Alignment of the gene Family HBG000273 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q675R7_OIKDI Q675R7_OIKDI -MRRPIYEKLDYFADLLEK-TIQCN--------------LDPVT-ELYYSSTGTEDKHAW Q4SY00_TETNG Q4SY00_TETNG RSRSNSGVKLDNYVRMVHQ-TILRHQPRSAPLVGPGQRLQHPVRLGPQ--PGLQEERGPG A2AHQ6_MOUSE A2AHQ6_MOUSE RSRSNSGVRLDGYARLVQQ-TILCY--------------QNPVT-GLL--SASHDQKDAW KPB2_MOUSE KPB2_MOUSE RSRSNSGVRLDGYARLVQQ-TILCY--------------QNPVT-GLL--SASHDQKDAW A2AHQ7_MOUSE A2AHQ7_MOUSE RSRSNSGVRLDGYARLVQQ-TILCY--------------QNPVT-GLL--SASHDQKDAW KPB2_HUMAN KPB2_HUMAN RSRSNSGVRLDGYARLVQQ-TILCY--------------QNPVT-GLL--SASHEQKDAW KPB2_RABIT KPB2_RABIT RSRSNSGVRLDGYARLVQQ-TILCY--------------QNPVT-GLL--SASHEQKDAW B2GUN6_XENTR B2GUN6_XENTR RSRSNSGVRLDRYAKLVQQ-TILCH--------------QNPVT-GLL--PASSDQKDAW KPB1_RAT KPB1_RAT RSRSNSGVRLDSYARLVQQHTILCH--------------QNPVT-GLL--PASYDQKDAW KPB1_MOUSE KPB1_MOUSE RSRSNSGVRLDGYARLVHQ-TILCH--------------QNPVT-GLL--PASYDQKDAW Q3UV91_MOUSE Q3UV91_MOUSE RSRSNSGVRLDGYARLVHQ-TILCH--------------QNPVT-GLL--PASYDQKDAW A2AI87_MOUSE A2AI87_MOUSE RSRSNSGVRLDGYARLVHQ-TILCH--------------QNPVT-GLL--PASYDQKDAW A2AI88_MOUSE A2AI88_MOUSE RSRSNSGVRLDGYARLVHQ-TILCH--------------QNPVT-GLL--PASYDQKDAW A2AI90_MOUSE A2AI90_MOUSE RSRSNSGVRLDGYARLVHQ-TILCH--------------QNPVT-GLL--PASYDQKDAW A2AI89_MOUSE A2AI89_MOUSE RSRSNSGVRLDGYARLVHQ-TILCH--------------QNPVT-GLL--PASYDQKDAW Q8BSV5_MOUSE Q8BSV5_MOUSE RSRSNSGVRLDGYARLVHQ-TILCH--------------QNPVT-GLL--PASYDQKDAW Q8CBA7_MOUSE Q8CBA7_MOUSE RSRSNSGVRLDGYARLVHQ-TILCH--------------QNPVT-GLL--PASYDQKDAW A2AI91_MOUSE A2AI91_MOUSE RSRSNSGVRLDGYARLVHQ-TILCH--------------QNPVT-GLL--PASYDQKDAW KPB1_RABIT KPB1_RABIT RSRSNSGVRLDSYARLVQQ-TILCH--------------QNPVT-GLL--PASYDQKDAW B7ZL07_HUMAN B7ZL07_HUMAN RSRSNSGVRLDGYARLVQQ-TILCH--------------QNPVT-GLL--PASYDQKDAW A6NIT2_HUMAN A6NIT2_HUMAN RSRSNSGVRLDGYARLVQQ-TILCH--------------QNPVT-GLL--PASYDQKDAW A6NMN0_HUMAN A6NMN0_HUMAN RSRSNSGVRLDGYARLVQQ-TILCH--------------QNPVT-GLL--PASYDQKDAW KPB1_HUMAN KPB1_HUMAN RSRSNSGVRLDGYARLVQQ-TILCH--------------QNPVT-GLL--PASYDQKDAW MATCH * :** :. ::.: ** .** . ::: . CONSENSUS RSRSNSGVRLD?YARLV?Q?TILC???????????????QNPVT?GLL???AS?DQKDAW

Q675R7_OIKDI Q675R7_OIKDI IRDNL-----WAVQSVWALCLSYRKFGDTDDARAKFQMLAGSAT---------KTMRSLL Q4SY00_TETNG Q4SY00_TETNG RRQGQGLRAGAGLESCWG-GPGVRECGQADE-RDPAVHHEAGVCPGPGPPPGPSRLSGPP A2AHQ6_MOUSE A2AHQ6_MOUSE VRDNI-----YSILAVWGLGMAYRKNADRDEDKAKAYELEQNVV---------KLMRGLL KPB2_MOUSE KPB2_MOUSE VRDNI-----YSILAVWGLGMAYRKNADRDEDKAKAYELEQNVV---------KLMRGLL A2AHQ7_MOUSE A2AHQ7_MOUSE VRDNI-----YSILAVWGLGMAYRKNADRDEDKAKAYELEQNVV---------KLMRGLL KPB2_HUMAN KPB2_HUMAN VRDNI-----YSILAVWGLGMAYRKNADRDEDKAKAYELEQNVV---------KLMRGLL KPB2_RABIT KPB2_RABIT VRDNI-----YSILAVWGLGMAYRKNADRDEDKAKAYELEQNVV---------KLMRGLL B2GUN6_XENTR B2GUN6_XENTR IRDNV-----YTILAVWGLGLAYRKNADRDEDKAKAYELEQNVV---------KLMRGLL KPB1_RAT KPB1_RAT VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL KPB1_MOUSE KPB1_MOUSE VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL Q3UV91_MOUSE Q3UV91_MOUSE VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL A2AI87_MOUSE A2AI87_MOUSE VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL A2AI88_MOUSE A2AI88_MOUSE VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL A2AI90_MOUSE A2AI90_MOUSE VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL A2AI89_MOUSE A2AI89_MOUSE VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL Q8BSV5_MOUSE Q8BSV5_MOUSE VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL