(data stored in ACNUC27125 zone)

HOGENOM: YEASTXIII_PE87

ID   YEASTXIII_PE87                       STANDARD;      PRT;   604 AA.
AC   YEASTXIII_PE87; P14747; D6VZB7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit
DE   A2; EC=3.1.3 16;AltName: Full=Calcineurin A2;AltName:
DE   Full=Calmodulin-binding protein 2; (YEASTXIII.PE87).
GN   Name=CMP2; Synonyms=CNA2; OrderedLocusNames=YML057W;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTXIII.PE87.
CC       Saccharomyces cerevisiae chromosome XIII EF2 full sequence 1..924429
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:PP2B2_YEAST
CC   -!- FUNCTION: Calcium-dependent, calmodulin-stimulated protein
CC       phosphatase. This subunit may have a role in the calmodulin
CC       activation of calcineurin.
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- COFACTOR: Binds 1 Fe(3+) ion per subunit (By similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBUNIT: Composed of two components (A and B), the A component is
CC       the catalytic subunit and the B component confers calcium
CC       sensitivity.
CC   -!- INTERACTION:
CC       P25296:CNB1; NbExp=6; IntAct=EBI-12778, EBI-3968;
CC   -!- MISCELLANEOUS: Present with 7110 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-2B
CC       subfamily.
CC   -!- CAUTION: Was originally (PubMed:2557079) thought to originate from
CC       a rabbit cDNA library and was known as protein phosphatase 2Bw
CC       (PP2Bw).
CC   -!- GENE_FAMILY: HOG000172699 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YML057W;YML057W;YML057W.
DR   EMBL; M64840; - ;
DR   EMBL; X16804; - ;
DR   EMBL; X54964; - ;
DR   EMBL; Z46729; - ;
DR   UniProtKB/Swiss-Prot; P14747; D6VZB7; -.
DR   EMBL; M64840; AAA34466.1; -; Genomic_DNA.
DR   EMBL; X16804; CAA34722.1; -; mRNA.
DR   EMBL; Z46729; CAA86718.1; -; Genomic_DNA.
DR   EMBL; X54964; CAA38712.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA09841.1; -; Genomic_DNA.
DR   PIR; S49804; S49804.
DR   RefSeq; NP_013655.1; NM_001182415.1.
DR   ProteinModelPortal; P14747; -.
DR   SMR; P14747; 68-464.
DR   DIP; DIP-833N; -.
DR   IntAct; P14747; 13.
DR   MINT; MINT-519169; -.
DR   STRING; P14747; -.
DR   PeptideAtlas; P14747; -.
DR   EnsemblFungi; YML057W; YML057W; YML057W.
DR   GeneID; 854946; -.
DR   KEGG; sce:YML057W; -.
DR   NMPDR; fig|4932.3.peg.4693; -.
DR   CYGD; YML057w; -.
DR   SGD; S000004521; CMP2.
DR   eggNOG; fuNOG05461; -.
DR   GeneTree; EFGT00050000001947; -.
DR   OMA; TIQTFEE; -.
DR   OrthoDB; EOG45XC4G; -.
DR   PhylomeDB; P14747; -.
DR   NextBio; 978007; -.
DR   ArrayExpress; P14747; -.
DR   Genevestigator; P14747; -.
DR   GermOnline; YML057W; Saccharomyces cerevisiae.
DR   GO; GO:0005955; C:calcineurin complex; IDA:SGD.
DR   GO; GO:0005737; C:cytoplasm; TAS:SGD.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000754; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fuDR   GO; GO:0006873; P:cellular ion homeostasis; IMP:SGD.
DR   GO; GO:0006873; P:cellular ion homeostasis; IMP:SGD.
DR   InterPro; IPR004843; Metallo_PEstase_dom.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
DR   HOGENOMDNA; YEASTXIII.PE87; -.
KW   YML057W-A100026476820036002503210000011; YML057W-A1; PP2B2_YEAST; M64840;
KW   X54964; Z46729;
KW   Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding;
KW   Phosphoprotein; Protein phosphatase; Reference proteome; Zinc.
SQ   SEQUENCE   604 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSSDAIRNTE QINAAIKIIE NKTERPQSST TPIDSKASTV AAANSTATET SRDLTQYTLD
     DGRVVSTNRR IMNKVPAITS HVPTDEELFQ PNGIPRHEFL RDHFKREGKL SAAQAARIVT
     LATELFSKEP NLISVPAPIT VCGDIHGQYF DLLKLFEVGG DPATTSYLFL GDYVDRGSFS
     FECLIYLYSL KLNFNDHFWL LRGNHECKHL TSYFTFKNEM LHKYNLDIYE KCCESFNNLP
     LAALMNGQYL CVHGGISPEL NSLQDINNLN RFREIPSHGL MCDLLWADPI EEYDEVLDKD
     LTEEDIVNSK TMVPHHGKMA PSRDMFVPNS VRGCSYAFTY RAACHFLQET GLLSIIRAHE
     AQDAGYRMYK NTKTLGFPSL LTLFSAPNYL DTYNNKAAIL KYENNVMNIR QFNMTPHPYW
     LPDFMDVFTW SLPFVGEKVT EMLVAILNIC TEDELENDTP VIEELVGTDK KLPQAGKSEA
     TPQPATSASP KHASILDDEH RRKALRNKIL AVAKVSRMYS VLREETNKVQ FLKDHNSGVL
     PRGALSNGVK GLDEALSTFE RARKHDLINE KLPPSLDELK NENKKYYEKV WQKVHEHDAK
     NDSK
//

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