(data stored in ACNUC9435 zone)

HOGENOM: THIK1_1_PE1014

ID   THIK1_1_PE1014                       STANDARD;      PRT;   330 AA.
AC   THIK1_1_PE1014; D5WZL4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase; EC=5.1.3
DE   20;AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
DE   (THIK1_1.PE1014).
GN   Name=hldD; OrderedLocusNames=Tint_1036;
OS   THIOMONAS INTERMEDIA K12.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Thiomonas.
OX   NCBI_TaxID=75379;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS THIK1_1.PE1014.
CC       Thiomonas intermedia K12 chromosome, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:D5WZL4_THIK1
CC   -!- FUNCTION: Catalyzes the interconversion between ADP-D-glycero-
CC       beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an
CC       epimerization at carbon 6 of the heptose (By similarity).
CC   -!- CATALYTIC ACTIVITY: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-
CC       D-manno-heptose.
CC   -!- COFACTOR: Binds 1 NADP(+) per subunit (By similarity).
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-
CC       manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose
CC       from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
CC   -!- SUBUNIT: Homopentamer (By similarity).
CC   -!- DOMAIN: Contains a large N-terminal NADP-binding domain, and a
CC       smaller C-terminal substrate-binding domain (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family. HldD subfamily.
CC   -!- GENE_FAMILY: HOG000167987 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D5WZL4; -.
DR   EMBL; CP002021; ADG30430.1; -; Genomic_DNA.
DR   RefSeq; YP_003642760.1; NC_014153.1.
DR   ProteinModelPortal; D5WZL4; -.
DR   GeneID; 9151767; -.
DR   GenomeReviews; CP002021_GR; Tint_1036.
DR   KEGG; tin:Tint_1036; -.
DR   GO; GO:0008712; F:ADP-glyceromanno-heptose 6-epimerase activity; IEA:HAMAP.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:HAMAP.
DR   GO; GO:0044237; P:cellular metabolic process; IEA:InterPro.
DR   HAMAP; MF_01601; Heptose_epimerase; 1; -.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR011912; Heptose_epim.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR10366:SF29; Heptose_epim; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   TIGRFAMs; TIGR02197; Heptose_epim; 1.
DR   HOGENOMDNA; THIK1_1.PE1014; -.
KW   ADP-L-glycero-D-manno-heptose-6-epimerase;
KW   Carbohydrate metabolism; Complete proteome; Isomerase; NADP.
SQ   SEQUENCE   330 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRVIVTGAAG FIGSNLVKGL NARGITEVIA VDNLTRGDKF HNLVDLQICD YLDKTVFFEQ
     FASGHYGKVE AVFHQGACSD TMEHDGRYML DNNYRNSRML LDAGQKQGVR LLYASSAATY
     GASSVFRESP EFERPLNVYG YSKMLFDQVV RRVLPHATTQ IAGFRYFNVY GPREQHKGRM
     ASVAFHHFNQ YREYGQVKLF GEYQGYGPGL QERDFVWIDD VVAVNLWFFD HPGKSGIFNL
     GSGRAQPFND VAQTVVNTLR QEAGQPALSL AELVDCGEIA YIAFPDALVG KYQCHTQADL
     SHLRAAGCTH HFATVEEGTA QYMRALLAAA
//

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