Q8CBA7_MOUSE Q8CBA7_MOUSE VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL A2AI91_MOUSE A2AI91_MOUSE VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL KPB1_RABIT KPB1_RABIT VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL B7ZL07_HUMAN B7ZL07_HUMAN VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL A6NIT2_HUMAN A6NIT2_HUMAN VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL A6NMN0_HUMAN A6NMN0_HUMAN VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL KPB1_HUMAN KPB1_HUMAN VRDNV-----YSILAVWGLGLAYRKNADRDEDKAKAYELEQSVV---------KLMRGLL MATCH *:. : : *. . *: .: *: : .. . : . CONSENSUS VRDN??????YSILAVWGLG?AYRKNADRDEDKAKAYELEQ?VV?????????KLMRGLL

Q675R7_OIKDI Q675R7_OIKDI MCMM--RQSSKIECFKKTKATEDAIHAKFNVRTLSTVVGDHDWGHLQLDATGLFVLQLAQ Q4SY00_TETNG Q4SY00_TETNG DPSVPPSQMDKVEKFKYSRSTSDSLHAKYNTRTCATVVGDDQWGHLQVDATSLFLLFLAQ A2AHQ6_MOUSE A2AHQ6_MOUSE QCMM--RQVDKVEKFKHTQSTKDSLHAKYNTATCSTVVGDDQWGHLQVDATSLFLLFLAQ KPB2_MOUSE KPB2_MOUSE QCMM--RQVDKVEKFKHTQSTKDSLHAKYNTATCSTVVGDDQWGHLQVDATSLFLLFLAQ A2AHQ7_MOUSE A2AHQ7_MOUSE QCMM--RQVDKVEKFKHTQSTKDSLHAKYNTATCSTVVGDDQWGHLQVDATSLFLLFLAQ KPB2_HUMAN KPB2_HUMAN QCMM--RQVAKVEKFKHTQSTKDSLHAKYNTATCGTVVGDDQWGHLQVDATSLFLLFLAQ KPB2_RABIT KPB2_RABIT QCMM--RQVDKVEKFKYTQSTKDSLHAKYNTATCSTVVGDDQWGHLQVDATSLFLLFLAQ B2GUN6_XENTR B2GUN6_XENTR QCMM--RQVSKVEEFKYSQNTKDALHAKYNTNTCSTVVGDDQWGHLQLDATSIYLLFLAQ KPB1_RAT KPB1_RAT HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ KPB1_MOUSE KPB1_MOUSE HCMI--RQVDKVESFKYSQSTPDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ Q3UV91_MOUSE Q3UV91_MOUSE HCMI--RQVDKVESFKYSQSSKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ A2AI87_MOUSE A2AI87_MOUSE HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ A2AI88_MOUSE A2AI88_MOUSE HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ A2AI90_MOUSE A2AI90_MOUSE HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ A2AI89_MOUSE A2AI89_MOUSE HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ Q8BSV5_MOUSE Q8BSV5_MOUSE HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ Q8CBA7_MOUSE Q8CBA7_MOUSE HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ A2AI91_MOUSE A2AI91_MOUSE HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ KPB1_RABIT KPB1_RABIT HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ B7ZL07_HUMAN B7ZL07_HUMAN HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ A6NIT2_HUMAN A6NIT2_HUMAN HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ A6NMN0_HUMAN A6NMN0_HUMAN HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ KPB1_HUMAN KPB1_HUMAN HCMI--RQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQ MATCH : * *:* ** :: : *::***:*. * .*****.:*****:***.:::* *** CONSENSUS ?CM???RQVDKVE?FK??QSTKDSLHAKYNT?TC?TVVGDDQWGHLQ?DATS??LLFLAQ

Q675R7_OIKDI Q675R7_OIKDI MTAS-----------------------GLQIVFSLEEVDFIQNLVFYIESAYKTVDYGIW Q4SY00_TETNG Q4SY00_TETNG MTASGEPVRVRLPSAGPAEPLSLLLLPGLHIVYTQDEVDLVQNLMFYIEAAYKVADYGMW A2AHQ6_MOUSE A2AHQ6_MOUSE MTAS-----------------------GLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMW KPB2_MOUSE KPB2_MOUSE MTAS-----------------------GLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMW A2AHQ7_MOUSE A2AHQ7_MOUSE MTAS-----------------------GLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMW KPB2_HUMAN KPB2_HUMAN MTAS-----------------------GLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMW KPB2_RABIT KPB2_RABIT MTAS-----------------------GLRIIFTLDEVAFIQNLVFYIEAAYKVADYGMW B2GUN6_XENTR B2GUN6_XENTR