(data stored in ACNUC14238 zone)

HOGENOM: YEASTIII_PE10

ID   YEASTIII_PE10                        STANDARD;      PRT;   1096 AA.
AC   YEASTIII_PE10;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mediator of replication checkpoint protein 1;AltName:
DE   Full=DNA replication checkpoint mediator MRC1; (YEASTIII.PE10).
GN   Name=MRC1; OrderedLocusNames=YCL061C; ORFNames=YCL61C/YCL60C;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTIII.PE10.
CC       Saccharomyces cerevisiae chromosome III EF2 full sequence 1..316617
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MRC1_YEAST
CC   -!- FUNCTION: Required for normal DNA replication. Phosphorylated in
CC       response to DNA replication stress. Phosphorylation allows it to
CC       mediate the activation of RAD53.
CC   -!- SUBUNIT: Interacts with CDC45 in S phase.
CC   -!- INTERACTION:
CC       Q08032:CDC45; NbExp=3; IntAct=EBI-412442, EBI-4292;
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Associated with chromatin
CC       during S phase.
CC   -!- PTM: Phosphorylated by MEC1 and RAD53.
CC   -!- MISCELLANEOUS: Present with 721 molecules/cell in log phase SD
CC       medium.
CC   -!- GENE_FAMILY: HOG000057086 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YCL061C;YCL061C;YCL061C.
DR   EMBL; X53998; - ;
DR   EMBL; X59720; - ;
DR   UniProtKB/Swiss-Prot; P25588; D6VQV6; P25589; P27513; P87003; Q07218; Q8NIN2; -.
DR   EMBL; X59720; CAC42953.1; -; Genomic_DNA.
DR   EMBL; X53998; CAA37945.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07425.1; -; Genomic_DNA.
DR   PIR; S74279; S74279.
DR   RefSeq; NP_009871.2; NM_001178704.1.
DR   ProteinModelPortal; P25588; -.
DR   DIP; DIP-1017N; -.
DR   IntAct; P25588; 9.
DR   MINT; MINT-2732058; -.
DR   STRING; P25588; -.
DR   EnsemblFungi; YCL061C; YCL061C; YCL061C.
DR   GeneID; 850297; -.
DR   KEGG; sce:YCL061C; -.
DR   NMPDR; fig|4932.3.peg.589; -.
DR   CYGD; YCL061c; -.
DR   SGD; S000000566; MRC1.
DR   eggNOG; fuNOG08021; -.
DR   GeneTree; EFGT00050000000138; -.
DR   OMA; DSEVEKM; -.
DR   OrthoDB; EOG4WDHM4; -.
DR   PhylomeDB; P25588; -.
DR   NextBio; 965670; -.
DR   ArrayExpress; P25588; -.
DR   Genevestigator; P25588; -.
DR   GermOnline; YCL061C; Saccharomyces cerevisiae.
DR   GO; GO:0031298; C:replication fork protection complex; IDA:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD.
DR   GO; GO:0006348; P:chromatin silencing at telomere; IMP:SGD.
DR   GO; GO:0006281; P:DNA repair; IMP:SGD.
DR   GO; GO:0000076; P:DNA replication checkpoint; IMP:SGD.
DR   GO; GO:0031573; P:intra-S DNA damage checkpoint; IMP:SGD.
DR   GO; GO:0043570; P:maintenance of DNA repeat elements; IMP:SGD.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; IMP:SGD.
DR   GO; GO:0048478; P:replication fork protection; IMP:SGD.
DR   GO; GO:0000723; P:telomere maintenance; IMP:SGD.
DR   InterPro; IPR018564; Repl_chkpnt_MRC1_dom.
DR   Pfam; PF09444; MRC1; 1.
DR   HOGENOMDNA; YEASTIII.PE10; -.
KW   YCL061C-A100026476820036002503210000011; YCL061C-A1; MRC1_YEAST; X53998;
KW   X59720;
KW   Coiled coil; Complete proteome; DNA replication; Nucleus;
KW   Phosphoprotein; Reference proteome.
SQ   SEQUENCE   1096 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDDALHALSS LTAKKRTTTY KKVAVPILDE NDNTNGNGPN DIDNPPELTG NGFLFANATL
     NRVKNRLEGK KAPEQNHNNG KDRSENSLPT QLISNLYDGG EELEKSEVKD NSYSEKNVSS
     SFTQTQRIPV SIQQDKVFNV PIHSVNDGKP TQLIKEDGLV NETSQALKTP LTTGRPGATQ
     RIDSSGATSQ TQPIKSIEPQ SQIITTSSNH SNALSPKIPI IPTELIGTSP LFQSIQNRGP
     DTQMDVPPQT AHDEDKTQAI GIPQATHQEQ KTQIDTVAQT LQDEVPHTLK IREIQSELAS
     EDSKREKARN VEYKKPQKPI PTKKFFSKES FLADFDDSSS NEDDDIKLEN AHPKPVQNDD
     ELHENKSVEL NLTDETRINE KRVPLLSSYA NNLKREIDSS KCITLDLDSD SDEYGDDDMD
     SIKLSKDESV LPISQLSKAT ILNLKARLSK QNQKLSQRPN KSKDPKVDHN VLLNTLRKAS
     RKQILDHQKE VIETKGLKLE DMAKEKEIVE NLLEQEILRN KRIRQKEKRR EKLEENDFQL
     NAHDSGSDSG SESSGFALSG NEIADYESSG SENDNRRESD SEKEDDEIIL KQKKSHHVKH
     IINESDSDTE VEAKPKEKAD ESLPKRIAIN LGHYGDNIGE DTDKFQETNV LDTQNIEEVM
     AERNTIENEV KDDVYVNEEA DEAIRRQLID KEKLQLKQKE KEHEAKIKEL KKRGVTNFFE
     MEAEESEDEW HGIGGADGEG SDDYDSDLEK MIDDYSKNNF NPHEIREMLA AENKEMDIKM
     INKILYDIKN GGFRNKRAKN SLELELSDDD EDDVLQQYRL KRRELMRKRR LEIGDDAKLV
     KNPKSSAFFE SMVEDIIEYK NPFGAEEEYN LDITSTATDL DTQDNSINVG DNTGNNEQKP
     VDQKNKKVII SEDFVQKSLS FLKSNNYEDF ETDKELSRIQ HGNDEAIEDL YTLKQNSSIK
     SFTNSQTDST TSKTVNTIID LEKRPEDEDE VENGDTSLVG VFKHPSIIKS FASRTDINDK
     FKEGNKTVKI LKSYKTVGSS KASITYMGKT RKLIAPKRKT EGSHRYHHDH HNKKMKMKTK
     TKSNKLFESG QDSFDN
//

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