(data stored in ACNUC7421 zone)

HOGENOM: YEASTXVI_PE418

ID   YEASTXVI_PE418                       STANDARD;      PRT;   411 AA.
AC   YEASTXVI_PE418; Q06489; D6W4B7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (YEASTXVI.PE418).
GN   Name=MRI1; OrderedLocusNames=YPR118W; ORFNames=P9642.7;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTXVI.PE418.
CC       Saccharomyces cerevisiae chromosome XVI EF2 full sequence 1..948062
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MTNA_YEAST
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-
CC       P).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- MISCELLANEOUS: Present with 922 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YPR118W;YPR118W;YPR118W.
DR   EMBL; U40828; - ;
DR   UniProtKB/Swiss-Prot; Q06489; D6W4B7; -.
DR   EMBL; U40828; AAB68059.1; -; Genomic_DNA.
DR   EMBL; BK006949; DAA11533.1; -; Genomic_DNA.
DR   PIR; S69011; S69011.
DR   RefSeq; NP_015443.1; NM_001184215.1.
DR   PDB; 1W2W; X-ray; 1.75 A; A/E/I/M=1-211, B/F/J/N=221-411.
DR   PDBsum; 1W2W; -.
DR   ProteinModelPortal; Q06489; -.
DR   SMR; Q06489; 1-211, 221-411.
DR   DIP; DIP-4685N; -.
DR   IntAct; Q06489; 2.
DR   MINT; MINT-505844; -.
DR   STRING; Q06489; -.
DR   PeptideAtlas; Q06489; -.
DR   EnsemblFungi; YPR118W; YPR118W; YPR118W.
DR   GeneID; 856234; -.
DR   KEGG; sce:YPR118W; -.
DR   NMPDR; fig|4932.3.peg.6580; -.
DR   CYGD; YPR118w; -.
DR   SGD; S000006322; MRI1.
DR   eggNOG; fuNOG06631; -.
DR   GeneTree; EFGT00050000003245; -.
DR   OMA; EDGWKVI; -.
DR   OrthoDB; EOG4S1XGM; -.
DR   PhylomeDB; Q06489; -.
DR   NextBio; 981488; -.
DR   ArrayExpress; Q06489; -.
DR   Genevestigator; Q06489; -.
DR   GermOnline; YPR118W; Saccharomyces cerevisiae.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IDA:SGD.
DR   GO; GO:0019509; P:L-methionine salvage from methylthioadenosine; IMP:SGD.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; YEASTXVI.PE418; -.
KW   YPR118W-A100026476820036002503210000011; YPR118W-A1; MTNA_YEAST; U40828;
KW   3D-structure; Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Isomerase; Methionine biosynthesis; Nucleus; Phosphoprotein;
KW   Reference proteome.
SQ   SEQUENCE   411 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSLEAIVFDR SEPENVSVKV LDQLLLPYTT KYVPIHTIDD GYSVIKSMQV RGAPAIAIVG
     SLSVLTEVQL IKHNPTSDVA TLYSLVNWES TKTVLNKRLD FLLSSRPTAV NLSNSLVEIK
     NILKSSSDLK AFDGSLYNYV CELIDEDLAN NMKMGDNGAK YLIDVLQKDG FKDEFAVLTI
     CNTGSLATSG YGTALGVIRS LWKDSLAKTD KADSGLDNEK CPRMGHVFPL ETRPYNQGSR
     LTAYELVYDK IPSTLITDSS IAYRIRTSPI PIKAAFVGAD RIVRNGDTAN KIGTLQLAVI
     CKQFGIKFFV VAPKTTIDNV TETGDDIIVE ERNPEEFKVV TGTVINPENG SLILNESGEP
     ITGKVGIAPL EINVWNPAFD ITPHELIDGI ITEEGVFTKN SSGEFQLESL F
//

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