ID   112436 PHOGENOM6 55 seq.
AC   HOG000112436
IO   0
KW   HOG000112436 // 
LA   441
ND   55
NF   50
CC   -!- TREE CALCULATED WITH PHYML  -d aa -q -n 1  -b -4  -m JTT -v e -c 4  -a e -s BEST
CC   -!- GBLOCKS OPTIONS -b1=26 -b2=26 -b5=a Gblocks alignment:  214 positions (48 %) in 6 selected block(s)
TR   ((((((((((NOISO|ERIEUGS_7838_PE3:0.111633,((NOISO|HS1_PE58:0.010940,NOISO|GORGO1_2_PE6:0.000001)0.996000:0.084276,NOISO|DIPOR39700_PE1:0.071075)0.611000:0.005958)0.770000:0.016202,(NOISO|MICMUGS_4066_PE1:0.098738,NOISO|CAVPO186_2_PE11:0.140870)0.424000:0.032778)0.590000:0.006362,(NOISO|RAT5_PE2131:0.009888,NOISO|MOUSE4_PE3729:0.026728)0.998000:0.069370)0.845000:0.015099,(NOISO|OTOGAGS_4832_PE1:0.308653,(NOISO|LOXAF26_23_PE28:0.103630,NOISO|ECHTE240998_PE1:0.040178)0.000000:0.007079)0.294000:0.029669)0.000000:0.000001,((NOISO|FELCAGS_5080_PE12:0.064454,(NOISO|CANFA5_61_PE16:0.065671,ENSAMEG00000013642|AILMEGL194360_1_PE6:0.035704)0.904000:0.030451)0.969000:0.050748,(((NOISO|SPETRGS_5214_PE1:0.058521,NOISO|FUGRU213_PE1:0.694426)0.780000:0.128751,(((NOISO|BOVIN16_49_PE44:0.081734,NOISO|PIG6_44_PE19:0.076732)0.000000:0.002375,NOISO|TURTRGS_2240_PE4:0.068889)0.887000:0.017879,NOISO|HORSE2_50_PE18:0.054776)0.696000:0.006094)0.692000:0.011474,NOISO|PTEVAGS_2563_PE5:0.105196)0.689000:0.003178)0.945000:0.027826)0.941000:0.079098,(((NOISO|DANRE23_26_PE27:0.029749,(NOISO|GASACGROUPXII_16_PE5:0.020432,NOISO|TETNG9_PE740:0.066402)0.212000:0.018035)1.000000:0.211224,((NOISO|XENTR390_1_PE7:0.106667,NOISO|ANOCA3025_PE1:0.051220)0.787000:0.014736,(NOISO|CHICK21_PE132:0.016928,NOISO|POEGU21_7_PE8:0.168521)0.742000:0.022192)0.622000:0.012317)0.942000:0.066940,NOISO|MACEUGS_8890_PE1:0.093218)0.967000:0.116280)0.888000:0.148369,NOISO|STRPU_77578_PE1:0.698945)0.947000:0.233203,(((ENSSSCG00000016337|PIG15_133_PE11:0.037021,(((NOISO|CAVPO13_27_PE5:0.122776,ENSBTAG00000030208|BOVIN3_128_PE9:0.103304)0.808000:0.016049,(NOISO|RAT9_PE969:0.028808,ENSMUSG00000047443|MOUSE1_PE1289:0.010095)1.000000:0.071446)0.801000:0.010577,(((NOISO|HORSE6_26_PE4:0.240736,NOISO|CANFA25_53_PE16:0.220794)0.997000:0.222103,((ENSG00000178752|HS2_PE6412:0.000001,ENSGGOG00000000095|GORGO2B_131_PE15:0.016021)0.962000:0.031654,NOISO|CALJA6_163_PE21:0.169724)0.769000:0.011622)0.598000:0.009921,(ENSOCUG00000017440|RABITUN0271_PE7:0.106564,(NOISO|SPETRGS_4351_PE2:0.111096,NOISO|OTOGAGS_4003_PE2:0.179287)0.801000:0.024761)0.803000:0.012411)0.883000:0.016034)0.754000:0.006291)0.821000:0.021643,NOISO|LOXAF55_2_PE6:0.101894)0.881000:0.106998,((ENSOANG00000015594|ORNAN7_34_PE4:0.060460,NOISO|ANOCA14_4_PE19:0.370980)0.874000:0.047868,NOISO|MONDO7_258_PE28:0.163820)0.000000:0.045726)0.981000:0.228354)1.000000:0.377371,NOISO|DANRE2_6_PE2:0.217352)0.989000:0.194610,ENSORLG00000007187|ORYLA17_12_PE25:0.228657,NOISO|GASAC120_PE25:0.129827);
CC   -!- ALIGNMENT CALCULATED WITH CLUSTALOMEGA
AL   ENSAMEG00000013642|AILMEGL194360_1_PE6 1 324 1.00 -------------MHWAWAA--AAVALWLQLTLLGGVGARREP-KRPRPPRQRTEPPTATT--SNSEGLLGSPEPPEALG-SEFSDAHTTWLNFVRRPDEG-ASKKRCRG--RDKKSVSPG-VTQGRGGCGPTGTLTFSCLPPARPLWPGPPGPPXXX----XXXLGEFQEMLKA-----------------------EATERRFLGLLGP-----------------W------------------LPEGTG---RQLVAEAFHCALKGPVVVDEKTLVELH-----------GFQAPT-AQGAFLRGSGLSLASGRFTAPVTAIFQFS----ASLHVDH-----RGLQ-GR-----ARPRARDTVRVLVCIESLCHRHTSLEAISGLESRGRVFTVHVEGLLQLQAGQY-ASVFVDNGSGTALTIQSGSSFSGLLLGT-
AL   ISOFORMIN|AILMEGL194360_1_PE7       1 188 1.00 ------------AMHWAWAA--AAVALWLQLTLLGGVGARREP-KRPRPPRQRTEPPTATT--SNSEGLLGSPEPPEALG-SEFSDAHTTWLNFVRRPDEG-ASKKRCRG--RDKKSRGL----------------------------SGPPGPPGP---------REFQEMLK------------------------EATERRFLGLLGP-----------------W------------------LPEGTG---RQLVAEAFHCALKGPVVVDEKTLVELH-----------GFQAPT-AQGAFLRGSGLSLASGRFT-------------------------------------------------------------------------------------------------------------------------
