Alignment of the gene Family HBG000104 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU -------------------------------------------------------MENPK Q64ID6_MACEU Q64ID6_MACEU AALKPNESKLNTLVQKLHDFLAHSSEESEDAHSPPRLTLSKVIDKSSRSGNSSDPMEISK Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE TAEPMSGNKLSTLVQKLHDFLAHSSEESEETCSSPRLVMNQSTDKICGSGLNSDMMENNK A2ADH4_MOUSE A2ADH4_MOUSE TAEPMSGNKLSTLVQKLHDFLAHSSEESEETCSSPRLVMNQSTDKICGSGLNSDMMENNK Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY TAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSK ATRX_PANTR ATRX_PANTR TAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSK A4LAA3_HUMAN A4LAA3_HUMAN TAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSK ATRX_HUMAN ATRX_HUMAN TAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSK MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU DEGGGHSEGLKPSCSERKLKP-------INSDDEQNVDESTY--EFQSDEDSNNLLRKNF Q64ID6_MACEU Q64ID6_MACEU EEAHTSSEKAKSVGPSRSKRKPTVVTKYVGSDSEQGF-DETISTDVPIDTTETDIAMQSL Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE EEGASTSEKSRSSGSSRSKRKPSIVTKYVESDDEKP-TDENVNEKAATENSENDITMQSL A2ADH4_MOUSE A2ADH4_MOUSE EEGASTSEKSRSSGSSRSKRKPSIVTKYVESDDEKP-TDENVNEKAATENSENDITMQSL Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY EEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSL ATRX_PANTR ATRX_PANTR EEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSL A4LAA3_HUMAN A4LAA3_HUMAN EEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSL ATRX_HUMAN ATRX_HUMAN EEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSL MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU TEGQ---------QPPSQQQRGKSSESVSSFPGDQALLFGEE-LRRNVICTACGQQVNQF Q64ID6_MACEU Q64ID6_MACEU PKGTVVVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEEGLHGIVSCTACGQQVNHF Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE PKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKADNLIKRGEDGLHGIVSCTACGQQVNHF A2ADH4_MOUSE A2ADH4_MOUSE PKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKADNLKKRGEDGLHGIVSCTACGQQVNHF Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY PKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHF ATRX_PANTR ATRX_PANTR PKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHF A4LAA3_HUMAN A4LAA3_HUMAN PKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHF ATRX_HUMAN ATRX_HUMAN PKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHF MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU QKDSIYRHPTLNVLICKNCYKYYMSDDISRDSEGIDEQCRWCAEGGNLICCDSCHNAFCK Q64ID6_MACEU Q64ID6_MACEU QKDSIYRHPTLKVLICKNCYKYYMSDDISRDADGMDEQCRWCAEGGNLICCDFCHNAFCK Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE QKDSIYRHPSLKVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCK A2ADH4_MOUSE A2ADH4_MOUSE QKDSIYRHPSLKVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCK Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY QKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCK ATRX_PANTR ATRX_PANTR QKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCK A4LAA3_HUMAN A4LAA3_HUMAN QKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCK ATRX_HUMAN ATRX_HUMAN QKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCK MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU KCIWRNLGRKEISKIMNEKNEWHCYICCPEPLLDLIAVCDSVLENLSHLKQQ---KVKAA Q64ID6_MACEU Q64ID6_MACEU KCILRNLGRKELSAIMDENSQWYCYICRPEPLLDLVTACDSVFENLEQLLQQNKKKIKVE Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE KCILRNLGRKELSTIMDENNQWYCYICQPEPLLDLVTACNSVFENLEQLLQQNKKKIKVD A2ADH4_MOUSE A2ADH4_MOUSE KCILRNLGRKELSTIMDENNQWYCYICQPEPLLDLVTACNSVFENLEQLLQQNKKKIKVD Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY KCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFDNLEQLLQQNKKKIKVD ATRX_PANTR ATRX_PANTR KCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVD A4LAA3_HUMAN A4LAA3_HUMAN KCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVD ATRX_HUMAN ATRX_HUMAN KCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVD MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU VKKSGKTSDCPHEFHSSTKRESNAEEKSQLDNSYSGTV--AHSFSSLNIPVDLIKKTITV Q64ID6_MACEU Q64ID6_MACEU SEKSNKLFEHTHRFSPKKNVSSCNGEEKKSDDAYSGSV--TYSFTALMVPKDIVKKTKKL Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE SEKTSKVCDQTSKFSPKKSSSSCNGEEKKLEESCSGSVSSTYSHSALSVPKEMIKKTTKL A2ADH4_MOUSE A2ADH4_MOUSE SEKTSKVCDQTSKFSPKKSSSSCNGEEKKLEESCSGSVSSTYSHSALSVPKEMIKKTTKL Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY SEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSV--TYSYSALIVPKEMIKKAKKL ATRX_PANTR ATRX_PANTR SEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSV--TYSYSALIVPKEMIKKAKKL A4LAA3_HUMAN A4LAA3_HUMAN SEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSV--TYSYSALIVPKEMIKKAKKL ATRX_HUMAN ATRX_HUMAN SEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSV--TYSYSALIVPKEMIKKAKKL MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU VENTAVMNSSFLTFLEQTTSNSEITSNTKLNQLTAIRSVISDISKAHKVLEEHLNKKISS Q64ID6_MACEU Q64ID6_MACEU VETTASMNTSFVRFLKQASENPEVSPVTKLRQLKAFKSVLNDVKKVHLALEGSLNVEIRT Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE IETTSNMNSSYIKFLKQAADNSEMTSAMKLCQLKSFKSVLDDIKKAHLALEEDLNSEIQA A2ADH4_MOUSE A2ADH4_MOUSE IETTSNMNSSYIKFLKQAADNSEMTSAMKLCQLKSFKSVLDDIKKAHLALEEDLNSEIQA Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY IETTANMNSSYVKFLKQATDNSEINSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRA ATRX_PANTR ATRX_PANTR IETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRA A4LAA3_HUMAN A4LAA3_HUMAN IETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRA ATRX_HUMAN ATRX_HUMAN IETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRA MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU LVVRDEEKNNKERKN-----DAKIKNVDKKLEEENK-FATKTKKFLSDKMDKEIMVPRAT Q64ID6_MACEU Q64ID6_MACEU LEALNKETVTKEHKAEGVKPDTEVTKVEVYCEPKKKDFSKCDTKLSVKQVDSEIVGQSLP Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE LDDVHKEKNTKDLKSTDAKSETKLGKGEKSYSTEKREFLKLDARSSVKAIDG-------- A2ADH4_MOUSE A2ADH4_MOUSE LDDVHKEKNTKDLKSTDAKSETKLGKGEKSYSTEKREFLKLDARSSVKAIDG-------- Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY MDAVSKEKNTKEHKVIEAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMYQNVP ATRX_PANTR ATRX_PANTR MDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMDQNVP A4LAA3_HUMAN A4LAA3_HUMAN MDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVP ATRX_HUMAN ATRX_HUMAN MDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVP MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU TDEVNTN-------------EELQNEPPCTSKSLDMDLPSFPSSRPEVIFKNVETSVTIQ Q64ID6_MACEU Q64ID6_MACEU VVGQPVHKTTSAEDKKSSRKD-PHFEPANTSEALDMDIVSVPSSVPEDIFENLEAAMEVQ Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE -EEQRAHKSTSGEHKGSGRKDGSQYEPTNTPEDLDMDIVSVPSSVPEDIFDSLESAMEVQ A2ADH4_MOUSE A2ADH4_MOUSE -EEQRAHKSTSGEHKGSGRKDGSQYEPTNTPEDLDMDIVSVPSSVPEDIFDSLESAMEVQ Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY TEEQRANKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQ ATRX_PANTR ATRX_PANTR TEEQRANKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQ A4LAA3_HUMAN A4LAA3_HUMAN TEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQ ATRX_HUMAN ATRX_HUMAN TEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU N------DENTEVFKDTEKCPLETNESSEVGKKRPKLKTS---TRKLYVKLSPISKSDFS Q64ID6_MACEU Q64ID6_MACEU SSSDHQRDGSSAADRDVE-NSVKSNVTSKDHKGGTKFKITAKVTKELYVKLTPVSLSDSP Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE SSADYQGDGNSGTEPELESSSVKLNVSSKDSRGNIKSKVTAKVRKELFVKLTPVSLSNSP A2ADH4_MOUSE A2ADH4_MOUSE SSADYQGDGNSGTEPELESSSVKLNVSSKDSRGNIKSKVTAKVRKELFVKLTPVSLSNSP Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY SSVDHQGDGSSGTEQEVESSSVKLSISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSP ATRX_PANTR ATRX_PANTR SSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSP A4LAA3_HUMAN A4LAA3_HUMAN SSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSP ATRX_HUMAN ATRX_HUMAN SSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLPNSP MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU LKDTIDQEKIEDE-------YQQETSITGNTEVLKENIIIPGNDTTLLKEETDL------ Q64ID6_MACEU Q64ID6_MACEU VKAADCQEATQEKEESKSSGLTPKTESHSSRKERSDDD-LVDNDIPLVSEEADLRRSPRV Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE IKGVDCQEVSQEKNGRKSSGVARSSEKCRPREEISDH----ENNVTILLEDSDLRRSPRV A2ADH4_MOUSE A2ADH4_MOUSE IKGVDCQEVSQEKNGRKSSGVARSSEKCRPREEISDH----ENNVTILLEDSDLRRSPRV Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY IKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRV ATRX_PANTR ATRX_PANTR IKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRV A4LAA3_HUMAN A4LAA3_HUMAN IKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRV ATRX_HUMAN ATRX_HUMAN IKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRV MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU QTTPLIGQIEKELVKSNSEQ---------------------------------------- Q64ID6_MACEU Q64ID6_MACEU KTTPLRRPTEANPITSNSEEESNDGYNEKRKRKSLVQSVKKDKRTSSDSAIDSPKPNKVP Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE KTTPLRRQTESNPAMSNSDEESNGTMKEKQKMSGPIR--KKDKRNSADCATDNPKPHKVP A2ADH4_MOUSE A2ADH4_MOUSE KTTPLRRQTESNPAMSNSDEESNGTMKEKQKMSGPIR--KKDKRNSADCATDNPKPHKVP Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY KTTPLRRQTETNPVTSNSDEECNETVKEKQKLSVPVR--KKDKRNSSDSAIDNPKPNKLP ATRX_PANTR ATRX_PANTR KTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVR--KKDKRNSSDSAIDNPKPNKLP A4LAA3_HUMAN A4LAA3_HUMAN KTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVR--KKDKRNSSDSAIDNPKPNKLP ATRX_HUMAN ATRX_HUMAN KTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVR--KKDKRNSSDSAIDNPKPNKLP MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU ----------------------------------------------------------SN Q64ID6_MACEU Q64ID6_MACEU KCKPLETVAASSDSDEMPAVLKEVAMLSH-SSSDTEHKETNENVPKKSLYDIKAQPSKGG Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE KAKQPVIGDQNSDSDEMLAVLKEASQMGHSSSSDTDINEPQMN--H------KGKTGKDD A2ADH4_MOUSE A2ADH4_MOUSE KAKQPVIGDQNSDSDEMLAVLKEASQMGHSSSSDTDINEPQMN--H------KGKTGKDD Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY KSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTN--HKTLYDLKTQAGKDD ATRX_PANTR ATRX_PANTR KSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTN--HKTLYDLKTQAGKDD A4LAA3_HUMAN A4LAA3_HUMAN KSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTN--HKTLYDLKTQAGKDD ATRX_HUMAN ATRX_HUMAN KSKQSETVDQNSDSDEMLAILKGVSRMSHSSSSDTDINEIHTN--HKTLYDLKTQAGKDD MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU KKRREKSSGQWG-----KKGR--------------------------------------- Q64ID6_MACEU Q64ID6_MACEU KRKRKRKTSTSGSDFDTKKGKEVKSFTSSKKKRQNHSDSSNYDSELEREIKTMSKI-VAK Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE NGKRKRKNSTSGSDFDTKKGKSTETSIISKKKRQNYSESSNYDSELEREIKTMSRIGAAR A2ADH4_MOUSE A2ADH4_MOUSE NGKRKRKNSTSGSDFDTKKGKSTETSIISKKKRQNYSESSNYDSELEREIKTMSRIGAAR Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAAR ATRX_PANTR ATRX_PANTR KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAAR A4LAA3_HUMAN A4LAA3_HUMAN KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAAR ATRX_HUMAN ATRX_HUMAN KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAAR MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU ------------------------------------------------------------ Q64ID6_MACEU Q64ID6_MACEU KPHTRHSKKEDYDSSEDEKQIKKGMGKQKKKDPKFVVHESSDDDEDKQK-----SSCFSE Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE ---KSVPEKKEEDSSEDEKQGKKVVDNGGHERAKTTQEGSSADDTGDTEGRQGGSCSIAG A2ADH4_MOUSE A2ADH4_MOUSE ---KSVPEKKEEDSSEDEKQGKKVVDNGGHERAKTTQEGSSADDTGDTEGRQGGSCSIAG Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERE---NFSSAE ATRX_PANTR ATRX_PANTR TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERE---NFSSAE A4LAA3_HUMAN A4LAA3_HUMAN TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERE---TFSSAE ATRX_HUMAN ATRX_HUMAN TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERE---TFSSAE MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU ------------------------------KISLPEEKF--------------------- Q64ID6_MACEU Q64ID6_MACEU DTVDKEKMNMEVGDQISKK--DASTSADANKFSVKEEPCPSPEASKETEGSEKSSRLKKK Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE GSIEKVRSGVEFREMLCK---PGVSSDGAEKPSVKEENVNSPEDKRVSKTKEKTKHLRSR A2ADH4_MOUSE A2ADH4_MOUSE GSIEKVRSGVEFREMLCK---PGVSSDGAEKPSVKEENVNSPEDKRVSKTKEKTKHLRSR Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY GTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEEGFTSLEVRKVAETKEKSKHLKTK ATRX_PANTR ATRX_PANTR GTVDKDTTIMELRDRLPKKQQASASTDGVDKFSGKEESFTSLEVRKVAETKEKSKHLKTK A4LAA3_HUMAN A4LAA3_HUMAN GTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEESFTSLEVRKVAETKEKSKHLKTK ATRX_HUMAN ATRX_HUMAN GTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTK MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN -----------------------NEKSDGEDKNKEKKEEKKEERENKIKEEVLKSDAEME Q2Y0Q4_MACEU Q2Y0Q4_MACEU ---------------KLSNRESNSDSSEKPKKEAKNSSESD----TDLKDENIQKE---- Q64ID6_MACEU Q64ID6_MACEU PFKKAQESSFDDVAEKSSQREESSDSSEDDKKQTKR-TETKEKKTTYLKE--IPQEEKDE Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE QSRKGKG-GSSDGTDRFPKKEQSDESSEGEKKQSRQRPGTKGKKAPDLKGETLKREQEWD A2ADH4_MOUSE A2ADH4_MOUSE QSRKGKG-GSSDGTDRFPKKEQSDESSEGEKKQSRQRPGTKGKKAPDLKGETLKREQEWD Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY ICKKVQD-GLSDITEKFLKKDQSDETSEDDKKQSKKGTEEK-KKTSDFKKKVIKMEQQYE ATRX_PANTR ATRX_PANTR TCKKVQD-GLSDTAEKFLKKDQSDETSEDDKKQSKKGTEEK-KKPSDFKKKVIKMEQQYE A4LAA3_HUMAN A4LAA3_HUMAN TCKKVQD-GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEK-KKPSDFKKKVIKMEQQYE ATRX_HUMAN ATRX_HUMAN TCKKVQD-GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEK-KKPSDFKKKVIKMEQQYE MATCH CONSENSUS ??????????????????????????S????K????????????????K???????????

