(data stored in ACNUC22857 zone)

HOGENOM: YEASTXI_PE94

ID   YEASTXI_PE94                         STANDARD;      PRT;   726 AA.
AC   YEASTXI_PE94; P36000; D6VX61;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=AP-1 complex subunit beta-1;AltName:
DE   Full=Beta-1-adaptin;AltName: Full=Clathrin assembly protein complex 1
DE   beta-1 large chain;AltName: Full=Clathrin assembly protein large beta-1
DE   chain; (YEASTXI.PE94).
GN   Name=APL2; OrderedLocusNames=YKL135C;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTXI.PE94.
CC       Saccharomyces cerevisiae chromosome XI EF2 full sequence 1..666454
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:AP1B1_YEAST
CC   -!- FUNCTION: Adaptins are components of the adaptor complexes which
CC       link clathrin to receptors in coated vesicles. Clathrin-associated
CC       protein complexes are believed to interact with the cytoplasmic
CC       tails of membrane proteins, leading to their selection and
CC       concentration. The AP-1 complex interacts directly with clathrin.
CC   -!- SUBUNIT: Assembly protein complex 1 (AP-1) is a heterotetramer
CC       composed of two large adaptins (gamma-type subunit APL4 and beta-
CC       type subunit APL2), a medium adaptin (mu-type subunit APM1) and a
CC       small adaptin (sigma-type subunit APS1). Interacts with CHC1.
CC       Interacts with APM2, probably forming an alternative AP-1-like
CC       complex.
CC   -!- INTERACTION:
CC       Q12028:APL4; NbExp=6; IntAct=EBI-2206, EBI-33025;
CC       Q00776:APM1; NbExp=9; IntAct=EBI-2206, EBI-2624;
CC       P38700:APM2; NbExp=7; IntAct=EBI-2206, EBI-2705;
CC       P35181:APS1; NbExp=5; IntAct=EBI-2206, EBI-2612;
CC       P22137:CHC1; NbExp=3; IntAct=EBI-2206, EBI-4766;
CC   -!- SUBCELLULAR LOCATION: Cell membrane. Membrane, coated pit;
CC       Peripheral membrane protein; Cytoplasmic side. Note=Component of
CC       the coat surrounding the cytoplasmic face of coated vesicles in
CC       the plasma membrane.
CC   -!- MISCELLANEOUS: Present with 2690 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC   -!- GENE_FAMILY: HOG000163270 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YKL135C;YKL135C;YKL135C.
DR   EMBL; Z28135; - ;
DR   EMBL; Z30212; - ;
DR   UniProtKB/Swiss-Prot; P36000; D6VX61; -.
DR   EMBL; Z30212; CAA82931.1; -; Genomic_DNA.
DR   EMBL; Z28135; CAA81977.1; -; Genomic_DNA.
DR   EMBL; BK006944; DAA09027.1; -; Genomic_DNA.
DR   PIR; S37964; S37964.
DR   RefSeq; NP_012787.1; NM_001179701.1.
DR   ProteinModelPortal; P36000; -.
DR   SMR; P36000; 22-603.
DR   DIP; DIP-1199N; -.
DR   IntAct; P36000; 52.
DR   MINT; MINT-404361; -.
DR   STRING; P36000; -.
DR   PeptideAtlas; P36000; -.
DR   PRIDE; P36000; -.
DR   EnsemblFungi; YKL135C; YKL135C; YKL135C.
DR   GeneID; 853723; -.
DR   KEGG; sce:YKL135C; -.
DR   NMPDR; fig|4932.3.peg.3768; -.
DR   CYGD; YKL135c; -.
DR   SGD; S000001618; APL2.
DR   eggNOG; fuNOG06950; -.
DR   GeneTree; EFGT00050000000022; -.
DR   OMA; ENPYVRK; -.
DR   OrthoDB; EOG49GPQW; -.
DR   PhylomeDB; P36000; -.
DR   NextBio; 974749; -.
DR   ArrayExpress; P36000; -.
DR   Genevestigator; P36000; -.
DR   GermOnline; YKL135C; Saccharomyces cerevisiae.
DR   GO; GO:0030121; C:AP-1 adaptor complex; IPI:SGD.
DR   GO; GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030276; F:clathrin binding; IPI:SGD.
DR   GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
DR   GO; GO:0006896; P:Golgi to vacuole transport; IMP:SGD.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   InterPro; IPR016342; AP_complex_bsu.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   Gene3D; G3DSA:1.25.10.10; ARM-like; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SUPFAM; SSF48371; ARM-type_fold; 1.
DR   HOGENOMDNA; YEASTXI.PE94; -.
KW   YKL135C-A100026476820036002503210000011; YKL135C-A1; AP1B1_YEAST; Z28135;
KW   Z30212;
KW   Cell membrane; Coated pit; Complete proteome; Membrane;
KW   Phosphoprotein; Reference proteome.
SQ   SEQUENCE   726 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPPLDKRIKK FLKDSIRIAP KISGKGELSE LRTGLVSQYP QTRKDAIKKT IQQMTLGKDV
     SSLFPDVLKN IATIDVEQKK LVYLYVMNYA ETHPELCILA VNTFITDAQD PNPLIRCMAI
     RTMSMIRVDK ILEYIETPLR RTLHDDNAYV RKTAVICVAK LFQLNKDLCV ELGVVEDLVN
     ALDDSNPLVI ANATAALIEI HNMDMDAVDL SSLIQSHVSQ FLLALNECTE WARIIILGTL
     SEYSAKDSLE AQDIIDRVTA HLQHVNPAVV LATIKVIVRN LPQIEYSSNS LIMKRLSSAF
     VSLMSTPPEM QYVALKNIRI ILEKYPELLT KELRIFYVKF NDPLYVKLEK IDILVRLVDP
     SNLKQCTLLL TELKEYAMEY EPEFVSRAIQ ALSQLGIKYA QESFVSKVLD ILLELLERQD
     TIKDDCCISL CDLLRHCPGN DKMAKQVCAV FNTWSNPEVL LQSDIAKCNY VWLLGQHPNN
     FSDLESKINI FIENFVQEEA LTQMSLLMTI VRLHATLTGS MLQSVLELAT QQTHELDVRD
     MAMMYWRCLS MPNNESLVND LCQNKLPMIS NTLEKFSPEV LEKLLMELGT ISSIYFKPDS
     NRRKGKKYVQ NIVKGKHIEE LESMAKNEIS SKANDDVLLD FDERDDVTNT NAGMLNTLTT
     LGDLDDLFDF GPSEDATQIN TNDTKAVQGL KELKLGGDSN GISSGGKNNP DVSGGNIVSQ
     DLLDLF
//

If you have problems or comments...

PBIL Back to PBIL home page