   RefSeq; YP_145110.1; NC_006461.1.
DR   ProteinModelPortal; P05378; -.
DR   STRING; P05378; -.
DR   GeneID; 3168049; -.
DR   GenomeReviews; AP008226_GR; TTHA1844.
DR   KEGG; ttj:TTHA1844; -.
DR   eggNOG; COG0147; -.
DR   OMA; RTIYGRA; -.
DR   ProtClustDB; CLSK445246; -.
DR   BioCyc; TTHE300852:TTHA1844-MON; -.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR005256; Anth_synth_I_PabB.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   TIGRFAMs; TIGR00564; TrpE_most; 1.
DR   HOGENOMDNA; THET8_1.PE1844; -.
KW   anthranilate synthase component I (TrpE);
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Reference proteome; Tryptophan biosynthesis.
SQ   SEQUENCE   462 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MERIRPYRKT FLADLETPVT AYLKLAEKAP VSFLLESVER GRQSRFSIVG VGARRTFRLK
     DGVFTVNGER VETRDPLRAL YERVYAPLER HPDLPPFFGG VVGYAAYDLV RYYERLPSLK
     PDDLGLPDLL FVEPEVVAVF DHLKNLLHLV APGRDPEEAE ARLFWAERRL KGPLPGVPGE
     RAGGRARFQA DFSREAYLEA VRRALDYIRA GDIFQVVLSL RLSSPLTVHP FALYRALRSV
     NPSPYMGYLD LGEVVLVSAS PESLLRSDGR RVVTRPIAGT RPRGKDEEED KRLAEELLRD
     EKEVAEHVML LDLSRNDIGR VAAFGTVRVL EPLHVEHYSH VMHLVSTVEG ILAEGKTPLD
     ALASVLPMGT VSGAPKIRAM EIIEELEPHR RGPYGGSFGY LAYDGAMDMA LTLRTFVVAK
     GWMHVQAGAG IVADSVPERE YEECWNKARA LLKAVEMAEA GL
//

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