AL   NOISO|ANOCA14_4_PE19                1 154 1.00 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEAAFYCQIQKNLSVERRSLKELQ-----------LYYIPK-KGEAFHRGLGLNLTSGQYQAPFSGYYIFS----VTLHVVL-----NDYA------RKSQPCARDRLRLLICVQSLCRQNISLKTVRHLDKNRERFTISLTGTLFLQVGQY-ASVFVDNASGSSLVVQRGSDFSAVLLGV-
AL   NOISO|ANOCA3025_PE1                 1 149 1.00 ----------------------------------------------------------------------------------------------------------------------GLV----------------GPPGPPGPPGPPGAPGAEVTQ----EVLLQEFKEMLK-------------------------EATERRSSPELP---------------------------------------VAP---SERVEEAFHCKLKGQLVVDKKTLMELQ-----------NFQMPL-AKGAFLRGSGLNLTTGRFTASISGIYQFS----ANVHIDH-----SELK-SK-----LQLRARDNIRVLICIESLCHRYT------------------------------------------------------------
AL   NOISO|BOVIN16_49_PE44               1 311 1.00 RCGLRTRQL-AANMRWAWVA--ATVLLWPQISFLGGNGARREP-KRPRQSSQRPMAPSTTT--LGSEGLLGFPKLPEASG-PEFTDAHVTWLNFVRRPDHG-PSKKRCRG--QDKKSRGLS-------------------GP------PGHPSVEAPQ----ESALREFQDMLK------------------------EATEHRSLGLLGP-----------------V------------------LPEGIG---RQLVAEAFHCRLRGPVLVDKKTLVELQ-----------GFQAPA-AQGAFLRGSGLSLASGRFTAPVTAIFQFS----ASLHVDP-----RELQ-GR-----VRPRARDTVRVLVCIESLCHRHMSLEAISSLESSGSVFSMHVQGLLQLQAGQY-TSVFVDNGSGAALTVQSSSSFSGLLLGP-
AL   ISOFORMIN|BOVIN3_128_PE10           1 269 1.00 ---------------------------------------------RP-RSTEGGN--WPP---------ENSPGEPPVERAHGLSDPRDAWMLFVRQSDKGINSKRGGRGKAKKPKLG-----------------LPGPPGPPGPQGPPGP---ITPP----EVLLKEFQLLLKGAVRTRECAEPE-----P--------------GPRVP---AAVPAAR-------PEDDEEAAAGGAGMLALLAAPLAPGPR-AQRVEAAFHCRLRRDASVERRALHELG-----------LYYLVS-PGRA---GPG--------------------------------------R------GRAGASRXDHLRLLICLESRCQHHASLEAVVGLEGSSELFTISVNGVLYLQAGQY-TSVFLDNASGSALTVRSGSHFSAVLLGV-
AL   ENSBTAG00000030208|BOVIN3_128_PE9   1 309 1.00 --MAPSRCPARA-LLLAYASLLAA-AVGLGSPEPGA---PSESRARE-ETPPGNELPAGP---------AARPPEPPVERAHGLSDPRDAWMLFVRQSDKGINSKRGGRGKAKKPKLG-----------------LPGPPGPPGPQGPPGP---ITPP----EVLLKEFQLLLKGAVRTRECAEPE-----P--------------GPRVP---AAVPAAR-------PEDDEEAAAGGAGMLALLAAPLAPGPR-AQRVEAAFHCRLRRDASVERRALHELG-----------LYYLVS-PGRA---GPG--------------------------------------R------GRAGASRXDHLRLLICLESRCQHHASLEAVVGLEGSSELFTISVNGVLYLQAGQY-TSVFLDNASGSALTVRSGSHFSAVLLGV-
AL   NOISO|CALJA6_163_PE21               1 286 1.00 --------------------------------------------------------------------------EPTAERAHSV-DPRDAWMLFVRQSDKGVNGKRRSRGKAKKLKPG-----------------LFLPPGGLGPEGLMAP---VCSI----RARCAATAHSVPGAVRQRERAE-P-----RP--------CTR--GPAGPVAASLAPVSA-------SAREDDDDA-AEVVLALLAASQAPG---PPRVEAAFHCRLRQDVSVERRELHEIG-----------AYYLPD-AEGAFHRGPGLNLTSGQYRAPVTGFYTLA----ATLHVAL-----GEPP------RRGPLRPRDRLRLLICIQSQCQRNASLEAVMGLESSSELFTISVNGVLYLQMGQW-ASVFLDNASGSSLTVRSGSHFSAILLGV-
AL   NOISO|CANFA25_53_PE16               1 353 1.00 --MARARRPAGARLLLAWAALLAAAAPGLGSPAPEP---RRA-RREP-RPGNANQPPAGPG--HSLAGPPSGPPEPATDGTRNF-DPRDAWMLFIRQSDKGVNGKRGGRGKARKLKLG-----------------LPGPPGPPGPQGPPGP---IIPR----EVLLKEFQLLLKGRGRAHTPPAPQ-----L--------PCRA--ARAADGAAGTVVWQEQRRG-----------------------EAGEAGG-VRRPRA-PSFPVVRAPRARGA-AAGSGRCSHGPCGAGGVRGSPDPKGGGCQHSAGWVPAKGQVRGGGGGHWGQARPVTAPLPAAL-----AEQP------RRGPPRPRDRLRLLICIQSRCQQNASLEAVMGLESSSELFTISVNGVLYLQTGQY-TSVFLDNASGSPLTVRSGSHFSAVLLGV-
AL   NOISO|CANFA5_61_PE16                1 319 1.00 -------------MHWVCAAA-VVALLWLQLMLFGGVGARREP-KRPRQPSQRTE-PTATT--SNREGLLGSPKPPEALG-SEFSDAHMTWLNFVRRPDDV-ASKKRCRG--RDQKSVSPRVCTQGRGGCGPTGALTSSCLP------PGPPGAAITQ----EALLREFQEMLKA-----------------------EATERRFLGLLGS-----------------L------------------LPEGTG---RQLVAEAFHCVLKGPMVVEEKTLVELH-----------GFQAPA-AQGAFLRGSGLSLASGRFTAPMTAIFQFS----ASLHVDH-----REMQ-GR-----MRLRARDTVRVLVCIESLCHRHASLVAISGLESRARVFTLHVEGLLQLQAGQY-ASVFVDNGSGTSLTIQSGSSFSGLLLGT-
