(data stored in ACNUC27125 zone)

HOGENOM: YEASTXV_PE507

ID   YEASTXV_PE507                        STANDARD;      PRT;   521 AA.
AC   YEASTXV_PE507; Q08777; D6W306;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Riboflavin transporter MCH5; (YEASTXV.PE507).
GN   Name=MCH5; OrderedLocusNames=YOR306C;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTXV.PE507.
CC       Saccharomyces cerevisiae chromosome XV EF2  sequence 1..1091289
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MCH5_YEAST
CC   -!- FUNCTION: Riboflavin transporter involved in riboflavin (vitamin
CC       B2) uptake. Does not act in the transport of monocarboxylic acids
CC       across the plasma membrane.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Kinetic parameters:
CC         KM=17 uM for riboflavin;
CC       pH dependence:
CC         Optimum pH is 7.5;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family.
CC   -!- GENE_FAMILY: HOG000162199 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YOR306C;YOR306C;YOR306C.
DR   EMBL; Z75214; - ;
DR   UniProtKB/Swiss-Prot; Q08777; D6W306; -.
DR   EMBL; Z75214; CAA99626.1; -; Genomic_DNA.
DR   EMBL; BK006948; DAA11072.2; -; Genomic_DNA.
DR   PIR; S67210; S67210.
DR   RefSeq; NP_014951.2; NM_001183726.2.
DR   ProteinModelPortal; Q08777; -.
DR   IntAct; Q08777; 1.
DR   STRING; Q08777; -.
DR   TCDB; 2.A.1.13.4; major facilitator superfamily (MFS).
DR   EnsemblFungi; YOR306C; YOR306C; YOR306C.
DR   GeneID; 854483; -.
DR   KEGG; sce:YOR306C; -.
DR   NMPDR; fig|4932.3.peg.6064; -.
DR   CYGD; YOR306c; -.
DR   SGD; S000005833; MCH5.
DR   eggNOG; fuNOG06281; -.
DR   GeneTree; EFGT00050000000299; -.
DR   OMA; RYSTMYF; -.
DR   OrthoDB; EOG4DV8W3; -.
DR   PhylomeDB; Q08777; -.
DR   NextBio; 976801; -.
DR   ArrayExpress; Q08777; -.
DR   Genevestigator; Q08777; -.
DR   GermOnline; YOR306C; Saccharomyces cerevisiae.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR   GO; GO:0032217; F:riboflavin transporter activity; IGI:SGD.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS_gen_substrate_transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   HOGENOMDNA; YEASTXV.PE507; -.
KW   YOR306C-A100026476820036002503210000011; YOR306C-A1; MCH5_YEAST; Z75214;
KW   Cell membrane; Complete proteome; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
SQ   SEQUENCE   521 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSSDSLTPKD TIVPEEQTNQ LRQPDLDEDS IHYDPEADDL ESLETTASYA STSVSAKVYT
     KKEVNKGTDI ESQPHWGENT SSTHDSDKEE DSNEEIESFP EGGFKAWVVT FGCFLGLIAC
     FGLLNSTGVI ESHLQDNQLS SESVSTIGWL FSLFLFVCSA SCIISGTYFD RNGFRTIMIV
     GTVFHVAGLF ATANSTKYWH FILSFAIVCG FGNGIVLSPL VSVPAHYFFK RRGTALAMAT
     IGGSVGGVVF PIMLRSFFSM KSDTDPTYGF VWGIRTLGFL DLALLTLSII LVKERLPHVI
     ENSKDGESRW RYILRVYILQ CFDAKAFLDM KYLFCVLGTV FSELSINSAL TYYGSYATSH
     GISANDAYTL IMIINVCGIP GRWVPGYLSD KFGRFNVAIA TLLTLFIVMF VGWLPFGTNL
     TNMYVISALY GFCSGSVFSL LPVCCGQISK TEEFGKRYST MYFVVGFGTL VGIPITGAII
     SIKTTADYQH YIIFSGLATF VSAVCYIISR AYCVGFKWVR F
//

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