(data stored in ACNUC9435 zone)

HOGENOM: THIK1_1_PE1009

ID   THIK1_1_PE1009                       STANDARD;      PRT;   347 AA.
AC   THIK1_1_PE1009; D5WZK9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase; EC=6.3.3
DE   1;AltName: Full=AIR synthase;AltName: Full=AIRS;AltName:
DE   Full=Phosphoribosyl-aminoimidazole synthetase; (THIK1_1.PE1009).
GN   Name=purM; OrderedLocusNames=Tint_1031;
OS   THIOMONAS INTERMEDIA K12.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Thiomonas.
OX   NCBI_TaxID=75379;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS THIK1_1.PE1009.
CC       Thiomonas intermedia K12 chromosome, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:D5WZK9_THIK1
CC   -!- CATALYTIC ACTIVITY: ATP + 2-(formamido)-N(1)-(5-phospho-D-
CC       ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the AIR synthase family.
CC   -!- GENE_FAMILY: HOG000229090 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D5WZK9; -.
DR   EMBL; CP002021; ADG30425.1; -; Genomic_DNA.
DR   RefSeq; YP_003642755.1; NC_014153.1.
DR   ProteinModelPortal; D5WZK9; -.
DR   GeneID; 9151762; -.
DR   GenomeReviews; CP002021_GR; Tint_1031.
DR   KEGG; tin:Tint_1031; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00741_B; AIRS_B; 1; -.
DR   InterPro; IPR000728; AIR_synth.
DR   InterPro; IPR010918; AIR_synth_C.
DR   InterPro; IPR004733; PurM_cligase.
DR   InterPro; IPR016188; PurM_N-like.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   SUPFAM; SSF56042; AIR_synth_C; 1.
DR   SUPFAM; SSF55326; PurM_N-like; 1.
DR   TIGRFAMs; TIGR00878; PurM; 1.
DR   HOGENOMDNA; THIK1_1.PE1009; -.
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
SQ   SEQUENCE   347 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQKTPLTYRD AGVDIDAGDA LVDAIKPLAR RTLRDGVLAG IGGFGALFEV PKRYREPVLV
     SGTDGVGTKL KLAFEWNRHD TVGIDLVAMS VNDVLVQGAE PLFFLDYFAC GKLAVQTATQ
     VIGGVAQGCE QAGCALIGGE TAEMPGMYPA GEYDLAGFAV GAVEKSGIID GRTIAAGDRV
     IGLASSGAHS NGYSLVRKII ARSGPNELPT TLDGQDFRSA VMAPTRIYCK PVLKALAQHT
     IKGMAHITGG GLSENIPRVL PESVQCVLDP STWGQTELFA WLQREGGVDD AEMRRTFNCG
     VGFVLVVAAA EAEAVLATLR AEGETGWIIG EIQPRPHADS HQVRYTG
//

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