(data stored in ACNUC7421 zone)

HOGENOM: YEPES1_1_PE14

ID   YEPES1_1_PE14                        STANDARD;      PRT;   322 AA.
AC   YEPES1_1_PE14; O68703;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Cysteine protease yopT; EC=3.4.22 -; (YEPES1_1.PE14).
GN   Name=yopT; OrderedLocusNames=YPCD1.20, y5059, y0065, YP_pCD67;
OS   YERSINIA PESTIS CO92.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=214092;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEPES1_1.PE14.
CC       Yersinia pestis CO92 plasmid pCD1, complete sequence.
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:YOPT_YERPE
CC   -!- FUNCTION: Cysteine protease, which is translocated into infected
CC       cells and plays a central role in pathogenesis by cleaving the C-
CC       terminus end of the human small GTPase RhoA/ARHA, a regulator of
CC       cytoskeleton. Once cleaved, ARHA loses its lipid modification, and
CC       is released from the cell membrane, leading to the subsequent
CC       disruption of actin cytoskeleton of the host cell.
CC   -!- SUBUNIT: Interacts with human ARHA.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=In infected cells, it is
CC       cytoplasmic. Translocated into the host cell by the type III
CC       secretion apparatus with the help of the sycT chaperone.
CC   -!- SIMILARITY: Belongs to the peptidase C58 family.
CC   -!- GENE_FAMILY: HOG000266867 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; O68703; -.
DR   EMBL; AF074612; AAC69833.1; -; Genomic_DNA.
DR   EMBL; AF053946; AAC62582.1; -; Genomic_DNA.
DR   EMBL; AL117189; CAB54897.1; -; Genomic_DNA.
DR   EMBL; AE017043; AAS58582.1; -; Genomic_DNA.
DR   PIR; T43601; T43601.
DR   RefSeq; NP_395155.1; NC_003131.1.
DR   RefSeq; NP_857758.1; NC_004836.1.
DR   RefSeq; NP_857958.1; NC_004839.1.
DR   RefSeq; NP_995391.1; NC_005813.1.
DR   ProteinModelPortal; O68703; -.
DR   MEROPS; C58.001; -.
DR   GeneID; 1149322; -.
DR   GeneID; 1172665; -.
DR   GeneID; 2700511; -.
DR   GeneID; 2767512; -.
DR   GenomeReviews; AE017043_GR; YP_pCD67.
DR   GenomeReviews; AL117189_GR; YPCD1.20.
DR   KEGG; ype:YPCD1.20; -.
DR   KEGG; ypm:YP_pCD67; -.
DR   OMA; PISSINH; -.
DR   ProtClustDB; CLSK862118; -.
DR   BioCyc; YPES214092:YPCD1.20-MON; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR022767; Pept_C58_YopT/NopT.
DR   InterPro; IPR003951; Peptidase_C58.
DR   InterPro; IPR006473; Peptidase_C58_Yopt.
DR   Pfam; PF03543; Peptidase_C58; 1.
DR   PRINTS; PR01376; BACSURFANTGN.
DR   TIGRFAMs; TIGR01586; YopT_cys_prot; 1.
DR   HOGENOMDNA; YEPES1_1.PE14; -.
KW   Yop targeted effector;
KW   Complete proteome; Hydrolase; Plasmid; Protease; Reference proteome;
KW   Secreted; Thiol protease; Virulence.
SQ   SEQUENCE   322 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNSIHGHYHI QLSNYSAGEN LQSATLTEGV IGAHRVKVET ALSHSNLQKK LSATIKHNQS
     GRSMLDRKLT SDGKANQRSS FTFSMIMYRM IHFVLSTRVP AVRESVANYG GNINFKFAQT
     KGAFLHKIIK HSDTASGVCE ALCAHWIRSH AQGQSLFDQL YVGGRKGKFQ IDTLYSIKQL
     QIDGCKADVD QDEVTLDWFK KNGISERMIE RHCLLRPVDV TGTTESEGLD QLLNAILDTH
     GIGYGYKKIH LSGQMSAHAI AAYVNEKSGV TFFDPNFGEF HFSDKEKFRK WFTNSFWGNS
     MYHYPLGVGQ RFRVLTFDSK EV
//

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