(data stored in ACNUC7421 zone)

HOGENOM: YEASTIV_PE263

ID   YEASTIV_PE263                        STANDARD;      PRT;   751 AA.
AC   YEASTIV_PE263; P32356; D6VRY8; E9P9U7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Neutral trehalase; EC=3.2.1 28;AltName:
DE   Full=Alpha,alpha-trehalase;AltName: Full=Alpha,alpha-trehalose
DE   glucohydrolase; (YEASTIV.PE263).
GN   Name=NTH1; Synonyms=NTH; OrderedLocusNames=YDR001C;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTIV.PE263.
CC       Saccharomyces cerevisiae chromosome IV EF2  sequence 1..1531919
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:TREA_YEAST
CC   -!- CATALYTIC ACTIVITY: Alpha,alpha-trehalose + H(2)O = 2 D-glucose.
CC   -!- ENZYME REGULATION: Activated by cAMP-dependent phosphorylation.
CC   -!- SUBUNIT: Homodimer.
CC   -!- INTERACTION:
CC       Q06151:DCS1; NbExp=2; IntAct=EBI-19509, EBI-38973;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- MISCELLANEOUS: Present with 1840 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC   -!- GENE_FAMILY: HOG000192885 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YDR001C;YDR001C;YDR001C.
DR   EMBL; M13000; - ;
DR   EMBL; X65925; - ;
DR   EMBL; Z48008; - ;
DR   UniProtKB/Swiss-Prot; P32356; D6VRY8; E9P9U7; -.
DR   EMBL; X65925; CAA46718.1; -; Genomic_DNA.
DR   EMBL; Z48008; CAA88061.1; -; Genomic_DNA.
DR   EMBL; M13000; AAA66896.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA11848.1; -; Genomic_DNA.
DR   PIR; S50982; S50982.
DR   RefSeq; NP_010284.1; NM_001180309.1.
DR   ProteinModelPortal; P32356; -.
DR   DIP; DIP-1479N; -.
DR   IntAct; P32356; 15.
DR   MINT; MINT-392566; -.
DR   STRING; P32356; -.
DR   CAZy; GH37; Glycoside Hydrolase Family 37.
DR   PeptideAtlas; P32356; -.
DR   EnsemblFungi; YDR001C; YDR001C; YDR001C.
DR   GeneID; 851564; -.
DR   KEGG; sce:YDR001C; -.
DR   NMPDR; fig|4932.3.peg.1026; -.
DR   CYGD; YDR001c; -.
DR   SGD; S000002408; NTH1.
DR   eggNOG; fuNOG05742; -.
DR   OMA; RQWDYPY; -.
DR   OrthoDB; EOG4WQ49Q; -.
DR   PhylomeDB; P32356; -.
DR   NextBio; 969004; -.
DR   ArrayExpress; P32356; -.
DR   Genevestigator; P32356; -.
DR   GermOnline; YDR001C; Saccharomyces cerevisiae.
DR   GO; GO:0005829; C:cytosol; TAS:SGD.
DR   GO; GO:0004555; F:alpha,alpha-trehalase activity; TAS:SGD.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006950; P:response to stress; TAS:SGD.
DR   GO; GO:0005993; P:trehalose catabolic process; TAS:SGD.
DR   InterPro; IPR008928; 6-hairpin_glycosidase-like.
DR   InterPro; IPR001661; Glyco_hydro_37.
DR   InterPro; IPR018232; Glyco_hydro_37_CS.
DR   InterPro; IPR011120; Trehalase_Ca-bd.
DR   PANTHER; PTHR23403; Glyco_hydro_37; 1.
DR   Pfam; PF01204; Trehalase; 1.
DR   Pfam; PF07492; Trehalase_Ca-bi; 1.
DR   PRINTS; PR00744; GLHYDRLASE37.
DR   SUPFAM; SSF48208; Glyco_trans_6hp; 1.
DR   PROSITE; PS00927; TREHALASE_1; 1.
DR   PROSITE; PS00928; TREHALASE_2; 1.
DR   HOGENOMDNA; YEASTIV.PE263; -.
KW   YDR001C-A100026476820036002503210000011; YDR001C-A1; TREA_YEAST;
KW   M13000; X65925; Z48008;
KW   Complete proteome; Cytoplasm; Glycosidase; Hydrolase; Phosphoprotein;
KW   Reference proteome.
SQ   SEQUENCE   751 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSQVNTSQGP VAQGRQRRLS SLSEFNDPFS NAEVYYGPPT DPRKQKQAKP AKINRTRTMS
     VFDNVSPFKK TGFGKLQQTR RGSEDDTYSS SQGNRRFFIE DVDKTLNELL AAEDTDKNYQ
     ITIEDTGPKV LKVGTANSYG YKHINIRGTY MLSNLLQELT IAKSFGRHQI FLDEARINEN
     PVNRLSRLIN TQFWNSLTRR VDLNNVGEIA KDTKIDTPGA KNPRIYVPYD CPEQYEFYVQ
     ASQMHPSLKL EVEYLPKKIT AEYVKSVNDT PGLLALAMEE HFNPSTGEKT LIGYPYAVPG
     GRFNELYGWD SYMMALGLLE ANKTDVARGM VEHFIFEINH YGKILNANRS YYLCRSQPPF
     LTEMALVVFK KLGGRSNPDA VDLLKRAFQA SIKEYKTVWT ASPRLDPETG LSRYHPNGLG
     IPPETESDHF DTVLLPYASK HGVTLDEFKQ LYNDGKIKEP KLDEFFLHDR GVRESGHDTT
     YRFEGVCAYL ATIDLNSLLY KYEIDIADFI KEFCDDKYED PLDHSITTSA MWKEMAKIRQ
     EKITKYMWDD ESGFFFDYNT KIKHRTSYES ATTFWALWAG LATKEQAQKM VEKALPKLEM
     LGGLAACTER SRGPISISRP IRQWDYPFGW APHQILAWEG LRSYGYLTVT NRLAYRWLFM
     MTKAFVDYNG IVVEKYDVTR GTDPHRVEAE YGNQGADFKG AATEGFGWVN ASYILGLKYM
     NSHARRALGA CIPPISFFSS LRPQERNLYG L
//

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