Alignment of the gene Family HBG000053 of HOVERGEN

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Isoforms are ON
Q8VDV4_MOUSE Q8VDV4_MOUSE ------------------------------ Q9NWG2_HUMAN Q9NWG2_HUMAN ------------------------------ B8JMJ3_DANRE B8JMJ3_DANRE ------------------------------ Q502G3_DANRE Q502G3_DANRE ------------------------------ Q4T3X4_TETNG Q4T3X4_TETNG ELSEAERVVELGLVQAEAGEARQLWECVWG B5X112_SALSA B5X112_SALSA ------------------------------ Q4SHX2_TETNG Q4SHX2_TETNG ------------------------------ Q501W5_DANRE Q501W5_DANRE ------------------------------ Q9D7B2_MOUSE Q9D7B2_MOUSE ------------------------------ B4F6Z9_XENTR B4F6Z9_XENTR ------------------------------ Q6GMB2_XENLA Q6GMB2_XENLA ------------------------------ A7LBJ1_XENLA A7LBJ1_XENLA ------------------------------ Q6INR9_XENLA Q6INR9_XENLA ------------------------------ Q5ZL81_CHICK Q5ZL81_CHICK ------------------------------ Q6IYF7_CHICK Q6IYF7_CHICK ------------------------------ A4FV50_BOVIN A4FV50_BOVIN ------------------------------ B7Z483_HUMAN B7Z483_HUMAN ------------------------------ B7Z7R3_HUMAN B7Z7R3_HUMAN ------------------------------ B7Z907_HUMAN B7Z907_HUMAN ------------------------------ LIMS1_HUMAN LIMS1_HUMAN ------------------------------ A8CVP1_MOUSE A8CVP1_MOUSE ------------------------------ Q4ZJB3_MOUSE Q4ZJB3_MOUSE ------------------------------ LIMS1_MOUSE LIMS1_MOUSE ------------------------------ A8CVP4_MOUSE A8CVP4_MOUSE ------------------------------ Q5PQM7_RAT Q5PQM7_RAT ------------------------------ LIMS2_MOUSE LIMS2_MOUSE ------------------------------ LIMS2_BOVIN LIMS2_BOVIN ------------------------------ B3KNZ3_HUMAN B3KNZ3_HUMAN ------------------------------ B4DMV1_HUMAN B4DMV1_HUMAN ------------------------------ LIMS2_HUMAN LIMS2_HUMAN ------------------------------ Q7Z4I5_HUMAN Q7Z4I5_HUMAN ------------------------------ Q7Z4I3_HUMAN Q7Z4I3_HUMAN ------------------------------ Q7Z4I4_HUMAN Q7Z4I4_HUMAN ------------------------------ Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------------------------ MATCH CONSENSUS ??????????????????????????????

Q8VDV4_MOUSE Q8VDV4_MOUSE ------------------------------ Q9NWG2_HUMAN Q9NWG2_HUMAN ---------------------------MTG B8JMJ3_DANRE B8JMJ3_DANRE ------------------------------ Q502G3_DANRE Q502G3_DANRE -------------------MEAEAEAPELN Q4T3X4_TETNG Q4T3X4_TETNG TLQVRMESRGRALAPPIPEEGEAPGGVLHR B5X112_SALSA B5X112_SALSA ---------------------------MLG Q4SHX2_TETNG Q4SHX2_TETNG ------------------------------ Q501W5_DANRE Q501W5_DANRE ---------------------------MLG Q9D7B2_MOUSE Q9D7B2_MOUSE ---MAFPGRARPCTIPENEEIPQTALNSVL B4F6Z9_XENTR B4F6Z9_XENTR ----------------------------MS Q6GMB2_XENLA Q6GMB2_XENLA ---------------------------MLG A7LBJ1_XENLA A7LBJ1_XENLA ---------------------------MLG Q6INR9_XENLA Q6INR9_XENLA ---------------------------MLG Q5ZL81_CHICK Q5ZL81_CHICK ---------------------------MLG Q6IYF7_CHICK Q6IYF7_CHICK ------------------------------ A4FV50_BOVIN A4FV50_BOVIN ---------------------------MLG B7Z483_HUMAN B7Z483_HUMAN ---------------------------MLG B7Z7R3_HUMAN B7Z7R3_HUMAN ---MAFSGRARPCIIPENEEIPRAALNTVH B7Z907_HUMAN B7Z907_HUMAN ---------------------------MTA LIMS1_HUMAN LIMS1_HUMAN ------------------------------ A8CVP1_MOUSE A8CVP1_MOUSE --------------------------MTTL Q4ZJB3_MOUSE Q4ZJB3_MOUSE ---MAFPGRARPCTIPENEEIPQTALNSVL LIMS1_MOUSE LIMS1_MOUSE ------------------------------ A8CVP4_MOUSE A8CVP4_MOUSE ------------------------------ Q5PQM7_RAT Q5PQM7_RAT ------------------------------ LIMS2_MOUSE LIMS2_MOUSE ---------------------------MTG LIMS2_BOVIN LIMS2_BOVIN ---------------------------MTG B3KNZ3_HUMAN B3KNZ3_HUMAN ------------------------------ B4DMV1_HUMAN B4DMV1_HUMAN ------------------MTGRKRKWGETG LIMS2_HUMAN LIMS2_HUMAN ---------------------------MTG Q7Z4I5_HUMAN Q7Z4I5_HUMAN ------------------------------ Q7Z4I3_HUMAN Q7Z4I3_HUMAN ------------------------------ Q7Z4I4_HUMAN Q7Z4I4_HUMAN ------------------------------ Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------------------------ MATCH CONSENSUS ??????????????????????????????

Q8VDV4_MOUSE Q8VDV4_MOUSE ------------------------------ Q9NWG2_HUMAN Q9NWG2_HUMAN S----------------------------- B8JMJ3_DANRE B8JMJ3_DANRE ------------------------------ Q502G3_DANRE Q502G3_DANRE V-DGLQQNQTAGEPEVPKRSDVKVYKEFCD Q4T3X4_TETNG Q4T3X4_TETNG E-TNGFQTELPVSRSQRRRSDVKVYKEFCD B5X112_SALSA B5X112_SALSA V-V-EMTGS--------------------- Q4SHX2_TETNG Q4SHX2_TETNG ------------------------------ Q501W5_DANRE Q501W5_DANRE V-S-EMTGS--------------------- Q9D7B2_MOUSE Q9D7B2_MOUSE E-ANGNEDERAVSNLQRRHSDVKVYKEFCD B4F6Z9_XENTR B4F6Z9_XENTR A-LQLKELSQSDLYRRRKERPDSLGLNGIH Q6GMB2_XENLA Q6GMB2_XENLA V-V-GMTNS--------------------- A7LBJ1_XENLA A7LBJ1_XENLA V-V-GMTNS--------------------- Q6INR9_XENLA Q6INR9_XENLA V-V-GMTNS--------------------- Q5ZL81_CHICK Q5ZL81_CHICK VAAAGLPGS--------------------- Q6IYF7_CHICK Q6IYF7_CHICK ------------------------------ A4FV50_BOVIN A4FV50_BOVIN V-ASGMTNS--------------------- B7Z483_HUMAN B7Z483_HUMAN V-AAGMTHS--------------------- B7Z7R3_HUMAN B7Z7R3_HUMAN E-ANGTEDERAVSKLQRRHSDVKVYKEFCD B7Z907_HUMAN B7Z907_HUMAN LQLKELSHS--GLYRRRRDRPDSLRVNGLP LIMS1_HUMAN LIMS1_HUMAN ------------------------------ A8CVP1_MOUSE A8CVP1_MOUSE Q-LKELSQS--GLYRRRRERPESLRVNGHA Q4ZJB3_MOUSE Q4ZJB3_MOUSE E-ANGNEDERAVSNLQRRHSDVKVYKEFCD LIMS1_MOUSE LIMS1_MOUSE ------------------------------ A8CVP4_MOUSE A8CVP4_MOUSE ------------------------------ Q5PQM7_RAT Q5PQM7_RAT ------------------------------ LIMS2_MOUSE LIMS2_MOUSE S----------------------------- LIMS2_BOVIN LIMS2_BOVIN S----------------------------- B3KNZ3_HUMAN B3KNZ3_HUMAN ------------------------------ B4DMV1_HUMAN B4DMV1_HUMAN T-GSGAAPAAALRWS--------------- LIMS2_HUMAN LIMS2_HUMAN S----------------------------- Q7Z4I5_HUMAN Q7Z4I5_HUMAN ------------------------------ Q7Z4I3_HUMAN Q7Z4I3_HUMAN ------------------------------ Q7Z4I4_HUMAN Q7Z4I4_HUMAN -------ME--------------------- Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------------------------ MATCH CONSENSUS ??????????????????????????????