Q4H3V6_CIOIN Q4H3V6_CIOIN C----------------------------------------------------------- Q2Y0Q4_MACEU Q2Y0Q4_MACEU ---------LVSKAKCHTRKGVKAKRK--------------------------------- Q64ID6_MACEU Q64ID6_MACEU TSSDGTEKLLEKGDNSHLSEDLDPNKQGSTEMEKKSKKLREKSSKKKEELSDDTEKLPGK Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE SSSDGTERLPEEEEIGPFSKGIKQSKTDTAGGEKKGKKWKDKSCEKKEELSDSVDKLPGK A2ADH4_MOUSE A2ADH4_MOUSE SSSDGTERLPEEEEIGPFSKGIKQSKTDTAGGEKKGKKWKDKSCEKKEELSDSVDKLPGK Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY SSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKNKKIRDKTSKKKDELSDYAEKSTGK ATRX_PANTR ATRX_PANTR SSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGK A4LAA3_HUMAN A4LAA3_HUMAN SSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGK ATRX_HUMAN ATRX_HUMAN SSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGK MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU -----------------------------------------------REDSVTNLD---- Q64ID6_MACEU Q64ID6_MACEU EESVDFSEGKK---GVSSKERKKEHLGEKSSKTAQDGSSSDIEKCLTKEECYDSSDEKRR Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE GDSCDSSEDKKTRNRVSLREKKRFSLPAKSPGKRPECSSSDTEK-SLKGQCCDSTE-KRP A2ADH4_MOUSE A2ADH4_MOUSE GDSCDSSEDKKTRNRVSLREKKRFSLPAKSPGKRPECSSSDTEK-SLKGQCCDSTE-KRP Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY GDSCDSSEDKKSKNGAYGREKKRCTLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSD-KRL ATRX_PANTR ATRX_PANTR GDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSD-KRL A4LAA3_HUMAN A4LAA3_HUMAN GDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSD-KRL ATRX_HUMAN ATRX_HUMAN GDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSD-KRL MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU ------------------------------------------------------------ Q64ID6_MACEU Q64ID6_MACEU KRIESRERRNLSTKRSVIK-QSGSSSSDAEEMYSEDGKRKKKLSLTKSKKKENIKDKKKK Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE KRIDLRERRNSSSKRNTKEVKSASSSSDAEG-SSEDNKKQKKQRTSAKKKTGNTKEKKRN A2ADH4_MOUSE A2ADH4_MOUSE KRIDLRERRNSSSKRNTKEVKSASSSSDAEG-SSEDNKKQKKQRTSAKKKTGNTKEKKRN Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY KRIELRERRNLSSKRNTKEIQSGSSSSDAEE-SSEDNKK-KKQRTSSKKKAVIVKEKKRN ATRX_PANTR ATRX_PANTR KRIELRERRNLSSKRNTKEIQSGSSSSDAEE-SSEDNKK-KQQRTSSKKKAVIVKEKKRN A4LAA3_HUMAN A4LAA3_HUMAN KRIELRERRNLSSKRNTKEIQSGSSSSDAEE-SSEDNKK-KKQRTSSKKKAVIVKEKKRN ATRX_HUMAN ATRX_HUMAN KRIELRERRNLSSKRNTKEIQSGSSSSDAEE-SSEDNKK-KKQRTSSKKKAVIVKEKKRN MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------------------------ Q2Y0Q4_MACEU Q2Y0Q4_MACEU ---------------------------------NDDKKSKASTEN--------------- Q64ID6_MACEU Q64ID6_MACEU SPRRSAKKPQ-EIVSSSSDEVGDDDHNSTGEGSGDEQKIKPVTENPAI------YHSSGE Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------TENLVLPSHTGFCQSSGD ATRX_MOUSE ATRX_MOUSE SLRATPKRKQVDIT-SSSSDIGDDDQNSAGEESSDEQKIKPVTENLVLPSHTGFCQSSGD A2ADH4_MOUSE A2ADH4_MOUSE SLRATPKRKQVDIT-SSSSDIGDDDQNSAGEESSDEQKIKPVTENLVLPSHTGFCQSSGD Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY SLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGD ATRX_PANTR ATRX_PANTR SLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGD A4LAA3_HUMAN A4LAA3_HUMAN SLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGD ATRX_HUMAN ATRX_HUMAN SLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGD MATCH CONSENSUS ??????????????????????????????????????????TEN???????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN --------ITIESDSHDENVGSK------------------------------------- Q2Y0Q4_MACEU Q2Y0Q4_MACEU ----------IKKQQDENDFSSP------------------------------------- Q64ID6_MACEU Q64ID6_MACEU EA-DRPGPVTLDDDEDEDDPENRIAKKMLLEEIQANISSDEDASSDEEPA-KIKKRIVKQ Q3UZ76_MOUSE Q3UZ76_MOUSE EALSKSVPATVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPDGGGKKRIGKQ ATRX_MOUSE ATRX_MOUSE EALSKSVPATVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPDGGGKKRIGKQ A2ADH4_MOUSE A2ADH4_MOUSE EALSKSVPATVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPDGGGKKRIGKQ Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPE-EGKKRTGKQ ATRX_PANTR ATRX_PANTR EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPE-EGKKRTGKQ A4LAA3_HUMAN A4LAA3_HUMAN EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPE-EGKKRTGKQ ATRX_HUMAN ATRX_HUMAN EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPE-EGKKRTGKQ MATCH CONSENSUS ?????????T???D?D??D?????????????????????????????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------------------------------------------SKKITSMSSDSDEDVGFK Q2Y0Q4_MACEU Q2Y0Q4_MACEU ----------------SSDMFNSD------------------KSEMTITESTDA------ Q64ID6_MACEU Q64ID6_MACEU NEENTGDESEPLKDE-NDERGNSDTDSDSEQSKKPRYRHRLLRHKLSVSDGESGEEKKAR Q3UZ76_MOUSE Q3UZ76_MOUSE SEESPADDGELRREQLAVNQVNSESDSDSEESKKPRYRHRLLRHKLTLSDGESGEEKPTK ATRX_MOUSE ATRX_MOUSE SEESPADDGELRREQLAVNQVNSESDSDSEESKKPRYRHRLLRHKLTLSDGESGEEKPTK A2ADH4_MOUSE A2ADH4_MOUSE SEESPADDGELRREQLAVNQVNSESDSDSEESKKPRYRHRLLRHKLTLSDGESGEEKPTK Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------SDGESGEEKPTK ATRX_PONPY ATRX_PONPY NEENPGDEE-------AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK ATRX_PANTR ATRX_PANTR NEENPGDEE-------AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK A4LAA3_HUMAN A4LAA3_HUMAN NEENPGDEE-------AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK ATRX_HUMAN ATRX_HUMAN NEENPGDEE-------AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK MATCH .. . CONSENSUS ?????????????????????NS?????????????????????K?T?SDGESGEEK??K

