Alignment of the gene Family HBG000101 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q4RQ60_TETNG Q4RQ60_TETNG ------------------------------------------------------------ Q90XA6_DANRE Q90XA6_DANRE AKQSSLFNFFSKSPPLAVKAKSSP---------SPAEGDAPGRSNTSPKEEAKVNSKKTP B8JLI1_DANRE B8JLI1_DANRE AKQSSLFNFFSKSPPLAVKAKSSP---------SPAEGDAPGRSNTSPKEEAKVNSKKTP Q803S7_DANRE Q803S7_DANRE AKQSSLFNFFSKSPPLAVKAKSSP---------SPAEGDAPGRSNTSPKEEAKVNSKKTP B1H3I3_XENTR B1H3I3_XENTR SKQKTLFSFFHKSPPISSSTKSGKAS-------SPTEADVPSSGGKKSSSSPKEGAKER- Q5FWN5_XENLA Q5FWN5_XENLA SKQKTLFSFFTKSPPVSSSTKSGKVSS------SPTEADVPSSGGKKSSSSPKEGAKEK- MSH6_MOUSE MSH6_MOUSE SRQSTLYSFFPKSPALGDTKKAAAEASRQG---AAASGASASRGGDAAWSEAEPGSRSA- Q6GTK8_MOUSE Q6GTK8_MOUSE SRQSTLYSFFPKSPALGDTKKAAAEASRQG---AAASGASASRGGDAAWSEAEPGSRSA- Q8C2N9_MOUSE Q8C2N9_MOUSE SRQSTLYSFFPKSPALGDTKKAAAEASRQG---AAASGASASRGGDAAWSEAEPGSRSA- Q1L838_HUMAN Q1L838_HUMAN SRQSTLYSFFPKSPALSDANKASARASREGGRAAGCPRGLSFPRRGCGLERGWAWARPL- B4DF41_HUMAN B4DF41_HUMAN SRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPL- MSH6_HUMAN MSH6_HUMAN SRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPL- B4E3I4_HUMAN B4E3I4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ??Q??L??FF?KSP??????K???????????????????????????????????????

Q4RQ60_TETNG Q4RQ60_TETNG --------------------------------FSAGALVWAKLEGHPWWPCMVVPQPVSG Q90XA6_DANRE Q90XA6_DANRE AKPPSKTQAIAGHAKLFGEKAVTTKERKQSPVFSAGSLVWAKMEGHPWWPCMVVPQPLSG B8JLI1_DANRE B8JLI1_DANRE AKPPSKTQAIAGHAKLFGEKAATTKERKQSPVFSAGSLVWAKMEGHPWWPCMVVPQPLSG Q803S7_DANRE Q803S7_DANRE AKPPSKTQAIAGHAKLFGEKAATTKERKQSPVFSAGSLVWAKMEGHPWWPCMVVPQPLSG B1H3I3_XENTR B1H3I3_XENTR GTP-----GRAHGGKAPRSAA-----PSAVSDFNPGDLVWAKMPGHPWWPSLVYNHPKED Q5FWN5_XENLA Q5FWN5_XENLA AAGAA---ARTPGGKAPKSAA-----PSTACDFNPGDLVWAKMLGHPWWPSLVYNHPKEG MSH6_MOUSE MSH6_MOUSE AVSASSPDGKDLNGGLRRASSSAQAVPPSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG Q6GTK8_MOUSE Q6GTK8_MOUSE AVSASSPEAKDLNGGLRRASSSAQAVPPSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG Q8C2N9_MOUSE Q8C2N9_MOUSE AVSASSPEAKDLNGGLRRASSSAQAVPPSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG Q1L838_HUMAN Q1L838_HUMAN ARSASPPKAKNLNGGLRRSVAPA---APTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG B4DF41_HUMAN B4DF41_HUMAN ARSASPPKAKNLNGGLRRS----------------------------------------- MSH6_HUMAN MSH6_HUMAN ARSASPPKAKNLNGGLRRSVAPA---APTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG B4E3I4_HUMAN B4E3I4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????F??G?LVWAK??G?PWWP??V???P???

Q4RQ60_TETNG Q4RQ60_TETNG QQMRGRGRDQRIHVHFFDEPPTRGWVSTRYVREYQGSDSSGAKPGGLFFCGKPVIQQAMK Q90XA6_DANRE Q90XA6_DANRE QQMRGRGRDQRLHVHFFDEPPTRGWVNTKYIREYQGSNSADAKSGGMFFSGKPVIRKAME B8JLI1_DANRE B8JLI1_DANRE QQMRGRGRDQRLHVHFFDEPPTRGWVNTKYIREYQGSNSADAKSGGMFFSGKPVIRKAME Q803S7_DANRE Q803S7_DANRE QQMRGRGRDQRLHVHFFDEPPTRGWVNTKYIREYQGSNSAVAKSGGMFFSGKPVIRKAME B1H3I3_XENTR B1H3I3_XENTR THLRGKGKSLNIHVQFFDDSPTRGWVGAKYMKPFSGSTAAEAQKGGLFFSTKPEIRKAIK Q5FWN5_XENLA Q5FWN5_XENLA THLRGKGKSLHVHVQFFDDSPTRGWTGAKYIKPFSGSTAAETQKGGMFFSTKPEIKKAMK MSH6_MOUSE MSH6_MOUSE TFIRKKGKSVRVHVQFFDDSPTRGWVSKRMLKPYTGSKSKEAQKGGHFYSSKSEILRAMQ Q6GTK8_MOUSE Q6GTK8_MOUSE TFIRKKGKSVRVHVQFFDDSPTRGWVSKRMLKPYTGSKSKEAQKGGHFYSSKSEILRAMQ Q8C2N9_MOUSE Q8C2N9_MOUSE TFIGKKGKSVRVHVQFFDDSPTRGWVSKRMLKPYTGSKSKEAQKGGHFYSSKSEILRAMQ Q1L838_HUMAN Q1L838_HUMAN TFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQ B4DF41_HUMAN B4DF41_HUMAN ------------------------------------------------------------ MSH6_HUMAN MSH6_HUMAN TFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQ B4E3I4_HUMAN B4E3I4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ??????G?????HV?FFD??PTRGW??????????GS???????GG?F???K??I??A??