Q8VDV4_MOUSE Q8VDV4_MOUSE ------------------------PA---- Q9NWG2_HUMAN Q9NWG2_HUMAN -----NMSDALANAVCQRCQARFSPAERIV B8JMJ3_DANRE B8JMJ3_DANRE -----NMTNALANAVCERCKSSFSPTEKMV Q502G3_DANRE Q502G3_DANRE FYVRYNMTNALANAVCERCKSSFSPTEKMV Q4T3X4_TETNG Q4T3X4_TETNG FYARFNMANALANAMCERCKSGFAPLEKMV B5X112_SALSA B5X112_SALSA -----NMANALANASCERCKSGFAPAEKIV Q4SHX2_TETNG Q4SHX2_TETNG ------IANALANATCERCKSGFAATEKIV Q501W5_DANRE Q501W5_DANRE -----NMANALANASCERCKSGFAPAEKIV Q9D7B2_MOUSE Q9D7B2_MOUSE FYAKFNMANALASATCERCKGGFAPAEKIV B4F6Z9_XENTR B4F6Z9_XENTR ADKLSNMANALANAICERCRSGFAPSEKIV Q6GMB2_XENLA Q6GMB2_XENLA -----NMANALANAICERCRAGFAASEKIV A7LBJ1_XENLA A7LBJ1_XENLA -----NMANALANAICERCRSGFAPSEKIV Q6INR9_XENLA Q6INR9_XENLA -----NMANALANAICERCRSGFAPSEKIV Q5ZL81_CHICK Q5ZL81_CHICK -----NMANALANAICERCRGGFAPAEKIV Q6IYF7_CHICK Q6IYF7_CHICK ------MANALANAICERCRGGFAPAEKIV A4FV50_BOVIN A4FV50_BOVIN -----NMANALANASCERCRGGFAPAEKIV B7Z483_HUMAN B7Z483_HUMAN -----NMANALASATCERCKGGFAPAEKIV B7Z7R3_HUMAN B7Z7R3_HUMAN FYAKFNMANALASATCERCKGGFAPAEKIV B7Z907_HUMAN B7Z907_HUMAN EEELSNMANALASATCERCKGGFAPAEKIV LIMS1_HUMAN LIMS1_HUMAN ------MANALASATCERCKGGFAPAEKIV A8CVP1_MOUSE A8CVP1_MOUSE EEELSNMANALASATCERCKGGFAPAEKIV Q4ZJB3_MOUSE Q4ZJB3_MOUSE FYAKFNMANALASATCERCKGGFAPAEKIV LIMS1_MOUSE LIMS1_MOUSE ------MANALASATCERCKGGFAPAEKIV A8CVP4_MOUSE A8CVP4_MOUSE ------MANALASATCERCKGGFAPAEKIV Q5PQM7_RAT Q5PQM7_RAT ------MSECLADAMCQRCQARFAPTERIV LIMS2_MOUSE LIMS2_MOUSE -----NMSECLADAMCQRCQARFAPTERIV LIMS2_BOVIN LIMS2_BOVIN -----NMSNALANAVCQRCQARFAPAERIV B3KNZ3_HUMAN B3KNZ3_HUMAN ------MSDALANAVCQRCQARFSPAERIV B4DMV1_HUMAN B4DMV1_HUMAN -----NMSDALANAVCQRCQARFSPAERIV LIMS2_HUMAN LIMS2_HUMAN -----NMSDALANAVCQRCQARFSPAERIV Q7Z4I5_HUMAN Q7Z4I5_HUMAN ------------------------------ Q7Z4I3_HUMAN Q7Z4I3_HUMAN ------------------------------ Q7Z4I4_HUMAN Q7Z4I4_HUMAN -----SRHPAVAEIACT-CWALLHPAN--- Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------------------------ MATCH CONSENSUS ??????M??ALA?A?C?RC???F?P?E??V

Q8VDV4_MOUSE Q8VDV4_MOUSE ------------------------------ Q9NWG2_HUMAN Q9NWG2_HUMAN NSNGELYHEHCFVCAQCFRPFPEGLFYEFE B8JMJ3_DANRE B8JMJ3_DANRE NSNGELYHEQCFTCAQCFQQLIQGLFYEFE Q502G3_DANRE Q502G3_DANRE NSNGELYHEQCFTCAQCFQQLIQGLFYEFE Q4T3X4_TETNG Q4T3X4_TETNG NSNGELYHEQCFVCAQCFQQFPEGLFYEFE B5X112_SALSA B5X112_SALSA NSNGELYHEGCFVCAQCFQQFPEGLFYEFE Q4SHX2_TETNG Q4SHX2_TETNG NSNGELYHEQCFVCAQCFQQFPEGLFYEFE Q501W5_DANRE Q501W5_DANRE NSNGELYHEQCFVCAQCFQQFPEGLFYEFE Q9D7B2_MOUSE Q9D7B2_MOUSE NSNGELYHEQCFVCAQCFQQFPEGLFYEFE B4F6Z9_XENTR B4F6Z9_XENTR NSNGELYHEQCFVCAQCFQQFPEGLFYEFE Q6GMB2_XENLA Q6GMB2_XENLA NSNGELYHEQCFVCAQCFQQFPEGLFYEFE A7LBJ1_XENLA A7LBJ1_XENLA NSNGELYHEQCFVCAQCFQQFPEGLFYEFE Q6INR9_XENLA Q6INR9_XENLA NSNGELYHEQCFVCAQCFQQFPEGLFYEFE Q5ZL81_CHICK Q5ZL81_CHICK NSNGELYHEQCFVCAQCFQQFPEGLFYEFE Q6IYF7_CHICK Q6IYF7_CHICK NSNGELYHEQCFVCAQCFQQFPEGLFYEFE A4FV50_BOVIN A4FV50_BOVIN NSNGELYHEQCFVCAQCFQQFPEGLFYEFE B7Z483_HUMAN B7Z483_HUMAN NSNGELYHEQCFVCAQCFQQFPEGLFYEFE B7Z7R3_HUMAN B7Z7R3_HUMAN NSNGELYHEQCFVCAQCFQQFPEGLFYEFE B7Z907_HUMAN B7Z907_HUMAN NSNGELYHEQCFVCAQCFQQFPEGLFYEFE LIMS1_HUMAN LIMS1_HUMAN NSNGELYHEQCFVCAQCFQQFPEGLFYEFE A8CVP1_MOUSE A8CVP1_MOUSE NSNGELYHEQCFVCAQCFQQFPEGLFYEFE Q4ZJB3_MOUSE Q4ZJB3_MOUSE NSNGELYHEQCFVCAQCFQQFPEGLFYEFE LIMS1_MOUSE LIMS1_MOUSE NSNGELYHEQCFVCAQCFQQFPEGLFYEFE A8CVP4_MOUSE A8CVP4_MOUSE NSNGELYHEQCFVCAQCFQQFPEGLFYEFE Q5PQM7_RAT Q5PQM7_RAT NSNGELYHEHCFVCAQCFRPFPEGLFYEFE LIMS2_MOUSE LIMS2_MOUSE NSNGELYHEHCFVCAQCFRPFPEGLFYEFE LIMS2_BOVIN LIMS2_BOVIN NSNGELYHEHCFVCAQCFRPFPEGLFYEFE B3KNZ3_HUMAN B3KNZ3_HUMAN NSNGELYHEHCFVCAQCFRPFPEGLFYEFE B4DMV1_HUMAN B4DMV1_HUMAN NSNGELYHEHCFVCAQCFRPFPEGLFYEFE LIMS2_HUMAN LIMS2_HUMAN NSNGELYHEHCFVCAQCFRPFPEGLFYEFE Q7Z4I5_HUMAN Q7Z4I5_HUMAN ------------------------------ Q7Z4I3_HUMAN Q7Z4I3_HUMAN -----------------MPPPPAGISAGL- Q7Z4I4_HUMAN Q7Z4I4_HUMAN ---------------------PEG------ Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------------------------ MATCH CONSENSUS NSNGELYHE?CF?CAQCF???PEGLFYEFE