Q4H3V6_CIOIN Q4H3V6_CIOIN PKKKQ--------------------KGQTWLDDFYKVEDVSDDGVGSIKK---EAQTRSY Q2Y0Q4_MACEU Q2Y0Q4_MACEU --------SHFQLSVNTDQSLHSELEGKKVVDDI--TEHVQQPGTSSAKSIMVHSNQRSY Q64ID6_MACEU Q64ID6_MACEU PKETKETKRRNRRKVSSEDSVDTDFQESGVSEEVSESEDDQRPRTRSAKKAELEENQRSY Q3UZ76_MOUSE Q3UZ76_MOUSE PKEHKEAKGRNRRKVSSEDSEDTDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY ATRX_MOUSE ATRX_MOUSE PKEHKEAKGRNRRKVSSEDSEDTDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY A2ADH4_MOUSE A2ADH4_MOUSE PKEHKEAKGRNRRKVSSEDSEDTDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY Q3TSV4_MOUSE Q3TSV4_MOUSE PKEHKEAKGRNRRKVSSEDSEDTDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY ATRX_PONPY ATRX_PONPY PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY ATRX_PANTR ATRX_PANTR PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY A4LAA3_HUMAN A4LAA3_HUMAN PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY ATRX_HUMAN ATRX_HUMAN PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY MATCH : . ::. *. . . * *. . : *** CONSENSUS PKE?KE?K?RNRRKVSSEDS?D?DFQESGVSEEVSESED?QRPRTRSAKKAELEENQRSY