MTAS-----------------------GLHIIYNLDEVNFIQNLVFYVEAAYKTADFGMW KPB1_RAT KPB1_RAT MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW KPB1_MOUSE KPB1_MOUSE MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW Q3UV91_MOUSE Q3UV91_MOUSE MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW A2AI87_MOUSE A2AI87_MOUSE MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW A2AI88_MOUSE A2AI88_MOUSE MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW A2AI90_MOUSE A2AI90_MOUSE MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW A2AI89_MOUSE A2AI89_MOUSE MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW Q8BSV5_MOUSE Q8BSV5_MOUSE MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW Q8CBA7_MOUSE Q8CBA7_MOUSE MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW A2AI91_MOUSE A2AI91_MOUSE MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW KPB1_RABIT KPB1_RABIT MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW B7ZL07_HUMAN B7ZL07_HUMAN MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW A6NIT2_HUMAN A6NIT2_HUMAN MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW A6NMN0_HUMAN A6NMN0_HUMAN MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW KPB1_HUMAN KPB1_HUMAN MTAS-----------------------GLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIW MATCH **** **:*:.. :** ::***:**:*:***..*:*:* CONSENSUS MTAS???????????????????????GL?II??LDEV?FIQNLVFYIEAAYK?AD?G?W

Q675R7_OIKDI Q675R7_OIKDI ERGDKTNHGVPELNASSIGMCLAALEAIDGLDLFQCQGGYRSIIHVSPDEKARCQ----- Q4SY00_TETNG Q4SY00_TETNG ERGDKTNQGITEINASSIGMAKAALEALDELNLFGAKGGPGSVVHALADDIQHCQVSGRP A2AHQ6_MOUSE A2AHQ6_MOUSE ERGDKTNQGIPELNASSVGVAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQ----- KPB2_MOUSE KPB2_MOUSE ERGDKTNQGIPELNASSVGVAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQ----- A2AHQ7_MOUSE A2AHQ7_MOUSE ERGDKTNQGIPELNASSVGVAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQ----- KPB2_HUMAN KPB2_HUMAN ERGDKTNQGIPELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQ----- KPB2_RABIT KPB2_RABIT ERGDKTNQGIPELNASSVGMAKAALEAIDELDLFGAHGGRKSVIHVLPDEVEHCQ----- B2GUN6_XENTR B2GUN6_XENTR ERGDKTNQGITELNASSVGMAKAALESLDELNLFGAKGGPQSVIHVLSDEIQHCQ----- KPB1_RAT KPB1_RAT ERGDKTNQGISELNACSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- KPB1_MOUSE KPB1_MOUSE ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- Q3UV91_MOUSE Q3UV91_MOUSE ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- A2AI87_MOUSE A2AI87_MOUSE ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- A2AI88_MOUSE A2AI88_MOUSE ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- A2AI90_MOUSE A2AI90_MOUSE ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- A2AI89_MOUSE A2AI89_MOUSE ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- Q8BSV5_MOUSE Q8BSV5_MOUSE ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- Q8CBA7_MOUSE Q8CBA7_MOUSE ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- A2AI91_MOUSE A2AI91_MOUSE ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- KPB1_RABIT KPB1_RABIT ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- B7ZL07_HUMAN B7ZL07_HUMAN ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- A6NIT2_HUMAN A6NIT2_HUMAN ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- A6NMN0_HUMAN A6NMN0_HUMAN ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- KPB1_HUMAN KPB1_HUMAN ERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQ----- MATCH *******:*:.*:**.*:*:. ****::* *:** :** *::*. .*: :** CONSENSUS ERGDKTNQGI?ELNASSVGMAKAALEA?DELDLFG??GG??SVIHVL?DEV?HCQ?????

