(data stored in ACNUC30630 zone)

HOGENOM: THKOD1_1_PE255

ID   THKOD1_1_PE255                       STANDARD;      PRT;   433 AA.
AC   THKOD1_1_PE255; Q9YGB3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (THKOD1_1.PE255).
GN   Name=trpE; OrderedLocusNames=TK0254;
OS   THERMOCOCCUS KODAKARENSIS KOD1.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS THKOD1_1.PE255.
CC       Thermococcus kodakarensis KOD1, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:TRPE_PYRKO
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q9YGB3; -.
DR   EMBL; AB030011; BAA82547.1; -; Genomic_DNA.
DR   EMBL; AP006878; BAD84443.1; -; Genomic_DNA.
DR   PIR; T43924; T43924.
DR   RefSeq; YP_182667.1; NC_006624.1.
DR   ProteinModelPortal; Q9YGB3; -.
DR   EnsemblBacteria; EBPYRT00000006409; EBPYRP00000006190; EBPYRG00000006408.
DR   GeneID; 3235373; -.
DR   GenomeReviews; AP006878_GR; TK0254.
DR   KEGG; tko:TK0254; -.
DR   NMPDR; fig|69014.3.peg.1; -.
DR   eggNOG; arNOG04620; -.
DR   GeneTree; EBGT00050000022507; -.
DR   OMA; YETERKM; -.
DR   PhylomeDB; Q9YGB3; -.
DR   ProtClustDB; PRK13572; -.
DR   BioCyc; TKOD69014:TK0254-MON; -.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR010116; Anthranilate_synth_I_arc.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   TIGRFAMs; TIGR01820; TrpE-arch; 1.
DR   HOGENOMDNA; THKOD1_1.PE255; -.
KW   anthranilate synthase component I;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Reference proteome; Tryptophan biosynthesis.
SQ   SEQUENCE   433 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPLKKLKPVD PLKLYSALRD FGMPFMLRSA EKDSRKARFT YISAEPEFVV EVGEGTEIDG
     ERVSDERNPL RALKGLMGER VEGRRFMGGF VGYVSYDSVH SIIGGKIEEP SVFGYYPWTF
     IYDHSTGALS FFYLREAPFD PEALVERARR EESRLEDGGS EVISTDAGME EFVEIVRAGK
     EYIYSGDVFQ VVLSREYRVR TDLDALEIYK RLVELNPSPY TFILEFEKTV VGASPETMGS
     VEGRTFKINP IAGTAPRGRT GEEDRELEKA LLSDEKERAE HVMLVDLARN DVRRVSKPGS
     VRLTRFFDVL KYSHVQHIES EVVGELDEGK NAFDAMEAAF PAGTLTGAPK IRAMEIIDEL
     ERSRRKVYGG AVGYFSLTGD ADMAIAIRMA EIEGRKASVR AGAGIVADSV PEKEFFETEN
     KMRAVLKALG VRE
//

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