Q4H3V6_CIOIN Q4H3V6_CIOIN NKVKKRRRIK---DSGSEDSNK-----------------------DSMDDFHDSGKKMGR Q2Y0Q4_MACEU Q2Y0Q4_MACEU KQ-KKRKHIKVKENLSTEHNKNL----------------------SENDESKSPEQ--SR Q64ID6_MACEU Q64ID6_MACEU KQKKKRRRIKVQEDSSSENKSNS-------------------EEEDENDDSKSPGK--GR Q3UZ76_MOUSE Q3UZ76_MOUSE KQKKKRRRIKVQEDSSSENKSHS--EEDKKEGDEEDEEDEDEDEEDENDDSKSPGK--GR ATRX_MOUSE ATRX_MOUSE KQKKKRRRIKVQEDSSSENKSHS--EEDKKEGDEEDEEDEDEDEEDENDDSKSPGK--GR A2ADH4_MOUSE A2ADH4_MOUSE KQKKKRRRIKVQEDSSSENKSHS--EEDKKEGDEEDEEDEDEDEEDENDDSKSPGK--GR Q3TSV4_MOUSE Q3TSV4_MOUSE KQKKKRRRIKVQEDSSSENKSHS--EEDKKEGDEEDEEDEDEDEEDENDDSKSPGK--GR ATRX_PONPY ATRX_PONPY KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGK--GR ATRX_PANTR ATRX_PANTR KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGK--GR A4LAA3_HUMAN A4LAA3_HUMAN KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGK--GR ATRX_HUMAN ATRX_HUMAN KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGK--GR MATCH :: ***::** : .:*...: .. *: :.. : .* CONSENSUS KQKKKRRRIKVQEDSSSENKS?S????????????????????EEDENDDSKSPGK??GR