Q4RQ60_TETNG Q4RQ60_TETNG LADEAMSDSPKKRLKMPLCMDLSDEEDEEEE-MEVDKSTLTDEEISEEEQGSEKEKPARG Q90XA6_DANRE Q90XA6_DANRE LADVAMKDSPEQRLKMPLCMDPSDEEEEDEEDIEIEKSTVSDAEMSEEEVK----EKTKP B8JLI1_DANRE B8JLI1_DANRE LADVAMKDSPEQRLKMPLCMDPSDEEEEDEEDMEIEKSTVSDAEMSEEEVK----EKTKP Q803S7_DANRE Q803S7_DANRE LADVAMKDSPEQRLKMPLCMDPSDEEEEDEEDMEIEKSTVSDAEMSEEEVK----EKTKP B1H3I3_XENTR B1H3I3_XENTR MADDAMAQDKQKRLELAVCMEPSD-SEEDME-LEDEGSSASHDE--AEDVK-----KRQP Q5FWN5_XENLA Q5FWN5_XENLA MADDAVTLDKQKRLELAVCMEPSD-SEEDME-VEENSSASHDEE--VK--------TKTP MSH6_MOUSE MSH6_MOUSE RADEALSKDTAERLQLAVCDEPSE-PEEEEE-TEVHEAYLSDKS--EEDNYNESEEEAQP Q6GTK8_MOUSE Q6GTK8_MOUSE RADEALSKDTAERLQLAVCDEPSE-PEEEEE-TEVHEAYLSDKS--EEDNYNESEEEAQP Q8C2N9_MOUSE Q8C2N9_MOUSE RADEALSKDTAERLQLAVCDEPSE-PEEEEE-TEVHEAYLSDKS--EEDNYNESEEEAQP Q1L838_HUMAN Q1L838_HUMAN RADEALNKDKIKRLELAVCDEPSE-PEEEEE-MEVGTTYVTDKS--EEDNEIESEEEVQP B4DF41_HUMAN B4DF41_HUMAN ----------------------------------VGTTYVTDKS--EEDNEIESEEEVQP MSH6_HUMAN MSH6_HUMAN RADEALNKDKIKRLELAVCDEPSE-PEEEEE-MEVGTTYVTDKS--EEDNEIESEEEVQP B4E3I4_HUMAN B4E3I4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ?AD?A???????RL????C???S????E??E??E???????D?????E???????????P

Q4RQ60_TETNG Q4RQ60_TETNG SRQSSRASAPQGNKPKRRRIIEASDSD-------------GSVSSDEED----------- Q90XA6_DANRE Q90XA6_DANRE SRRPPRAAAEKSQKSKRRRIVVASDSDDSGEEFDPNKAGGSSDEDEEEEEGVNSGAEEEE B8JLI1_DANRE B8JLI1_DANRE SRRPPRAAAEKSQKSKRRRIVVASDSDDSGEEFDPNKAGGSSDEDKEEEEGVNSGAEEEE Q803S7_DANRE Q803S7_DANRE SRRPPRAAAEKSQKSKRRRIVVASDSDDSGEEFDPNKAGGSSDEDKEEEEGVNSGAEEEE B1H3I3_XENTR B1H3I3_XENTR VRESKKNG-----KPKRRRITIESDSDNEGSDDEFKPE--DSASSDEASSGVDEAKLSEP Q5FWN5_XENLA Q5FWN5_XENLA SRESKRKG-----QPKRRRIMIESDSDNEGSDDEFKPE--DSASSDEASSGVDEAGLSEP MSH6_MOUSE MSH6_MOUSE SVQGPRRSS---RQVKKRRVISDSESDIGGSDVEFKPDTKQEGSSDDASSGVG------- Q6GTK8_MOUSE Q6GTK8_MOUSE SVQGPRRSS---RQVKKRRVISDSESDIGGSDVEFKPDTKQEGSSDDASSGVG------- Q8C2N9_MOUSE Q8C2N9_MOUSE SVQGPRRSS---RQVKKRRVISDSESDIGGSDVEFKPDTKQEGSSDDASSGVG------- Q1L838_HUMAN Q1L838_HUMAN KTQGSRRSS---RQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVG------- B4DF41_HUMAN B4DF41_HUMAN KTQGSRRSS---RQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVG------- MSH6_HUMAN MSH6_HUMAN KTQGSRRSS---RQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVG------- B4E3I4_HUMAN B4E3I4_HUMAN ------------------------------------------------------------ MATCH CONSENSUS ?????R?????????K?RR????S?SD??G????????????????????GV????????

Q4RQ60_TETNG Q4RQ60_TETNG TSQETEEDSPVK-PTKRKRVAAKSPPAKAKAPPTPSGPPKPARAALSADTKSRLSAFSAP Q90XA6_DANRE Q90XA6_DANRE SEPETEPDSPVK-PIKRKR--PTEKPTKSKSKPETPKRAPAALPSVSTDAKSRLSAFSAP B8JLI1_DANRE B8JLI1_DANRE SEPETEPDSPVK-PIKRKR--PTEKPTKSKSKPETPKRAPAALPSVSTDAKSRLSAFSAP Q803S7_DANRE Q803S7_DANRE SEPETEPDSPVK-PIKRKR--PTEKPTKSKSKPETPKRAPAALPSVSTDAKSRLSAFSAP B1H3I3_XENTR B1H3I3_XENTR DSETEE-DSPVKVPLKRKRGNPDKPTGPKKRLQDELSETPKRASNVSAEAKLKLSSFSAP Q5FWN5_XENLA Q5FWN5_XENLA DSEAED-NSPVKVPLKRKRGIPDKASGPKKRLQNEQSETPKRTSNVSTEAKLKLSSFSAP MSH6_MOUSE MSH6_MOUSE DSDSEDLGTFGKGAPKRKRAMVAQGGLRRKSLKKETGSAKRATPILS-ETKSTLSAFSAP Q6GTK8_MOUSE Q6GTK8_MOUSE DSDSEDLGTFGKGAPKRKRAMVAQGGLRRKSLKKETGSAKRATPILS-ETKSTLSAFSAP Q8C2N9_MOUSE Q8C2N9_MOUSE DSDSEDLGTFGKGAPKRKRAMVAQGGLRRKSLKKETGSAKRATPILS-ETKSTLSAFSAP Q1L838_HUMAN Q1L838_HUMAN DSESEGLNSPVKVARKRKRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAP B4DF41_HUMAN B4DF41_HUMAN DSESEGLNSPVKVARKRKRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAP MSH6_HUMAN MSH6_HUMAN DSESEGLNSPVKVARKRKRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAP B4E3I4_HUMAN B4E3I4_HUMAN -------------------MVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAP MATCH . * . . :* ::* * :**** CONSENSUS ???????????K???KRKR??????????K????????????????S???K??L?AFSAP

