(data stored in ACNUC7421 zone)

HOGENOM: YEASTV_PE76

ID   YEASTV_PE76                          STANDARD;      PRT;   551 AA.
AC   YEASTV_PE76; P39998; D3DLN5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Enhancer of mRNA-decapping protein 3; (YEASTV.PE76).
GN   Name=EDC3; Synonyms=LSM16; OrderedLocusNames=YEL015W;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTV.PE76.
CC       Saccharomyces cerevisiae chromosome V EF2 full sequence 1..576869 annot
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:EDC3_YEAST
CC   -!- FUNCTION: Stimulates decapping of both stable and unstable mRNA
CC       during mRNA decay. Does not affect nonsense-mediated mRNA decay.
CC       Required for normal P-body assembly.
CC   -!- SUBUNIT: Homodimer. Interacts with DCP2.
CC   -!- INTERACTION:
CC       Q12517:DCP1; NbExp=5; IntAct=EBI-22300, EBI-38519;
CC       P53550:DCP2; NbExp=6; IntAct=EBI-22300, EBI-270;
CC       P39517:DHH1; NbExp=3; IntAct=EBI-22300, EBI-158;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body. Note=Is concentrated in
CC       several cytoplasmic foci called P bodies (or cytoplasmic
CC       processing bodies) which represent sites of mRNA decapping and 5'
CC       to 3' exonucleotidic decay.
CC   -!- MISCELLANEOUS: Present with 2340 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the EDC3 family.
CC   -!- SIMILARITY: Contains 1 DFDF domain.
CC   -!- SIMILARITY: Contains 1 YjeF N-terminal domain.
CC   -!- GENE_FAMILY: HOG000246503 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YEL015W;YEL015W;YEL015W.
DR   EMBL; BK006939; - ;
DR   EMBL; U18530; - ;
DR   UniProtKB/Swiss-Prot; P39998; D3DLN5; -.
DR   EMBL; U18530; AAB64492.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07639.1; -; Genomic_DNA.
DR   PIR; S50444; S50444.
DR   RefSeq; NP_010901.1; NM_001178830.1.
DR   ProteinModelPortal; P39998; -.
DR   SMR; P39998; 2-67.
DR   DIP; DIP-842N; -.
DR   IntAct; P39998; 24.
DR   MINT; MINT-385078; -.
DR   STRING; P39998; -.
DR   PeptideAtlas; P39998; -.
DR   EnsemblFungi; YEL015W; YEL015W; YEL015W.
DR   GeneID; 856700; -.
DR   KEGG; sce:YEL015W; -.
DR   NMPDR; fig|4932.3.peg.1957; -.
DR   CYGD; YEL015w; -.
DR   SGD; S000000741; EDC3.
DR   eggNOG; fuNOG05594; -.
DR   GeneTree; EFGT00050000003947; -.
DR   OMA; LAMFDKK; -.
DR   OrthoDB; EOG4350GH; -.
DR   PhylomeDB; P39998; -.
DR   NextBio; 982763; -.
DR   ArrayExpress; P39998; -.
DR   Genevestigator; P39998; -.
DR   GermOnline; YEL015W; Saccharomyces cerevisiae.
DR   GO; GO:0000932; C:cytoplasmic mRNA processing body; IDA:SGD.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:SGD.
DR   GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IMP:SGD.
DR   InterPro; IPR019050; DFDF_motif.
DR   InterPro; IPR004443; YjeF_N.
DR   Gene3D; G3DSA:3.40.50.10260; G3DSA:3.40.50.10260; 1.
DR   Pfam; PF09532; DFDF; 1.
DR   Pfam; PF03853; YjeF_N; 1.
DR   SUPFAM; SSF64153; YjeF_N; 1.
DR   PROSITE; PS51512; DFDF; 1.
DR   PROSITE; PS51385; YJEF_N; 1.
DR   HOGENOMDNA; YEASTV.PE76; -.
KW   YEL015W-A100026476820036002503210000011; YEL015W-A1; EDC3_YEAST;
KW   BK006939; U18530;
KW   Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome.
SQ   SEQUENCE   551 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSQFVGFGVQ VELKDGKLIQ GKIAKATSKG LTLNDVQFGD GGKSQAFKVR ASRLKDLKVL
     TVASQSGKRK QQRQQQQQND YNQNRGEHID WQDDDVSKIK QQEDFDFQRN LGMFNKKDVF
     AQLKQNDDIL PENRLQGHNR KQTQLQQNNY QNDELVIPDA KKDSWNKISS RNEQSTHQSQ
     PQQDAQDDLV LEDDEHEYDV DDIDDPKYLP ITQSLNITHL IHSATNSPSI NDKTKGTVIN
     DKDQVLAKLG QMIISQSRSN STSLPAANKQ TTIRSKNTKQ NIPMATPVQL LEMESITSEF
     FSINSAGLLE NFAVNASFFL KQKLGGRARL RLQNSNPEPL VVILASDSNR SGAKALALGR
     HLCQTGHIRV ITLFTCSQNE LQDSMVKKQT DIYKKCGGKI VNSVSSLESA METLNSPVEI
     VIDAMQGYDC TLSDLAGTSE VIESRIKSMI SWCNKQRGST KVWSLDIPNG FDAGSGMPDI
     FFSDRIEATG IICSGWPLIA INNLIANLPS LEDAVLIDIG IPQGAYSQRT SLRKFQNCDL
     FVTDGSLLLD L
//

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