Q4H3V6_CIOIN Q4H3V6_CIOIN RNIRKILDNTNLSKMTQDAEKMEKARRKRL-EQDQDLEEEVIIIDDEASPQKKKKVTTHL Q2Y0Q4_MACEU Q2Y0Q4_MACEU KKIKNILDNDKLQRETQKALKEEERRRKRIAEKQQEREKLREVVD-SSASPTECPITIKL Q64ID6_MACEU Q64ID6_MACEU KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPIKCPITTKL Q3UZ76_MOUSE Q3UZ76_MOUSE KKIRKIIKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKL ATRX_MOUSE ATRX_MOUSE KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKL A2ADH4_MOUSE A2ADH4_MOUSE KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKL Q3TSV4_MOUSE Q3TSV4_MOUSE KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKL ATRX_PONPY ATRX_PONPY KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKL ATRX_PANTR ATRX_PANTR KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKL A4LAA3_HUMAN A4LAA3_HUMAN KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKL ATRX_HUMAN ATRX_HUMAN KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKL MATCH ::*::*:.: :* **.* * *: ****: *:::: *: ::: . :. : :* :* CONSENSUS KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKL

Q4H3V6_CIOIN Q4H3V6_CIOIN VL-----SKKPLVEVESAILRALKPHQVEGIKFLWRNVIESVARANKSRGDGCILAHCMG Q2Y0Q4_MACEU Q2Y0Q4_MACEU VLDEDEETKEPLVQIHRNLVTKLKPHQIDGVQFMWDCCCESVIQTKKSAGSGCILAHCMG Q64ID6_MACEU Q64ID6_MACEU VLDEDEETKEPLVQVHRNMVTKLKPHQVDGVQFMWDCCCESVSKTKKSAGSGCILAHCMG Q3UZ76_MOUSE Q3UZ76_MOUSE VLDENEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVEKTKKSPGSGCILAHCMG ATRX_MOUSE ATRX_MOUSE VLDENEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVEKTKKSPGSGCILAHCMG A2ADH4_MOUSE A2ADH4_MOUSE VLDENEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVEKTKKSPGSGCILAHCMG Q3TSV4_MOUSE Q3TSV4_MOUSE VLDENEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVEKTKKSPGSGCILAHCMG ATRX_PONPY ATRX_PONPY VLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMG ATRX_PANTR ATRX_PANTR VLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMG A4LAA3_HUMAN A4LAA3_HUMAN VLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMG ATRX_HUMAN ATRX_HUMAN VLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMG MATCH ** :*:***::. :: *****::*::*:* *** :::** *.********* CONSENSUS VLDE?EETKEPLVQVHRNMV?KLKPHQVDGVQFMWDCCCESV?KTKKS?GSGCILAHCMG

Q4H3V6_CIOIN Q4H3V6_CIOIN LGKTLQVVAFLHTVLHSSHLPKQRTALVVCPLGTVLNWAREFDMWTRPCK--QSMDTYSI Q2Y0Q4_MACEU Q2Y0Q4_MACEU LGKTLQVVTFLHTVLLCDKL-NFTTALVVCPLNTALNWINEFEKWQEVLEDDKKLKVSEL Q64ID6_MACEU Q64ID6_MACEU LGKTLQVVSFLHTVLLCDKL-DFSTALVVCPLNTALNWMNEFEKWQDGLDDEEKLEVSEL Q3UZ76_MOUSE Q3UZ76_MOUSE LGKTLQVVSFLHTVLLCDKL-DFSTALVVCPLNTALNWMNEFEKWQEGLNDNEKLEVSEL ATRX_MOUSE ATRX_MOUSE LGKTLQVVSFLHTVLLCDKL-DFSTALVVCPLNTALNWMNEFEKWQEGLNDNEKLEVSEL A2ADH4_MOUSE A2ADH4_MOUSE LGKTLQVVSFLHTVLLCDKL-DFSTALVVCPLNTALNWMNEFEKWQEGLNDNEKLEVSEL Q3TSV4_MOUSE Q3TSV4_MOUSE LGKTLQVVSFLHTVLLCDKL-DFSTALVVCPLNTALNWMNEFEKWQEGLNDNEKLEVSEL ATRX_PONPY ATRX_PONPY LGKTLQVVSFLHTVLLCDKL-DFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSEL ATRX_PANTR ATRX_PANTR LGKTLQVVSFLHTVLLCDKL-DFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSEL A4LAA3_HUMAN A4LAA3_HUMAN LGKTLQVVSFLHTVLLCDKL-DFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSEL ATRX_HUMAN ATRX_HUMAN LGKTLQVVSFLHTVLLCDKL-DFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSEL MATCH ********:****** ..:* . ********.*.*** .**: * . :.:.. .: CONSENSUS LGKTLQVVSFLHTVLLCDKL?DFSTALVVCPLNTALNWMNEFEKWQEGL?D?EKLEVSEL

Q4H3V6_CIOIN Q4H3V6_CIOIN MDNKSLHDRAIILKRWHKRGGVLVTGYKMFMTMVTNTRKQYSRYNKSFIEMMLDPGPDIV Q2Y0Q4_MACEU Q2Y0Q4_MACEU GTMKRAQDRSDLLQKWQDNGGVMVIGYEMYRNLVQGRNVKSRKFKEIFNKTLIDPGPDFV Q64ID6_MACEU Q64ID6_MACEU ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFV Q3UZ76_MOUSE Q3UZ76_MOUSE ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKDIFNKALVDPGPDFV ATRX_MOUSE ATRX_MOUSE ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKDIFNKALVDPGPDFV A2ADH4_MOUSE A2ADH4_MOUSE ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKDIFNKALVDPGPDFV Q3TSV4_MOUSE Q3TSV4_MOUSE ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKDIFNKALVDPGPDFV ATRX_PONPY ATRX_PONPY ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFV ATRX_PANTR ATRX_PANTR ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFV A4LAA3_HUMAN A4LAA3_HUMAN ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFV ATRX_HUMAN ATRX_HUMAN ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFV MATCH * ::*: :*::*:. ***:: **:*: .:. . . : : :. * : ::*****:* CONSENSUS ATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLK?IFNKALVDPGPDFV

