(data stored in ACNUC7421 zone)

HOGENOM: YEASTII_PE253

ID   YEASTII_PE253                        STANDARD;      PRT;   966 AA.
AC   YEASTII_PE253; P14922; D6VQB2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=General transcriptional corepressor CYC8;AltName:
DE   Full=Glucose repression mediator protein CYC8; (YEASTII.PE253).
GN   Name=CYC8; Synonyms=CRT8, SSN6; OrderedLocusNames=YBR112C;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTII.PE253.
CC       Saccharomyces cerevisiae chromosome II EF2 full sequence 1..813178
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CYC8_YEAST
CC   -!- FUNCTION: Acts as component of the CYC8-TUP1 corepressor complex
CC       which is involved in the repression of many genes in a wide
CC       variety of physiological processes including heme-regulated and
CC       catabolite repressed genes. May also be involved in the
CC       derepression of at least some target genes. The complex is
CC       recruited to target genes by interaction with DNA-bound
CC       transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1.
CC       The complex recruits histone deacetylases to produce a repressive
CC       chromatin structure, interacts with hypoacetylated N-terminal
CC       tails of histones H3 and H4 that have been programmed for
CC       repression by the action of histone deacetylases and interferes
CC       directly with the transcriptional machinery by associating with
CC       the RNA polymerase II mediator complex.
CC   -!- SUBUNIT: Associates with TUP1 to form the CYC8-TUP1 (or TUP1-SSN6)
CC       corepressor complex that is composed of 4 copies of TUP1 and one
CC       copy of CYC8. Interacts with MATALPHA2, CTI6, MIG1, TUP1, SUT1,
CC       RFX1, PGD1, HOS1, HOS2 AND RPD3.
CC   -!- INTERACTION:
CC       P53096:HOS2; NbExp=4; IntAct=EBI-18215, EBI-8475;
CC       P40356:PGD1; NbExp=3; IntAct=EBI-18215, EBI-13268;
CC       P48743:RFX1; NbExp=2; IntAct=EBI-18215, EBI-15036;
CC       P32561:RPD3; NbExp=6; IntAct=EBI-18215, EBI-15864;
CC       P16649:TUP1; NbExp=7; IntAct=EBI-18215, EBI-19654;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- MISCELLANEOUS: Present with 3890 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the CYC8/SSN6 family.
CC   -!- SIMILARITY: Contains 10 TPR repeats.
CC   -!- GENE_FAMILY: HBG000000000 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YBR112C;YBR112C;YBR112C.
DR   EMBL; M17826; - ;
DR   EMBL; M23440; - ;
DR   EMBL; X66247; - ;
DR   EMBL; X78993; - ;
DR   EMBL; Z35981; - ;
DR   UniProtKB/Swiss-Prot; P14922; D6VQB2; -.
DR   EMBL; M23440; AAA34545.1; -; Genomic_DNA.
DR   EMBL; M17826; AAA35103.1; -; Genomic_DNA.
DR   EMBL; X66247; CAA46973.1; -; Genomic_DNA.
DR   EMBL; X78993; CAA55615.1; -; Genomic_DNA.
DR   EMBL; Z35981; CAA85069.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07232.1; -; Genomic_DNA.
DR   PIR; S25365; S25365.
DR   RefSeq; NP_009670.1; NM_001178460.1.
DR   ProteinModelPortal; P14922; -.
DR   SMR; P14922; 32-398.
DR   DIP; DIP-696N; -.
DR   IntAct; P14922; 9.
DR   MINT; MINT-579675; -.
DR   STRING; P14922; -.
DR   PeptideAtlas; P14922; -.
DR   EnsemblFungi; YBR112C; YBR112C; YBR112C.
DR   GeneID; 852410; -.
DR   KEGG; sce:YBR112C; -.
DR   SGD; S000000316; CYC8.
DR   eggNOG; fuNOG07743; -.
DR   GeneTree; EFGT00050000000156; -.
DR   OrthoDB; EOG4KPXK4; -.
DR   ArrayExpress; P14922; -.
DR   Genevestigator; P14922; -.
DR   GermOnline; YBR112C; Saccharomyces cerevisiae.
DR   GO; GO:0017053; C:transcriptional repressor complex; IDA:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003713; F:transcription coactivator activity; IGI:SGD.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:SGD.
DR   GO; GO:0016584; P:nucleosome positioning; IDA:SGD.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR001440; TPR-1.
DR   InterPro; IPR013026; TPR-contain.
DR   InterPro; IPR011990; TPR-like_helical.
DR   InterPro; IPR019734; TPR_repeat.
DR   Gene3D; G3DSA:1.25.40.10; TPR-like_helical; 2.
DR   Pfam; PF00515; TPR_1; 4.
DR   SMART; SM00028; TPR; 10.
DR   PROSITE; PS50005; TPR; 9.
DR   PROSITE; PS50293; TPR_REGION; 1.
DR   HOGENOMDNA; YEASTII.PE253; -.
KW   YBR112C-A100026476820036002503210000011; YBR112C-A1; CYC8_YEAST; M17826;
KW   X66247; X78993; Z35981;
KW   Complete proteome; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat; Repressor; TPR repeat; Transcription;
KW   Transcription regulation.
SQ   SEQUENCE   966 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNPGGEQTIM EQPAQQQQQQ QQQQQQQQQQ AAVPQQPLDP LTQSTAETWL SIASLAETLG
     DGDRAAMAYD ATLQFNPSSA KALTSLAHLY RSRDMFQRAA ELYERALLVN PELSDVWATL
     GHCYLMLDDL QRAYNAYQQA LYHLSNPNVP KLWHGIGILY DRYGSLDYAE EAFAKVLELD
     PHFEKANEIY FRLGIIYKHQ GKWSQALECF RYILPQPPAP LQEWDIWFQL GSVLESMGEW
     QGAKEAYEHV LAQNQHHAKV LQQLGCLYGM SNVQFYDPQK ALDYLLKSLE ADPSDATTWY
     HLGRVHMIRT DYTAAYDAFQ QAVNRDSRNP IFWCSIGVLY YQISQYRDAL DAYTRAIRLN
     PYISEVWYDL GTLYETCNNQ LSDALDAYKQ AARLDVNNVH IRERLEALTK QLENPGNINK
     SNGAPTNASP APPPVILQPT LQPNDQGNPL NTRISAQSAN ATASMVQQQH PAQQTPINSS
     ATMYSNGASP QLQAQAQAQA QAQAQAQAQA QAQAQAQAQA QAQAQAQAQA QAQAQAHAQA
     QAQAQAQAQA QAQAQAQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQLQP LPRQQLQQKG
     VSVQMLNPQQ GQPYITQPTV IQAHQLQPFS TQAMEHPQSS QLPPQQQQLQ SVQHPQQLQG
     QPQAQAPQPL IQHNVEQNVL PQKRYMEGAI HTLVDAAVSS STHTENNTKS PRQPTHAIPT
     QAPATGITNA EPQVKKQKLN SPNSNINKLV NTATSIEENA KSEVSNQSPA VVESNTNNTS
     QEEKPVKANS IPSVIGAQEP PQEASPAEEA TKAASVSPST KPLNTEPESS SVQPTVSSES
     STTKANDQST AETIELSTAT VPAEASPVED EVRQHSKEEN GTTEASAPST EEAEPAASRD
     AEKQQDETAA TTITVIKPTL ETMETVKEEA KMREEEQTSQ EKSPQENTLP RENVVRQVEE
     DENYDD
//

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