(data stored in ACNUC30630 zone)

HOGENOM: YEASTV_PE207

ID   YEASTV_PE207                         STANDARD;      PRT;   507 AA.
AC   YEASTV_PE207; P00899; D3DLZ7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (YEASTV.PE207).
GN   Name=TRP2; OrderedLocusNames=YER090W;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTV.PE207.
CC       Saccharomyces cerevisiae chromosome V EF2 full sequence 1..576869 annot
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:TRPE_YEAST
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II.
CC   -!- INTERACTION:
CC       P00937:TRP3; NbExp=4; IntAct=EBI-19575, EBI-19585;
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- MISCELLANEOUS: Present with 6510 molecules/cell in log phase SD
CC       medium.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YER090W;YER090W;YER090W.
DR   EMBL; BK006939; - ;
DR   EMBL; K01388; - ;
DR   EMBL; U18839; - ;
DR   EMBL; X68327; - ;
DR   UniProtKB/Swiss-Prot; P00899; D3DLZ7; -.
DR   EMBL; K01388; AAA35175.1; -; Genomic_DNA.
DR   EMBL; X68327; CAA48402.1; -; Genomic_DNA.
DR   EMBL; U18839; AAB64645.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07751.1; -; Genomic_DNA.
DR   PIR; A49701; NNBY1.
DR   RefSeq; NP_011014.1; NM_001178981.1.
DR   ProteinModelPortal; P00899; -.
DR   SMR; P00899; 35-495.
DR   DIP; DIP-542N; -.
DR   IntAct; P00899; 27.
DR   MINT; MINT-533017; -.
DR   STRING; P00899; -.
DR   PeptideAtlas; P00899; -.
DR   EnsemblFungi; YER090W; YER090W; YER090W.
DR   GeneID; 856824; -.
DR   KEGG; sce:YER090W; -.
DR   NMPDR; fig|4932.3.peg.2088; -.
DR   SGD; S000000892; TRP2.
DR   eggNOG; fuNOG04537; -.
DR   GeneTree; EFGT00050000003836; -.
DR   OMA; SDEKQCA; -.
DR   OrthoDB; EOG4KH63B; -.
DR   PhylomeDB; P00899; -.
DR   NextBio; 983112; -.
DR   ArrayExpress; P00899; -.
DR   Genevestigator; P00899; -.
DR   GermOnline; YER090W; Saccharomyces cerevisiae.
DR   GO; GO:0005950; C:anthranilate synthase complex; IPI:SGD.
DR   GO; GO:0004049; F:anthranilate synthase activity; IDA:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IMP:SGD.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR005256; Anth_synth_I_PabB.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   TIGRFAMs; TIGR00564; TrpE_most; 1.
DR   HOGENOMDNA; YEASTV.PE207; -.
KW   YER090W-B100026476820036002503210000011; YER090W-B1; TRPE_YEAST;
KW   BK006939; K01388; U18839; X68327;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Direct protein sequencing; Lyase; Phosphoprotein;
KW   Reference proteome; Tryptophan biosynthesis.
SQ   SEQUENCE   507 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTASIKIQPD IDSLKQLQQQ NDDSSINMYP VYAYLPSLDL TPHVAYLKLA QLNNPDRKES
     FLLESAKTNN ELDRYSFIGI SPRKTIKTGP TEGIETDPLE ILEKEMSTFK VAENVPGLPK
     LSGGAIGYIS YDCVRYFEPK TRRPLKDVLR LPEAYLMLCD TIIAFDNVFQ RFQIIHNINT
     NETSLEEGYQ AAAQIITDIV SKLTDDSSPI PYPEQPPIKL NQTFESNVGK EGYENHVSTL
     KKHIKKGDII QGVPSQRVAR PTSLHPFNIY RHLRTVNPSP YLFYIDCLDF QIIGASPELL
     CKSDSKNRVI THPIAGTVKR GATTEEDDAL ADQLRGSLKD RAEHVMLVDL ARNDINRICD
     PLTTSVDKLL TIQKFSHVQH LVSQVSGVLR PEKTRFDAFR SIFPAGTVSG APKVRAMELI
     AELEGERRGV YAGAVGHWSY DGKTMDNCIA LRTMVYKDGI AYLQAGGGIV YDSDEYDEYV
     ETMNKMMANH STIVQAEELW ADIVGSA
//

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