Q4RQ60_TETNG Q4RQ60_TETNG ESLESQANGSGTGAEA---AAWDHEKLEWLQEGRRRDGRRRRQSDADYDAATLYVPEDFL Q90XA6_DANRE Q90XA6_DANRE DNFDSQNSANGTEGGS---TVWDHEKLEWLQDGKRKDAQRKRQSDENYDPTTLYVPEDFL B8JLI1_DANRE B8JLI1_DANRE DNFDSQNSANGTEGGS---TVWDHEKLEWLQDGKRKDAQRKRQSDENYDPTTLYVPEDFL Q803S7_DANRE Q803S7_DANRE DNFDSQSSANGTEGGS---TVWDHEKLEWLQDGKRKDAQRKRQSDENYDPTTLYVPEDFL B1H3I3_XENTR B1H3I3_XENTR ESFESQTNAGGTGSVS----VWDHEKFDWLQDGRRKDLKRKKQNDADYDPSTLYVPDDFL Q5FWN5_XENLA Q5FWN5_XENLA ESFESQANTGGTGAVS----IWEHEKFDWLQDGKRKDMKRKRQTDADYDPSTLYIPDDFL MSH6_MOUSE MSH6_MOUSE QNSESQTHVSGGGNDSSGPTVWYHETLEWLKQKKRRDEHRRRPDHPEFNPTTLYVPEEFL Q6GTK8_MOUSE Q6GTK8_MOUSE QNSESQTHVSGGGNDSSGPTVWYHETLEWLKPEKRRDEHRRRPDHPEFNPTTLYVPEEFL Q8C2N9_MOUSE Q8C2N9_MOUSE QNSESQTHVSGGGNDSSGPTVWYHETLEWLKPEKRRDEHRRRPDHPEFNPTTLYVPEEFL Q1L838_HUMAN Q1L838_HUMAN QNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFL B4DF41_HUMAN B4DF41_HUMAN QNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFL MSH6_HUMAN MSH6_HUMAN QNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFL B4E3I4_HUMAN B4E3I4_HUMAN QNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFL MATCH :. :** .* : * **.::**: :*:* :*:: . :::.:***:*::** CONSENSUS ????SQ????G????S????VW?HE?LEWL???KR?D??R?R?????????TLYVPE?FL

Q4RQ60_TETNG Q4RQ60_TETNG NRVTPGMRRWWQLKSQMFDTVIFYKVGKFYELYHMDAVVGVNELGLTFMKGTWAHSGFPE Q90XA6_DANRE Q90XA6_DANRE NRTTPGMRRWWQLKSEMFDTVLFYKVGKFYELYHMDAVIGVNELNLTFMKGTWAHSGFPE B8JLI1_DANRE B8JLI1_DANRE NRTTPGMRRWWQLKSEMFDTVLFYKVGKFYELYHMDAVIGVNELNLTFMKGTWAHSGFPE Q803S7_DANRE Q803S7_DANRE NRTTPGMRRWWQLKSEMFDTVLFYKVGKFYELYHMDAVIGVNELNLTFMKGTWAHSGFPE B1H3I3_XENTR B1H3I3_XENTR NKCTPGMRKWWQLKSQNFDTVIFYKVGKFYELYHMDAVIGVNELGLTFMKGAWAHSGFPE Q5FWN5_XENLA Q5FWN5_XENLA NKCTPGVRKWWQLKSQNFDTVIFYKVGKFYELYHMDAVIGVNELGLTFMKGTWAHSGFPE MSH6_MOUSE MSH6_MOUSE NSCTPGMRKWWQLKSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPE Q6GTK8_MOUSE Q6GTK8_MOUSE NSCTPGMRKWWQLKSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPE Q8C2N9_MOUSE Q8C2N9_MOUSE NSCTPGMRKWWQLKSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPE Q1L838_HUMAN Q1L838_HUMAN NSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPE B4DF41_HUMAN B4DF41_HUMAN NSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPE MSH6_HUMAN MSH6_HUMAN NSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPE B4E3I4_HUMAN B4E3I4_HUMAN NSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPE MATCH * ***:*:***:**: ** *: **************::**.**.* **** ******** CONSENSUS N??TPGMR?WWQ?KS??FD?V??YKVGKFYELYHMDA?IGV?EL?L?FMKG?WAHSGFPE

Q4RQ60_TETNG Q4RQ60_TETNG IGFGRFSDGLVQKGYKVARVEQTETPEMMEARCKAMAKPSKFDRVVRREVCRVLTRGTQT Q90XA6_DANRE Q90XA6_DANRE IGFGRFSDVLVQKGYKVARVEQTETPDMMEARCKKLARPTKFDKVVKREVCRIITRGTQT B8JLI1_DANRE B8JLI1_DANRE IGFGRFSDVLVQKGYKVARVEQTETPDMMEARCKKLARPTKFDKVVKREVCRIITRGTQT Q803S7_DANRE Q803S7_DANRE IGFGRFSDVLVQKGYKVARVEQTETPNMMEARCKKLARPTKFDKVVKREVCRIITRGTQT B1H3I3_XENTR B1H3I3_XENTR IAFGRFSDVLVQKGYKVARVEQTETPEMMEVRCKSMSHPSKFDRVVRREICRIITKGTQT Q5FWN5_XENLA Q5FWN5_XENLA IAFGRFSDVLVQKGYKVSRVEQTETPEMMEARCKSMSHPSKFDRVVRREICRIITKGTQT MSH6_MOUSE MSH6_MOUSE IAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQT Q6GTK8_MOUSE Q6GTK8_MOUSE IAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQT Q8C2N9_MOUSE Q8C2N9_MOUSE IAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQT Q1L838_HUMAN Q1L838_HUMAN IAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQT B4DF41_HUMAN B4DF41_HUMAN IAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQT MSH6_HUMAN MSH6_HUMAN IAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQT B4E3I4_HUMAN B4E3I4_HUMAN IAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQT MATCH *.***:** ********:********:***.**: ::: :*:*:**:**:**::*:**** CONSENSUS I?FGR?SD?LVQKGYKVARVEQTETP?MMEARC???A???K?D?VV?RE?CRIIT?GTQT