Q675R7_OIKDI Q675R7_OIKDI ------------DVLESLLP------RESKSKEVGAA--------LLPVVLY-------- Q4SY00_TETNG Q4SY00_TETNG GAPSVPFLSSLNVLVFAVVPSVHPDLHAAQSLHVQGGGRRAAGHHLLPRLRRGGRGHRHH A2AHQ6_MOUSE A2AHQ6_MOUSE ------------SILFSMLP------RASTSKEIDAG--------LLSIISF-------- KPB2_MOUSE KPB2_MOUSE ------------SILFSMLP------RASTSKEIDAG--------LLSIISF-------- A2AHQ7_MOUSE A2AHQ7_MOUSE ------------SILFSMLP------RASTSKEIDAG--------LLSIISF-------- KPB2_HUMAN KPB2_HUMAN ------------SILFSMLP------RASTSKEIDAG--------LLSIISF-------- KPB2_RABIT KPB2_RABIT ------------SILFSMLP------RASTSKEIDAG--------LLSIISF-------- B2GUN6_XENTR B2GUN6_XENTR ------------SILHSMLP------RASTSKEIDAG--------VLSVISF-------- KPB1_RAT KPB1_RAT ------------SILNTLLP------RASTSKEVDAS--------LLSVISF-------- KPB1_MOUSE KPB1_MOUSE ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- Q3UV91_MOUSE Q3UV91_MOUSE ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- A2AI87_MOUSE A2AI87_MOUSE ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- A2AI88_MOUSE A2AI88_MOUSE ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- A2AI90_MOUSE A2AI90_MOUSE ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- A2AI89_MOUSE A2AI89_MOUSE ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- Q8BSV5_MOUSE Q8BSV5_MOUSE ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- Q8CBA7_MOUSE Q8CBA7_MOUSE ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- A2AI91_MOUSE A2AI91_MOUSE ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- KPB1_RABIT KPB1_RABIT ------------SILNSLLP------RASTSKEVDAS--------LLSVISF-------- B7ZL07_HUMAN B7ZL07_HUMAN ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- A6NIT2_HUMAN A6NIT2_HUMAN ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- A6NMN0_HUMAN A6NMN0_HUMAN ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- KPB1_HUMAN KPB1_HUMAN ------------SILNSLLP------RASTSKEVDAS--------LLSVVSF-------- MATCH :: :::* : : * .: .. :*. : CONSENSUS ????????????SIL?S?LP??????RASTSKE?DA?????????LLS??SF????????

Q675R7_OIKDI Q675R7_OIKDI -------PAFALSNAD---IVTKTLAVIDE----KLQGRFGYIRFQRDGYCTPIE----- Q4SY00_TETNG Q4SY00_TETNG DQGGDHLQAAGAEEEKTSFLPRLLAVDLLPSSALSVQGRYGCCRFLRDGHKTPKEVKSEA A2AHQ6_MOUSE A2AHQ6_MOUSE -------PAFAVEDVN---LVNVTKNEIIS----KLQGRYGCCRFLRDGYKTPRE----- KPB2_MOUSE KPB2_MOUSE -------PAFAVEDVN---LVNVTKNEIIS----KLQGRYGCCRFLRDGYKTPRE----- A2AHQ7_MOUSE A2AHQ7_MOUSE -------PAFAVEDVN---LVNVTKNEIIS----KLQGRYGCCRFLRDGYKTPRE----- KPB2_HUMAN KPB2_HUMAN -------PAFAVEDVN---LVNVTKNEIIS----KLQGRYGCCRFLRDGYKTPRE----- KPB2_RABIT KPB2_RABIT -------PAFAVEDAN---LVNVTKSEIIS----KLQGRYGCCRFLRDGYKTPRE----- B2GUN6_XENTR B2GUN6_XENTR -------PAFAVEDSH---LVRITKQEIID----KLQGRYGCCRFLRDGYRTPKE----- KPB1_RAT KPB1_RAT -------PAFAVEDSK---LVEITKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- KPB1_MOUSE KPB1_MOUSE -------PAFAVEDSH---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- Q3UV91_MOUSE Q3UV91_MOUSE -------PAFAVEDSH---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- A2AI87_MOUSE A2AI87_MOUSE -------PAFAVEDSH---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- A2AI88_MOUSE A2AI88_MOUSE -------PAFAVEDSH---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- A2AI90_MOUSE A2AI90_MOUSE -------PAFAVEDSH---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- A2AI89_MOUSE A2AI89_MOUSE -------PAFAVEDSH---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- Q8BSV5_MOUSE Q8BSV5_MOUSE -------PAFAVEDSH---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- Q8CBA7_MOUSE Q8CBA7_MOUSE -------PAFAVEDSH---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- A2AI91_MOUSE A2AI91_MOUSE -------PAFAVEDSH---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- KPB1_RABIT KPB1_RABIT -------PAFAVEDSK---LVEITKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- B7ZL07_HUMAN B7ZL07_HUMAN -------PAFAVEDSQ---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- A6NIT2_HUMAN A6NIT2_HUMAN -------PAFAVEDSQ---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- A6NMN0_HUMAN A6NMN0_HUMAN -------PAFAVEDSQ---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- KPB1_HUMAN KPB1_HUMAN -------PAFAVEDSQ---LVELTKQEIIT----KLQGRYGCCRFLRDGYKTPKE----- MATCH * . .: . : : .:***:* ** ***: ** * CONSENSUS ???????PAFAVED?????LV??TK?EII?????KLQGRYGCCRFLRDGYKTP?E?????

