(data stored in ACNUC7421 zone)

HOGENOM: YALIP1_2_PE501

ID   YALIP1_2_PE501                       STANDARD;      PRT;   372 AA.
AC   YALIP1_2_PE501; Q6CGS4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (YALIP1_2.PE501).
GN   Name=MRI1; OrderedLocusNames=YALI0A16698g;
OS   YARROWIA LIPOLYTICA CLIB122.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YALIP1_2.PE501.
CC       Yarrowia lipolytica (strain E 150 / CLIB 122) chromosome A, complete
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:MTNA_YARLI
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q6CGS4; -.
DR   EMBL; CR382127; CAG84070.1; -; Genomic_DNA.
DR   RefSeq; XP_500138.1; XM_500138.1.
DR   ProteinModelPortal; Q6CGS4; -.
DR   STRING; Q6CGS4; -.
DR   GeneID; 2906518; -.
DR   GenomeReviews; CR382127_GR; YALI0A16698g.
DR   KEGG; yli:YALI0A16698g; -.
DR   eggNOG; fuNOG06631; -.
DR   OMA; EDGWKVI; -.
DR   OrthoDB; EOG4S1XGM; -.
DR   PhylomeDB; Q6CGS4; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; YALIP1_2.PE501; -.
KW   CAG84070.100026476820036002503210000011;
KW   Methylthioribose-1-phosphate isomerase ;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; Isomerase;
KW   Methionine biosynthesis; Nucleus; Reference proteome.
SQ   SEQUENCE   372 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSLEAIRYDE KNHTLTILDQ LRLPHESEYV PINNSDDGWK AIKDMVVRGA PAIAIVAILS
     LAVELVHGGK VSRDQTRAEV GSFISDRLDY LNTSRPTAVN LSDAVGSFKK LVQTQTGSAS
     ELIEAFLSAS HKMLLDDVQD NKNIGKYGLE WIQKNVPQAA NGHKISALTI CNTGSLATAG
     YGTALGIIRA LHEAGVLERV YALETRPYNQ GSRLTAYELV HDGIPATLVT DSMAAALLRK
     NKDIGVIIVG ADRVVLNGDT ANKIGTFQLS ILANHFDRKF IVAAPTTSID VQTKSGEDIE
     IEERPAIELT QVKGVDANKQ PLTVSVAAPG IEVWNPAFDY APYKLIDAIV TEKGVAEKTG
     GEFNLKEFKS AN
//

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