Q4RQ60_TETNG Q4RQ60_TETNG YSVLDGAPAECQSKFLLGLKEKAEEESSGRSRTYGVCFVDASVGCFHVGQFADDRHCSRL Q90XA6_DANRE Q90XA6_DANRE YSVLDGAPSETQSKYLLSIKEKSEEDSTGHGHIYGVCFIDTSVGRFHIGQFQDDRHCSRL B8JLI1_DANRE B8JLI1_DANRE YSVLDGAPSETQSKYLLSIKEKSEEDSTGHGHIYGVCFIDTSVGRFHIGQFQDDRHCSRL Q803S7_DANRE Q803S7_DANRE YSVLDGAPSETQSKYLLSIKEKSEEDSTGHGHIYGVCFIDTSVGRFHIGQFQDDRHCSRL B1H3I3_XENTR B1H3I3_XENTR YSVLDGNPSESHSKYLLCFKEK-MDDSSGQRRIYGVSFVDTSVGKFHVGQFEDDRHCSRF Q5FWN5_XENLA Q5FWN5_XENLA YSVLDGNPSESHSKYLLCFKEK-MDDSSGQRRVYGVSFVDTSVGKFHVGQFEDDRHCSRF MSH6_MOUSE MSH6_MOUSE YSVLDGDPSENYSRYLLSLKEK-EEETSGHTRVYGVCFVDTSLGKFFIGQFSDDRHCSRF Q6GTK8_MOUSE Q6GTK8_MOUSE YSVLDGDPSENYSRYLLSLKEK-EEETSGHTRVYGVCFVDTSLGKFFIGQFSDDRHCSRF Q8C2N9_MOUSE Q8C2N9_MOUSE YSVLDGDPSENYSRYLLSLKEK-EEETSGHTRVYGVCFVDTSLGKFFIGQFSDDRHCSRF Q1L838_HUMAN Q1L838_HUMAN YSVLEGDPSENYSKYLLSLKEK-EEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRF B4DF41_HUMAN B4DF41_HUMAN YSVLEGDPSENYSKYLLSLKEK-EEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRF MSH6_HUMAN MSH6_HUMAN YSVLEGDPSENYSKYLLSLKEK-EEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRF B4E3I4_HUMAN B4E3I4_HUMAN YSVLEGDPSENYSKYLLSLKEK-EEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRF MATCH ****:* *:* *::** :*** ::::*: : ***.*:*:*:* *.:*** *******: CONSENSUS YSVL?G?PSE??S?YLL??KEK?EE???G????YGVCF?DTS?G?F??GQF?DDRHCSR?

Q4RQ60_TETNG Q4RQ60_TETNG RTLIAHHPPAEVLFERGNPSGETRKVLKASLSSALQEGLSAGSQFWDAQKTLKSLSEEDY Q90XA6_DANRE Q90XA6_DANRE RTLVAHYSPAQVIFEKGNPSIETLKIFKAIVASSLQEGLNAGSQFWDAQKTLKVLAEEDY B8JLI1_DANRE B8JLI1_DANRE RTLVAHYSPAQVIFEKGNPSIETLKIFKAIVASSLQEGLNAGSQFWDAQKTLKVLAEEDY Q803S7_DANRE Q803S7_DANRE RTLVAHYSPAQVIFEKGNPSIETLKIFKAIVASSLQEGLNAGSQFWDAQKTLKVLAEEDY B1H3I3_XENTR B1H3I3_XENTR RTLVAHFPPIQILFEKGNPSSDTKKVLKSCLSTSIQESLQPTSQFWDAFKTLKTLAEEAY Q5FWN5_XENLA Q5FWN5_XENLA RTLVAHFPPVQILFEKGNPSSDTKKVLKSCLSTSIQESLQPTSQFWDASRTLKTLAEEAY MSH6_MOUSE MSH6_MOUSE RTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTLLEGGY Q6GTK8_MOUSE Q6GTK8_MOUSE RTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTLLEGGY Q8C2N9_MOUSE Q8C2N9_MOUSE RTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTLLEGGY Q1L838_HUMAN Q1L838_HUMAN RTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEY B4DF41_HUMAN B4DF41_HUMAN RTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEY MSH6_HUMAN MSH6_HUMAN RTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEY B4E3I4_HUMAN B4E3I4_HUMAN RTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEY MATCH ***:**..* :::**:** * :* .::*. :: .:**.* . ****** :**: * * * CONSENSUS RTLVAH??P?Q??FEKGN?S?ET????K??????LQEGL??GSQFWDA?KTL??L?E??Y

Q4RQ60_TETNG Q4RQ60_TETNG FREGADEGQEGRRALPAPLKQMTSDSDSLGLTPRDGYELALSALGACTFYLKKCLVDQEL Q90XA6_DANRE Q90XA6_DANRE FKESKDDNKKESV-LPPALKAMTSECDALSLTPKTGYELALSALGGCMFYLKKCLVDQEL B8JLI1_DANRE B8JLI1_DANRE FKESKDDNKKASV-LPPALKAMTSECDALSLTPKTGYELALSALGGCMFYLKKCLVDQEL Q803S7_DANRE Q803S7_DANRE FKESKDDNKKASV-LPPALKAMTPECDALSLTPKTGYELALSALGGCMFYLKKCLVDQEL B1H3I3_XENTR B1H3I3_XENTR FEKDFQP--GSGN-LPTVLKNLTSENDSLALTPGEKSELALSALGACIYYLKKCLIDQEL Q5FWN5_XENLA Q5FWN5_XENLA FEKDFQPATGNGN-LPSVLKSMTSESDSLALTPGEKCELALSALGACIYYLKKCLIDQEL MSH6_MOUSE MSH6_MOUSE FTGNGDS----STVLPLVLKGMTSESDSVGLTPGEESELALSALGGIVFYLKKCLIDQEL Q6GTK8_MOUSE Q6GTK8_MOUSE FTGNGDS----STVLPLVLKGMTSESDSVGLTPGEESELALSALGGIVFYLKKCLIDQEL Q8C2N9_MOUSE Q8C2N9_MOUSE FTGNGDS----STVLPLVLKGMTSESDSVGLTPGEESELALSALGGIVFYLKKCLIDQEL Q1L838_HUMAN Q1L838_HUMAN FREKLSD--GIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQEL B4DF41_HUMAN B4DF41_HUMAN FREKLSD--GIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQEL MSH6_HUMAN MSH6_HUMAN FREKLSD--GIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQEL B4E3I4_HUMAN B4E3I4_HUMAN FREKLSD--GIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQEL MATCH * . ** ** :*.: *::.*** ********. :******:**** CONSENSUS F?????????????LP??LK?MTSE?D???LTP????ELALSALG???FYLKKCL?DQEL

