(data stored in ACNUC8465 zone)

HOGENOM: YEASTXVI_PE152

ID   YEASTXVI_PE152                       STANDARD;      PRT;   506 AA.
AC   YEASTXVI_PE152; P32491; D6W3M8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=MAP kinase kinase MKK2/SSP33; EC=2.7.12 2;
DE   (YEASTXVI.PE152).
GN   Name=MKK2; Synonyms=SSP33; OrderedLocusNames=YPL140C; ORFNames=LPI6C;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTXVI.PE152.
CC       Saccharomyces cerevisiae chromosome XVI EF2 full sequence 1..948062
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MKK2_YEAST
CC   -!- FUNCTION: Serine/threonine protein kinase involved in a signal
CC       transduction pathway that play a role in yeast cell morphogenesis
CC       and cell growth. This pathway seems to starts by SMP3; then
CC       involves the kinase PKC1 that may act on the BCK1 kinase that then
CC       phosphorylates MKK1 and MKK2 which themselves phosphorylate the
CC       MPK1 kinase.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- INTERACTION:
CC       Q00772:SLT2; NbExp=5; IntAct=EBI-10973, EBI-17372;
CC   -!- MISCELLANEOUS: Present with 1950 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YPL140C;YPL140C;YPL140C.
DR   EMBL; D13785; - ;
DR   EMBL; U10280; - ;
DR   EMBL; U43703; - ;
DR   UniProtKB/Swiss-Prot; P32491; D6W3M8; -.
DR   EMBL; D13785; BAA02933.1; -; Genomic_DNA.
DR   EMBL; U43703; AAB68220.1; -; Genomic_DNA.
DR   EMBL; U10280; AAB40938.1; -; Genomic_DNA.
DR   EMBL; BK006949; DAA11294.1; -; Genomic_DNA.
DR   PIR; S69045; S69045.
DR   RefSeq; NP_015185.1; NM_001183954.1.
DR   ProteinModelPortal; P32491; -.
DR   SMR; P32491; 211-497.
DR   DIP; DIP-1447N; -.
DR   IntAct; P32491; 29.
DR   MINT; MINT-395755; -.
DR   STRING; P32491; -.
DR   PeptideAtlas; P32491; -.
DR   EnsemblFungi; YPL140C; YPL140C; YPL140C.
DR   GeneID; 855963; -.
DR   KEGG; sce:YPL140C; -.
DR   NMPDR; fig|4932.3.peg.6315; -.
DR   CYGD; YPL140c; -.
DR   SGD; S000006061; MKK2.
DR   eggNOG; fuNOG04753; -.
DR   GeneTree; EFGT00050000000597; -.
DR   OMA; MFRPPES; -.
DR   OrthoDB; EOG4D29ZP; -.
DR   PhylomeDB; P32491; -.
DR   BRENDA; 2.7.12.2; 984.
DR   NextBio; 980765; -.
DR   ArrayExpress; P32491; -.
DR   Genevestigator; P32491; -.
DR   GermOnline; YPL140C; Saccharomyces cerevisiae.
DR   GO; GO:0005622; C:intracellular; TAS:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030242; P:peroxisome degradation; IGI:SGD.
DR   GO; GO:0007165; P:signal transduction; IMP:SGD.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; YEASTXVI.PE152; -.
KW   YPL140C-A100026476820036002503210000011; YPL140C-A1; MKK2_YEAST; D13785;
KW   U43703;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   506 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MASMFRPPES NRSHQKTPKL TLPVNLVQNA KSTNDGQHLN RSPYSSVNES PYSNNSTSAT
     STTSSMASNS TLLYNRSSTT TIKNRPVPPP LPPLVLTQKK DGIEYRVAGD SQLSERFSNL
     HVDITYKELL SSAPISTKLS NIDTTFIKKD LDTPEGEDSY PSTLLSAYDF SSSGSNSAPL
     SANNIISCSN LIQGKDVDQL EEEAWRFGHL KDEITTLGIL GEGAGGSVAK CRLKNGKKVF
     ALKTINTMNT DPEYQKQIFR ELQFNKSFKS DYIVQYYGMF TDEQSSSIYI AMEYMGGKSL
     EATYKNLLKR GGRISERVIG KIAESVLRGL SYLHERKVIH RDIKPQNILL NEKGEIKLCD
     FGVSGEAVNS LAMTFTGTSF YMAPERIQGQ PYSVTCDVWS LGLTLLEVAG GRFPFESDKI
     TQNVAPIELL TMILTFSPQL KDEPELDISW SKTFRSFIDY CLKKDARERP SPRQMLKHPW
     IVGQMKKKVN MERFVKKCWE KEKDGI
//

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