(data stored in ACNUC8465 zone)

HOGENOM: YEASTXV_PE429

ID   YEASTXV_PE429                        STANDARD;      PRT;   508 AA.
AC   YEASTXV_PE429; P32490; D6W2T5; Q2VQW6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=MAP kinase kinase MKK1/SSP32; EC=2.7.12 2; (YEASTXV.PE429).
GN   Name=MKK1; Synonyms=SSP32; OrderedLocusNames=YOR231W; ORFNames=O5095;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTXV.PE429.
CC       Saccharomyces cerevisiae chromosome XV EF2  sequence 1..1091289
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MKK1_YEAST
CC   -!- FUNCTION: Involved in a signal transduction pathway that play a
CC       role in yeast cell morphogenesis and cell growth. This pathway
CC       seems to starts by SMP3; then involve the kinase PKC1 that may act
CC       on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which
CC       themselves phosphorylate the MPK1 kinase.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- INTERACTION:
CC       Q12263:GIN4; NbExp=2; IntAct=EBI-10968, EBI-7595;
CC   -!- MISCELLANEOUS: Present with 1040 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YOR231W;YOR231W;YOR231W.
DR   EMBL; AY899252; - ;
DR   EMBL; D13001; - ;
DR   EMBL; Z75139; - ;
DR   UniProtKB/Swiss-Prot; P32490; D6W2T5; Q2VQW6; -.
DR   EMBL; D13001; BAA02364.1; -; Genomic_DNA.
DR   EMBL; Z75139; CAA99451.1; -; Genomic_DNA.
DR   EMBL; AY899252; AAX83937.1; -; mRNA.
DR   EMBL; BK006948; DAA11001.1; -; Genomic_DNA.
DR   PIR; A48069; A48069.
DR   RefSeq; NP_014874.1; NM_001183650.1.
DR   ProteinModelPortal; P32490; -.
DR   SMR; P32490; 220-508.
DR   DIP; DIP-2224N; -.
DR   IntAct; P32490; 12.
DR   MINT; MINT-548860; -.
DR   STRING; P32490; -.
DR   EnsemblFungi; YOR231W; YOR231W; YOR231W.
DR   GeneID; 854406; -.
DR   KEGG; sce:YOR231W; -.
DR   NMPDR; fig|4932.3.peg.5986; -.
DR   CYGD; YOR231w; -.
DR   SGD; S000005757; MKK1.
DR   eggNOG; fuNOG04753; -.
DR   GeneTree; EFGT00050000000597; -.
DR   OMA; SEYIVRY; -.
DR   OrthoDB; EOG4D29ZP; -.
DR   PhylomeDB; P32490; -.
DR   BRENDA; 2.7.12.2; 984.
DR   NextBio; 976589; -.
DR   ArrayExpress; P32490; -.
DR   Genevestigator; P32490; -.
DR   GermOnline; YOR231W; Saccharomyces cerevisiae.
DR   GO; GO:0005934; C:cellular bud tip; IDA:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030242; P:peroxisome degradation; IGI:SGD.
DR   GO; GO:0007165; P:signal transduction; IMP:SGD.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; YEASTXV.PE429; -.
KW   YOR231W-A100026476820036002503210000011; YOR231W-A1; MKK1_YEAST;
KW   D13001; Z75139;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase.
SQ   SEQUENCE   508 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MASLFRPPES AKCNPNSPRL KLPLLRNNQV DENNIYLTSN GSSTTAYSSH TPEPLTSSTS
     TLFSQTRLHP SDSSMTLNTM KKRPAPPSLP SLSINSQSKC KTLPELVPIA DVSDGKHDLG
     LKQRVIAENE LSGNSDLTPS SMASPFSHTN TSSPYLRNDL SNSVGSDFSN LISAYEQSSS
     PIKSSSQPKS SSESYIDLNS VRDVDQLDEN GWKYANLKDR IETLGILGEG AGGSVSKCKL
     KNGSKIFALK VINTLNTDPE YQKQIFRELQ FNRSFQSEYI VRYYGMFTDD ENSSIYIAME
     YMGGRSLDAI YKNLLERGGR ISEKVLGKIA EAVLRGLSYL HEKKVIHRDI KPQNILLNEN
     GQVKLCDFGV SGEAVNSLAT TFTGTSFYMA PERIQGQPYS VTSDVWSLGL TILEVANGKF
     PCSSEKMAAN IAPFELLMWI LTFTPELKDE PESNIIWSPS FKSFIDYCLK KDSRERPSPR
     QMINHPWIKG QMKKNVNMEK FVRKCWKD
//

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