Q675R7_OIKDI Q675R7_OIKDI ------DNQRLHYDPLELEQFEKIECQWPLFLCMRLVSKCFQRGPSKPQIDEEIVELLCL Q4SY00_TETNG Q4SY00_TETNG RRPRTRDPNRLYYESAELKLFENIECEWPLFWTYLILDGIFSNSLEQVQEYQEALE--GI A2AHQ6_MOUSE A2AHQ6_MOUSE ------DPHRLHYDPAELKLFENIECEWPVFWTYLIIDGIFNGDAVQVQEYREALE--GI KPB2_MOUSE KPB2_MOUSE ------DPHRLHYDPAELKLFENIECEWPVFWTYLIIDGIFNGDAVQVQEYREALE--GI A2AHQ7_MOUSE A2AHQ7_MOUSE ------DPHRLHYDPAELKLFENIECEWPVFWTYLIIDGIFNGDAVQVQEYREALE--GI KPB2_HUMAN KPB2_HUMAN ------DPNRLHYDPAELKLFENIECEWPVFWTYFIIDGVFSGDAVQVQEYREALE--GI KPB2_RABIT KPB2_RABIT ------DPNRLHYDPAELKLFENIECEWPVFWTYFIIDGIFNGDALQVQEYQEALE--GI B2GUN6_XENTR B2GUN6_XENTR ------DPGRLYYEPAELKLFENIECEWPLFWTYFILDGIFSSNHEQVQEYKQAID--EV KPB1_RAT KPB1_RAT ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNTEQVQEYREALD--AV KPB1_MOUSE KPB1_MOUSE ------DPQRLYYNPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALD--AV Q3UV91_MOUSE Q3UV91_MOUSE ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALD--AV A2AI87_MOUSE A2AI87_MOUSE ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALD--AV A2AI88_MOUSE A2AI88_MOUSE ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALD--AV A2AI90_MOUSE A2AI90_MOUSE ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALD--AV A2AI89_MOUSE A2AI89_MOUSE ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALD--AV Q8BSV5_MOUSE Q8BSV5_MOUSE ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALD--AV Q8CBA7_MOUSE Q8CBA7_MOUSE ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALD--AV A2AI91_MOUSE A2AI91_MOUSE ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALD--AV KPB1_RABIT KPB1_RABIT ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGVFSGNAEQVQEYREALE--AV B7ZL07_HUMAN B7ZL07_HUMAN ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGVFSGNAEQVQEYKEALE--AV A6NIT2_HUMAN A6NIT2_HUMAN ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGVFSGNAEQVQEYKEALE--AV A6NMN0_HUMAN A6NMN0_HUMAN ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGVFSGNAEQVQEYKEALE--AV KPB1_HUMAN KPB1_HUMAN ------DPNRLYYEPAELKLFENIECEWPLFWTYFILDGVFSGNAEQVQEYKEALE--AV MATCH * **:*:. **: **:***:**:* ::. *. . : * .: :: : CONSENSUS ??????DP?RL?Y?PAELKLFENIECEWP?FWTY?I?DG?F?G???QVQEY?EAL?????

Q675R7_OIKDI Q675R7_OIKDI IIPTK---PYLPMAYAIDKDSVAMERKNRGSAKRESVGFLPHIWGQSLYILSRLLVEDFV Q4SY00_TETNG Q4SY00_TETNG LIKQKDGIRLLPELYSVPAEKVEEEYVNPPSVERIPMGKCPLMWGQSLYILGNLLSEGLL A2AHQ6_MOUSE A2AHQ6_MOUSE LIRGKDGIHLVPELYAIPPDKVDEEYKNPHTVDRVPLGKLPHLWGQSLYILSSLLAEGFL KPB2_MOUSE KPB2_MOUSE LIRGKDGIHLVPELYAIPPDKVDEEYKNPHTVDRVPLGKLPHLWGQSLYILSSLLAEGFL A2AHQ7_MOUSE A2AHQ7_MOUSE LIRGKDGIHLVPELYAIPPDKVDEEYKNPHTVDRVPLGKLPHLWGQSLYILSSLLAEGFL KPB2_HUMAN KPB2_HUMAN LIRGKNGIRLVPELYAVPPNKVDEEYKNPHTVDRVPMGKVPHLWGQSLYILSSLLAEGFL KPB2_RABIT KPB2_RABIT LIRGKDGIRLVPELYAIPPNKVDEEYKNPHTVDRVPLGKLPHLWGQSLYILSSLLAEGFL B2GUN6_XENTR B2GUN6_XENTR LIKGKSGVRLVPELYSVPEDKVEVEYEHPHTVDRIPLGKLPHMWGQSLYILGCLMSEGFL KPB1_RAT KPB1_RAT LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGNLMAEGFL KPB1_MOUSE KPB1_MOUSE LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL Q3UV91_MOUSE Q3UV91_MOUSE LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL A2AI87_MOUSE A2AI87_MOUSE LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL A2AI88_MOUSE A2AI88_MOUSE LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL A2AI90_MOUSE A2AI90_MOUSE LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL A2AI89_MOUSE A2AI89_MOUSE LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL Q8BSV5_MOUSE Q8BSV5_MOUSE LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL Q8CBA7_MOUSE Q8CBA7_MOUSE LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPKGKLPHMWGQSLYILGSLMAEGFL A2AI91_MOUSE A2AI91_MOUSE LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL KPB1_RABIT KPB1_RABIT LIKGKNGVPLLPELYSVPPDKVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL B7ZL07_HUMAN B7ZL07_HUMAN LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL A6NIT2_HUMAN A6NIT2_HUMAN LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL A6NMN0_HUMAN A6NMN0_HUMAN LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL KPB1_HUMAN KPB1_HUMAN LIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFL MATCH :* * :* *:: : * * : :..* . * * :********. *: *.:: CONSENSUS LI?GK?G??L?PELY??PPD?VDEEY?NPHTVDRVP?GKLPH?WGQSLYIL?SL?AEGFL

