(data stored in SCRATCH3701 zone)

HOGENOM6: THIS3_1_PE2178

ID   THIS3_1_PE2178                       STANDARD;      PRT;   868 AA.
AC   THIS3_1_PE2178; D6CUI0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; EC=5.99.1 3; (THIS3_1.PE2178).
GN   Name=gyrA; OrderedLocusNames=THI_2307;
OS   THIOMONAS SP. 3AS.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Thiomonas.
OX   NCBI_TaxID=426114;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS THIS3_1.PE2178.
CC       Thiomonas sp. (strain 3As) chromosome, complete sequence.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:D6CUI0_THIS3
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D6CUI0; -.
DR   EMBL; FP475956; CAZ88949.1; -; Genomic_DNA.
DR   GenomeReviews; FP475956_GR; THI_2307.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; THIS3_1.PE2178; -.
DR   PRODOM; THIS3_1_PE2178.
DR   SWISS-2DPAGE; THIS3_1_PE2178.
KW   CAZ88949.123.19671820036002503210000011;
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   868 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSVFAKETLP ISLETEMRRS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMHELSNAWN
     RPYKKSARIV GDVIGKYHPH GDQSVYDTIV RMAQDFSLRY MLVDGQGNFG SVDGDNAAAM
     RYTEIRLSKI AHEMLADIDK ETVDFGPNYD GSEQEPLLLP ARLPNLLING SSGIAVGMAT
     NIPPHNLGEV LDACLHLLRN PGATIEELME RVPAPDFPTA GIIYGTSGVR DAYRTGRGRV
     VMRARCHFED LEKGQRQAII VDELPYQVNK RTLLERIAEL VQEKKIEGIS HIQDESDKSG
     MRVVIELKRG EVPEVVLNNL YKQTQLQDTF GVNMVALVDG QPRLLNLQQM IAAFLSHRRE
     IITRRTVFDL RKARERGHVL EGLAVALANV DRMIELIKAA PTPPVAKERL LAQAWEPGEA
     RAMLSRVEGD ITQFQPDDLD ARYGLKPDGY YLSETQAQEI LQMRLQRLTG LEQDKIVGEY
     KDVMEQIADL LDILAKPERM TEIITTEMSA LRAEFGDARR SHIEVNAYDI DVEDLITPQD
     LVVTISHSGY VKSQPLAEYR AQRRGGRGKL ATGTKEDDWV EQLFVANTHD MLLCFSNRGR
     VYWMKVYESP MGGRGSRGKP LVNLFPLQAG EKITTVLPVK AFDEQHYVFM ATARGTVKKT
     PLTAFVNRRT AGIIAVALDE DDYLIGAAIT DGQHDVMLFS DAGKAVRFDE ADVRPMGREA
     RGVRGMQLEA DQSVIALLVA EDETQSVLTA TENGYGKRTS ITEYTRHGRG TKGMIAIQTS
     ERNGKVVAAC LVRTSDEIML ITDTGVLVRT RVEEIREMGR ATQGVTLIAL DAKAHLIQVQ
     PVVEADDDEL PPTELPPAED GGADTAAE
//

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