Q8VDV4_MOUSE Q8VDV4_MOUSE GKR----------TPMCAHCNQVIRGPFLV Q9NWG2_HUMAN Q9NWG2_HUMAN GRKYCEHDFQMLFAPCCGSCGEFIIGRVIK B8JMJ3_DANRE B8JMJ3_DANRE GRKYCEHDFQMLFAPCCHQCGEFVVGRVIK Q502G3_DANRE Q502G3_DANRE GRKYCEHDFQMLFAPCCHQCGEFVVGRVIK Q4T3X4_TETNG Q4T3X4_TETNG GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK B5X112_SALSA B5X112_SALSA GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK Q4SHX2_TETNG Q4SHX2_TETNG GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK Q501W5_DANRE Q501W5_DANRE GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK Q9D7B2_MOUSE Q9D7B2_MOUSE GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK B4F6Z9_XENTR B4F6Z9_XENTR GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK Q6GMB2_XENLA Q6GMB2_XENLA GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK A7LBJ1_XENLA A7LBJ1_XENLA GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK Q6INR9_XENLA Q6INR9_XENLA GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK Q5ZL81_CHICK Q5ZL81_CHICK GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK Q6IYF7_CHICK Q6IYF7_CHICK GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK A4FV50_BOVIN A4FV50_BOVIN GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK B7Z483_HUMAN B7Z483_HUMAN GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK B7Z7R3_HUMAN B7Z7R3_HUMAN GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK B7Z907_HUMAN B7Z907_HUMAN GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK LIMS1_HUMAN LIMS1_HUMAN GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK A8CVP1_MOUSE A8CVP1_MOUSE GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK Q4ZJB3_MOUSE Q4ZJB3_MOUSE GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK LIMS1_MOUSE LIMS1_MOUSE GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK A8CVP4_MOUSE A8CVP4_MOUSE GRKYCEHDFQMLFAPCCHQCGEFIIGRVIK Q5PQM7_RAT Q5PQM7_RAT GRKYCEHDFQMLFAPCCGFCGEFVIGRVIK LIMS2_MOUSE LIMS2_MOUSE GRKYCEHDFQMLFAPCCGFCGEFVIGRVIK LIMS2_BOVIN LIMS2_BOVIN GRKYCEHDFQMLFAPCCGSCGEFIIGRVIK B3KNZ3_HUMAN B3KNZ3_HUMAN GRKYCEHDFQMLFAPCCGSCGEFIIGRVIK B4DMV1_HUMAN B4DMV1_HUMAN GRKYCEHDFQMLFAPCCGSCGEFIIGRVIK LIMS2_HUMAN LIMS2_HUMAN GRKYCEHDFQMLFAPCCGSCGEFIIGRVIK Q7Z4I5_HUMAN Q7Z4I5_HUMAN ------------------------------ Q7Z4I3_HUMAN Q7Z4I3_HUMAN ------------------------------ Q7Z4I4_HUMAN Q7Z4I4_HUMAN ------------------------------ Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------------------------ MATCH CONSENSUS GRKYCEHDFQMLFAPCC??CGEF??GRVIK

Q8VDV4_MOUSE Q8VDV4_MOUSE ALGKSWHPEEFNCAHCKNTMAYIGFVEE-- Q9NWG2_HUMAN Q9NWG2_HUMAN ------------------------------ B8JMJ3_DANRE B8JMJ3_DANRE AMNSSWHPDCFCCEVCEAVLADVGFVKSGG Q502G3_DANRE Q502G3_DANRE AMNSSWHPDCFCCEVCEAVLADVGFVKSGG Q4T3X4_TETNG Q4T3X4_TETNG AMNNSWHPDCFCCNLCQAVLADVGFVKNAG B5X112_SALSA B5X112_SALSA AMNNSWHPDCFCCDICQAVLADVGFVKNAG Q4SHX2_TETNG Q4SHX2_TETNG AMNNSWHPDCFCCDICQAVLADVGFVKNAG Q501W5_DANRE Q501W5_DANRE AMNNSWHPDCFCCDICQAVLADVGFVKNAG Q9D7B2_MOUSE Q9D7B2_MOUSE AMNNSWHPECFRCDLCQEVLADIGFVKNAG B4F6Z9_XENTR B4F6Z9_XENTR AMNNSWHPECFRCDICQQVLADIGFVKNAG Q6GMB2_XENLA Q6GMB2_XENLA AMNNSWHPECFRCDICQQVLADIGFVKNAG A7LBJ1_XENLA A7LBJ1_XENLA AMNNSWHPECFRCDICQQVLADIGFVKNAG Q6INR9_XENLA Q6INR9_XENLA AMNNSWHPECFRCDICQQVLADIGFVKNAG Q5ZL81_CHICK Q5ZL81_CHICK AMNNSWHPDCFCCDICHKVLADIGFVKNAG Q6IYF7_CHICK Q6IYF7_CHICK AMNNSWHPDCFCCDICHKVLADIGFVKNAG A4FV50_BOVIN A4FV50_BOVIN AMNNSWHPECFRCDLCQEVLADIGFVKNAG B7Z483_HUMAN B7Z483_HUMAN AMNNSWHPECFRCDLCQEVLADIGFVKNAG B7Z7R3_HUMAN B7Z7R3_HUMAN AMNNSWHPECFRCDLCQEVLADIGFVKNAG B7Z907_HUMAN B7Z907_HUMAN AMNNSWHPECFRCDLCQEVLADIGFVKNAG LIMS1_HUMAN LIMS1_HUMAN AMNNSWHPECFRCDLCQEVLADIGFVKNAG A8CVP1_MOUSE A8CVP1_MOUSE AMNNSWHPECFRCDLCQEVLADIGFVKNAG Q4ZJB3_MOUSE Q4ZJB3_MOUSE AMNNSWHPECFRCDLCQEVLADIGFVKNAG LIMS1_MOUSE LIMS1_MOUSE AMNNSWHPECFRCDLCQEVLADIGFVKNAG A8CVP4_MOUSE A8CVP4_MOUSE AMNNSWHPECFRCDLCQEVLADIGFVKNAG Q5PQM7_RAT Q5PQM7_RAT AMNANWHPGCFRCELCDVELADLGFVKNAG LIMS2_MOUSE LIMS2_MOUSE AMNANWHPGCFRCELCDVELADLGFVKNAG LIMS2_BOVIN LIMS2_BOVIN AMNNNWHPGCFRCELCDVELADLGFVKNAG B3KNZ3_HUMAN B3KNZ3_HUMAN AMNNNWHPGCFRCELCDVELADLGFVKNAG B4DMV1_HUMAN B4DMV1_HUMAN AMNNNWHPGCFRCELCDVELAGLGFVKNAG LIMS2_HUMAN LIMS2_HUMAN AMNNNWHPGCFRCELCDVELADLGFVKNAG Q7Z4I5_HUMAN Q7Z4I5_HUMAN -MNNNWHPGCFRCELCDVELADLGFVKNAG Q7Z4I3_HUMAN Q7Z4I3_HUMAN ----------------------------AT Q7Z4I4_HUMAN Q7Z4I4_HUMAN -----------------------------R Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------------------------ MATCH CONSENSUS AMN??WHP?CF?C??C???LAD?GFVK?AG