Q4RQ60_TETNG Q4RQ60_TETNG LSMANFEEYVPVDVQMEKAAGPDSFFAQTRQRMVVDGVTLANLEIFQNGS-GGAEGTLLE Q90XA6_DANRE Q90XA6_DANRE FSMGNFEEYVPVDVEMEQAGGASCFFAKTNQRMVLDGVTLANLEILQNSSTGGPEGTLLE B8JLI1_DANRE B8JLI1_DANRE FSMGNFEEYVPVDVEMEQAGGASCFFAKTNQRMVLDGVTLANLEILQNSSTGGPEGTLLE Q803S7_DANRE Q803S7_DANRE FSMGNFEEYVPVDVEMEQAGGASCFFAKTNQRMVLDGVTLANLEILQNSSTGGPEGTLLE B1H3I3_XENTR B1H3I3_XENTR LSMANFEEYIPVDTGIEKAQASSSFFAKTSQRMVLDGVTLTNLEILQNGTNGSTEGTLLE Q5FWN5_XENLA Q5FWN5_XENLA LSMANFEEYVPVDTDVEKAQTSSNFFAKTSRRMVLDGVTLTNLEILQNGTNGSTEGTLLE MSH6_MOUSE MSH6_MOUSE LSMANFEEYFPLDSDTVSTVKPGAVFTKASQRMVLDAVTLNNLEIFLNGTNGSTEGNLLE Q6GTK8_MOUSE Q6GTK8_MOUSE LSMANFEEYFPLDSDTVSTVKPGAVFTKASQRMVLDAVTLNNLEIFLNGTNGSTEGTLLE Q8C2N9_MOUSE Q8C2N9_MOUSE LSMANFEEYFPLDSDTVSTVKPGAVFTKASQRMVLDAVTLNNLEIFLNGTNGSTEGTLLE Q1L838_HUMAN Q1L838_HUMAN LSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLE B4DF41_HUMAN B4DF41_HUMAN LSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLE MSH6_HUMAN MSH6_HUMAN LSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLE B4E3I4_HUMAN B4E3I4_HUMAN LSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLE MATCH :**.*****.*:* .: .. .*::: :***:*.*** ****: *.: *..**.*** CONSENSUS ?SM?NFEEY?P?D????????????F?K??QRMVLD?VTL?NLEI??N???G??EGTLLE

Q4RQ60_TETNG Q4RQ60_TETNG RLDTCSTPFGKRLLKQWLCAPLCNPSSIKERLDAVEDLMGLQAQAGEVSDLLKKLPDLER Q90XA6_DANRE Q90XA6_DANRE RLDTCCTPFGKRLLKQWICAPLCNPSSIGDRLDALEDLMGAPSQTSEVTDLLKKLPDLER B8JLI1_DANRE B8JLI1_DANRE RLDTCCTPFGKRLLKQWICAPLCNPSSIGDRLDALEDLMGAPSQTSEVTDLLKKLPDLER Q803S7_DANRE Q803S7_DANRE RLDTCCTPFGKRLLKQWICAPLCNLSSIGDRLDALEDLMGAPSQTSEVTDLLKKLPDLER B1H3I3_XENTR B1H3I3_XENTR KLDTCSTPFGKRLLKQWLCAPLCNPFSINDRLNAVEDLMDLPDKVSEVSDLLKKLPDLER Q5FWN5_XENLA Q5FWN5_XENLA KLDTCSTPFGKRLLKQWLCAPLCNPFSINDRLNAVEDLMALPGKVSEVSELLKKLPDLER MSH6_MOUSE MSH6_MOUSE RLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAVEDLMAVPYKVTEVADLLKKLPDLER Q6GTK8_MOUSE Q6GTK8_MOUSE RLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAVEDLMAVPDKVTEVADLLKKLPDLER Q8C2N9_MOUSE Q8C2N9_MOUSE RLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAVEDLMAVPDKVTEVADLLKKLPDLER Q1L838_HUMAN Q1L838_HUMAN RVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLER B4DF41_HUMAN B4DF41_HUMAN RVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLER MSH6_HUMAN MSH6_HUMAN RVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLER B4E3I4_HUMAN B4E3I4_HUMAN RVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLER MATCH ::*** ***********:*****. :* :**:*:**** : ** :********** CONSENSUS R?DTC?TPFGKRLLKQW?CAPLC????I?DRLDA?EDLM??P????EV??LLKKLPDLER

Q4RQ60_TETNG Q4RQ60_TETNG LLSKIHGIGTPLKGQDHPDSRAVLYEEVTYSKRKIADFLSALEGFKTMQEIISVLAAVSG Q90XA6_DANRE Q90XA6_DANRE LLSKIHSMGTPLKGQDHPDSRAILYEEVVYSKRKIADFLAALEGFKVMKEIVSIMEPVGE B8JLI1_DANRE B8JLI1_DANRE LLSKIHSMGTPLKGQDHPDSRAILYEEVVYSKRKIADFLAALEGFKVMKEIVSIMEPVGE Q803S7_DANRE Q803S7_DANRE LLSKIHSMGTPLKGQDHPDSRAILYEEVVYSKRKIADFLAALEGFKVMKEIVSIMEPVGE B1H3I3_XENTR B1H3I3_XENTR LLSKIHSIGSPLKSQNHPDSRAVMYEEIAYSKKKIADFLSALEGFKVMREVISILEDAAA Q5FWN5_XENLA Q5FWN5_XENLA LLSKIHSIGSPLKSQNHPDSRAVMYEEITYSKKKIADFLSTLEGFKVMREVISIMEDDVA MSH6_MOUSE MSH6_MOUSE LLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKVSGLLEEVAG Q6GTK8_MOUSE Q6GTK8_MOUSE LLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKVSGLLEEVAG Q8C2N9_MOUSE Q8C2N9_MOUSE LLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKVSGLLEEVAG Q1L838_HUMAN Q1L838_HUMAN LLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVAD B4DF41_HUMAN B4DF41_HUMAN LLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVAD MSH6_HUMAN MSH6_HUMAN LLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVAD B4E3I4_HUMAN B4E3I4_HUMAN LLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVVCKIIGIMEEVAD MATCH ******.:*:***.*:******::*** .***:** ***::*****.: :: .:: CONSENSUS LLSKIH??G?PLK?Q?HPDSRA??YEE??YSK?KI?DFL?ALEGFKVM???????E?V??

