(data stored in ACNUC8465 zone)

HOGENOM: YEASTXII_PE324

ID   YEASTXII_PE324                       STANDARD;      PRT;   191 AA.
AC   YEASTXII_PE324; P19073; D6VYN1; Q05978;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Cell division control protein 42;AltName: Full=Suppressor
DE   of RHO3 protein 2;Flags: Precursor; (YEASTXII.PE324).
GN   Name=CDC42; Synonyms=SRO2; OrderedLocusNames=YLR229C;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTXII.PE324.
CC       Saccharomyces cerevisiae chromosome XII EF2  sequence 1..1078175
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CDC42_YEAST
CC   -!- FUNCTION: Involved in development of cell polarity during the cell
CC       division cycle, and essential for bud emergence. Affects signaling
CC       in the pheromone-response pathway through the STE20 protein
CC       kinase. Negatively regulated by the GTPase-activating proteins
CC       RGA1, BEM3, and BEM4.
CC   -!- SUBUNIT: Unteracts with AXL2.
CC   -!- INTERACTION:
CC       Q12434:RDI1; NbExp=2; IntAct=EBI-4274, EBI-7525;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC       CDC42 subfamily.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YLR229C;YLR229C;YLR229C.
DR   EMBL; AY557933; - ;
DR   EMBL; U19027; - ;
DR   EMBL; X51906; - ;
DR   UniProtKB/Swiss-Prot; P19073; D6VYN1; Q05978; -.
DR   EMBL; X51906; CAA36186.1; -; Genomic_DNA.
DR   EMBL; U19027; AAB67416.1; -; Genomic_DNA.
DR   EMBL; AY557933; AAS56259.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09547.1; -; Genomic_DNA.
DR   PIR; S51452; S51452.
DR   RefSeq; NP_013330.1; NM_001182116.1.
DR   ProteinModelPortal; P19073; -.
DR   SMR; P19073; 1-179.
DR   DIP; DIP-862N; -.
DR   IntAct; P19073; 6.
DR   MINT; MINT-393961; -.
DR   STRING; P19073; -.
DR   PeptideAtlas; P19073; -.
DR   EnsemblFungi; YLR229C; YLR229C; YLR229C.
DR   GeneID; 850930; -.
DR   KEGG; sce:YLR229C; -.
DR   NMPDR; fig|4932.3.peg.4343; -.
DR   CYGD; YLR229c; -.
DR   SGD; S000004219; CDC42.
DR   eggNOG; fuNOG06758; -.
DR   GeneTree; EFGT00070000008719; -.
DR   OMA; EITHHCQ; -.
DR   OrthoDB; EOG4G1QRM; -.
DR   PhylomeDB; P19073; -.
DR   NextBio; 967367; -.
DR   ArrayExpress; P19073; -.
DR   Genevestigator; P19073; -.
DR   GermOnline; YLR229C; Saccharomyces cerevisiae.
DR   GO; GO:0005935; C:cellular bud neck; TAS:SGD.
DR   GO; GO:0005934; C:cellular bud tip; TAS:SGD.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0043332; C:mating projection tip; IDA:SGD.
DR   GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR   GO; GO:0005625; C:soluble fraction; IDA:SGD.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IDA:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004871; F:signal transducer activity; TAS:SGD.
DR   GO; GO:0007118; P:budding cell apical bud growth; IMP:SGD.
DR   GO; GO:0007119; P:budding cell isotropic bud growth; IMP:SGD.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030010; P:establishment of cell polarity; TAS:SGD.
DR   GO; GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
DR   GO; GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IGI:SGD.
DR   GO; GO:0045921; P:positive regulation of exocytosis; IGI:SGD.
DR   GO; GO:0007124; P:pseudohyphal growth; IMP:SGD.
DR   GO; GO:0007096; P:regulation of exit from mitosis; IMP:SGD.
DR   GO; GO:0031384; P:regulation of initiation of mating projection growth; IMP:SGD.
DR   GO; GO:0032889; P:regulation of vacuole fusion, non-autophagic; IMP:SGD.
DR   GO; GO:0007266; P:Rho protein signal transduction; TAS:SGD.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; YEASTXII.PE324; -.
KW   YLR229C-A100026476820036002503210000011; YLR229C-A1; CDC42_YEAST;
KW   U19027; X51906;
KW   Cell cycle; Cell division; Cell membrane; Complete proteome;
KW   GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding;
KW   Pheromone response; Prenylation; Reference proteome.
SQ   SEQUENCE   191 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQTLKCVVVG DGAVGKTCLL ISYTTNQFPA DYVPTVFDNY AVTVMIGDEP YTLGLFDTAG
     QEDYDRLRPL SYPSTDVFLV CFSVISPPSF ENVKEKWFPE VHHHCPGVPC LVVGTQIDLR
     DDKVIIEKLQ RQRLRPITSE QGSRLARELK AVKYVECSAL TQRGLKNVFD EAIVAALEPP
     VIKKSKKCAI L
//

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