Q8VDV4_MOUSE Q8VDV4_MOUSE ------------------------------ Q9NWG2_HUMAN Q9NWG2_HUMAN ------------------------------ B8JMJ3_DANRE B8JMJ3_DANRE RPLCRSCHSRQKALSLGKHVCQKCLCVVEE Q502G3_DANRE Q502G3_DANRE RPLCRSCHSRQKALSLGKHVCQKCLCVVEE Q4T3X4_TETNG Q4T3X4_TETNG RHLCRPCHNREKARGLGKYVCQKCHAIIEE B5X112_SALSA B5X112_SALSA RHLCRPCHNREKARGLGKYICQKCHAIIED Q4SHX2_TETNG Q4SHX2_TETNG RHLCRPCHNREKARGLGKYICQKCHAIIEE Q501W5_DANRE Q501W5_DANRE RHLCRPCHNREKARGLGKYICQKCHAIIEE Q9D7B2_MOUSE Q9D7B2_MOUSE RHLCRPCHNREKARGLGKYICQKCHAIIDE B4F6Z9_XENTR B4F6Z9_XENTR RHLCRPCHNREKARGLGKYICQKCHAIIDE Q6GMB2_XENLA Q6GMB2_XENLA RHLCRPCHNREKARGLGKYICQKCHAIIDE A7LBJ1_XENLA A7LBJ1_XENLA RHLCRPCHNREKARGLGKYICQKCHAIIEE Q6INR9_XENLA Q6INR9_XENLA RHLCRPCHNREKARGLGKYICQKCHAIIEE Q5ZL81_CHICK Q5ZL81_CHICK RHLCRSCHNKEKARGLGKYICQKCHAIIDE Q6IYF7_CHICK Q6IYF7_CHICK RHLCRSCHNKEKARGLGKYICQKCHAIIDE A4FV50_BOVIN A4FV50_BOVIN RHLCRPCHNREKARGLGKYICQKCHAIIDE B7Z483_HUMAN B7Z483_HUMAN RHLCRPCHNREKARGLGKYICQKCHAIIDE B7Z7R3_HUMAN B7Z7R3_HUMAN RHLCRPCHNREKARGLGKYICQKCHAIIDE B7Z907_HUMAN B7Z907_HUMAN RHLCRPCHNREKARGLGKYICQKCHAIIDE LIMS1_HUMAN LIMS1_HUMAN RHLCRPCHNREKARGLGKYICQKCHAIIDE A8CVP1_MOUSE A8CVP1_MOUSE RHLCRPCHNREKARGLGKYICQKCHAIIDE Q4ZJB3_MOUSE Q4ZJB3_MOUSE RHLCRPCHNREKARGLGKYICQKCHAIIDE LIMS1_MOUSE LIMS1_MOUSE RHLCRPCHNREKARGLGKYICQKCHAIIDE A8CVP4_MOUSE A8CVP4_MOUSE RHLCRPCHNREKARGLGKYICQKCHAIIDE Q5PQM7_RAT Q5PQM7_RAT RHLCRPCHNREKAKGLGKFICQRCHLAIDE LIMS2_MOUSE LIMS2_MOUSE RHLCRPCHNREKAKGLGKFICQRCHLAIDE LIMS2_BOVIN LIMS2_BOVIN RHLCRPCHNREKAKGLGKYICQRCHLVIDE B3KNZ3_HUMAN B3KNZ3_HUMAN RHLCRPCHNREKAKGLGKYICQRCHLVIDE B4DMV1_HUMAN B4DMV1_HUMAN RHLCRPCHNREKAKGLGKYICQRCHLVIDE LIMS2_HUMAN LIMS2_HUMAN RHLCRPCHNREKAKGLGKYICQRCHLVIDE Q7Z4I5_HUMAN Q7Z4I5_HUMAN RHLCRPCHNREKAKGLGKYICQRCHLVIDE Q7Z4I3_HUMAN Q7Z4I3_HUMAN RHLCRPCHNREKAKGLGKYICQRCHLVIDE Q7Z4I4_HUMAN Q7Z4I4_HUMAN GHLCRPCHNREKAKGLGKYICQRCHLVIDE Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------------------------ MATCH CONSENSUS RHLCR?CHNREKA?GLGK?ICQ?CH??I?E

Q8VDV4_MOUSE Q8VDV4_MOUSE ------------------------------ Q9NWG2_HUMAN Q9NWG2_HUMAN ------------------------------ B8JMJ3_DANRE B8JMJ3_DANRE -PLMYRSDPYHPDHFNCSHCGKELTADARE Q502G3_DANRE Q502G3_DANRE -PLMYRSDPYHPDHFNCSHCGKELTADARE Q4T3X4_TETNG Q4T3X4_TETNG QPLLFKNDPYHPDHFNCNNCGKELTSDARE B5X112_SALSA B5X112_SALSA SPLIFKNDPYHPDHFNCNNCGKELTADARE Q4SHX2_TETNG Q4SHX2_TETNG QPLIFKNDPYHPDHFNCNNCGKELTADARE Q501W5_DANRE Q501W5_DANRE QPLIFKNDPYHPDHFNCSDCGKELTADARE Q9D7B2_MOUSE Q9D7B2_MOUSE QPLIFKNDPYHPDHFNCANCGKELTADARE B4F6Z9_XENTR B4F6Z9_XENTR QPLIFKNDPYHPDHFNCANCGKELTADARE Q6GMB2_XENLA Q6GMB2_XENLA HPLIFKNDPYHPDHFNCANCGKELTADARE A7LBJ1_XENLA A7LBJ1_XENLA HPLIFKNDPYHPDHFNCANCGKELTADARE Q6INR9_XENLA Q6INR9_XENLA HPLIFKNDPYHPDHFNCANCGKELTADVRE Q5ZL81_CHICK Q5ZL81_CHICK QPLIFKNDPYHPDHFNCANCGKELTADARE Q6IYF7_CHICK Q6IYF7_CHICK QPLIFKNDPYHPDHFNCANCGKELTADARE A4FV50_BOVIN A4FV50_BOVIN QPLIFKNDPYHPDHFNCANCGKELTADARE B7Z483_HUMAN B7Z483_HUMAN QPLIFKNDPYHPDHFNCANCGKELTADARE B7Z7R3_HUMAN B7Z7R3_HUMAN QPLIFKNDPYHPDHFNCANCGKELTADARE B7Z907_HUMAN B7Z907_HUMAN QPLIFKNDPYHPDHFNCANCGKELTADARE LIMS1_HUMAN LIMS1_HUMAN QPLIFKNDPYHPDHFNCANCGKELTADARE A8CVP1_MOUSE A8CVP1_MOUSE QPLIFKNDPYHPDHFNCANCGKELTADARE Q4ZJB3_MOUSE Q4ZJB3_MOUSE QPLIFKNDPYHPDHFNCANCGKELTADARE LIMS1_MOUSE LIMS1_MOUSE QPLIFKNDPYHPDHFNCANCGKELTADARE A8CVP4_MOUSE A8CVP4_MOUSE QPLIFKNDPYHPDHFNCANCGKELTADARE Q5PQM7_RAT Q5PQM7_RAT QPLMFKNDPYHPDHFSCSHCGKELTSDARE LIMS2_MOUSE LIMS2_MOUSE QPLMFKNDPYHPDHFSCSNCGKELTSDARE LIMS2_BOVIN LIMS2_BOVIN QPLMFKNDAYHPDHFSCTHCGKELTAEARE B3KNZ3_HUMAN B3KNZ3_HUMAN QPLMFRSDAYHPDHFNCTHCGKELTAEARE B4DMV1_HUMAN B4DMV1_HUMAN QPLMFRSDAYHPDHFNCTHCGKELTAEARE LIMS2_HUMAN LIMS2_HUMAN QPLMFRSDAYHPDHFNCTHCGKELTAEARE Q7Z4I5_HUMAN Q7Z4I5_HUMAN QPLMFRSDAYHPDHFNCTHCGKELTAEARE Q7Z4I3_HUMAN Q7Z4I3_HUMAN QPLMFRSDAYHPDHFNCTHCGKELTAEARE Q7Z4I4_HUMAN Q7Z4I4_HUMAN QPLMFRSDAYHPDHFNCTHCGKELTAEARE Q7Z4I2_HUMAN Q7Z4I2_HUMAN ---MFRSDAYHPDHFNCTHCGKELTAEARE MATCH CONSENSUS ?PL?F??D?YHPDHFNC??CGKELTA?ARE

