(data stored in ACNUC14511 zone)

HOGENOM: YEASTX_PE62

ID   YEASTX_PE62                          STANDARD;      PRT;   352 AA.
AC   YEASTX_PE62; P08524; D6VW20; P15495;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Farnesyl pyrophosphate synthase; Short=FPP synthase;
DE   Short=FPS; EC=2.5.1.10;AltName: Full=(2E,6E)-farnesyl diphosphate
DE   synthase;AltName: Full=Dimethylallyltranstransferase; EC=2.5.1 1;AltName:
DE   Full=Farnesyl diphosphate synthase;AltName: Full=Geranyltranstransferase;
DE   (YEASTX.PE62).
GN   Name=ERG20; Synonyms=BOT3, FDS1, FPP1; OrderedLocusNames=YJL167W;
OS   SACCHAROMYCES CEREVISIAE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEASTX.PE62.
CC       Saccharomyces cerevisiae chromosome X EF2 full sequence 1..745741 annot
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:FPPS_YEAST
CC   -!- FUNCTION: Catalyzes the sequential condensation of isopentenyl
CC       pyrophosphate with the allylic pyrophosphates, dimethylallyl
CC       pyrophosphate, and then with the resultant geranylpyrophosphate to
CC       the ultimate product farnesyl pyrophosphate.
CC   -!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
CC       diphosphate = diphosphate + geranyl diphosphate.
CC   -!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
CC       = diphosphate + (2E,6E)-farnesyl diphosphate.
CC   -!- COFACTOR: Binds 3 magnesium ions per subunit (By similarity).
CC   -!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate
CC       biosynthesis; farnesyl diphosphate from geranyl diphosphate and
CC       isopentenyl diphosphate: step 1/1.
CC   -!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate
CC       biosynthesis; geranyl diphosphate from dimethylallyl diphosphate
CC       and isopentenyl diphosphate: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC   -!- GENE_FAMILY: HOG000160912 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Saccharomyces_cerevisiae;YJL167W;YJL167W;YJL167W.
DR   EMBL; J05091; - ;
DR   EMBL; X05550; - ;
DR   EMBL; Z49442; - ;
DR   UniProtKB/Swiss-Prot; P08524; D6VW20; P15495; -.
DR   EMBL; J05091; AAA34606.1; -; Genomic_DNA.
DR   EMBL; Z49442; CAA89462.1; -; Genomic_DNA.
DR   EMBL; X05550; CAA29064.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08636.1; -; Genomic_DNA.
DR   PIR; A34441; A34441.
DR   RefSeq; NP_012368.1; NM_001181600.1.
DR   ProteinModelPortal; P08524; -.
DR   SMR; P08524; 5-352.
DR   DIP; DIP-1163N; -.
DR   IntAct; P08524; 8.
DR   MINT; MINT-555012; -.
DR   STRING; P08524; -.
DR   PeptideAtlas; P08524; -.
DR   EnsemblFungi; YJL167W; YJL167W; YJL167W.
DR   GeneID; 853272; -.
DR   KEGG; sce:YJL167W; -.
DR   NMPDR; fig|4932.3.peg.3332; -.
DR   CYGD; YJL167w; -.
DR   SGD; S000003703; ERG20.
DR   eggNOG; fuNOG05213; -.
DR   GeneTree; EFGT00050000002300; -.
DR   OMA; RDFMAVF; -.
DR   OrthoDB; EOG4SFDFW; -.
DR   PhylomeDB; P08524; -.
DR   BioCyc; MetaCyc:MONOMER-655; -.
DR   NextBio; 973547; -.
DR   ArrayExpress; P08524; -.
DR   Genevestigator; P08524; -.
DR   GermOnline; YJL167W; Saccharomyces cerevisiae.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:SGD.
DR   GO; GO:0004161; F:dimethylallyltranstransferase activity; IDA:SGD.
DR   GO; GO:0004337; F:geranyltranstransferase activity; IDA:SGD.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045337; P:farnesyl diphosphate biosynthetic process; IDA:SGD.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR008949; Terpenoid_synth.
DR   Gene3D; G3DSA:1.10.600.10; Terpenoid_synth; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   SUPFAM; SSF48576; Terpenoid_synth; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
DR   HOGENOMDNA; YEASTX.PE62; -.
KW   YJL167W-A100026476820036002503210000011; YJL167W-A1; FPPS_YEAST; J05091;
KW   Z49442;
KW   Cholesterol biosynthesis; Complete proteome; Cytoplasm;
KW   Isoprene biosynthesis; Lipid synthesis; Magnesium; Metal-binding;
KW   Reference proteome; Steroid biosynthesis; Sterol biosynthesis;
KW   Transferase.
SQ   SEQUENCE   352 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MASEKEIRRE RFLNVFPKLV EELNASLLAY GMPKEACDWY AHSLNYNTPG GKLNRGLSVV
     DTYAILSNKT VEQLGQEEYE KVAILGWCIE LLQAYFLVAD DMMDKSITRR GQPCWYKVPE
     VGEIAINDAF MLEAAIYKLL KSHFRNEKYY IDITELFHEV TFQTELGQLM DLITAPEDKV
     DLSKFSLKKH SFIVTFKTAY YSFYLPVALA MYVAGITDEK DLKQARDVLI PLGEYFQIQD
     DYLDCFGTPE QIGKIGTDIQ DNKCSWVINK ALELASAEQR KTLDENYGKK DSVAEAKCKK
     IFNDLKIEQL YHEYEESIAK DLKAKISQVD ESRGFKADVL TAFLNKVYKR SK
//

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