Q4RQ60_TETNG Q4RQ60_TETNG DCRSTLLRQVIRVK-REGGGLFPDLSVELRRWEKAFDHQKARNTGVITPKAGFDPEYDQA Q90XA6_DANRE Q90XA6_DANRE GLKSKLLRQVVLLKTENEDGLFPDLSPELKRWDTAFDHQKARTTGVITPKAGFDPEYDQA B8JLI1_DANRE B8JLI1_DANRE DLKSKLLRQVVLLKTENEDGLFPDLSPELKRWDTAFDHQKARTTGVITPKAGFDPEYDQA Q803S7_DANRE Q803S7_DANRE DLKSKLLRQVVLLKTENEDGLFPDLSPELKRWDTAFDHQKARTTGVITPKAGFDPEYDQA B1H3I3_XENTR B1H3I3_XENTR NFKSSILKQIVSIKGKTPQGHFPDLSAELKRWDTSFDHEKARKTGVITPKVGFDPDYDEA Q5FWN5_XENLA Q5FWN5_XENLA HFKSSILKQIVCVKDKASHGRFPDLSAELKRWDTSFDHEKARKTGVITPKAGFDPDYDEA MSH6_MOUSE MSH6_MOUSE GFTSKTLKQVVTLQSKSPKGRFPDLTAELQRWDTAFDHEKARKTGLITPKAGFDSDYDQA Q6GTK8_MOUSE Q6GTK8_MOUSE GFTSKTLKQVVTLQSKSPKGRFPDLTAELQRWDTAFDHEKARKTGLITPKAGFDSDYDQA Q8C2N9_MOUSE Q8C2N9_MOUSE GFTSKTLKQVVTLQSKSPKGRFPDLTAELQRWDTAFDHEKARKTGLITPKAGFDSDYDQA Q1L838_HUMAN Q1L838_HUMAN GFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQA B4DF41_HUMAN B4DF41_HUMAN GFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQA MSH6_HUMAN MSH6_HUMAN GFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQA B4E3I4_HUMAN B4E3I4_HUMAN GFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQA MATCH *. *:*:: :: . * ****: **.**:.:***:***.**:****.***.:**:* CONSENSUS ???S??L?QV?????????G?FPDL??EL?RWDTAFDH?KAR?TG?ITPKAGFD??YDQA

Q4RQ60_TETNG Q4RQ60_TETNG LAGIRGREGELNDYLDRQRKRLGCRNMAYWGTGRNRYQMEVPDSVSERSVPQEYEVKSTK Q90XA6_DANRE Q90XA6_DANRE LNGIKECERDLQDYLDRQKKRLGCKNLSYWGTGRNRYQLEVPESVSERSLPEEYEVRSTK B8JLI1_DANRE B8JLI1_DANRE LNGIKECERDLQDYLDRQKKRLGCKNLSYWGTGRNRYQLEVPESVSERSLPEEYEVRSTK Q803S7_DANRE Q803S7_DANRE LNGIKECERDLQDYLDRQKKRLGCKNLSYWGTGRNRYQLEVPESVSERSLPEEYEVRSTK B1H3I3_XENTR B1H3I3_XENTR LKDIKTTEQDLNEYLDKQRKRLSCKTVVYWGTAKNRYQMEIPESVTERNLPEEYELKKKK Q5FWN5_XENLA Q5FWN5_XENLA LKDVKQAEQDLNEYLDKQRKRLGCKTVVYWGTAKNRYQMEIPENIADRNLPEEYTLKSTK MSH6_MOUSE MSH6_MOUSE LADIRENEQSLLEYLDKQRSRLGCKSIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTK Q6GTK8_MOUSE Q6GTK8_MOUSE LADIRENEQSLLEYLDKQRSRLGCKSIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTK Q8C2N9_MOUSE Q8C2N9_MOUSE LADIRENEQSLLEYLDKQRSRLGCKSIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTK Q1L838_HUMAN Q1L838_HUMAN LADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTK B4DF41_HUMAN B4DF41_HUMAN LADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTK MSH6_HUMAN MSH6_HUMAN LADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTK B4E3I4_HUMAN B4E3I4_HUMAN LADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTK MATCH * .:: * .* :**::*:.*:.*:.: *** .:****:*:*:..: *.:*:** ::..* CONSENSUS L??I???E??L??YL??Q??R?GC????YWG?GRNRYQ?E?PE????R?LPEEYE??STK

Q4RQ60_TETNG Q4RQ60_TETNG KGWKRYVTKETERLFSELQAFEEKRDAALKDCMRRLFYNFDKNYRDWKAAVECMAVLGNR Q90XA6_DANRE Q90XA6_DANRE KGWKRYSTKDIERMFSELQSWEDKRDAALKDCMRRLFYNFDKNYKDWQTAVECMAVL--- B8JLI1_DANRE B8JLI1_DANRE KGWKRYSTKDIERMFSELQSWEDKRDAALKDCMRRLFYNFDKNYKDWQTAVECMAVL--- Q803S7_DANRE Q803S7_DANRE KGWKRYSTKDIERMFSELQSWEDKRDAALKDCMRRLFYNFDKNYKDWQTAVECMAVL--- B1H3I3_XENTR B1H3I3_XENTR ------------------------------------------------------------ Q5FWN5_XENLA Q5FWN5_XENLA KGFKRYWTKAIEKMFGDLVNAEERRDAALKDCMRRLFYNFDKNYKEWQTAVECFAVL--- MSH6_MOUSE MSH6_MOUSE KGCKRYWTKTIEKKLANLINAEERRDTSLKDCMRRLFCNFDKNHKDWQSAVECIAVL--- Q6GTK8_MOUSE Q6GTK8_MOUSE KGCKRYWTKTIEKKLANLINAEERRDTSLKDCMRRLFCNFDKNHKDWQSAVECIAVL--- Q8C2N9_MOUSE Q8C2N9_MOUSE KGCKRYWTKTIEKKLANLINAEERRDTSLKDCMRRLFCNFDKNHKDWQSAVECIAVL--- Q1L838_HUMAN Q1L838_HUMAN KGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVL--- B4DF41_HUMAN B4DF41_HUMAN KGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVL--- MSH6_HUMAN MSH6_HUMAN KGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVL--- B4E3I4_HUMAN B4E3I4_HUMAN KGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVL--- MATCH CONSENSUS KG?KRY?TK?IE?????L???E??RD??LKDCMRRLF?NFDKN?KDWQ?AVEC?AVL???