AL   NOISO|CAVPO13_27_PE5                1 337 1.00 --MALARRTAGALLLLIHMAPLLV-HAGLGTPEPAG---SHTHP-HL-QPPPRTLL---PA--KSRVRPPARPPEPGTERAHSV-DPRDAWMLFIRQSDKGINSKR-SRGKARGPKLGS---------------ALTLPWPWPGRDLAPGP---LILP----EALLKEFQLLLKGAVQQREHVESE--------------LCTR--GPAELA----------------VTQGEDDDVDAEAELALPA-----ALP-APRVEAAFHCRLRRDAEVERRTLHELS-----------VYYLPD-TEGAFRRGPGLNLTSGQYTAPVAGFYTLA----ATLHVAL-----AEQP------RRVSPRPRDRLRLLICIQSRCQRNASLEAIMGLEGSVELFTISVNGVLYLQVGQY-TSVFLDNASGSALTVRGGSHFSAVLLGV-
AL   NOISO|CAVPO186_2_PE11               1 306 1.00 ------------MQCWAAA-A-AVALLWPQLTLFSCAGARREP-KRPRQLDQRTESPNTTV--SNSEGLPGSAKPLEASG-PEFSNAHMTWLNFVRRPDDG-ASKRRCRC--RDKKLQGRPT-------------------ASEVSEPRAASGSEVTP----ESLLQEFQEMLR------------------------EATERRFSALLDT-----------------W------------------LPQVGG---QQQVVEAFHCRLKGPMLVDQRTLVELR-----------GFQAPT-AQRAFLRGSGLSLASGRFTAPISAIFQFS----ASLHVDH-----GALQ-GR-----ARLRARDTVRVLICIESLCHRHMSLEAISGLESNSRVFTVQVQGLLQLQAGQY-ASVFVDNGSGVALTIQGGSIFSGLLLGT-
AL   NOISO|CHICK21_PE132                 1 325 1.00 ----PSLCK-MKGCTWVLVA---TLLCHQFCLFR--VMAAKKERKIKKEPNQYTEPFNATL--SNSEELHGHPKILESPD-PRITDPRRTWISFVHRPDDGNTSKRKCKG--KDKKLRGLV----------------GPPGPPGPQGPPGAPGAEVTR----EVLLQEFKEILK-------------------------EAIERRASLAIS-----------------AHPSQLPP-------LLLSLEEVSP---YRRVEEAFHCKLKGQVVVDKKTLVELQ-----------NFQSPL-AKGAFLRGTGLNLATGRFTAPVSGIYQFS----ANVHIDH-----SELK-SK-----VQLRARDNVRVLICIESLCHRYTSLEVIAGLESNSKIFTVYVHGLLQLQAGQY-TSIFVDNSAGAPITIQNGSDFMGMLMGA-
AL   NOISO|DANRE23_26_PE27               1 318 1.00 ------------MRCWVLAV--VTAVLWSQCIPLGWAEGRKVPKRLKEGAPQHTEAFNTTL--SNSEELDGSPKQ--VGE-NQRVDPLGSWMDFVKRPVGNF--PGKCRK--RKRPLPGPP----------------GPPGPPGPQGPPGAPGAEVTQ----EVLLREFKEMIK------------------------EATE-RRAAVDRP-----------------SEPSQLPT-------ALITLEGMTS---YRRIEEAFHCKLKGPVVVDKKTLAELQ-----------NFQTPP-AKGAFLRGTGMDQSTGRFTAPVTGIYQFS----ANVHIDH-----TEVKRSK-----SQLRARDNVRVLICIESLCHRYTSLEMIVGLESNSKIFTVSVHGLLELQAGQY-TSIFVDNAAGASITIQNGSDFMGMLLGV-
AL   NOISO|DANRE2_6_PE2                  1 294 1.00 -------------MKLRYGAFWALPALLLCLLLTTC---STQDSEE---------FTMERQ--EENSTVSTESPDTVSSDITPV-SPHMTWIAFRDNYNKGGNKK--PRGNKRLSKHG-----------------LPGPPGPPGPQGPPGPPGPLLP---YHAEFIKDFQFKL---------------------------------------------------------------------KEMVGTYCVYCD-QPPRVATAFRCRIQHNQLVHRRSLQELQ-----------PFNTPSNTEQFHQRGQGFNISSGRYTAPVSGFYQLS----ANLLLES----NSESQ------KKAHGRQRDSVRASICIESLCQSNVSLETVTGVSATGGVFSILLSGTLYLQAGEY-VSILIDNGTGSALTVLQDSLFSGILIGV-
AL   NOISO|DIPOR39700_PE1                1 186 1.00 ------------------------------------------------------------------------------------------------------------------------------------------------------------------EALLQEFQEMLK------------------------EAAEHRFSGLTDT-----------------V------------------LRQGPP----RLVAEAFHCWLKV-LRWDKKTLVELK-----------GFEAPA-AQGAFLRGSGLSLASGRFTAPVSAIFQFS----ASLQVDH-----SELR-GR-----GRLRARDAVRVLICIQSLCHRHASLEAVSGLESNSRVFTAQVQGLLQLQAGQY-TSVFVDNGSGAVLTIQSGSSFSGLLLGA-
AL   NOISO|ECHTE240998_PE1               1 167 1.00 --------------------------------------------------------------------------PPGTSG-PEFSDAHMTWLNFVRRPDDG-ASKKRCRA--RDKKSRG-------------------LSGP------PGPPGAEITQ----EALLQEFQEMLQ------------------------EATERRFLGLLGP-----------------L------------------LPEGPG---RRLVTEAFHCQLRGPVLVDKKTLVELQ-----------GFQAPA-AQGAFLRGSGLSLASGRFTAPVSAIFQFS----ASLHVDL-----SEVR-GK-----PQLRA------------------------------------------------------------------------------