Q8VDV4_MOUSE Q8VDV4_MOUSE -KGALYCELCYEKFFAPECGRCQRKILGEV Q9NWG2_HUMAN Q9NWG2_HUMAN ------------------------------ B8JMJ3_DANRE B8JMJ3_DANRE LKGELYCLPCHDKLGVPICGACRRPVEGRV Q502G3_DANRE Q502G3_DANRE LKGELYCLPCHDKLGVPICGACRRPVEGRV Q4T3X4_TETNG Q4T3X4_TETNG LKGELYCLPCHDKMGVPICGACRRPIEGRV B5X112_SALSA B5X112_SALSA LKGELYCLPCHDKMGVPICGACRRPIEGRV Q4SHX2_TETNG Q4SHX2_TETNG LKGELYCLPCHDKMGVPICGACRRPIEGRV Q501W5_DANRE Q501W5_DANRE LKGELYCLPCHDKMGVPICGACRRPIEGRV Q9D7B2_MOUSE Q9D7B2_MOUSE LKGELYCLPCHDKMGVPICGACRRPIEGRV B4F6Z9_XENTR B4F6Z9_XENTR LKGELYCLPCHDKMGVPICGACRRPIEGRV Q6GMB2_XENLA Q6GMB2_XENLA LKGELYCLPCHDKMGVPICGACRRPIEGRV A7LBJ1_XENLA A7LBJ1_XENLA LKGELYCLPCHDKMGVPICGACRRPIEGRV Q6INR9_XENLA Q6INR9_XENLA LKGELYCLPCHDKMGVPICGACRRPIEGRV Q5ZL81_CHICK Q5ZL81_CHICK LKGELYCLPCHDKMGVPICGACRRPIEGRV Q6IYF7_CHICK Q6IYF7_CHICK LKGELYCLPCHDKMGVPICGACRRPIEGRV A4FV50_BOVIN A4FV50_BOVIN LKGELYCLPCHDKMGVPICGACRRPIEGRV B7Z483_HUMAN B7Z483_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV B7Z7R3_HUMAN B7Z7R3_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV B7Z907_HUMAN B7Z907_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV LIMS1_HUMAN LIMS1_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV A8CVP1_MOUSE A8CVP1_MOUSE LKGELYCLPCHDKMGVPICGACRRPIEGRV Q4ZJB3_MOUSE Q4ZJB3_MOUSE LKGELYCLPCHDKMGVPICGACRRPIEGRV LIMS1_MOUSE LIMS1_MOUSE LKGELYCLPCHDKMGVPICGACRRPIEGRV A8CVP4_MOUSE A8CVP4_MOUSE LKGELYCLPCHDKMGVPICGACRRPIEGRV Q5PQM7_RAT Q5PQM7_RAT LKGELYCLPCHDKMGIPICGACRRPIEGRV LIMS2_MOUSE LIMS2_MOUSE LKGELYCLPCHDKMGIPICGACRRPIEGRV LIMS2_BOVIN LIMS2_BOVIN LKGELYCLPCHDKMGVPICGACRRPIEGRV B3KNZ3_HUMAN B3KNZ3_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV B4DMV1_HUMAN B4DMV1_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV LIMS2_HUMAN LIMS2_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV Q7Z4I5_HUMAN Q7Z4I5_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV Q7Z4I3_HUMAN Q7Z4I3_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV Q7Z4I4_HUMAN Q7Z4I4_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV Q7Z4I2_HUMAN Q7Z4I2_HUMAN LKGELYCLPCHDKMGVPICGACRRPIEGRV MATCH CONSENSUS LKGELYCLPCHDKMGVPICGACRRPIEGRV

Q8VDV4_MOUSE Q8VDV4_MOUSE INALKQTWHVS------------------- Q9NWG2_HUMAN Q9NWG2_HUMAN ------------------------------ B8JMJ3_DANRE B8JMJ3_DANRE VNAMGKQWHVE------------------- Q502G3_DANRE Q502G3_DANRE VNAMGKQWHVE------------------- Q4T3X4_TETNG Q4T3X4_TETNG VNAMGKQWHVEHHVCTVCERPFQGHPFYER B5X112_SALSA B5X112_SALSA VNAMGKQWHVE------------------- Q4SHX2_TETNG Q4SHX2_TETNG VNAMGKQWHVE------------------- Q501W5_DANRE Q501W5_DANRE VNAMGKQWHVE------------------- Q9D7B2_MOUSE Q9D7B2_MOUSE VNAMGKQWHVE------------------- B4F6Z9_XENTR B4F6Z9_XENTR VNAMGKQWHVE------------------- Q6GMB2_XENLA Q6GMB2_XENLA VNAMGKQWHVE------------------- A7LBJ1_XENLA A7LBJ1_XENLA VNAMGKQWHVE------------------- Q6INR9_XENLA Q6INR9_XENLA VNAMGKQWHVE------------------- Q5ZL81_CHICK Q5ZL81_CHICK VNAMGKQWHVE------------------- Q6IYF7_CHICK Q6IYF7_CHICK VNAMGKQWHVE------------------- A4FV50_BOVIN A4FV50_BOVIN VNAMGKQWHVE------------------- B7Z483_HUMAN B7Z483_HUMAN VNAMGKQWHVE------------------- B7Z7R3_HUMAN B7Z7R3_HUMAN VNAMGKQWHVE------------------- B7Z907_HUMAN B7Z907_HUMAN VNAMGKQWHVE------------------- LIMS1_HUMAN LIMS1_HUMAN VNAMGKQWHVE------------------- A8CVP1_MOUSE A8CVP1_MOUSE VNAMGKQWHVE------------------- Q4ZJB3_MOUSE Q4ZJB3_MOUSE VNAMGKQWHVE------------------- LIMS1_MOUSE LIMS1_MOUSE VNAMGKQWHVE------------------- A8CVP4_MOUSE A8CVP4_MOUSE VNAMGKQWHVE------------------- Q5PQM7_RAT Q5PQM7_RAT VNALGKQWHVE------------------- LIMS2_MOUSE LIMS2_MOUSE VNALGKQWHVE------------------- LIMS2_BOVIN LIMS2_BOVIN VNALGKQWHVE------------------- B3KNZ3_HUMAN B3KNZ3_HUMAN VNALGKQWHVE------------------- B4DMV1_HUMAN B4DMV1_HUMAN VNALGKQWHVE------------------- LIMS2_HUMAN LIMS2_HUMAN VNALGKQWHVE------------------- Q7Z4I5_HUMAN Q7Z4I5_HUMAN VNALGKQWHVE------------------- Q7Z4I3_HUMAN Q7Z4I3_HUMAN VNALGKQWHVE------------------- Q7Z4I4_HUMAN Q7Z4I4_HUMAN VNALGKQWHVE------------------- Q7Z4I2_HUMAN Q7Z4I2_HUMAN VNALGKQWHVE------------------- MATCH CONSENSUS VNA?GKQWHVE???????????????????