Q4RQ60_TETNG Q4RQ60_TETNG ARSSSSLVRGAVAFECVDECDDISESGSSADVLLAFSRYSQGGDGPMARPEVAPPSRG-- Q90XA6_DANRE Q90XA6_DANRE ------------------------------DVLLSMCRYSQSADGSMARPEMALPGDGSY B8JLI1_DANRE B8JLI1_DANRE ------------------------------DVLLSMCRYSQSADGSMARPEMALPGDGSY Q803S7_DANRE Q803S7_DANRE ------------------------------DVLLSMCRYSQSADGSMARPEMALPGDGSY B1H3I3_XENTR B1H3I3_XENTR ------------------------------------------------------------ Q5FWN5_XENLA Q5FWN5_XENLA ------------------------------DVLISLSQYSQGGDGPVCRPEIVLQENG-- MSH6_MOUSE MSH6_MOUSE ------------------------------DVLLCLANYSQGGDGPMCRPEIVLPGED-- Q6GTK8_MOUSE Q6GTK8_MOUSE ------------------------------DVLLCLANYSQGGDGPMCRPEIVLPGED-- Q8C2N9_MOUSE Q8C2N9_MOUSE ------------------------------DVLLCLANYSQGGDGPMCRPEIVLPGED-- Q1L838_HUMAN Q1L838_HUMAN ------------------------------------------------------------ B4DF41_HUMAN B4DF41_HUMAN ------------------------------DVLLCLANYSRGGDGPMCRPVILLPED--- MSH6_HUMAN MSH6_HUMAN ------------------------------DVLLCLANYSRGGDGPMCRPVILLPED--- B4E3I4_HUMAN B4E3I4_HUMAN ------------------------------DVLLCLANYSRGGDGPMCRPVILLPED--- MATCH CONSENSUS ??????????????????????????????DVL?????YS???DG???RP??????????

Q4RQ60_TETNG Q4RQ60_TETNG RAPFLELTGSRHPCVTKTFFGDDFIPNDIFIGC---RGSGEEEEKGDATCVLVTGPNMGG Q90XA6_DANRE Q90XA6_DANRE SAPFLDLRGSRHPCVTKTFFGDDFIPNDIFIGCPGDEEEAQDDAKALAPCVLVTGPNMGG B8JLI1_DANRE B8JLI1_DANRE SAPFLDLRGSRHPCVTKTFFGDDFIPNDIFIGCPGDEEEAQDDTKALAPCVLVTGPNMGG Q803S7_DANRE Q803S7_DANRE SAPFLDLRGSRHPCVTKTFFGDDFIPNDIFIGCPGDEEEAQDDTKALAPCVLVTGPNMGG B1H3I3_XENTR B1H3I3_XENTR ------------------------------------------------------------ Q5FWN5_XENLA Q5FWN5_XENLA -SPFLELKGSRHPCITKTFFGDDFIPNDILVGC---KEEDSDDGSDEAHCVLVTGPNMGG MSH6_MOUSE MSH6_MOUSE THPFLEFKGSRHPCITKTFFGDDFIPNDILIGC---EEEAEEHG--KAYCVLVTGPNMGG Q6GTK8_MOUSE Q6GTK8_MOUSE THPFLEFKGSRHPCITKTFFGDDFIPNDILIGC---EEEAEEHG--KAYCVLVTGPNMGG Q8C2N9_MOUSE Q8C2N9_MOUSE THPFLEFKGSRHPCITKTFFGDDFIPNDILIGC---EEEAEEHG--KAYCVLVTGPNMGG Q1L838_HUMAN Q1L838_HUMAN -----------------------------------------------------------G B4DF41_HUMAN B4DF41_HUMAN TPPFLELKGSRHPCITKTFFGDDFIPNDILIGC---EEEEQENG--KAYCVLVTGPNMGG MSH6_HUMAN MSH6_HUMAN TPPFLELKGSRHPCITKTFFGDDFIPNDILIGC---EEEEQENG--KAYCVLVTGPNMGG B4E3I4_HUMAN B4E3I4_HUMAN TPPFLELKGSRHPCITKTFFGDDFIPNDILIGC---EEEEQENG--KAYCVLVTGPNMGG MATCH CONSENSUS ??PFL???GSRHPC?TKTFFGDDFIPNDI??GC??????????????A?CVLVTGPNMGG

