(data stored in ACNUC6288 zone)

HOGENOM: YEASTVII_PE363

ID   YEASTVII_PE363                       STANDARD;      PRT;   651 AA.
AC   YEASTVII_PE363; P12754; D6VUL5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Translation initiation factor eIF-2B subunit delta;AltName:
DE   Full=GCD complex subunit GCD2;AltName: Full=Guanine nucleotide exchange
DE   factor subunit GCD2;AltName: Full=eIF-2B GDP-GTP exchange factor subunit
DE   delta; (YEASTVII.PE363).
GN   Name=GCD2; Synonyms=TIF224; OrderedLocusNames=YGR083C;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTVII.PE363.
CC       Saccharomyces cerevisiae chromosome VII EF2  sequence 1..1090947
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:EI2BD_YEAST
CC   -!- FUNCTION: Acts as essential component of the translation
CC       initiation factor 2B (eIF2-B or GCD complex), which catalyzes the
CC       exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for
CC       GTP and is regulated by phosphorylated eIF-2. It activates the
CC       synthesis of GCN4 in yeast under amino acid starvation conditions
CC       by suppressing the inhibitory effects of multiple AUG codons
CC       present in the leader of GCN4 mRNA. It may promote either
CC       repression or activation of GCN4 expression depending on amino
CC       acid availability. GCD2 is also required for cell viability. Its
CC       function can partially be replaced by GCN3 under normal growth
CC       conditions in GCD2-defective mutants, under AA starvation
CC       conditions GCN3 is an antagonist (GCN4 translational activator).
CC   -!- SUBUNIT: Translation initiation factor 2B (eIF2-B) is composed of
CC       five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1),
CC       delta (GCD2) and epsilon (GCD6). A regulatory subcomplex
CC       comprising GCN3, GCD7 and GCD2 interacts preferentially with
CC       phosphorylated eIF-2 and has no exchange activity in vitro.
CC   -!- INTERACTION:
CC       P32502:GCD7; NbExp=7; IntAct=EBI-6265, EBI-6260;
CC       P14741:GCN3; NbExp=5; IntAct=EBI-6265, EBI-6253;
CC   -!- MISCELLANEOUS: Present with 10300 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family.
CC   -!- GENE_FAMILY: HOG000176924 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YGR083C;YGR083C;YGR083C.
DR   EMBL; X15658; - ;
DR   EMBL; Z72868; - ;
DR   UniProtKB/Swiss-Prot; P12754; D6VUL5; -.
DR   EMBL; X15658; CAA33693.1; -; Genomic_DNA.
DR   EMBL; Z72868; CAA97085.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA08176.1; -; Genomic_DNA.
DR   PIR; S05809; RGBYD2.
DR   RefSeq; NP_011597.1; NM_001181212.1.
DR   ProteinModelPortal; P12754; -.
DR   SMR; P12754; 291-649.
DR   DIP; DIP-2343N; -.
DR   IntAct; P12754; 16.
DR   MINT; MINT-485124; -.
DR   STRING; P12754; -.
DR   PeptideAtlas; P12754; -.
DR   EnsemblFungi; YGR083C; YGR083C; YGR083C.
DR   GeneID; 852974; -.
DR   KEGG; sce:YGR083C; -.
DR   NMPDR; fig|4932.3.peg.2714; -.
DR   CYGD; YGR083c; -.
DR   SGD; S000003315; GCD2.
DR   eggNOG; fuNOG04966; -.
DR   GeneTree; EFGT00050000003246; -.
DR   OMA; PVILREY; -.
DR   OrthoDB; EOG4B01Z5; -.
DR   PhylomeDB; P12754; -.
DR   NextBio; 972768; -.
DR   ArrayExpress; P12754; -.
DR   Genevestigator; P12754; -.
DR   GermOnline; YGR083C; Saccharomyces cerevisiae.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:SGD.
DR   GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:SGD.
DR   GO; GO:0030234; F:enzyme regulator activity; IMP:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003743; F:translation initiation factor activity; IMP:SGD.
DR   GO; GO:0006446; P:regulation of translational initiation; IDA:SGD.
DR   InterPro; IPR000649; IF-2B-related.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   HOGENOMDNA; YEASTVII.PE363; -.
KW   YGR083C-A100026476820036002503210000011; YGR083C-A1; EI2BD_YEAST; X15658;
KW   Z72868;
KW   Complete proteome; Initiation factor; Phosphoprotein;
KW   Protein biosynthesis; Reference proteome; Repressor;
KW   Translation regulation.
SQ   SEQUENCE   651 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSESEAKSRS ATPPSKAKQA TPTTTAAANG EKKLTNKELK ELKKQEKAAK RAAMKQANGI
     SIEQQQQQAQ MKKEKKQLQR EQQQKREQKQ KNANKKKQNE RNVKKSTLFG HLETTEERRA
     TILALTSAVS SPKTSRITAA GLMVPVVASA LSGSNVLTAS SLMPVGPNAS STVSASAPAS
     TTTTLPASSA ALSAGTSSAS TNTPTAIQQE IASSNASDVA KTLASISLEA GEFNVIPGIS
     SVIPTVLEQS FDNSSLISSV KELLLNKDLI HPSILLLTSH LAHYKIVGSI PRCIAMLEVF
     QIVIKDYQTP KGTTLSRNLT SYLSHQIDLL KKARPLSVTM GNAIRWLKQE ISLIDPSTPD
     KAAKKDLCEK IGQFAKEKIE LADQLIIDNA STQIEESTTI VTYGSSKVLT ELLLHNAISL
     KKNIKVIVVD SRPLFEGRKM AETLRNAGVN VMYALITSLD TIFNMDVDYV FLGAHSILSN
     GFLYSRAGTA MLAMSAKRRN IPVLVCCESL KFSQRVQLDS VTFNELADPN DLVNIDYENP
     VERRGNKGAL LNQFIKERKF EKKKLAMENK PKGNKIGGKK GSEGESKDAS NEEDSNSKNI
     LDGWQELPSL NIVNILYDLT PPEYIKKVIT EFGALPPSSV PVILREYKGS A
//

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