(data stored in ACNUC3659 zone)

HOVERGEN: VSP1M_TRIST

ID   VSP1M_TRIST             Reviewed;         260 AA.
AC   Q8AY82;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 35.
DE   RecName: Full=Venom serine protease 1 homolog;
DE   Flags: Precursor;
OS   Trimeresurus stejnegeri (Chinese green tree viper).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea;
OC   Viperidae; Crotalinae; Viridovipera.
OX   NCBI_TaxID=39682;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Lee W.-H., Zhang Y.;
RT   "Molecular cloning and sequence comparison of serine proteases from
RT   the venom of Trimeresurus stejnegeri.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thrombin-like snake venom serine protease.
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
CC   -!- CAUTION: Lacks the conserved His at position 67, which is expected
CC       to be an active site residue.
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CC   -!- GENE_FAMILY: HBG013304 [ FAMILY / ALN / TREE ]
DR   EMBL; AF545575; AAN52346.1; -; mRNA.
DR   HSSP; P00760; 1EZX.
DR   SMR; Q8AY82; 25-260.
DR   HOVERGEN; Q8AY82; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR018114; Peptidase_S1/S6_AS.
DR   InterPro; IPR001254; Peptidase_S1_S6.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q8AY82.
DR   SWISS-2DPAGE; Q8AY82.
KW   Disulfide bond; Glycoprotein; Secreted; Serine protease homolog;
KW   Signal; Toxin.
FT   DOMAIN       10     66       PRODOM:2005.1:PD474467  1445
FT   DOMAIN       68    113       PRODOM:2005.1:PD623661  90
FT   DOMAIN      118    153       PRODOM:2005.1:PD702116  144
FT   DOMAIN      157    195       PRODOM:2005.1:PD745353  91
FT   DOMAIN      196    248       PRODOM:2005.1:PD000068  1525
FT   SIGNAL        1     18       Potential.
FT   PROPEP       19     24       By similarity.
FT                                /FTId=PRO_0000295840.
FT   CHAIN        25    260       Venom serine protease 1 homolog.
FT                                /FTId=PRO_0000295841.
FT   DOMAIN       25    251       Peptidase S1.
FT   CARBOHYD     83     83       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    123    123       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    124    124       N-linked (GlcNAc...) (Potential).
FT   DISULFID     31    165       By similarity.
FT   DISULFID     52     68       By similarity.
FT   DISULFID    100    258       By similarity.
FT   DISULFID    144    212       By similarity.
FT   DISULFID    176    191       By similarity.
FT   DISULFID    202    227       By similarity.
SQ   SEQUENCE   260 AA;  28710 MW;  AC898723EB01ABCD CRC64;
     MVLIRVLANL LILQLSYAQK SSELIIGGDE CNINEHRFLV ALYTFRSRRF HCSGTLINQE
     WVLSAARCDR KNIRIKLGMH STNVTNEDVQ TRVPKEKFFC LSSKTYTKWN KDIMLIRLKR
     PVNNSTHIAP VSLPSNPPSL GSVCRVMGWG TISATKETHP DVPHCANINI LDYSVCRAAY
     ARLPATSRTL CAGILEGGKD TCHGDSGGPL ICNGQVQGIV SWGGHPCGLP RKPGLYTKVF
     DHLDWIKSII AGNKDATCPP
//

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