Q8VDV4_MOUSE Q8VDV4_MOUSE ------------CFVCVACGKPIRNNVFHL Q9NWG2_HUMAN Q9NWG2_HUMAN ----------------AKCEKPFLGHRHYE B8JMJ3_DANRE B8JMJ3_DANRE ------------HFVCVKCEKPFLGHRHYE Q502G3_DANRE Q502G3_DANRE ------------HFVCVKCEKPFLGHRHYE Q4T3X4_TETNG Q4T3X4_TETNG GGHAYCERHFDMHFVCAKCEKPFLGHRHYE B5X112_SALSA B5X112_SALSA ------------HFVCAKCEKPFLGHRHYE Q4SHX2_TETNG Q4SHX2_TETNG ------------HFVCAKCEKPFLGHRHYE Q501W5_DANRE Q501W5_DANRE ------------HFVCAKCEKPFLGHRHYE Q9D7B2_MOUSE Q9D7B2_MOUSE ------------HFVCAKCEKPFLGHRHYE B4F6Z9_XENTR B4F6Z9_XENTR ------------HFVCAKCEKPFLGHRHYE Q6GMB2_XENLA Q6GMB2_XENLA ------------HFVCAKCEKPFLGHRHYE A7LBJ1_XENLA A7LBJ1_XENLA ------------HFVCAKCEKPFLGHRHYE Q6INR9_XENLA Q6INR9_XENLA ------------HFVCAKCEKPFLGHRHYE Q5ZL81_CHICK Q5ZL81_CHICK ------------HFVCAKCEKPFLGHRHYE Q6IYF7_CHICK Q6IYF7_CHICK ------------HFVCAKCEKPFLGHRHYE A4FV50_BOVIN A4FV50_BOVIN ------------HFVCAKCEKPFLGHRHYE B7Z483_HUMAN B7Z483_HUMAN ------------HFVCAKCEKPFLGHRHYE B7Z7R3_HUMAN B7Z7R3_HUMAN ------------HFVCAKCEKPFLGHRHYE B7Z907_HUMAN B7Z907_HUMAN ------------HFVCAKCEKPFLGHRHYE LIMS1_HUMAN LIMS1_HUMAN ------------HFVCAKCEKPFLGHRHYE A8CVP1_MOUSE A8CVP1_MOUSE ------------HFVCAKCEKPFLGHRHYE Q4ZJB3_MOUSE Q4ZJB3_MOUSE ------------HFVCAKCEKPFLGHRHYE LIMS1_MOUSE LIMS1_MOUSE ------------HFVCAKCEKPFLGHRHYE A8CVP4_MOUSE A8CVP4_MOUSE ------------HFVCAKCEKPFLGHRHYE Q5PQM7_RAT Q5PQM7_RAT ------------HFVCAKCEKPFLGHRHYE LIMS2_MOUSE LIMS2_MOUSE ------------HFVCAKCEKPFLGHRHYE LIMS2_BOVIN LIMS2_BOVIN ------------HFVCAKCEKPFLGHRHYE B3KNZ3_HUMAN B3KNZ3_HUMAN ------------HFVCAKCEKPFLGHRHYE B4DMV1_HUMAN B4DMV1_HUMAN ------------HFVCAKCEKPFLGHRHYE LIMS2_HUMAN LIMS2_HUMAN ------------HFVCAKCEKPFLGHRHYE Q7Z4I5_HUMAN Q7Z4I5_HUMAN ------------HFVCAKCEKPFLGHRHYE Q7Z4I3_HUMAN Q7Z4I3_HUMAN ------------HFVCAKCEKPFLGHRHYE Q7Z4I4_HUMAN Q7Z4I4_HUMAN ------------HFVCAKCEKPFLGHRHYE Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------HFVCAKCEKPFLGHRHYE MATCH . * **: .: .: CONSENSUS ????????????HFVCAKCEKPFLGHRHYE

Q8VDV4_MOUSE Q8VDV4_MOUSE EDGEPYCETDYYALFGTICRGCEFPIEAGD Q9NWG2_HUMAN Q9NWG2_HUMAN KKGLAYCETHYNQLFGDVCYNCSHVIE-GD B8JMJ3_DANRE B8JMJ3_DANRE RKGLAYCETHYNQLFGDVCFQCNRVIE-GD Q502G3_DANRE Q502G3_DANRE RKGLAYCETHYNQLFGDVCFQCNRVIE-GD Q4T3X4_TETNG Q4T3X4_TETNG RKGLAYCETHYNQLFGDVCYHCNRVIE-GD B5X112_SALSA B5X112_SALSA RKGLAYCETHYNQLFGDVCYHCNRVIE-GD Q4SHX2_TETNG Q4SHX2_TETNG RKGLAYCETHYNQLFGDVCYHCNRVIE-GD Q501W5_DANRE Q501W5_DANRE RKGLAYCETHYNQLFGDVCYHCNRVIE-GD Q9D7B2_MOUSE Q9D7B2_MOUSE RKGLAYCETHYNQLFGDVCFHCNRVIE-GD B4F6Z9_XENTR B4F6Z9_XENTR RKGLAYCETHYNQLFGDVCFHCNRVIE-GD Q6GMB2_XENLA Q6GMB2_XENLA RKGLAYCETHYNQLFGDVCFHCNRVIE-GD A7LBJ1_XENLA A7LBJ1_XENLA RKGLAYCETHYNQLFGDVCFHCNRVIE-GD Q6INR9_XENLA Q6INR9_XENLA RKGLAYCETHYNQLFGDVCFHCNRVIE-GD Q5ZL81_CHICK Q5ZL81_CHICK RKGLAYCETHYNQLFGDVCFHCNRVIE-GD Q6IYF7_CHICK Q6IYF7_CHICK RKGLAYCETHYNQLFGDVCFHCNRVIE-GD A4FV50_BOVIN A4FV50_BOVIN RKGLAYCETHYNQLFGDVCFHCNRVIE-GD B7Z483_HUMAN B7Z483_HUMAN RKGLAYCETHYNQLFGDVCFHCNRVIE-GD B7Z7R3_HUMAN B7Z7R3_HUMAN RKGLAYCETHYNQLFGDVCFHCNRVIE-GD B7Z907_HUMAN B7Z907_HUMAN RKGLAYCETHYNQLFGDVCFHCNRVIE-GD LIMS1_HUMAN LIMS1_HUMAN RKGLAYCETHYNQLFGDVCFHCNRVIE-GD A8CVP1_MOUSE A8CVP1_MOUSE RKGLAYCETHYNQLFGDVCFHCNRVIE-GD Q4ZJB3_MOUSE Q4ZJB3_MOUSE RKGLAYCETHYNQLFGDVCFHCNRVIE-GD LIMS1_MOUSE LIMS1_MOUSE RKGLAYCETHYNQLFGDVCFHCNRVIE-GD A8CVP4_MOUSE A8CVP4_MOUSE RKGLAYCETHYNQLFGDVCFHCNRVIE-GD Q5PQM7_RAT Q5PQM7_RAT KKGLAYCETHYNQLFGDVCYNCSHVIE-GD LIMS2_MOUSE LIMS2_MOUSE KKGLAYCETHYNQLFGDVCYNCSHVIE-GD LIMS2_BOVIN LIMS2_BOVIN KKGLAYCETHYNQLFGDVCYTCSHVIE-GD B3KNZ3_HUMAN B3KNZ3_HUMAN KKGLAYCETHYNQLFGDVCYNCSRVIE-GD B4DMV1_HUMAN B4DMV1_HUMAN KKGLAYCETHYNQLFGDVCYNCSHVIE-GD LIMS2_HUMAN LIMS2_HUMAN KKGLAYCETHYNQLFGDVCYNCSHVIE-GD Q7Z4I5_HUMAN Q7Z4I5_HUMAN KKGLAYCETHYNQLFGDVCYNCSHVIE-GD Q7Z4I3_HUMAN Q7Z4I3_HUMAN KKGLAYCETHYNQLFGDVCYNCSHVIE-GD Q7Z4I4_HUMAN Q7Z4I4_HUMAN KKGLAYCETHYNQLFGDVCYNCSHVIE-GD Q7Z4I2_HUMAN Q7Z4I2_HUMAN KKGLAYCETHYNQLFGDVCYNCSHVIE-GD MATCH ..* .****.* *** :* *. ** ** CONSENSUS ?KGLAYCETHYNQLFGDVC??C??VIE?GD