Q675R7_OIKDI Q675R7_OIKDI SPGELDPLNRRMAMQKRPEVIVQVSFLALDDLTQETFNEHGHHFQRAEDITKVRVHPVTV Q4SY00_TETNG Q4SY00_TETNG APGEIDPLNRRFSTIPKPDVVVQVSILAETEEIKELLMRSDIEVETVADIHPIHVQPSRV A2AHQ6_MOUSE A2AHQ6_MOUSE ATGEIDPLNRRFSTSVKPDVVVQVAVLAENSHIKGLLKEHGMTVQSIADVHPIRVQPGRI KPB2_MOUSE KPB2_MOUSE ATGEIDPLNRRFSTSVKPDVVVQVAVLAENSHIKGLLKEHGMTVQSIADVHPIRVQPGRI A2AHQ7_MOUSE A2AHQ7_MOUSE ATGEIDPLNRRFSTSVKPDVVVQVAVLAENSHIKGLLKEHGMTVQSIADVHPIRVQPGRI KPB2_HUMAN KPB2_HUMAN AAGEIDPLNRRFSTSVKPDVVVQVTVLAENNHIKDLLRKHGVNVQSIADIHPIQVQPGRI KPB2_RABIT KPB2_RABIT ATGEIDPLNRRFSTSVKPDVVVQVTVLAENSHIKELLRKHGVDVQSIADIYPIRVQPGRI B2GUN6_XENTR B2GUN6_XENTR APGEIDPLNRRFSTVPKPDVVVQVSILAETDEIQEILKKHGIEAETVAGVYPIRVQPARI KPB1_RAT KPB1_RAT APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI KPB1_MOUSE KPB1_MOUSE APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI Q3UV91_MOUSE Q3UV91_MOUSE APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI A2AI87_MOUSE A2AI87_MOUSE APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI A2AI88_MOUSE A2AI88_MOUSE APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI A2AI90_MOUSE A2AI90_MOUSE APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI A2AI89_MOUSE A2AI89_MOUSE APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI Q8BSV5_MOUSE Q8BSV5_MOUSE APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI Q8CBA7_MOUSE Q8CBA7_MOUSE APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI A2AI91_MOUSE A2AI91_MOUSE APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARI KPB1_RABIT KPB1_RABIT APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGINVETIAEVYPIRVQPARI B7ZL07_HUMAN B7ZL07_HUMAN APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKTILKDKGIYVETIAEVYPIRVQPARI A6NIT2_HUMAN A6NIT2_HUMAN APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKTILKDKGIYVETIAEVYPIRVQPARI A6NMN0_HUMAN A6NMN0_HUMAN APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKTILKDKGIYVETIAEVYPIRVQPARI KPB1_HUMAN KPB1_HUMAN APGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKTILKDKGIYVETIAEVYPIRVQPARI MATCH :.**:******:: :*:*:***:.** . : : . : : ::*:* : CONSENSUS A?GEIDPLNRRFST??KPDVVVQV??LAE???IK??LK??G??V??IA?V?PIRVQP?RI

Q675R7_OIKDI Q675R7_OIKDI LSDLYKNLGKSDMLGLSGRPKGRIGVLSTSKFYELGDGTMTFFYPEFSNIDQNWIAADVN Q4SY00_TETNG Q4SY00_TETNG LS-------RNPKLGLTGRPYRRIGVRGPPKFYIIRNTMFA-FTPQFIDHQQFYMALDNK A2AHQ6_MOUSE A2AHQ6_MOUSE LSHIYAKLGRNKNMKLSGRPYRHIGVLGTSKLYVIRNHIFT-FTPQFTDQHHFYLALDNE KPB2_MOUSE KPB2_MOUSE LSHIYAKLGRNKNMKLSGRPYRHIGVLGTSKLYVIRNHIFT-FTPQFTDQHHFYLALDNE A2AHQ7_MOUSE A2AHQ7_MOUSE LSHIYAKLGRNKNMKLSGRPYRHIGVLGTSKLYVIRNHIFT-FTPQFTDQHHFYLALDNE KPB2_HUMAN KPB2_HUMAN LSHIYAKLGRNKNMNLSGRPYRHIGVLGTSKLYVIRNQIFT-FTPQFTDQHHFYLALDNE KPB2_RABIT KPB2_RABIT LSHIYAKLGRNKNMKLSGRPYRHIGVLGTSKLYVIRNQIFT-FTPQFTDQHHFYLALDNE B2GUN6_XENTR B2GUN6_XENTR LSHIYARLGRNRKMNLSGRPYRNMGVLGTSKLYTIRQNIFA-FTPQFIDQQQFYLALDNR KPB1_RAT KPB1_RAT LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIYT-FTPQFIDQQQFYLALDNQ KPB1_MOUSE KPB1_MOUSE LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNQ Q3UV91_MOUSE Q3UV91_MOUSE LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNQ A2AI87_MOUSE A2AI87_MOUSE LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNQ A2AI88_MOUSE A2AI88_MOUSE LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNQ A2AI90_MOUSE A2AI90_MOUSE LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNQ A2AI89_MOUSE A2AI89_MOUSE LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNQ Q8BSV5_MOUSE Q8BSV5_MOUSE LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNQ Q8CBA7_MOUSE Q8CBA7_MOUSE LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNQ A2AI91_MOUSE A2AI91_MOUSE LSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNQ KPB1_RABIT KPB1_RABIT LSHIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNK B7ZL07_HUMAN B7ZL07_HUMAN LSHIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNK A6NIT2_HUMAN A6NIT2_HUMAN LSHIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNK A6NMN0_HUMAN A6NMN0_HUMAN LSHIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNK KPB1_HUMAN KPB1_HUMAN LSHIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFT-FTPQFIDQQQFYLALDNK MATCH ** . : *:*** :** ...*:* : . : * *:* : .: ::* * . CONSENSUS LSHIY??LG?N??MKLSGRPYR??GVLGTSKLY?IR??IFT?FTPQF?DQ??FYLALDN?