AL   NOISO|ERIEUGS_7838_PE3              1 211 1.00 --------------------------------------------------------------------------PPEAPG-PEFSDAHKTWLNFIRRPDDG-VLKKRCRN--RDKKLQG-------------------LSGP------PGPPGAKVTQ----EALLQEFQEMLK------------------------EATERRFSGLLGP-----------------W------------------LPEVPA---GRLVLEAFHCRLKGPLQVDKKTLVELH-----------GFQAPT-TQGAFLRGSGLSLASGRFTAPVTAIFQFS----ASLHLDP-----RELQ-GR-----ARPRARDTVRAFICIESLCHRHTSLEAVLGLESSSRVFTVQVQGLLQLQ----------------------------------
AL   NOISO|FELCAGS_5080_PE12             1 259 1.00 --------------------------------------------------------PAATA--SNSEGLPGSPKPPEALG-PEFSDAHMTWLNFVRRPDDG-ASKRRCRG--RDKKSRG-------------------LSGP------PGPPGAAVNQ----EALLREFQEMLK------------------------EATERRFLGLLSP-----------------L------------------LPEGTG---RWLVAEAFHCGLKGPTVVDERTLLELR-----------GFQAPT-AQGAFLRGSGLSLASGRFTAPVTAIFQFS----ASLHVDH-----REPQ-GR-----ARLRARDTVRALVCIESLCHRHMSLEAISGLESRGRVFTMQVQGLLHLQAGQY-ASIFVDNGSGTALTIQSGSSFSGLLLGT-
AL   NOISO|FUGRU213_PE1                  1 208 1.00 ----------------------------------------------------------------------------------------------------------------------GPP----------------GPPGPPGPQGPPGSPGAEVTQ----EVLLQEFKEMIKGSERVCRVPVA--------------------G----------------------------------------SGDCRTL---VPRVQEAFHCKLRGPALVDKKTLVELQ-----------NFQTVS-PRDAGGSPS-------PWLRTLFRVFNSS----VWFELRV-----GQLWRCVGGVGGGVLSP--AARRSRLFWSHAYKRDSLEMIVGLESNSKIFTVAVQGLLELQAGQY-TSIFVDNAAGAPITIQKGSDFMGMLLGA-
AL   NOISO|GASAC120_PE25                 1 284 1.00 ----------------------------------------------------------------------------------SV-SPLSSWLIFRRNSNKGDNRR--SKGTRRTSKHG-----------------LPGPPGPPGPQGPRGPPGPTTPLLPQQQEVLQELQLRLRVCVLHVRLLETHCSLSRRV-------FCSLSESLIGPGEKTFR------------HGSDE----PGAKVAYMEGVCFQCD-ATPRVSTSFLGRLHQDVIVPRRSLLELQ-----------PFSQPSDSERSLQRGRSFNSSSGRFTAAVSGFYQLT----ASLLID--------SG------DRGHARLRDSVRAAVCIESLCQSNLSVDSVVGVAAAGGTFSILLTGTLHLQAAEY-VSVFVDNSSGSALSVLRDSLFSGILLGV-
AL   NOISO|GASACGROUPXII_16_PE5          1 302 1.00 -------------------------------------------------HARRAGPFF--------PPRAHGNIH--VPD-NQRVDPLGSWMDFVKRPVGNF--PPKCRK--RKRPLPGPP----------------GPPGPPGPQGPPGSPGAEVTP----EVLLQDFKDMIKAFQRGPKFKSKHLGVDIKVAFILSEATERRAAALDRQ-----------------TSPSQQPT-------ALLTLEGMTS---YRRIEEAFHCKLRGPVVVDKKTLVELQ-----------NFQTPP-AKGAFLRGSGMDQSTGRFTAPITGIYQFS----ANVHIDH-----NEVKRSK-----SQLKARDNVRVLICIESLCHRYTSLEMIVGLESNSKIFTVSVQGLLELQAGQY-TSIFVDNAAGASITIQNGSDFMGMLLGV-
AL   NOISO|GORGO1_2_PE6                  1 302 1.00 ------------MRRWAWAA--VVVLLGPQLVLLGGVGARREA-QRTQQPGQRADPPNATASASSREGLPEAPKPSQASG-PEFSDAHMTWLNFVRRPDDG-ALRKRCGS--RDKKPRDLF-------------------GP------PGPPGAEVTT----ETLLHEFQELLK------------------------EAKERRFSGLLDL-----------------L------------------LPQGAG---LRLVGEAFHCRLQGPRRVDKRTLVELH-----------GFQAPA-AQGAFLRGSGLSLASGRFTAPVSGIFQFS----ASLHVDH-----SELQ-GK-----ARLRARDVVRVLICIESLCQRHTCLEAVSGLESNSRVFTVQVQGLLQLQAGQY-ASVFVDNGSGAVLTIQAGSSFSGLLLGT-
AL   ENSGGOG00000000095|GORGO2B_131_PE15 1 358 1.00 --MAPARRPAGARLLLVYAGLLAA-AAGLGSPEPGA---PSRSRARK-EPPPGNELPRGPG--ESRAGPAARPPEPTAERAHSV-DPRDAWMLFVRQSDKGVNGKKRSRGKAKKLKFG-----------------LPGPPGPPGPQGPPGP---IIPP----EALLKEFQLLLKGAVRQRERAE-P-----EP--------CTR--GPAGPVAASLAPVSA-------TAGEDDDDV-AEDVLALLAAPLALGPR-APRVEAAFLCRLRRDALVERRALHELG-----------VYYLPD-AEGAFRRGPGLNLTSGQYRAPVAGFYALA----ATLHVGEARGVGGSPA------LSPTPRPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQW-TSVFLDNASGCSLTVRSGSHFSAVLLGV-
AL   ISOFORMIN|GORGO2B_131_PE16          1 252 1.00 -------------------------------------------------------------------------------------DPRDAWMLFVRQSDKGVNGKKRSRGKAKKLKFG-----------------LPGPPGPPGPQGPPGP---IIPP----EALLKEFQLLLKGEPSERQRLV-Y-----GA--------A--------PVK-----------------------------LQSLILPPASLEN-VGGVEAAFLCRLRRDALVERRALHELG-----------VYYLPD-AEGAFRRGPGLNLTSGQYRAPVAGFYALA----ATLHVGEARGVGGSPA------LS----PTDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQW-TSVFLDNASGCSLTVRSGSHFSAVLLGV-
