(data stored in ACNUC9543 zone)

HOGENOM: YEASTV_PE107

ID   YEASTV_PE107                         STANDARD;      PRT;   1145 AA.
AC   YEASTV_PE107; P24384; D3DLR0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22;
DE   EC=3.6.4 13; (YEASTV.PE107).
GN   Name=PRP22; OrderedLocusNames=YER013W;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTV.PE107.
CC       Saccharomyces cerevisiae chromosome V EF2 full sequence 1..576869 annot
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:PRP22_YEAST
CC   -!- FUNCTION: Acts late in the splicing of pre-mRNA. Mediates the
CC       release of the spliced mRNA from spliceosomes.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- MISCELLANEOUS: Present with 907 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. DDX8/PRP22 sub-subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- SIMILARITY: Contains 1 S1 motif domain.
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YER013W;YER013W;YER013W.
DR   EMBL; BK006939; - ;
DR   EMBL; U18778; - ;
DR   EMBL; X58681; - ;
DR   UniProtKB/Swiss-Prot; P24384; D3DLR0; -.
DR   EMBL; X58681; CAA41530.1; -; Genomic_DNA.
DR   EMBL; U18778; AAB64546.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07664.1; -; Genomic_DNA.
DR   PIR; S13643; S13643.
DR   RefSeq; NP_010929.1; NM_001178904.1.
DR   ProteinModelPortal; P24384; -.
DR   SMR; P24384; 170-264, 473-1105.
DR   DIP; DIP-655N; -.
DR   IntAct; P24384; 6.
DR   MINT; MINT-648209; -.
DR   STRING; P24384; -.
DR   EnsemblFungi; YER013W; YER013W; YER013W.
DR   GeneID; 856732; -.
DR   KEGG; sce:YER013W; -.
DR   NMPDR; fig|4932.3.peg.1988; -.
DR   CYGD; YER013w; -.
DR   SGD; S000000815; PRP22.
DR   eggNOG; fuNOG04413; -.
DR   GeneTree; EFGT00050000000163; -.
DR   OrthoDB; EOG45TGW9; -.
DR   PhylomeDB; P24384; -.
DR   NextBio; 982846; -.
DR   ArrayExpress; P24384; -.
DR   Genevestigator; P24384; -.
DR   GermOnline; YER013W; Saccharomyces cerevisiae.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IMP:SGD.
DR   GO; GO:0071021; C:U2-type post-spliceosomal complex; IMP:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004004; F:ATP-dependent RNA helicase activity; IDA:SGD.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IDA:SGD.
DR   GO; GO:0000390; P:spliceosome disassembly; IMP:SGD.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR016027; NA-bd_OB-fold-like.
DR   InterPro; IPR003029; Rbsml_prot_S1_RNA-bd_dom.
DR   InterPro; IPR022967; RNA-binding_domain_S1.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; Nucleic_acid_OB; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50126; S1; 1.
DR   HOGENOMDNA; YEASTV.PE107; -.
KW   YER013W-A100026476820036002503210000011; YER013W-A1; PRP22_YEAST;
KW   BK006939; U18778; X58681;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; mRNA processing;
KW   mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein;
KW   Reference proteome.
SQ   SEQUENCE   1145 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSDISKLIGA IVGSDDPVII EFVLNIINKS GNLQEFIRNI QKLDAGISYE DSIKMYNAFL
     GKQEEEKVRN KVKSSPLSQK INQVLKDDVN LDDPVVTEFV LSILNKSKSI TEFQEQLNLM
     QSGLDNETIF KIYQIASPPV MKEEVSVLPS TKIPAKIEAK IEEEVQKIES LDPSPVLHKV
     YEGKVRNITT FGCFVQIFGT RMKNCDGLVH ISEMSDQRTL DPHDVVRQGQ HIFVEVIKIQ
     NNGKISLSMK NIDQHSGEIR KRNTESVEDR GRSNDAHTSR NMKNKIKRRA LTSPERWEIR
     QLIASGAASI DDYPELKDEI PINTSYLTAK RDDGSIVNGN TEKVDSKLEE QQRDETDEID
     VELNTDDGPK FLKDQQVKGA KKYEMPKITK VPRGFMNRSA INGSNAIRDH REEKLRKKRE
     IEQQIRKQQS FDDPTKNKKD SRNEIQMLKN QLIVTEWEKN RMNESISYGK RTSLPISAQR
     QTLPVYAMRS ELIQAVRDNQ FLVIVGETGS GKTTQITQYL DEEGFSNYGM IGCTQPRRVA
     AVSVAKRVAE EVGCKVGHDV GYTIRFEDVT GPDTRIKYMT DGMLQREALL DPEMSKYSVI
     MLDEAHERTV ATDVLFALLK KAAIKRPELK VIVTSATLNS AKFSEYFLNC PIINIPGKTF
     PVEVLYSQTP QMDYIEAALD CVIDIHINEG PGDILVFLTG QEEIDSCCEI LYDRVKTLGD
     SIGELLILPV YSALPSEIQS KIFEPTPKGS RKVVFATNIA ETSITIDGIY YVVDPGFAKI
     NIYNARAGIE QLIVSPISQA QANQRKGRAG RTGPGKCYRL YTESAFYNEM LENTVPEIQR
     QNLSHTILML KAMGINDLLK FDFMDPPPKN LMLNALTELY HLQSLDDEGK LTNLGKEMSL
     FPMDPTLSRS LLSSVDNQCS DEIVTIISML SVQNVFYRPK DRQLEADSKK AKFHHPYGDH
     LTLLNVYTRW QQANYSEQYC KTNFLHFRHL KRARDVKSQI SMIFKKIGLK LISCHSDPDL
     IRKTFVSGFF MNAAKRDSQV GYKTINGGTE VGIHPSSSLY GKEYEYVMYH SIVLTSREYM
     SQVTSIEPQW LLEVAPHFYK AGDAESQSRK KAKIIPLHNK FAKDQNSWRL SSIRQSRERA
     LGIKR
//

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