Q675R7_OIKDI Q675R7_OIKDI IFIEEVQTELNYIQSHWNHPGRPTIVIPLSSELIWNTSDSSLESEIINLVRKITSGYIAG Q4SY00_TETNG Q4SY00_TETNG MIVEMLRTEIAYLASRWRMTGRPTVTFPVSQTML-TEDHTELDPAVLATLKKLQDGYYGG A2AHQ6_MOUSE A2AHQ6_MOUSE MIVEMLRIELAYLCTCWRMTGRPTLTFPVTHTML-TNDGSDIHPAVLSTIRKLEDGYFGG KPB2_MOUSE KPB2_MOUSE MIVEMLRIELAYLCTCWRMTGRPTLTFPVTHTML-TNDGSDIHPAVLSTIRKLEDGYFGG A2AHQ7_MOUSE A2AHQ7_MOUSE MIVEMLRIELAYLCTCWRMTGRPTLTFPVTHTML-TNDGSDIHPAVLSTIRKLEDGYFGG KPB2_HUMAN KPB2_HUMAN MIVEMLRIELAYLCTCWRMTGRPTLTFPISRTML-TNDGSDIHSAVLSTIRKLEDGYFGG KPB2_RABIT KPB2_RABIT MIVEMLRIELAYLCTCWRMTGRPTLTFPITHTML-TNDGSDIHSAVLSTIRKLEDGYFGG B2GUN6_XENTR B2GUN6_XENTR MIVEMLRTDLSYLCSRWRMTGRPTITFPISHTML-DDSGNDLDPVVLATIRKLQDGYFGG KPB1_RAT KPB1_RAT MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGASLNSSILAALRKMQDGYFGG KPB1_MOUSE KPB1_MOUSE MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGTSLNSSILAALRKMQDGYFGG Q3UV91_MOUSE Q3UV91_MOUSE MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGTSLNSSILAALRKMQDGYFGG A2AI87_MOUSE A2AI87_MOUSE MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGTSLNSSILAALRKMQDGYFGG A2AI88_MOUSE A2AI88_MOUSE MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGTSLNSSILAALRKMQDGYFGG A2AI90_MOUSE A2AI90_MOUSE MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGTSLNSSILAALRKMQDGYFGG A2AI89_MOUSE A2AI89_MOUSE MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGTSLNSSILAALRKMQDGYFGG Q8BSV5_MOUSE Q8BSV5_MOUSE MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGTSLNSSILAALRKMQDGYFGG Q8CBA7_MOUSE Q8CBA7_MOUSE MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGTSLNSSILAALRKMQDGYFGG A2AI91_MOUSE A2AI91_MOUSE MIVEMLRTDLSYLCSRWRMTGQPTITFPISHTML-DEDGTSLNSSILAALRKMQDGYFGG KPB1_RABIT KPB1_RABIT MIVEMLRTDLSYLCSRWRMTGQPTITFPISQTML-DEDGTSLNSSILAALRKMQDGYFGG B7ZL07_HUMAN B7ZL07_HUMAN MIVEMLRTDLSYLCSRWRMTGQPTITFPISHSML-DEDGTSLNSSILAALRKMQDGYFGG A6NIT2_HUMAN A6NIT2_HUMAN MIVEMLRTDLSYLCSRWRMTGQPTITFPISHSML-DEDGTSLNSSILAALRKMQDGYFGG A6NMN0_HUMAN A6NMN0_HUMAN MIVEMLRTDLSYLCSRWRMTGQPTITFPISHSML-DEDGTSLNSSILAALRKMQDGYFGG KPB1_HUMAN KPB1_HUMAN MIVEMLRTDLSYLCSRWRMTGQPTITFPISHSML-DEDGTSLNSSILAALRKMQDGYFGG MATCH :::* :: :: *: : *. .*:**:.:*:: :: . .:.. :: ::*: .** .* CONSENSUS MIVEMLR??L?YLC??WRMTG?PT?TFP?SH?ML???DG???????L???RK??DGYFGG

Q675R7_OIKDI Q675R7_OIKDI VHVKSAKLEEFLPTSNVSKLQFADVN---------------------------------- Q4SY00_TETNG Q4SY00_TETNG ARIQTGKLSEFVTTSCLAHLSFLDEA---------------------------------- A2AHQ6_MOUSE A2AHQ6_MOUSE ARVKLGNLAEFLTTSFYTHLTFLDPDCDEKLFGDITDRSFSPDSEPDLGGYLEDSSPQES KPB2_MOUSE KPB2_MOUSE ARVKLGNLAEFLTTSFYTHLTFLDPDCDEKLFGDITDRSFSPDSEPDLGGYLEDSSPQES A2AHQ7_MOUSE A2AHQ7_MOUSE ARVKLGNLAEFLTTSFYTHLTFLDPDCDEKLFGDITDRSFSPDSEPDLGGYLEDSSPQES KPB2_HUMAN KPB2_HUMAN ARVKLGNLSEFLTTSFYTYLTFLDPDCDEKLFDNASEGTFSPDSDSDLVGYLEDTCNQES KPB2_RABIT KPB2_RABIT