AL   NOISO|HORSE2_50_PE18                1 308 1.00 -------------MRWAWAA--ALALLWPQLALLGGVGARRES-KRPRQPGQRTESPNATV--SNSEGLPASPKLPEALG-PEFSDAHMTWLNFVRRPDDG-VSKKRCRG--QNKKLRGLS---------GPPGP-PGPPGP------PGPPGAEITQ----EALLREFQEMLK------------------------EATERRFSGLLGP-----------------L------------------LPEGTG---ERLVAEGFHCQLKGPMRVDKKTLVELH-----------DFQAPT-AQGAFLRGSGLSLASGRFTAPVSAIFQFS----ASLHVDH-----RELQ-GR-----GQLRARDTVRALICIESLCHRHTSLEAISGLESNGRVFTVHVQGLLELQAGQY-TSVFVDNGSGAALTVQSSSSFSGLLLGM-
AL   NOISO|HORSE6_26_PE4                 1 286 1.00 --------------------------------------------------------------------------EPSTERARSI-DPHDAWMLFVRQSDKGVNSKSVSRGKAKKLKLG-----------------LPGPPGPPGPQGPPGP---VIPP----EVLLKEFQRLLKGAEIARPQHVGQ-------------------------HPGGPLFWSAAGGWSRRPAARNLHPESGDASLTLMKKQQREGGS-VRRIES-AECQFLQAPQVKTGSPVDSGVH----------------YTGEARRSLHVRAGPGSERGHLDASSGLDRPMTTPLPAAL-----GEQP------RRGPPRPRDRLRLLICIQSRCQRNASLEAVVGLESSSELFTISVNGVLYLQTGQY-TSVFLDNASGSSLTVRSGSHFSAILLGV-
AL   NOISO|HS1_PE58                      1 302 1.00 ------------MRRWAWAA--VVVLLGPQLVLLGGVGARREA-QRTQQPGQRADPPNATASASSREGLPEAPKPSQASG-PEFSDAHMTWLNFVRRPDDG-ALRKRCGS--RDKKPRDLF-------------------GP------PGPPGAEVTA----ETLLHEFQELLK------------------------EATERRFSGLLDP-----------------L------------------LPQGAG---LRLVGEAFHCRLQGPRRVDKRTLVELH-----------GFQAPA-AQGAFLRGSGLSLASGRFTAPVSGIFQFS----ASLHVDH-----SELQ-GK-----ARLRARDVVCVLICIESLCQRHTCLEAVSGLESNSRVFTLQVQGLLQLQAGQY-ASVFVDNGSGAVLTIQAGSSFSGLLLGT-
AL   ENSG00000178752|HS2_PE6412          1 354 1.00 --MAPARRPAGARLLLVYAGLLAAAAAGLGSPEPGA---PSRSRARR-EPPPGNELPRGPG--ESRAGPAARPPEPTAERAHSV-DPRDAWMLFVRQSDKGVNGKKRSRGKAKKLKFG-----------------LPGPPGPPGPQGPPGP---IIPP----EALLKEFQLLLKGAVRQRERAE-P-----EP--------CTC--GPAGPVAASLAPVSA-------TAGEDDDDV-VGDVLALLAAPLAPGPR-APRVEAAFLCRLRRDALVERRALHELG-----------VYYLPD-AEGAFRRGPGLNLTSGQYRAPVAGFYALA----ATLHVAL-----GEPP------RRGPPRPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQW-TSVFLDNASGCSLTVRSGSHFSAVLLGV-
AL   NOISO|LOXAF26_23_PE28               1 308 1.00 ------------MEGWVLA-A-AMALLWLQLAPLGGVGARQEP-KRPRQPSQRTVPLNATV--PNGEGVPGHVKLPEASG-PEFSDARKTWLDFVGRSDDT--VKKRCRA--RDKKSRVLP---------GPPGP-PGPPGP------PGSPGAEINK----EALFQEFQEMLK------------------------EATERRFLELLGP-----------------L------------------LPEGPG---GRLVAEAFHCQLKGPVLVDKKMLVELQ-----------GFQAPA-AQGAFLRGSGLSLASGRFTAPVSAIFQFS----ASLHVDL-----GELR-GK-----LQLRARDMVRVLICIESLCHHHMSLETITGLESNSRVLTVHVQGLLQLQAGQS-ASVFVDNGSGATLTIQSSSSFSGLLLGM-
AL   NOISO|LOXAF55_2_PE6                 1 331 1.00 --MAPGRRPAGARPLLVCAGLLAALPAGPDD-----------SRVRR-G---WEARPRGRD--LNSEPPAFLPRDPITQRAHGI-DPRDTWMLFVRQSDKGINGKRRSRGKAKRLKLG-----------------LPGPPGPPGPQGPPGP---IIPP----EVLLKEFQLLLKGAVRQRECAE-L-----EG-------PATP--GP------------A-------TTPAEEPEEEAAGVLALLTAPLGPG---LPRVDAAFHCRLRRDALVERRSLHELG-----------LYHVPN-AEGAFRRGPGLNLTSGQYTAPVGGFYAFA----AALHVAL-----VEPP------RRGPQRARDRLRLLVCIQSRCQHNASLEAIMGLESSSDLFTIAVNGVLYLQSGQY-ASIFLDNASGSSVTVRSGSRFSAVLLGV-
AL   NOISO|MACEUGS_8890_PE1              1 295 1.00 ------------MRLWVWVV--AAVLLWQQLTLLGGIS-AKRERKKAKEMVQYTEPFNATI--SNSEELPGHPKPPEAPG-PELTDAHKTWLNFVRRPDDV-TSRKKCKG--KDKRLPGPA----------------GPPG---------PPGAEVTQ----EALLQEFKDMLK------------------------EATERR-ASG--------------------------------------PLDSLVA---LWRVEEAFHCKLKP-SWIDKKTLMELH-----------NFQAPL-AKGAFLRGSGLNLSTGRFTAPVSGIYQFS----ANVHIDH-----SELK-SR-----AQLRARDNVRVLICIESLCHQHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQY-TSIFVDNSAGAALTIQNGSDFMELLMGL-