Q4H3V6_CIOIN Q4H3V6_CIOIN VCDEGHIIKNEATNLSNVMSRIKTRRRLVLTGTPLQNNLMEYYCMVNFIKPRLLGSAQEF Q2Y0Q4_MACEU Q2Y0Q4_MACEU VCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF Q64ID6_MACEU Q64ID6_MACEU VCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF Q3UZ76_MOUSE Q3UZ76_MOUSE VCDEGHILKNEASAVSKAMNSIKSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF ATRX_MOUSE ATRX_MOUSE VCDEGHILKNEASAVSKAMNSIKSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF A2ADH4_MOUSE A2ADH4_MOUSE VCDEGHILKNEASAVSKAMNSIKSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF Q3TSV4_MOUSE Q3TSV4_MOUSE VCDEGHILKNEASAVSKAMNSIKSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF ATRX_PONPY ATRX_PONPY VCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF ATRX_PANTR ATRX_PANTR VCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF A4LAA3_HUMAN A4LAA3_HUMAN VCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF ATRX_HUMAN ATRX_HUMAN VCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF MATCH *******:****: :*:.*. *::***::**********:**:******* .**** :** CONSENSUS VCDEGHILKNEASAVSKAMNSI?SRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEF

Q4H3V6_CIOIN Q4H3V6_CIOIN NNRFTHPIRNGQHVDSTERDVKLMKKRSHVLHELLAGCVQRKDVNCLREQLMPKHEYVLF Q2Y0Q4_MACEU Q2Y0Q4_MACEU RNRFINPIQNGQCADSSMADVRIMKKRAHILCEMLAGCVQRKDHTTLTKILPPKYEYVLA Q64ID6_MACEU Q64ID6_MACEU RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA Q3UZ76_MOUSE Q3UZ76_MOUSE RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA ATRX_MOUSE ATRX_MOUSE RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA A2ADH4_MOUSE A2ADH4_MOUSE RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA Q3TSV4_MOUSE Q3TSV4_MOUSE RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA ATRX_PONPY ATRX_PONPY RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA ATRX_PANTR ATRX_PANTR RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA A4LAA3_HUMAN A4LAA3_HUMAN RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA ATRX_HUMAN ATRX_HUMAN RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA MATCH .*** :**:*** .**: **::****:*:* *:********* . * : * **:**** CONSENSUS RNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLA

Q4H3V6_CIOIN Q4H3V6_CIOIN VRLTPVQIRLYEQYLSTFQC------GDVGNRKGQLFQDFKNLLLIVCHPKALLLDKIRR Q2Y0Q4_MACEU Q2Y0Q4_MACEU VRMTSVQCKLYQYYLDHLPVAESITEGGRGKAGAKLFQDFNILSRIWTHPWCLQLDYISK Q64ID6_MACEU Q64ID6_MACEU VRMTPIQCKLYQYYLDHLTGVGNSSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK Q3UZ76_MOUSE Q3UZ76_MOUSE VRMTAIQCKLYQYYLDHLTGVGNSTEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK ATRX_MOUSE ATRX_MOUSE VRMTAIQCKLYQYYLDHLTGVGNSTEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK A2ADH4_MOUSE A2ADH4_MOUSE VRMTAIQCKLYQYYLDHLTGVGNSTEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK Q3TSV4_MOUSE Q3TSV4_MOUSE VRMTAIQCKLYQYYLDHLTGVGNSTEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK ATRX_PONPY ATRX_PONPY VRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK ATRX_PANTR ATRX_PANTR VRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK A4LAA3_HUMAN A4LAA3_HUMAN VRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK ATRX_HUMAN ATRX_HUMAN VRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK MATCH **:*.:* :**: **. : *. *: .:*****: * * ** .* ** * : CONSENSUS VRMT?IQCKLYQYYLDHLTGVGN??EGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISK

Q4H3V6_CIOIN Q4H3V6_CIOIN ENQQNAEEAREDIRSFLNDEDETSEEDLEGEEPPSD----------DMSKISSMSVQDLK Q2Y0Q4_MACEU Q2Y0Q4_MACEU ENKGYFDEDRMD--KFIPSDSEETSTSLSSDDLPKKKK---YKGEINTSSSGS---DDEE Q64ID6_MACEU Q64ID6_MACEU ENKGYFDEDSMD--EFIASDSDETSMSLSSDEYTKKKKSKGKKGKKDSSSSGSGSDNDVE Q3UZ76_MOUSE Q3UZ76_MOUSE ENKGYFDEDSMD--EFIASDSDETSKSLSSDE--KKKP-KGKKGKKDSSSSGSGSDNDVE ATRX_MOUSE ATRX_MOUSE ENKGYFDEDSMD--EFIASDSDETSKSLSSDE--KKKP-KGKKGKKDSSSSGSGSDNDVE A2ADH4_MOUSE A2ADH4_MOUSE ENKGYFDEDSMD--EFIASDSDETSKSLSSDE--KKKP-KGKKGKKDSSSSGSGSDNDVE Q3TSV4_MOUSE Q3TSV4_MOUSE ENKGYFDEDSMD--EFIASDSDETSKSLSSDE--KKKP-KGKKGKKDSSSSGSGSDNDVE ATRX_PONPY ATRX_PONPY ENKGYFDEDSMD--EFIASDSDETSMSLSSDDYTKKKK-KGKKGKKDSSSSGSGSDNDVE ATRX_PANTR ATRX_PANTR ENKGYFDEDSMD--EFIASDSDETSMSLSSDDYTKKKK-KGKKGKKDSSSSGSGSDNDVE A4LAA3_HUMAN A4LAA3_HUMAN ENKGYFDEDSMD--EFIASDSDETSMSLSSDDYTKKKK-KGKKGKKDSSSSGSGSDNDVE ATRX_HUMAN ATRX_HUMAN ENKGYFDEDSMD--EFIASDSDETSMSLSSDDYTKKKK-KGKKGKKDSSSSGSGSDNDVE MATCH **: :* * .*: .:.: :. .*..:: .. : *. .* :* : CONSENSUS ENKGYFDEDSMD??EFIASDSDETS?SLSSD???KKK??KGKKGKKDSSSSGSGSDNDVE

