(data stored in SCRATCH3701 zone)

HOGENOM6: THSCO1_1_PE471

ID   THSCO1_1_PE471                       STANDARD;      PRT;   805 AA.
AC   THSCO1_1_PE471; E8PLN9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, subunit A; EC=5.99.1 3; (THSCO1_1.PE471).
GN   Name=gyrA; OrderedLocusNames=TSC_c04920;
OS   THERMUS SCOTODUCTUS SA-01.
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=743525;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS THSCO1_1.PE471.
CC       Thermus scotoductus SA-01 chromosome, complete genome.
CC       genome shotgun sequence.
CC   -!- ANNOTATIONS ORIGIN:E8PLN9_THESS
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E8PLN9; -.
DR   EMBL; CP001962; ADW21124.1; -; Genomic_DNA.
DR   RefSeq; YP_004201673.1; NC_014974.1.
DR   GeneID; 10176613; -.
DR   GenomeReviews; CP001962_GR; TSC_c04920.
DR   KEGG; tsc:TSC_c04920; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; THSCO1_1.PE471; -.
DR   PRODOM; THSCO1_1_PE471.
DR   SWISS-2DPAGE; THSCO1_1_PE471.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   805 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSQVLPVEIT EELKQSFINY AMSVIVDRAL PDVRDGLKPV QRRILFGAYQ EGVLPGRKHV
     KSAKIVGEVM GKYHPHGDAA IYDALARLAQ PWNLRYPLVD GQGNFGSLDG DPPAAQRYTE
     ARLSPLGAEM LLDIDKETVD FRPNYDGSLK EPEVLPSAIP NLLVNGASGI AVGMATSLPP
     HNLSEVVDAL VAMIDNPGIT LEEVMRYLPG PDFPTGGKLS RKGIQEAYAT GRGSLKVRAK
     VRIEEKGQRP MLVVTEIPYQ VNKAGLIAQI AALVKAKKIE DIVALRDESD RQGLRIAIEL
     KRGASPQVVL NQLYKHTALQ TSFTVNLLAI VNGEPKVLPL LSLMRHYLDH RKEVVRRRSL
     FDLKKAEERA HVLEGLLIAL DHIDEVIALI RASQDASEAR KGLMERFGLS EIQAQAILDM
     RLQRLVALER EKLLEEYREL MEEIARLKAI LEEEGRLWAE VKKDLLRVKE KYGDARRTVI
     TEFEDSFNPE DLIEDEPMVI TLTAQGFLKR LPLESYRAQG RGGKGLIAGK TKEEDEAIQV
     FVAQAHEDLL LFTNRGRVYR LKVYELPEMG RQARGVHVKT LLPLAEEEEV AALLSVRGLD
     GEGYLVFATE RGLVKRTALR EYQNLGAAGL IAIRLLEGDR LIGVALSDPE DEAILATEEG
     QAIRFALEEV RATGRDSQGV TGIRFKKPGD RVVSLVTVKP GEMVDLLAVS TRGYGKRTPL
     AEYPLQGRGG MGVITYKVST KVGRLAALLK VRGTEDLLVL SKKGLAIRTP VADIRQYSRD
     TAGVKVMNLP EDDEVVSAFA VEEEQ
//

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