Q4RQ60_TETNG Q4RQ60_TETNG KSTLMRQA--------------------------------------RESTFFVELSETAS Q90XA6_DANRE Q90XA6_DANRE KSTLMRQCGLVVILAQLGCYVPAESLRLTPVDRVFTRLGASDRIMSGESTFFVELSETAS B8JLI1_DANRE B8JLI1_DANRE KSTLMRQCGLVVILAQLGCYVPAESLRLTPVDRVFTRLGASDRIMSGESTFFVELSETAS Q803S7_DANRE Q803S7_DANRE KSTLMRQCGLVVILAQLGCYVPAESLRLTPVDRVFTRLGASDRIMSGESTFFVELSETAS B1H3I3_XENTR B1H3I3_XENTR ------------------------------------------------------------ Q5FWN5_XENLA Q5FWN5_XENLA KSTLLRQAGLQVVMAQLGCYVPADSCRLTPVDRVFTRLGASDRIMAGESTFFVELSETSS MSH6_MOUSE MSH6_MOUSE KSTLIRQAGLLAVMAQLGCYVPAEKCRLTPVDRVFTRLGASDRIMSGESTFFVELSETAS Q6GTK8_MOUSE Q6GTK8_MOUSE KSTLIRQAGLLAVMAQLGCYVPAEKCRLTPVDRVFTRLGASDRIMSGESTFFVELSETAS Q8C2N9_MOUSE Q8C2N9_MOUSE KSTLIRQAGLLAVMAQLGCYVPAEKCRLTPVDRVFTRLGASDRIMSGESTFFVELSETAS Q1L838_HUMAN Q1L838_HUMAN KT----------------------------LNKLVLRL---------------------- B4DF41_HUMAN B4DF41_HUMAN KSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETAS MSH6_HUMAN MSH6_HUMAN KSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETAS B4E3I4_HUMAN B4E3I4_HUMAN KSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETAS MATCH CONSENSUS KSTL?RQ?????????????????????????????RL?????????ESTFFVELSET?S

Q4RQ60_TETNG Q4RQ60_TETNG ILRHATKHSLVLLDELGRGTATYDGTAIASAVVKELAERICCRTLFSTHYHSLVEDYAKN Q90XA6_DANRE Q90XA6_DANRE ILLHATNHSLVLLDELGRGTATYDGTAIASAVVKELSEKICCRTLFSTHYHSLVEDHVQD B8JLI1_DANRE B8JLI1_DANRE ILLHATNHSLVLLDELGRGTATYDGTAIASAVVKELSEKICCRTLFSTHYHSLVEDHVQD Q803S7_DANRE Q803S7_DANRE ILLHATNHSLVLLDELGRGTATYDGTAIASAVVKELSEKICCRTLFSTHYHSLVEDHVQD B1H3I3_XENTR B1H3I3_XENTR ------------------------------------------------------------ Q5FWN5_XENLA Q5FWN5_XENLA ILQHATEHSLVLLDELGRGTATFDGTAIAGAVVKELSESIKCRTLFSTHYHSLVEDHSHS MSH6_MOUSE MSH6_MOUSE ILRHATAHSLVLVDELGRGTATFDGTAIASAVVKELAETIKCRTLFSTHYHSLVEDYSKS Q6GTK8_MOUSE Q6GTK8_MOUSE ILRHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSKS Q8C2N9_MOUSE Q8C2N9_MOUSE ILRHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSKS Q1L838_HUMAN Q1L838_HUMAN ------------------------------------------------------------ B4DF41_HUMAN B4DF41_HUMAN ILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQN MSH6_HUMAN MSH6_HUMAN ILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQN B4E3I4_HUMAN B4E3I4_HUMAN ILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQN MATCH CONSENSUS IL?HAT?HSLVL?DELGRGTAT?DGTAIA?AVVKEL?E?I?CRTLFSTHYHSLVED????

Q4RQ60_TETNG Q4RQ60_TETNG HAVRLGHMVRNTLQACMVENECEDPSQETITFLYKFISGACPKSYGFNAARLASLPEEVI Q90XA6_DANRE Q90XA6_DANRE PAVRLGHM------ACMVENECEDPSQETITFLYKFIRGACPKSYGFNAARLANIPEDVI B8JLI1_DANRE B8JLI1_DANRE PAVRLGHM------ACMVENECEDPSQETITFLYKFIRGACPKSYGFNAARLANIPEDVI Q803S7_DANRE Q803S7_DANRE PAVRLGHM------ACMVENECEDPSQETITFLYKFIRGACPKSYGFNAARLANIPEDVI B1H3I3_XENTR B1H3I3_XENTR ------------------------------------------------------------ Q5FWN5_XENLA Q5FWN5_XENLA QSVRLGHM------ACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLAHIPDEII MSH6_MOUSE MSH6_MOUSE VCVRLGHM------ACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVI Q6GTK8_MOUSE Q6GTK8_MOUSE VCVRLGHM------ACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVI Q8C2N9_MOUSE Q8C2N9_MOUSE VCVRLGHM------ACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVI Q1L838_HUMAN Q1L838_HUMAN ------------------------------------------------------------ B4DF41_HUMAN B4DF41_HUMAN VAVRLGHM------ACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVI MSH6_HUMAN MSH6_HUMAN VAVRLGHM------ACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVI B4E3I4_HUMAN B4E3I4_HUMAN VAVRLGHM------ACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVI MATCH CONSENSUS ??VRLGHM??????ACMVENECEDPSQETITFLYKFI?GACPKSYGFNAARLA??P???I

Q4RQ60_TETNG Q4RQ60_TETNG QCGQGKAREFERSTTSLRLFR-------------------------- Q90XA6_DANRE Q90XA6_DANRE QSGHKKARDFERSTVSLRIFKKLCSFAESPRAEREQLTTLIQTLRNL B8JLI1_DANRE B8JLI1_DANRE QSGHKKARDFERSTVSLRIFKKLCSFAESPRAEREQLTTLIQTLRNL Q803S7_DANRE Q803S7_DANRE QSGHKKARDFERSTVSLRIFKKLCSFAESPRAEREQLTTLIQTLRNL B1H3I3_XENTR B1H3I3_XENTR ----------------------------------------------- Q5FWN5_XENLA Q5FWN5_XENLA QVGHQKAREFESLTLSLKLFRELFLALDNGSPEGLALHKRLKLLQ-- MSH6_MOUSE MSH6_MOUSE QKGHRKAREFERMNQSLRLFRGVCLATEKPTINGEAIHRLLALINGL Q6GTK8_MOUSE Q6GTK8_MOUSE QKGHRKAREFERMNQSLQLFREVCLATEKPTINGEAIHRLLALINGL Q8C2N9_MOUSE Q8C2N9_MOUSE QKGHRKAREFERMNQSLQLFREVCLATEKPTINGEAIHRLLALINGL Q1L838_HUMAN Q1L838_HUMAN ----------------------------------------------- B4DF41_HUMAN B4DF41_HUMAN QKGHRKAREFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL MSH6_HUMAN MSH6_HUMAN QKGHRKAREFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL B4E3I4_HUMAN B4E3I4_HUMAN QKGHRKAREFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL MATCH CONSENSUS Q?G??KAR?FE????SL??F???????????????????????????


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