(data stored in ACNUC9543 zone)

HOGENOM: YEASTVII_PE149

ID   YEASTVII_PE149                       STANDARD;      PRT;   767 AA.
AC   YEASTVII_PE149; P53131; D6VU28;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43;
DE   EC=3.6.4 13;AltName: Full=Helicase JA1; (YEASTVII.PE149).
GN   Name=PRP43; OrderedLocusNames=YGL120C;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTVII.PE149.
CC       Saccharomyces cerevisiae chromosome VII EF2  sequence 1..1090947
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:PRP43_YEAST
CC   -!- FUNCTION: Pre-mRNA processing factor involved in disassembly of
CC       spliceosomes after the release of mature mRNA.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBUNIT: Component of the NTR complex (NTC-related complex),
CC       composed of NTR1, NTR2 and PRP43. Interacts with NTR1 and NTR2.
CC   -!- INTERACTION:
CC       Q06411:SPP382; NbExp=10; IntAct=EBI-505, EBI-576;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- MISCELLANEOUS: Present with 16900 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. DDX15/PRP43 sub-subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YGL120C;YGL120C;YGL120C.
DR   EMBL; U41851; - ;
DR   EMBL; Z72642; - ;
DR   UniProtKB/Swiss-Prot; P53131; D6VU28; -.
DR   EMBL; U41851; AAB86458.1; -; Genomic_DNA.
DR   EMBL; Z72642; CAA96828.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA07989.1; -; Genomic_DNA.
DR   PIR; S64130; S64130.
DR   RefSeq; NP_011395.1; NM_001180985.1.
DR   PDB; 2XAU; X-ray; 1.90 A; A/B=1-767.
DR   PDB; 3KX2; X-ray; 2.20 A; A/B=1-767.
DR   PDBsum; 2XAU; -.
DR   PDBsum; 3KX2; -.
DR   ProteinModelPortal; P53131; -.
DR   SMR; P53131; 1-755.
DR   DIP; DIP-5152N; -.
DR   IntAct; P53131; 80.
DR   MINT; MINT-497996; -.
DR   STRING; P53131; -.
DR   PeptideAtlas; P53131; -.
DR   EnsemblFungi; YGL120C; YGL120C; YGL120C.
DR   GeneID; 852757; -.
DR   KEGG; sce:YGL120C; -.
DR   NMPDR; fig|4932.3.peg.2500; -.
DR   CYGD; YGL120c; -.
DR   SGD; S000003088; PRP43.
DR   eggNOG; fuNOG07597; -.
DR   GeneTree; EFGT00050000000163; -.
DR   OMA; VIYNEFV; -.
DR   OrthoDB; EOG4S7NZ4; -.
DR   PhylomeDB; P53131; -.
DR   NextBio; 972201; -.
DR   ArrayExpress; P53131; -.
DR   Genevestigator; P53131; -.
DR   GermOnline; YGL120C; Saccharomyces cerevisiae.
DR   GO; GO:0030686; C:90S preribosome; IDA:SGD.
DR   GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IMP:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004004; F:ATP-dependent RNA helicase activity; IDA:SGD.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGDR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGDDR   GO; GO:000

0462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGDDR   GO; GO:0000390; P:spliceosome disassembly; IDA:SGD.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGDDR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGDDR   GO; GO:000

0390; P:spliceosome disassembly; IDA:SGD.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGDDR   GO; GO:0000390; P:spliceosome disassembly; IDA:SGD.
DR   GO; GO:0000390; P:spliceosome disassembly; IDA:SGD.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   HOGENOMDNA; YEASTVII.PE149; -.
KW   YGL120C-A100026476820036002503210000011; YGL120C-A1; PRP43_YEAST; U41851;
KW   Z72642;
KW   3D-structure; ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Reference proteome.
SQ   SEQUENCE   767 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGSKRRFSSE HPDPVETSIP EQAAEIAEEL SKQHPLPSEE PLVHHDAGEF KGLQRHHTSA
     EEAQKLEDGK INPFTGREFT PKYVDILKIR RELPVHAQRD EFLKLYQNNQ IMVFVGETGS
     GKTTQIPQFV LFDEMPHLEN TQVACTQPRR VAAMSVAQRV AEEMDVKLGE EVGYSIRFEN
     KTSNKTILKY MTDGMLLREA MEDHDLSRYS CIILDEAHER TLATDILMGL LKQVVKRRPD
     LKIIIMSATL DAEKFQRYFN DAPLLAVPGR TYPVELYYTP EFQRDYLDSA IRTVLQIHAT
     EEAGDILLFL TGEDEIEDAV RKISLEGDQL VREEGCGPLS VYPLYGSLPP HQQQRIFEPA
     PESHNGRPGR KVVISTNIAE TSLTIDGIVY VVDPGFSKQK VYNPRIRVES LLVSPISKAS
     AQQRAGRAGR TRPGKCFRLY TEEAFQKELI EQSYPEILRS NLSSTVLELK KLGIDDLVHF
     DFMDPPAPET MMRALEELNY LACLDDEGNL TPLGRLASQF PLDPMLAVML IGSFEFQCSQ
     EILTIVAMLS VPNVFIRPTK DKKRADDAKN IFAHPDGDHI TLLNVYHAFK SDEAYEYGIH
     KWCRDHYLNY RSLSAADNIR SQLERLMNRY NLELNTTDYE SPKYFDNIRK ALASGFFMQV
     AKKRSGAKGY ITVKDNQDVL IHPSTVLGHD AEWVIYNEFV LTSKNYIRTV TSVRPEWLIE
     IAPAYYDLSN FQKGDVKLSL ERIKEKVDRL NELKQGKNKK KSKHSKK
//

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