(data stored in ACNUC22857 zone)

HOGENOM: YEASTX_PE241

ID   YEASTX_PE241                         STANDARD;      PRT;   700 AA.
AC   YEASTX_PE241; P27351; D6VWH9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=AP-2 complex subunit beta;AltName:
DE   Full=Beta-2-adaptin;AltName: Full=Beta-adaptin;AltName: Full=Clathrin
DE   assembly protein complex 2 beta large chain;AltName: Full=Clathrin
DE   assembly protein large beta chain; (YEASTX.PE241).
GN   Name=APL1; Synonyms=YAP80; OrderedLocusNames=YJR005W; ORFNames=J1422;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTX.PE241.
CC       Saccharomyces cerevisiae chromosome X EF2 full sequence 1..745741 annot
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:AP2B_YEAST
CC   -!- FUNCTION: Adaptins are components of the adaptor complexes which
CC       link clathrin to receptors in coated vesicles. Clathrin-associated
CC       protein complexes are believed to interact with the cytoplasmic
CC       tails of membrane proteins, leading to their selection and
CC       concentration. Beta adaptin is a subunit of the plasma membrane
CC       adaptor.
CC   -!- SUBUNIT: Assembly protein complex 2 (AP-2) is a heterotetramer
CC       composed of two large adaptins (alpha-type subunit APL3 and beta-
CC       type subunit APL1), a medium chain (mu-type subunit APM4) and a
CC       small adaptin (sigma-type subunit APS2). Interacts with APS2.
CC   -!- SUBCELLULAR LOCATION: Cell membrane. Membrane, coated pit;
CC       Peripheral membrane protein; Cytoplasmic side. Note=Component of
CC       the coat surrounding the cytoplasmic face of coated vesicles in
CC       the plasma membrane.
CC   -!- MISCELLANEOUS: Present with 1670 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC   -!- GENE_FAMILY: HOG000163270 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YJR005W;YJR005W;YJR005W.
DR   EMBL; M28164; - ;
DR   EMBL; M64998; - ;
DR   EMBL; X87611; - ;
DR   EMBL; Z49505; - ;
DR   UniProtKB/Swiss-Prot; P27351; D6VWH9; -.
DR   EMBL; M64998; AAA35226.1; -; Genomic_DNA.
DR   EMBL; X87611; CAA60927.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Z49505; CAA89527.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08795.1; -; Genomic_DNA.
DR   PIR; S57020; S57020.
DR   RefSeq; NP_012538.1; NM_001181662.1.
DR   ProteinModelPortal; P27351; -.
DR   SMR; P27351; 4-601.
DR   DIP; DIP-915N; -.
DR   IntAct; P27351; 14.
DR   MINT; MINT-504477; -.
DR   STRING; P27351; -.
DR   PeptideAtlas; P27351; -.
DR   EnsemblFungi; YJR005W; YJR005W; YJR005W.
DR   GeneID; 853461; -.
DR   KEGG; sce:YJR005W; -.
DR   NMPDR; fig|4932.3.peg.3511; -.
DR   CYGD; YJR005w; -.
DR   SGD; S000003765; APL1.
DR   eggNOG; fuNOG04097; -.
DR   OMA; VLKWATE; -.
DR   OrthoDB; EOG476P7N; -.
DR   PhylomeDB; P27351; -.
DR   NextBio; 974041; -.
DR   ArrayExpress; P27351; -.
DR   Genevestigator; P27351; -.
DR   GermOnline; YJR005W; Saccharomyces cerevisiae.
DR   GO; GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; TAS:SGD.
DR   InterPro; IPR016342; AP_complex_bsu.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   Gene3D; G3DSA:1.25.10.10; ARM-like; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SUPFAM; SSF48371; ARM-type_fold; 1.
DR   HOGENOMDNA; YEASTX.PE241; -.
KW   YJR005W-A100026476820036002503210000011; YJR005W-A1; AP2B_YEAST;
KW   Q05162_YEAST; M28164; M64998; X87611; Z49505;
KW   Cell membrane; Coated pit; Complete proteome; Membrane;
KW   Phosphoprotein; Reference proteome.
SQ   SEQUENCE   700 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSDQKVFARY KANEIVTDLQ HFGVKKFKSN ITRRKNALRK IIANLVLGNY GEMSVLFSEL
     LKFWQIEDDL EVKRICHEYI RVIGALKPQQ AREALPFIMD DFKSRDEKLQ IMALRTLVLV
     PVKELSDQAF DCIISLVNHK SPPEQVTRTA IYALLDLDEI DHERVLGLSS ILHDIVKAQS
     SSPEVIVAAL HTLYSIHEKN ANMEPFRIPL ELAFDMLELL PELNEWNKAT VLEVLTTSVV
     PQHYLDTHEM IELALPYLQQ VNTYVVLNSL KFIMYLLNYV DVIKETLAEK LSNSVIALLD
     KPPELQFLVL RNVILLLLSR ESSLLRLDIS YFFIEYNDPI YIKDTKLECL YLLANKETLP
     RILEELEQYA TDIDIQMSRK SVRAIGNLAV KLDEDSVHDC VAVLLDLLEF GVDYVVQEII
     SVFRNILRKY PNNFKANVTE LVKHTEVVQE PESKNAMIWI ITQYSDVIPN YLELFRVFSS
     NMFSETLEVQ FSILNSAIKF FIRSPTKETE ELCMDLLKGC IDHENNPDLR DKTLMYWRLL
     SLTKTSRISN AITFESLKSV LDGELPLIEM NTKLDPTVLE ELELNIGTIV SIYLKPVSHI
     FRLNKTKLLP QSPILNPNKD LLPVVGNSFP PTGANRDRQN SESQSSTKSR KTAMMDDYDK
     PAEKINQLKG KRKSSSNNPS KLSRKPSTLL RKLSMKRPFS
//

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