Q4H3V6_CIOIN Q4H3V6_CIOIN KLIL----SKG---GSLQDCLEKKDLLQRAKDLLTTSATDDPTKEL--WFEKVMPSDNLL Q2Y0Q4_MACEU Q2Y0Q4_MACEU VIKVWNSRSRGGGEGNKEELTNISSVTAKTEGIGRVLYISNPGSPSPDWYKDFITDSDA- Q64ID6_MACEU Q64ID6_MACEU VIKVWNSRSRGGGEGTVEEASSIPTVSLKQEESKTSSSN--PSSPAPDWYKDFVTDADA- Q3UZ76_MOUSE Q3UZ76_MOUSE VIKVWNSRSRGGGDGNVDDTGNNPSVSLKLDESKTTSTSN-PSSPAPDWYKDFVTDTDA- ATRX_MOUSE ATRX_MOUSE VIKVWNSRSRGGGDGNMDDTGNNPSVSLKLDESKTTSTSN-PSSPAPDWYKDFVTDTDA- A2ADH4_MOUSE A2ADH4_MOUSE VIKVWNSRSRGGGDGNVDDTGNNPSVSLKLDESKTTSTSN-PSSPAPDWYKDFVTDTDA- Q3TSV4_MOUSE Q3TSV4_MOUSE VIKVWNSRSRGGGDGNVDDTGNNPSVSLKLDESKTTSTSN-PSSPAPDWYKDFVTDTDA- ATRX_PONPY ATRX_PONPY VIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSN-PSSPAPDWYKDFVTDADA- ATRX_PANTR ATRX_PANTR VIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSN-PSSPAPDWYKDFVTDADA- A4LAA3_HUMAN A4LAA3_HUMAN VIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSN-PSSPAPDWYKDFVTDADA- ATRX_HUMAN ATRX_HUMAN VIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSN-PSSPAPDWYKDFVTDADA- MATCH : : *:* *. :: . : : . * . *::..:.. : CONSENSUS VIKVWNSRSRGGG?GN?????N?PSVSLK??ESK?TS????PSSPAPDWYKDFVTD?DA?

Q4H3V6_CIOIN Q4H3V6_CIOIN YDSVEMSGKITLLLSILKSSTMMGDKVVLFSQSLLTLDLIEDILRYVTMDGSDNTRSPTG Q2Y0Q4_MACEU Q2Y0Q4_MACEU -KVLEHSGKMVLLFEILKMAEELGDKVLVFSQSLISLDLIEDFLELGSNEISDDKDKPRI Q64ID6_MACEU Q64ID6_MACEU -EVLEHSGKMVLLFEILRMAEELGDKVLVFSQSLISLDLIEDFLELASREKSDDKDKPLI Q3UZ76_MOUSE Q3UZ76_MOUSE -EVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKEKPLI ATRX_MOUSE ATRX_MOUSE -EVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKEKPLI A2ADH4_MOUSE A2ADH4_MOUSE -EVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKEKPLI Q3TSV4_MOUSE Q3TSV4_MOUSE -EVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKEKPLI ATRX_PONPY ATRX_PONPY -EVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLI ATRX_PANTR ATRX_PANTR -EVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLI A4LAA3_HUMAN A4LAA3_HUMAN -EVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLI ATRX_HUMAN ATRX_HUMAN -EVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLI MATCH . :* ***:.**:.**: : :****::*****::******:*. : : :::. .* CONSENSUS ?EVLEHSGKMVLLFEILRMAEE?GDKVLVFSQSLISLDLIEDFLELASREK??DK?KPLI

Q4H3V6_CIOIN Q4H3V6_CIOIN VR-IMKWYKDVDYYRMDGSTKNERRKTIIDQFNNESDTRCRLMLVSTRAGGIGINLVGAN Q2Y0Q4_MACEU Q2Y0Q4_MACEU YKGEGKWFRNIDYYRLDGSSSAQSRKKWAEEFNDETNVRGRLFLISTKAGSLGINLVAAN Q64ID6_MACEU Q64ID6_MACEU YKGEGKWFRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN Q3UZ76_MOUSE Q3UZ76_MOUSE YKGEGKWIRNIDYYRLDGSTNAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN ATRX_MOUSE ATRX_MOUSE YKGEGKWIRNIDYYRLDGSTNAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN A2ADH4_MOUSE A2ADH4_MOUSE YKGEGKWIRNIDYYRLDGSTNAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN Q3TSV4_MOUSE Q3TSV4_MOUSE YKGEGKWIRNIDYYRLDGSTNAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN ATRX_PONPY ATRX_PONPY YKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN ATRX_PANTR ATRX_PANTR YKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN A4LAA3_HUMAN A4LAA3_HUMAN YKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN ATRX_HUMAN ATRX_HUMAN YKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN MATCH : ** :::****:***:. : **. ::**:*::.* **:::**:**.:*****.** CONSENSUS YKGEGKW?RNIDYYRLDGST?AQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAAN

Q4H3V6_CIOIN Q4H3V6_CIOIN RAIVFDASWNPTHDVQSIFRIYRFGQTKPCYIYRFIAQGTMEEKIYDRQVVKQSLASRVV Q2Y0Q4_MACEU Q2Y0Q4_MACEU RVIVFDASWNPSYDIQSIFRVYRFGQSKPVFVYRFLAQGTMEDKIYERQVTKQSLSFRVI Q64ID6_MACEU Q64ID6_MACEU RVIIFDASWNPSYDIQSIFRVYRFGQNKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV Q3UZ76_MOUSE Q3UZ76_MOUSE RVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV ATRX_MOUSE ATRX_MOUSE RVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV A2ADH4_MOUSE A2ADH4_MOUSE RVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV Q3TSV4_MOUSE Q3TSV4_MOUSE RVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV ATRX_PONPY ATRX_PONPY RVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV ATRX_PANTR ATRX_PANTR RVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV A4LAA3_HUMAN A4LAA3_HUMAN RVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV ATRX_HUMAN ATRX_HUMAN RVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV MATCH *.*:*******::*:*****:*****.** ::***:******:***:***.****: **: CONSENSUS RVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVV

Q4H3V6_CIOIN Q4H3V6_CIOIN DEQQIERHYTANDIAELYTFKPERL---TKETIKSRPTPIKPKDQLLSDILLDPKSRDLI Q2Y0Q4_MACEU Q2Y0Q4_MACEU DQQQVERHFTLNELTELYAFEPDLLDVTDAEKKKKRDTPMLPKDTILAELL--RIHKEYI Q64ID6_MACEU Q64ID6_MACEU DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELL--QIHKEHI Q3UZ76_MOUSE Q3UZ76_MOUSE DQQQVERHFTMNELTELYTFEPDLLDDPNS------------------------------ ATRX_MOUSE ATRX_MOUSE DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELL--QIHKEHI A2ADH4_MOUSE A2ADH4_MOUSE DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELL--QIHKEHI Q3TSV4_MOUSE Q3TSV4_MOUSE DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELL--QIHKEHI ATRX_PONPY ATRX_PONPY DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELL--QIHKEHI ATRX_PANTR ATRX_PANTR DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELL--QIHKEHI A4LAA3_HUMAN A4LAA3_HUMAN DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELL--QIHKEHI ATRX_HUMAN ATRX_HUMAN DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELL--QIHKEHI MATCH *:**:***:* *:::***:*:*: * CONSENSUS DQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELL???IHKE?I