AL   NOISO|MICMUGS_4066_PE1              1 296 1.00 ------------MQHWAWAWAWAAALLWPQLTLLQGVRARRQ-------PSQYMEPPNNTT--SHSEWPPGAPKPSKASR-PEFSDAHMTWLNFVRRPDDG-ALKKRCRG--RDKKSQGLS-------------------GP------PGPPGAEVTP----EVLLQEXXXXXXX-----------------------XXXXX-XXXXXXX-----------------X------------------XXXXXX---XXXVDEAFHCRLRSPQLVDRRTLVELR-----------GFQAPT-AQGDFLRGSGLSLSSGRFTAPVSGIFQFS----ASLHVDH-----SALQ-GR-----PRPRARGTVRVLICIESLCHRHASLEAVSGLESNSRVSTAQVQGLLQLQAGQY-ASVLVDNRSGVVLTVQGGSSFSGLLLGT-
AL   NOISO|MONDO7_258_PE28               1 282 1.00 ---------------------------------------------------------------------------PVTEKPRSI-DPRDAWMLFVRQSNKGVNGKKRNTGKSKKYKLG-----------------LPGPPGPPGPQGPPGP---LILP----EELLKEFQLLLKGAVRHRQRLGPE--------------ACED--CGGGE-------AEA-------EDEERLAVAEEDGVLALVTGPLAESRR-PHRVEAAFRGRVRKSVSVERRSLRELQ-----------FYYVPE-KDGPFQRGPGLNLTSGQYTAPVTGFYTLA----ATLYIVQ----GGDHQ------KKGQPRSRDRLRVLICIQSLCQHNVSLEAIAGLEGGGDLFTVSVSGSLYLQAGQY-ASVFVDNATGSSLTIRSGSDFSAVFLGV-
AL   ENSMUSG00000047443|MOUSE1_PE1289    1 340 1.00 --MASTRRPVGARTLLACASLLAA--MGLGVPESAE---PVGTHARP-QP-PGAE---------LPAPPANSPPEPTIAHAHSV-DPRDAWMLFVKQSDKGINSKRRS--KARRLKLG-----------------LPGPPGPPGPQGPPGP---FIPS----EVLLKEFQLLLKGAVRQRESHL--------E-------HCTR--DLTTPASGSPSRVP---------AAQELDSQDPGALLALLAATLAQGPR-APRVEAAFHCRLRRDVQVDRRALHELG-----------IYYLPE-VEGAFHRGPGLNLTSGQYTAPVAGFYALA----ATLHVAL-----TEQP------RKGPTRPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQAGHY-TSVFLDNASGSSLTVRSGSHFSAILLGL-
AL   ISOFORMIN|MOUSE1_PE1290             1 304 1.00 ------------------------------------------MHAR--SR-PGPS---------CPPRQPTARREPTIAHAHSV-DPRDAWMLFVKQSDKGINSKRRS--KARRLKAW-----------------PARTPRATRSSGPPGP---FIPS----EVLLKEFQLLLKGAVRQRESHL--------E-------HCTR--DLTTPASGSPSRVP---------AAQELDSQDPGALLALLAATLAQGPR-APRVEAAFHCRLRRDVQVDRRALHELG-----------IYYLPE-VEGAFHRGPGLNLTSGQYTAPVAGFYALA----ATLHVAL-----TEQP------RKGPTRPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQAGHY-TSVFLDNASGSSLTVRSGSHFSAILLGL-
AL   NOISO|MOUSE4_PE3729                 1 308 1.00 --------------MWAWGWA-AAALLWLQT---AGAGARQEL-KKSRQLFARVDSPNITT--SNREGFPGSVKPPEASG-PELSDAHMTWLNFVRRPDDG-SSRKRCRG--RDKKSRGLSG-------------LPGPPGPPGPPGPPGSPGVGVTP----EALLQEFQEILK------------------------EATELRFSGLPDT-----------------L------------------LPQEPS---QRLVVEAFYCRLKGPVLVDKKTLVELQ-----------GFQAPT-TQGAFLRGSGLSLSLGRFTAPVSAIFQFS----ASLHVDH-----SELQ-GR-----GRLRTRDMVRVLICIESLCHRHTSLEAVSGLESNSRVFTVQVQGLLHLQSGQY-VSVFVDNSSGAVLTIQNTSSFSGMLLGT-
AL   ENSOANG00000015594|ORNAN7_34_PE4    1 299 1.00 -----------------------------------------------------PQALPAPS--STPLEPKGPHEETVTERTRSI-DPRDAWLLFVKQSNKGANGKKRSKGKSKKFKHG-----------------LPGPPGPPGPQGPPGP---LIPP----EELLKEFRLLLKGAVKRRERMSLP--------------TCED--CAGAE-------EEE-------GG---REAAEEADILALVTGPLAEGRQQQHHVEAAFHCRVRRNISIERRSLQELQ-----------VYYIPE-KEGSFHRGLGLNLTSGQYTAPVAGFYTFS----ATLHIVL-----GEHQ------RKGQPRARDRLRLLICIQSLCQRHVSLETVTGLESRSELFTLSVNGILYLQAGQY-ASVFIDNATGSSLVVRSGSDFSAVLLGM-
AL   ENSORLG00000007187|ORYLA17_12_PE25  1 309 1.00 ---------------------------------------RSADR-R---------VTAS-----DPQRDRNSPEETSSSEVSRL-SPLNSWLLFRKNSNKGENRR--TKGPKRTSKET-----------------WPSRTSRPS--RTSGTPGNFTSK----NILLSDFQLL----SL-----NNQVSKTETR-------FTHNSQGLAPPVSENLLFTSAC-------SGGYQPKHTFLMNSDMMGGECMQCD-RPLRVSTSFSSRLMQPLSVPRRSLQELH-----------PFSRPSDSEQNLQRGPSFDSSTGRYTAPVSGFYQLT----ASILIGL-----TESG------DRLQVRLRDSVRAAICIESLCKSNLSVESVMAVAAAGGTSSVLLTGTLYLQAGEY-VSVFVDNGTGSAISVLQDSLFSGILLGV-
AL   NOISO|OTOGAGS_4003_PE2              1 347 1.00 --MASARRLNRACLLLVYTGLLAI-AAGLDLLDSAA---PTDGCQPG-D------TPESSV--PSSTPPAACHVGPLPDQVHSI-DPRDAWMLFIRQSNKGVNGKRRGRTKAKKLKFG-----------------LPGPPGPPGPQGPPGP---IIPP----EALLKEFRLLLKGAVRQRQRQREE-----LE-------PCSV--SGLAPSSLVSGPATA-------GDDDQDDDEEADSMLALLAAHLAPGQR-APRVEAAFHCRLRRDASVARRALQELG-----------VYYLPD-ADGAFHRGLGLNLTSGQYTAPVTGFYALA----ATLHVGEPRGRVAGGG--------------GGKLTGSWVSGPCLGNSSLEAVLGMESSSELFTISVNGILYLQMGQY-TSVFLDNASGSSLTVRSGSHFSAVLLGV-
