(data stored in ACNUC7421 zone)

HOGENOM: TRBRU1_13_PE1059

ID   TRBRU1_13_PE1059                     STANDARD;      PRT;   386 AA.
AC   TRBRU1_13_PE1059; Q383H9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (TRBRU1_13.PE1059).
GN   ORFNames=Tb11.01.2780;
OS   TRYPANOSOMA BRUCEI TREU927.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS TRBRU1_13.PE1059.
CC       Trypanosoma brucei TREU927 chromosome 11 scaffold 1, whole genome shotg
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:MTNA_TRYB2
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q383H9; -.
DR   EMBL; CH464491; EAN80052.1; -; Genomic_DNA.
DR   RefSeq; XP_829164.1; XM_824071.1.
DR   ProteinModelPortal; Q383H9; -.
DR   SMR; Q383H9; 5-384.
DR   STRING; Q383H9; -.
DR   GeneID; 3665668; -.
DR   KEGG; tbr:Tb11.01.2780; -.
DR   EuPathDB; EupathDB:Tb11.01.2780; -.
DR   eggNOG; KOG1468; -.
DR   ProtClustDB; CLSZ2430389; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; TRBRU1_13.PE1059; -.
KW   translation initiation factor 2 subunit;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; Isomerase;
KW   Methionine biosynthesis; Nucleus.
SQ   SEQUENCE   386 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSSAHNTLES IKYRRGVLQL LDQRRLPLET VYCDITSIDD ICCAIKEMRV RGAPAIAVSA
     ALALAVVAER ELKEQRQNSV WKTADDMRQF LLMSCDKMMS ARPTAVNLSK VLIQLKKDIE
     TDKANTMEAV LETCVQLAEK IYAADVSFNE RIMRHGAAHL LKLASKERVN ILTICNTGAL
     ATSRYGTALG IVRQLFYEGH LQHLYACETR PWNQGARLTV YECVQENIPC TLICDSAVSA
     VMKTHDIDAV VVGADRICKN GDTANKIGTY NLAVAAAYHK VPFFVAAPST TLDPLTPDGE
     GVVIEEREAT EITHIASGGG GLQSDKSNSD YGRKRVVADG PHLKVWNPVF DITPASLITG
     GIITEHGVFP PATAGPLFDI SRIVEP
//

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