Q8VDV4_MOUSE Q8VDV4_MOUSE MFLEALGYTWHDTCFVCSVCCESLEGQ--- Q9NWG2_HUMAN Q9NWG2_HUMAN V-VSALNKAWCVSCFSCSTCNSKLTLK--- B8JMJ3_DANRE B8JMJ3_DANRE V-VSALNKAWCVRCFSCSTCTSRLTLK--- Q502G3_DANRE Q502G3_DANRE V-VSALNKAWCVRCFSCSTCTSRLTLK--- Q4T3X4_TETNG Q4T3X4_TETNG V-VSALNKAWCVNCFACSTCNSKLTLKDKF B5X112_SALSA B5X112_SALSA V-VSALNKAWCVNCFSCATCNTKLTLK--- Q4SHX2_TETNG Q4SHX2_TETNG V-VSALNKAWCVTCFSCSTCNTKLTLKDKF Q501W5_DANRE Q501W5_DANRE V-VSALNKAWCVNCFSCSTCNTKLTLK--- Q9D7B2_MOUSE Q9D7B2_MOUSE V-VSALNKAWCVSCFACSTCNTKLTLK--- B4F6Z9_XENTR B4F6Z9_XENTR V-VSALNKAWCVNCFACSTCNTKLTLK--- Q6GMB2_XENLA Q6GMB2_XENLA V-VSALNKAWCVNCFACSTCNTKLTLK--- A7LBJ1_XENLA A7LBJ1_XENLA V-VSALNKAWCVNCFACSTCNTKLTLK--- Q6INR9_XENLA Q6INR9_XENLA V-VSALNKAWCVNCFACSTCNTKLTLK--- Q5ZL81_CHICK Q5ZL81_CHICK V-VSALNKAWCVNCFACSTCNTKLTLK--- Q6IYF7_CHICK Q6IYF7_CHICK A-VSALNKAWCVNCFACSTCNTKLTLK--- A4FV50_BOVIN A4FV50_BOVIN V-VSALNKAWCVHCFACSTCSAKLTLK--- B7Z483_HUMAN B7Z483_HUMAN V-VSALNKAWCVNCFACSTCNTKLTLK--- B7Z7R3_HUMAN B7Z7R3_HUMAN V-VSALNKAWCVNCFACSTCNTKLTLK--- B7Z907_HUMAN B7Z907_HUMAN V-VSALNKAWCVNCFACSTCNTKLTLK--- LIMS1_HUMAN LIMS1_HUMAN V-VSALNKAWCVNCFACSTCNTKLTLK--- A8CVP1_MOUSE A8CVP1_MOUSE V-VSALNKAWCVSCFACSTCNTKLTLK--- Q4ZJB3_MOUSE Q4ZJB3_MOUSE V-VSALNKAWCVSCFACSTCNTKLTLK--- LIMS1_MOUSE LIMS1_MOUSE V-VSALNKAWCVSCFACSTCNTKLTLK--- A8CVP4_MOUSE A8CVP4_MOUSE V-VSALNKAWCVSCFACSTCNTKLTLK--- Q5PQM7_RAT Q5PQM7_RAT G-EASVPKPL-----------PPLLSP--- LIMS2_MOUSE LIMS2_MOUSE V-VSALSKAWCVNCFSCSTCNMKLTLK--- LIMS2_BOVIN LIMS2_BOVIN V-VSALNKAWCVHCFSCSTCNSRLTLK--- B3KNZ3_HUMAN B3KNZ3_HUMAN V-VSALNKAWCVSCFSCSTCNSKLTLK--- B4DMV1_HUMAN B4DMV1_HUMAN V-VSALNKAWCVSCFSCSTCNSKLTLK--- LIMS2_HUMAN LIMS2_HUMAN V-VSALNKAWCVSCFSCSTCNSKLTLK--- Q7Z4I5_HUMAN Q7Z4I5_HUMAN V-VSALNKAWCVSCFSCSTCNSKLTLK--- Q7Z4I3_HUMAN Q7Z4I3_HUMAN V-VSALNKAWCVSCFSCSTCNSKLTLK--- Q7Z4I4_HUMAN Q7Z4I4_HUMAN V-VSALNKAWCVSCFSCSTCNSKLTLK--- Q7Z4I2_HUMAN Q7Z4I2_HUMAN V-VSALNKAWCVSCFSCSTCNSKLTLK--- MATCH :: . * CONSENSUS V?VSALNKAWCV?CF?CSTCN?KLTLK???

Q8VDV4_MOUSE Q8VDV4_MOUSE ------------------------------ Q9NWG2_HUMAN Q9NWG2_HUMAN ------------------------------ B8JMJ3_DANRE B8JMJ3_DANRE ------------------------------ Q502G3_DANRE Q502G3_DANRE ------------------------------ Q4T3X4_TETNG Q4T3X4_TETNG VEVDLKPVCKRCYERLPEDMKRRLARRERD B5X112_SALSA B5X112_SALSA ------------------------------ Q4SHX2_TETNG Q4SHX2_TETNG VEIDLRPVCKHCYERMPEELKRRLARRKRD Q501W5_DANRE Q501W5_DANRE ------------------------------ Q9D7B2_MOUSE Q9D7B2_MOUSE ------------------------------ B4F6Z9_XENTR B4F6Z9_XENTR ------------------------------ Q6GMB2_XENLA Q6GMB2_XENLA ------------------------------ A7LBJ1_XENLA A7LBJ1_XENLA ------------------------------ Q6INR9_XENLA Q6INR9_XENLA ------------------------------ Q5ZL81_CHICK Q5ZL81_CHICK ------------------------------ Q6IYF7_CHICK Q6IYF7_CHICK ------------------------------ A4FV50_BOVIN A4FV50_BOVIN ------------------------------ B7Z483_HUMAN B7Z483_HUMAN ------------------------------ B7Z7R3_HUMAN B7Z7R3_HUMAN ------------------------------ B7Z907_HUMAN B7Z907_HUMAN ------------------------------ LIMS1_HUMAN LIMS1_HUMAN ------------------------------ A8CVP1_MOUSE A8CVP1_MOUSE ------------------------------ Q4ZJB3_MOUSE Q4ZJB3_MOUSE ------------------------------ LIMS1_MOUSE LIMS1_MOUSE ------------------------------ A8CVP4_MOUSE A8CVP4_MOUSE ------------------------------ Q5PQM7_RAT Q5PQM7_RAT ------------------------------ LIMS2_MOUSE LIMS2_MOUSE ------------------------------ LIMS2_BOVIN LIMS2_BOVIN ------------------------------ B3KNZ3_HUMAN B3KNZ3_HUMAN ------------------------------ B4DMV1_HUMAN B4DMV1_HUMAN ------------------------------ LIMS2_HUMAN LIMS2_HUMAN ------------------------------ Q7Z4I5_HUMAN Q7Z4I5_HUMAN ------------------------------ Q7Z4I3_HUMAN Q7Z4I3_HUMAN ------------------------------ Q7Z4I4_HUMAN Q7Z4I4_HUMAN ------------------------------ Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------------------------ MATCH CONSENSUS ??????????????????????????????

