(data stored in ACNUC9435 zone)

HOGENOM: YEPSE1_1_PE23

ID   YEPSE1_1_PE23                        STANDARD;      PRT;   219 AA.
AC   YEPSE1_1_PE23; P08008; Q663N9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Outer membrane virulence protein yopE; (YEPSE1_1.PE23).
GN   Name=yopE; Synonyms=yop25; OrderedLocusNames=pYV0025;
OS   YERSINIA PSEUDOTUBERCULOSIS IP 32953.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS YEPSE1_1.PE23.
CC       Yersinia pseudotuberculosis IP 32953 plasmid pYV, complete sequence.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:YOPE_YERPS
CC   -!- FUNCTION: Essential virulence determinant; cytotoxic effector,
CC       involved in resistance to phagocytosis.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- INDUCTION: At 37 degrees Celsius in the absence of calcium.
CC   -!- MISCELLANEOUS: N-terminal is important for export, C-terminal is
CC       indispensable for virulence.
CC   -!- SIMILARITY: Belongs to the yopE family.
CC   -!- GENE_FAMILY: HOG000219628 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P08008; Q663N9; -.
DR   EMBL; Y00543; CAA68609.1; -; Genomic_DNA.
DR   EMBL; BX936399; CAF25368.1; -; Genomic_DNA.
DR   PIR; S03766; S03766.
DR   RefSeq; YP_068436.1; NC_006153.2.
DR   PDB; 1L2W; X-ray; 2.00 A; I/J/K/L=17-85.
DR   PDBsum; 1L2W; -.
DR   ProteinModelPortal; P08008; -.
DR   SMR; P08008; 23-78, 100-219.
DR   GeneID; 2952918; -.
DR   GenomeReviews; BX936399_GR; pYV0025.
DR   KEGG; yps:pYV0025; -.
DR   OMA; KSEQYAN; -.
DR   ProtClustDB; CLSK862154; -.
DR   BioCyc; YPSE273123:PYV0025-MON; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0050765; P:negative regulation of phagocytosis; IEA:InterPro.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR014773; Uncharacterised_dom_YopE.
DR   InterPro; IPR003537; Vir_YopE.
DR   InterPro; IPR015110; YopE_N.
DR   Gene3D; G3DSA:1.20.120.260; Uncharacterised_dom_YopE; 1.
DR   Pfam; PF03545; YopE; 1.
DR   Pfam; PF09020; YopE_N; 1.
DR   PRINTS; PR01372; YERSINIAYOPE.
DR   SUPFAM; SSF47233; Vir_YopE; 1.
DR   HOGENOMDNA; YEPSE1_1.PE23; -.
KW   putative outer membrane virulence protein;
KW   3D-structure; Cell membrane; Cell outer membrane; Complete proteome;
KW   Membrane; Plasmid; Virulence.
SQ   SEQUENCE   219 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKISSFISTS LPLPTSVSGS SSVGEMSGRS VSQQTSDQYA NNLAGRTESP QGSSLASRII
     ERLSSVAHSV IGFIQRMFSE GSHKPVVTPA PTPAQMPSPT SFSDSIKQLA AETLPKYMQQ
     LNSLDAEMLQ KNHDQFATGS GPLRGSITQC QGLMQFCGGE LQAEASAILN TPVCGIPFSQ
     WGTIGGAASA YVASGVDLTQ AANEIKGLAQ QMQKLLSLM
//

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