Q4H3V6_CIOIN Q4H3V6_CIOIN VSYHEHDSLLGHQADEELSEADRRNAWDEYDRER--------------FPPVPHDS---- Q2Y0Q4_MACEU Q2Y0Q4_MACEU VGYHEHDSLLDHKEEEELTEEERKAAWEEYEAEKKGLSFHF------TFPSVTFSSESQF Q64ID6_MACEU Q64ID6_MACEU VGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNMPTGTSLPPVNFSSQTPY Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE VGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVTFTSQTPY A2ADH4_MOUSE A2ADH4_MOUSE VGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVTFTSQTPY Q3TSV4_MOUSE Q3TSV4_MOUSE VGYHEHDSLLDHKEEEELT----------------------------------------- ATRX_PONPY ATRX_PONPY VGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPY ATRX_PANTR ATRX_PANTR VGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPY A4LAA3_HUMAN A4LAA3_HUMAN VGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPY ATRX_HUMAN ATRX_HUMAN VGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPY MATCH CONSENSUS VGYHEHDSLLDHKEEEELTE??R??AW?EY??E????????????????P?V???S????

Q4H3V6_CIOIN Q4H3V6_CIOIN ------PLLKLGIATIKQLIDIAEKELEKNTKQLDSCKPETLDQIMLKVKYLNRSLKIEH Q2Y0Q4_MACEU Q2Y0Q4_MACEU VPFDMEALSSMNFQQLEDLINQGKEKVAEANKNVMSMKVQPLEDVITDFWKENTHMT--- Q64ID6_MACEU Q64ID6_MACEU IPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLT--- Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE IPFNLGALSAMSNQQLEDLINQGREKVVEATNSMTAVRIQPLEDIISTVWKENMNLS--- A2ADH4_MOUSE A2ADH4_MOUSE IPFNLGALSAMSNQQLEDLINQGREKVVEATNSMTAVRIQPLEDIISTVWKENMNLS--- Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY IPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLS--- ATRX_PANTR ATRX_PANTR IPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLS--- A4LAA3_HUMAN A4LAA3_HUMAN IPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLS--- ATRX_HUMAN ATRX_HUMAN IPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLS--- MATCH CONSENSUS ???????L??????????LI?????????????????????L??????????N???????

Q4H3V6_CIOIN Q4H3V6_CIOIN AEKCAHEIQLYKLSVRPQIERTRSY---------ILRKLEQLRFCQQRVKASN------V Q2Y0Q4_MACEU Q2Y0Q4_MACEU ------DAQIYSLALRKQASQERDAKHREAIYNDVSIRQQMLISCVQQMQRNKELLQESS Q64ID6_MACEU Q64ID6_MACEU ------EAQVQALALNRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYS Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE ------EAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLINCVQRILMNRRLQQQYT A2ADH4_MOUSE A2ADH4_MOUSE ------EAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLINCVQRILMNRRLQQQYT Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY ------EAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYN ATRX_PANTR ATRX_PANTR ------EAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYN A4LAA3_HUMAN A4LAA3_HUMAN ------EAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYN ATRX_HUMAN ATRX_HUMAN ------EAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYN MATCH CONSENSUS ????????Q???L????Q???????????????????????L??C?Q?????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN NPRVQNQPNGLYNLPPYVPRPNPQSSTFRPPHPNYPRNFAQHQQ---------------- Q2Y0Q4_MACEU Q2Y0Q4_MACEU QPQEDSTH--------HLVLPEPPDLGINPSCYQYIDVKGMYQPTVSGMEPQL------- Q64ID6_MACEU Q64ID6_MACEU QQQQQQMSYQQAALSHHLMMPKPPNLIMNPSNYQQIDMRGMYQSVAGGLQPPPLQRAPPP Q3UZ76_MOUSE Q3UZ76_MOUSE ------------------------------------------------------------ ATRX_MOUSE ATRX_MOUSE QQQQQQLTYQQATLS-HLMMPKPPNLIMTPSNYQQIDMRGMYQSVAGGMQPPPLQRAPPP A2ADH4_MOUSE A2ADH4_MOUSE QQQQQQLTYQQATLS-HLMMPKPPNLIMTPSNYQQIDMRGMYQSVAGGMQPPPLQRAPPP Q3TSV4_MOUSE Q3TSV4_MOUSE ------------------------------------------------------------ ATRX_PONPY ATRX_PONPY QQQQQQMTYQQATLG-HLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQRAPPP ATRX_PANTR ATRX_PANTR QQQQQQMTYQQATLG-HLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQRAPPP A4LAA3_HUMAN A4LAA3_HUMAN QQQQQQMTYQQATLG-HLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQRAPPP ATRX_HUMAN ATRX_HUMAN QQQQQQMTYQQATLG-HLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQRAPPP MATCH CONSENSUS ????????????????????P?P??????P????????????Q?????????????????

Q4H3V6_CIOIN Q4H3V6_CIOIN -FYPRNPRFSSFTHVPR Q2Y0Q4_MACEU Q2Y0Q4_MACEU -IRSKKSRTSQRKSM-- Q64ID6_MACEU Q64ID6_MACEU -MRSKNPGPSQGKSM-- Q3UZ76_MOUSE Q3UZ76_MOUSE ----------------- ATRX_MOUSE ATRX_MOUSE TVRSKNPGPSPGKSM-- A2ADH4_MOUSE A2ADH4_MOUSE TVRSKNPGPSPGKSM-- Q3TSV4_MOUSE Q3TSV4_MOUSE ----------------- ATRX_PONPY ATRX_PONPY -MRSKNPGPSQGKSM-- ATRX_PANTR ATRX_PANTR -MRSKNPGPSQGKSM-- A4LAA3_HUMAN A4LAA3_HUMAN -MRSKNPGPSQGKSM-- ATRX_HUMAN ATRX_HUMAN -MRSKNPGPSQGKSM-- MATCH CONSENSUS ?????????S???????


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