(data stored in ACNUC8465 zone)

HOGENOM: YEASTIV_PE95

ID   YEASTIV_PE95                         STANDARD;      PRT;   515 AA.
AC   YEASTIV_PE95; P06784; D6VRJ2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Serine/threonine-protein kinase STE7; EC=2.7.12 2;
DE   (YEASTIV.PE95).
GN   Name=STE7; OrderedLocusNames=YDL159W; ORFNames=D1525;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTIV.PE95.
CC       Saccharomyces cerevisiae chromosome IV EF2  sequence 1..1531919
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:STE7_YEAST
CC   -!- FUNCTION: Serine/threonine protein kinase required for cell-type-
CC       specific transcription and signal transduction in yeast. It is
CC       thought that it is phosphorylated by the ste11 protein kinase and
CC       that it can phosphorylate the FUS3 and or KSS1 kinases.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Phosphorylated at multiple sites in response to
CC       pheromone.
CC   -!- INTERACTION:
CC       Q00684:CDC14; NbExp=2; IntAct=EBI-18389, EBI-4192;
CC       P16892:FUS3; NbExp=11; IntAct=EBI-18389, EBI-7193;
CC       P32485:HOG1; NbExp=2; IntAct=EBI-18389, EBI-8437;
CC       P14681:KSS1; NbExp=15; IntAct=EBI-18389, EBI-9945;
CC       P32917:STE5; NbExp=8; IntAct=EBI-18389, EBI-18373;
CC   -!- MISCELLANEOUS: Present with 672 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YDL159W;YDL159W;YDL159W.
DR   EMBL; M14097; - ;
DR   EMBL; X97751; - ;
DR   EMBL; Z67750; - ;
DR   EMBL; Z74207; - ;
DR   UniProtKB/Swiss-Prot; P06784; D6VRJ2; -.
DR   EMBL; M14097; AAA35118.1; -; Genomic_DNA.
DR   EMBL; Z67750; CAA91587.1; -; Genomic_DNA.
DR   EMBL; Z74207; CAA98732.1; -; Genomic_DNA.
DR   EMBL; X97751; CAA66332.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA11702.1; -; Genomic_DNA.
DR   PIR; A25048; A25048.
DR   RefSeq; NP_010122.1; NM_001180219.1.
DR   ProteinModelPortal; P06784; -.
DR   SMR; P06784; 185-476.
DR   DIP; DIP-9N; -.
DR   IntAct; P06784; 12.
DR   MINT; MINT-411435; -.
DR   STRING; P06784; -.
DR   PeptideAtlas; P06784; -.
DR   EnsemblFungi; YDL159W; YDL159W; YDL159W.
DR   GeneID; 851396; -.
DR   KEGG; sce:YDL159W; -.
DR   NMPDR; fig|4932.3.peg.858; -.
DR   CYGD; YDL159w; -.
DR   SGD; S000002318; STE7.
DR   eggNOG; fuNOG07450; -.
DR   GeneTree; EFGT00050000000597; -.
DR   OMA; GLMIIEL; -.
DR   OrthoDB; EOG43V342; -.
DR   PhylomeDB; P06784; -.
DR   BRENDA; 2.7.12.2; 984.
DR   NextBio; 968558; -.
DR   ArrayExpress; P06784; -.
DR   Genevestigator; P06784; -.
DR   GermOnline; YDL159W; Saccharomyces cerevisiae.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0043332; C:mating projection tip; IDA:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IDA:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0071508; P:activation of MAPK activity involved in conjugation with cellular fusion; IMP:SGD.
DR   GO; GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
DR   GO; GO:0000196; P:MAPKKK cascade involved in cell wall biogenesis; IGI:SGD.
DR   GO; GO:0007124; P:pseudohyphal growth; IMP:SGD.
DR   GO; GO:0010525; P:regulation of transposition, RNA-mediated; IMP:SGD.
DR   GO; GO:0001402; P:signal transduction involved in filamentous growth; IMP:SGD.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; YEASTIV.PE95; -.
KW   YDL159W-A100026476820036002503210000011; YDL159W-A1; STE7_YEAST; M14097;
KW   Z67750; Z74207;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Pheromone response; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   515 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFQRKTLQRR NLKGLNLNLH PDVGNNGQLQ EKTETHQGQS RIEGHVMSNI NAIQNNSNLF
     LRRGIKKKLT LDAFGDDQAI SKPNTVVIQQ PQNEPVLVLS SLSQSPCVSS SSSLSTPCII
     DAYSNNFGLS PSSTNSTPST IQGLSNIATP VENEHSISLP PLEESLSPAA ADLKDTLSGT
     SNGNYIQLQD LVQLGKIGAG NSGTVVKALH VPDSKIVAKK TIPVEQNNST IINQLVRELS
     IVKNVKPHEN IITFYGAYYN QHINNEIIIL MEYSDCGSLD KILSVYKRFV QRGTVSSKKT
     WFNELTISKI AYGVLNGLDH LYRQYKIIHR DIKPSNVLIN SKGQIKLCDF GVSKKLINSI
     ADTFVGTSTY MSPERIQGNV YSIKGDVWSL GLMIIELVTG EFPLGGHNDT PDGILDLLQR
     IVNEPSPRLP KDRIYSKEMT DFVNRCCIKN ERERSSIHEL LHHDLIMKYV SPSKDDKFRH
     WCRKIKSKIK EDKRIKREAL DRAKLEKKQS ERSTH
//

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