AL   NOISO|OTOGAGS_4832_PE1              1 192 1.00 ---------------------------------------------------------------------------------------------------------------------QGLL----------------GPPGP---------------------KFLLEFQEMLKE------------------------ATEHEF-----------------------------PG------------LLQGL---GPLVSEAFHCQVRGLQMVDKMTLLELC-----------GFQAPT-AQGAFLRGSSLSLSSGQFTVPMSGIFQFS----ASVHVXX-----XXXXXXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAGQYATEVFVDNSSGIVFTIYSSSSFSGVLLGMR
AL   ENSSSCG00000016337|PIG15_133_PE11   1 314 1.00 --MAPVCCL-AGTLMLVYAGLLAA-AASLGSPEPGA---PSGSRDRE-EPPPGNELPAGP---------AALPSEPAAERAHGI-DPRDAWMLFVRQSDKGVNGKRGGRGKARKLKLG-----------------LPGPPGPPGRQGPPGP---ILPP----EVLLKEFQLLLKGRVTP-GGAE-P-----DP--------CDA--GPFLPLCAEPAPCPR-------GPAEDEEDAGGAGVLALLAAPLAPGPQ-APRVEAAFHCRLRRDASLERRALHELG-----------VYYVPD-AEGAFRRGPGLNLTSGQYTAPVAGFYALA----ATLHVAL-----AEQP------RRGPLRPRDRLRLLICIQSRCQHHASLEAVMGLESSSELFTISVNGVLYLQV---------------------------------
AL   ISOFORMIN|PIG15_133_PE12            1 298 1.00 --MAPVCCL-AGTLMLVYAGLLAA-AASLGSPEPGA---PSGSRDRE-EPPPGNELPAGP---------AALPSEPAAERAHGI-DPRDAWMLFVRQSDKGVNGKRGGRGKARKLKLG-----------------LPGPPGPPGRQGPPGP---Y-PP----EVLLKEFQLLLKGAVRT-------------------------------RECAEPAPCPR-------GPAEDEEDAGGAGVLALLAAPLAPGPQ-APRVEAAFHCRLRRDASLERRALHELG-----------VYYVPD-AEGAFRRGPGLNLTSGQYTAPVAGFYALA----ATLHVAL-----AEQP------RRGPLRPRDRLRLLICIQSRCQHHASLEAVMGLESSSELFTISVNGVLYLQ----------------------------------
AL   NOISO|PIG6_44_PE19                  1 308 1.00 ------------NMRWAWAT--TVALLWPQLMLLGGVRARREP-KRPRQPGQRLASLNATM--SSSEGLPGFPKLPEASG-PELTDAHMTWLNFVRRPDDG-ASKKRCRG--QDKKLRGLS---------GPPGP-PGPPGP------PGPPGSEVNQ----EAVLREFQKMLK------------------------EATEHRSLGLLDP-----------------V------------------LPEGTG---RRLVAEAFHCRLRGPVLVDKKTLAELQ-----------GFQAPP-ARG-LPAGVGLSLASGRFTGPVRAIFQFS----ASLHVDP-----KELQ-GR-----ARLRARDTVRVLVCIESLCHRHTSLEAISGLESSGRVFTVQVQGLLQLQAGQY-TSVFVDNGSGAALTIQSSSSFSGLLLGT-
AL   NOISO|POEGU21_7_PE8                 1 265 1.00 ------------------------------------------------------------------------PQLPEPAE-PRITDPRRTWISFVHRPDDGSGSKRRCKG--RDKKLRGLV----------------GPPGPPGPQGPPGAPGAEVTK----EILLQEFKEILK-------------------------ETIEHRASLALP-----------------AQPSPLPL-------LPLALAEAGS---QRRLLEAFHCKLKGHVLVDKKTLVELQ-----------NFQLPV-ARGAFLRGSGLNVATGRFTAPVGGIYQFS----ANVHLEH-----SELR-GR-----AALRARDSVRVLVCIESLCHRHASLEVIAGLESNSKTFTICVQGLLQLQAGQY-ASVFVDNGAGAAVTIQSGSDFMGMLLGA-
AL   NOISO|PTEVAGS_2563_PE5              1 300 1.00 ------------SGRWAWAA--APVLLWPQLVVLGGIVARREP-KRPRQPSQHTESPNATV--ANSEGLPGSPKPAEASG-PEFSDAHMTWLNFVRRPDDG-ASKKRCRG--RDKKLP-------------------GPPGP------PGPPGAEVTQ----EALLREFQEVLR------------------------EAAERRSSGLRGP-----------------L------------------LPEGLG---GWLVPEAFHCRLKGPVLVDRKTLLELQ-----------GFQAPA-AQGAFLRGSGLSLASGRFTAPVTAIFQFS----ASLHVDR-----RGLQ-GR-----APPRPRGTVRVLVCIESLCHRHTYVEAISGLDGSGRALTVLVQGLLQLQAGQY-ASVFVDNGSGAALTVQSGSSFSGLLLGT-
AL   ENSOCUG00000017440|RABITUN0271_PE7  1 301 1.00 -----------------------------------------MWRRQG-SPNPA----------SCPPRLSCSPWEPPGEQARGM-DPRDAWMLFVRQSDKGVNSKRRSRGKARKLKLG-----------------LPGPPGPPGPRGLPGP---IIPW----EALLRELQLLLKGRVHSPHA---V-----LQ-------PCPR--SPGGPAAASPAPGPG----------------GPGGVLALLAAPLALGPR-TPRVEAAFHCRLRRDVAVERRALQELG-----------AYYLPN-ADGSFRRGLGLNLTSGQYTAPVAGFYALA----ATLHVAL-----AEPL------RRGTPRPRDHLRLLICIESRCQRNSALEAVTGLDSSSELFTISVNGILYLQTGQH-TSVFLDNASGSPLTVRSGSHFSAVLLGV-