Q8VDV4_MOUSE Q8VDV4_MOUSE -------------TFFSKKDKPLCKKHAHS Q9NWG2_HUMAN Q9NWG2_HUMAN ------------NKFVEFDMKPVCKRCYEK B8JMJ3_DANRE B8JMJ3_DANRE ------------DKFVEIDLKPVCKHCYER Q502G3_DANRE Q502G3_DANRE ------------DKFVEIDLKPVCKHCYER Q4T3X4_TETNG Q4T3X4_TETNG SKDKKKKLPIPMNKFVEFDMKPVCKKCYEK B5X112_SALSA B5X112_SALSA ------------NKFVEFDMKPVCKKCYEK Q4SHX2_TETNG Q4SHX2_TETNG AKDRKKKPAVCLNKFVEFDMKPVCKKCYEK Q501W5_DANRE Q501W5_DANRE ------------NKFVEFDMKPVCKKCYEK Q9D7B2_MOUSE Q9D7B2_MOUSE ------------DKFVEIDLKPVCKYCYEK B4F6Z9_XENTR B4F6Z9_XENTR ------------NKFVEFDMKPVCKKCYEK Q6GMB2_XENLA Q6GMB2_XENLA ------------NKFVEFDMKPVCKKCYEK A7LBJ1_XENLA A7LBJ1_XENLA ------------NKFVEFDMKPVCKKCYEK Q6INR9_XENLA Q6INR9_XENLA ------------NKFVEFDMKPVCKKCYEK Q5ZL81_CHICK Q5ZL81_CHICK ------------NKFVEFDMKPVCKKCYEK Q6IYF7_CHICK Q6IYF7_CHICK ------------NKFVEFDMKPVCKKCYEK A4FV50_BOVIN A4FV50_BOVIN ------------NKFVEFDMKPVCKKCYEK B7Z483_HUMAN B7Z483_HUMAN ------------NKFVEFDMKPVCKKCYEK B7Z7R3_HUMAN B7Z7R3_HUMAN ------------NKFVEFDMKPVCKKCYEK B7Z907_HUMAN B7Z907_HUMAN ------------NKFVEFDMKPVCKKCYEK LIMS1_HUMAN LIMS1_HUMAN ------------NKFVEFDMKPVCKKCYEK A8CVP1_MOUSE A8CVP1_MOUSE ------------NKFVEFDMKPVCKECYEK Q4ZJB3_MOUSE Q4ZJB3_MOUSE ------------NKFVEFDMKPVCKECYEK LIMS1_MOUSE LIMS1_MOUSE ------------NKFVEFDMKPVCKKCYEK A8CVP4_MOUSE A8CVP4_MOUSE ------------NKFVEFDMKPVCKECYEK Q5PQM7_RAT Q5PQM7_RAT ------------NQSVLLVVGGA------- LIMS2_MOUSE LIMS2_MOUSE ------------NKFVEFDMKPVCKRCYER LIMS2_BOVIN LIMS2_BOVIN ------------NKFVEFDMKPVCKRCYEK B3KNZ3_HUMAN B3KNZ3_HUMAN ------------NKFVEFDMKPVCKRGYEK B4DMV1_HUMAN B4DMV1_HUMAN ------------NKFVEFDMKPVCKRCYEK LIMS2_HUMAN LIMS2_HUMAN ------------NKFVEFDMKPVCKRCYEK Q7Z4I5_HUMAN Q7Z4I5_HUMAN ------------NKFVEFDMKPVCKRCYEK Q7Z4I3_HUMAN Q7Z4I3_HUMAN ------------NKFVEFDMKPVCKRCYEK Q7Z4I4_HUMAN Q7Z4I4_HUMAN ------------NKFVEFDMKPVCKRCYEK Q7Z4I2_HUMAN Q7Z4I2_HUMAN ------------NKFVEFDMKPVCKRCYEK MATCH . CONSENSUS ????????????NKFVEFDMKPVCK?CYEK

Q8VDV4_MOUSE Q8VDV4_MOUSE VNF--------------------------- Q9NWG2_HUMAN Q9NWG2_HUMAN FPLELKKRL-KKLSELTSRKAQPKATDLNS B8JMJ3_DANRE B8JMJ3_DANRE MPDELKRRL-SREQESRDKRKRRPMCL--- Q502G3_DANRE Q502G3_DANRE MPDELKRRL-SREQESRDKRKRRPMCL--- Q4T3X4_TETNG Q4T3X4_TETNG FPLELKKRL-KKLSDAVARK---------- B5X112_SALSA B5X112_SALSA FPLELKKRL-KKLSETVGRK---------- Q4SHX2_TETNG Q4SHX2_TETNG FPLELKKRL-KKLAESLGRK---------- Q501W5_DANRE Q501W5_DANRE FPLELKKRL-KKLAETLGRK---------- Q9D7B2_MOUSE Q9D7B2_MOUSE MPEEFKRRLAKREREAKDKDKQRKRKPV-- B4F6Z9_XENTR B4F6Z9_XENTR FPLELKKRL-KKLSEPLARK---------- Q6GMB2_XENLA Q6GMB2_XENLA FPLELKKRL-KKLSEPLARK---------- A7LBJ1_XENLA A7LBJ1_XENLA FPLELKKRL-KKLSEPLAKK---------- Q6INR9_XENLA Q6INR9_XENLA FPLELKKRL-KKLSEPLAKK---------- Q5ZL81_CHICK Q5ZL81_CHICK FPLELKKRL-KKLAETVGRK---------- Q6IYF7_CHICK Q6IYF7_CHICK FPLELKKRL-KKLAETVGRK---------- A4FV50_BOVIN A4FV50_BOVIN FPLELKKRL-KKLAETLGRK---------- B7Z483_HUMAN B7Z483_HUMAN FPLELKKRL-KKLAETLGRK---------- B7Z7R3_HUMAN B7Z7R3_HUMAN FPLELKKRL-KKLAETLGRK---------- B7Z907_HUMAN B7Z907_HUMAN FPLELKKRL-KKLAETLGRK---------- LIMS1_HUMAN LIMS1_HUMAN FPLELKKRL-KKLAETLGRK---------- A8CVP1_MOUSE A8CVP1_MOUSE FPLELKKRL-KKLSETLGRK---------- Q4ZJB3_MOUSE Q4ZJB3_MOUSE FPLELKKRL-KKLSETLGRK---------- LIMS1_MOUSE LIMS1_MOUSE FPLELKKRL-KKLSETLGRK---------- A8CVP4_MOUSE A8CVP4_MOUSE FPLELKKRL-KKLSETLGRK---------- Q5PQM7_RAT Q5PQM7_RAT ----------GGVGGGLGDVGEWRNCGW-- LIMS2_MOUSE LIMS2_MOUSE FPLELKKRL-KKLSDLSSRKAQPKSVDVNS LIMS2_BOVIN LIMS2_BOVIN FPLELKKRL-KKLSELAARRAQPKSSGLHP B3KNZ3_HUMAN B3KNZ3_HUMAN FPLELKKRL-KKLSELTSRKAQPKATDLNS B4DMV1_HUMAN B4DMV1_HUMAN FPLELKKRL-KKLSELTSRKAQPKATDLNS LIMS2_HUMAN LIMS2_HUMAN FPLELKKRL-KKLSELTSRKAQPKATDLNS Q7Z4I5_HUMAN Q7Z4I5_HUMAN FPLELKKRL-KKLSELTSRKAQPKATDLNS Q7Z4I3_HUMAN Q7Z4I3_HUMAN FPLELKKRL-KKLSELTSRKAQPKATDLNS Q7Z4I4_HUMAN Q7Z4I4_HUMAN FPLELKKRL-KKLSELTSRKAQPKATDLNS Q7Z4I2_HUMAN Q7Z4I2_HUMAN FPLELKKRL-KKLSELTSRKAQPKATDLNS MATCH CONSENSUS FPLELKKRL?KKL?E????K??????????

Q8VDV4_MOUSE Q8VDV4_MOUSE - Q9NWG2_HUMAN Q9NWG2_HUMAN A B8JMJ3_DANRE B8JMJ3_DANRE - Q502G3_DANRE Q502G3_DANRE - Q4T3X4_TETNG Q4T3X4_TETNG - B5X112_SALSA B5X112_SALSA - Q4SHX2_TETNG Q4SHX2_TETNG - Q501W5_DANRE Q501W5_DANRE - Q9D7B2_MOUSE Q9D7B2_MOUSE - B4F6Z9_XENTR B4F6Z9_XENTR - Q6GMB2_XENLA Q6GMB2_XENLA - A7LBJ1_XENLA A7LBJ1_XENLA - Q6INR9_XENLA Q6INR9_XENLA - Q5ZL81_CHICK Q5ZL81_CHICK - Q6IYF7_CHICK Q6IYF7_CHICK - A4FV50_BOVIN A4FV50_BOVIN - B7Z483_HUMAN B7Z483_HUMAN - B7Z7R3_HUMAN B7Z7R3_HUMAN - B7Z907_HUMAN B7Z907_HUMAN - LIMS1_HUMAN LIMS1_HUMAN - A8CVP1_MOUSE A8CVP1_MOUSE - Q4ZJB3_MOUSE Q4ZJB3_MOUSE - LIMS1_MOUSE LIMS1_MOUSE - A8CVP4_MOUSE A8CVP4_MOUSE - Q5PQM7_RAT Q5PQM7_RAT - LIMS2_MOUSE LIMS2_MOUSE L LIMS2_BOVIN LIMS2_BOVIN A B3KNZ3_HUMAN B3KNZ3_HUMAN A B4DMV1_HUMAN B4DMV1_HUMAN A LIMS2_HUMAN LIMS2_HUMAN A Q7Z4I5_HUMAN Q7Z4I5_HUMAN A Q7Z4I3_HUMAN Q7Z4I3_HUMAN A Q7Z4I4_HUMAN Q7Z4I4_HUMAN A Q7Z4I2_HUMAN Q7Z4I2_HUMAN A MATCH CONSENSUS ?


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