AL   NOISO|RAT5_PE2131                   1 308 1.00 --------------MWAWGWA-AAALLWLQT---AGVRARQEL-KKPRQLVVRVDSPNITT--SSHEGFPGSIKPPEASG-PELSDAHMTWLNFVRRPDDG-ASRKRCRG--RDKKSRGLSG-------------LPGPPGPPGPPGPPGSPGLEVTP----EALLQEFQEMLK------------------------EAAELRFSGIPDS-----------------L------------------LPQEPR---QRLVVEAFHCRLKGPVTVDKKTLVELQ-----------GFQAPT-TQGAFLRGSGLSLSLGRFTAPVSAIFQFS----ASLHVDH-----SELQ-GR-----GRLRTRDTVRVLICIESLCHRHTSLEAVSGLESNSRVFTVQVQGLLYLQSGQY-VSVFVDNSSGAVLTIQNGSSFSGMLLGT-
AL   NOISO|RAT9_PE969                    1 341 1.00 --MASTRSPGGARTLLACASLLAA--MGLGVPESAE---PVGTQARP-QP-PGTE---------LPAPPAHSPPEPTIAHAHSV-DPRDAWMLFVKQSDKGINSKKRSRTKARRLKLG-----------------LPGPPGPPGPQGPPGP---FIPS----EVLLKEFQLLLKGAVRQRES-T--------E-------HCTR--DLTTPASGGPSRDP---------VTQELESQDQGAVLALLAATLAQSPR-APRVEAAFHCRLRRDVQVERRALHELG-----------VYYLPE-VEGAFRRGPGLNLTSGQYTAPVAGFYALA----ATLHVAL-----TKQP------RKGPPQPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQTGHY-TSVFLDNASGSSLTVRGGSHFSAILLGL-
AL   NOISO|SPETRGS_4351_PE2              1 199 1.00 --------------------------------------------------------------------------EPTTEPAHSV-DPRDAWMLFVRQSDKGINGKRRSKGKARRPKL------------------LPGPPGPPGPQGPPGP---PILP----ETLLKEFQLLLKXXXXXXXXXXXX-----XX-------XX------XXXXXXXX----S-------PASGSIEDDHGPGMLALLAAPLAP-PL-ARRVEAAFLCRLRRDAPVERRTLHELG-----------IYYVPE-SEGAFRRGLGLNLTSGQYTAPVAGFYLLA----ATVHVGEARGVG-----------------------------------------------------------------------------------------------
AL   NOISO|SPETRGS_5214_PE1              1 177 1.00 ------------MRRWAWAA--VLPLLWPQLALLCGVGAWRGA-QRLRQPGQLTEAPNGTA--SDSEGLPGSPKSLEPSG-PEFSDAHKTWLNFVRRPEDG-SSKKRCRCQGQDKKLRGLL-------------------GP------PGPPGVEVAP----AALLQEFKDMLK------------------------EATERRFSAWPDP-----------------P------------------LSRGAG---PWLMVEAFHCRLKGPVLVDKKTLVELQ-----------GFQA-----------------------------------------------------------------------------------------------------------------------------------------------
AL   NOISO|STRPU_77578_PE1               1 192 1.00 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAAERRAQIIIGE-----------------KCPSCLLNITEGTELHLPNLEELEL---LPTLPIAFHCKLSRDLDIPGKSLIEVV-----------NFRTPM-DTGSFRRGRGLDVRSGRFTAPRTAIYQLS----ANLHIGQ-----RLSDV-----KSRELKPRDNVRLLICINSMCQRHTSLEFVSGMESNSRVFTVAVSGLLRLEEGQY-ASVYIDNSSGRRIEIQGYVLYGTLN----
AL   NOISO|TETNG9_PE740                  1 249 1.00 -----------------------------------------------------------------------------------------SWMDFVKRPVENF--PTKCRK--RKRPLPGPP----------------GPPGPPGPQGPPGLPGAEVTQ----EDLLQEFKDMIK------------------------EATERRASALESQ-----------------TGPSQLPS-------TLLALDGTAA---HRRIDHAFHCKLKGPAVVDKKTLVELQ-----------NFQTPP-AKGAFLRGSGMDQSTGRFTAPVSGIYHFS----ANVHIDH-----NEVKRSK-----SQLKARDNVRVLICIESLCHRYTSLEMIVGLESNSRIFTVAVQGLLELQAGQY-TSIFVDNAAGAPITIQNGSDFMGMLLGV-
AL   NOISO|TURTRGS_2240_PE4              1 297 1.00 ------------NMRWVWAA--TTALLWAQLTLLGGVRARREP-KRPRKPGQHPAAPNXXXXXXXX-----XXXXXXXXL-PEFTDAHMTWLNFVRRPNDR-ASKKRCRG--QDKKSRGPP-------------------GP------PGPPGAEVTQ----EAVLREFQGMLK------------------------EATERQSSAPLGP-----------------P------------------LPEGTG---RWLVSEAFHCRLKGPVLVDKRTLVELQ-----------GFQAXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX----AIVHANP-----RELQ-GR-----ARLRARDTVRVLVCIESLCHRHTSLEAISGLESGGRVFTVHVQGLLQLQAGQY-TSVFVDNGSGAALTVQSSSSFSGLLLGT-
AL   NOISO|XENTR390_1_PE7                1 187 1.00 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------ATERRLMSGDIP-----------------EHTSELPP-------IVLPVEDLSP---YRRVDEGFHCRLKGQVIVDKKTLVELQ-----------NFQMPT-AKGSFLRGSGLNLATGRFTASVPGIYQFS----AHVHIDH-----SEIK-SK-----AQLRPRDNVRVLICIESMCHRYTSLEVIAGLESNSKIFTVHVQGLLQLQVGQY-TSIFVDNSAGAPITVQNGSDFMGILMGL-
CO                                            ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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