ARVQLGNLSEFLTTSFYTYLTFLDPDCDEKLFDDASEGSFSPDSDSDLGGYLEE---TYN B2GUN6_XENTR B2GUN6_XENTR ARTQTGFLSKFLNTSCCKHLSFMDAGVE-------------EDVD--------------- KPB1_RAT KPB1_RAT ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYDDELDS--GNWMDSYDSTRN KPB1_MOUSE KPB1_MOUSE ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDS--GNWMDSYDSTSN Q3UV91_MOUSE Q3UV91_MOUSE ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDS--GNWMDSYDSTS- A2AI87_MOUSE A2AI87_MOUSE ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDS--GNWMDSYDSTSN A2AI88_MOUSE A2AI88_MOUSE ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDS--GNWMDSYDSTSN A2AI90_MOUSE A2AI90_MOUSE ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDS--GNWMDSYDSTSN A2AI89_MOUSE A2AI89_MOUSE ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDS--GNWMDSYDSTSN Q8BSV5_MOUSE Q8BSV5_MOUSE ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDS--GNWMDSYDSTSN Q8CBA7_MOUSE Q8CBA7_MOUSE ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDS--GNWMDSYDSTS- A2AI91_MOUSE A2AI91_MOUSE ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDS--GNWMDSYDSTS- KPB1_RABIT KPB1_RABIT ARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDDNY-DELES--GDWMDGYNSTST B7ZL07_HUMAN B7ZL07_HUMAN ARVQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDDNY-DYLES--GNWMNDYDSTS- A6NIT2_HUMAN A6NIT2_HUMAN ARVQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDDNY-DYLES--GNWMNDYDSTSH A6NMN0_HUMAN A6NMN0_HUMAN ARVQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDDNY-DYLES--GNWMNDYDSTSH KPB1_HUMAN KPB1_HUMAN ARVQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDDNY-DYLES--GNWMNDYDSTSH MATCH .: : . * :*: ** * * * CONSENSUS AR???G?LSEFLTTS??THL?F?DP????KL?????????????????G???????????

Q675R7_OIKDI Q675R7_OIKDI ------DGLA----------------PKTCPSKTLSLPKL-------------------- Q4SY00_TETNG Q4SY00_TETNG ------DDLAQYLDHLLAHATPKK--PQRPAEGGLGRFKAVASKTKEMVALKNRAQGLDV A2AHQ6_MOUSE A2AHQ6_MOUSE Q-----DELDQYISHLLQSTSLKCYLPPLCKKSEDSHFFSAIHSTRDILSVMAKAKGLET KPB2_MOUSE KPB2_MOUSE Q-----DELDQYISHLLQSTSLKCYLPPLCKKSEDSHFFSAIHSTRDILSVMAKAKGLET A2AHQ7_MOUSE A2AHQ7_MOUSE Q-----DELDQYISHLLQSTSLKCYLPPLCKKSEDSHFFSAIHSTRDILSVMAKAKGLET KPB2_HUMAN KPB2_HUMAN Q-----DELDHYINHLLQSTSLRSYLPPLCKNTEDRHVFSAIHSTRDILSVMAKAKGLEV KPB2_RABIT KPB2_RABIT QVTESQDELDKYINHLLQSTYSKCHLPPLCKKMEDHNVFSAIHSTRDILSMMAKAKGLEV B2GUN6_XENTR B2GUN6_XENTR ------DEVSLYLNQLLGMSSPKP--SPTSQRGGRHRFKAAIHSTRDMLSLRSKAKGLNV KPB1_RAT KPB1_RAT A--RCGDEVARYLDHLLAHTGPHPKLTPTSRKGGLDRFRAAVQTTCDLMSLVAKAKELHI KPB1_MOUSE KPB1_MOUSE A--RCGDEVARYLDRLLAHTVPHPKLAPTSRKGGLDRFRAAVQTTCDLMSLVAKAKELHI Q3UV91_MOUSE Q3UV91_MOUSE ------------------------------------------------------------ A2AI87_MOUSE A2AI87_MOUSE A--RCGDEVARYLDRLLAHTVPHPKLAPTSRKGGLDRFRAAVQTTCDLMSLVAKAKELHI A2AI88_MOUSE A2AI88_MOUSE A--RCGDEVARYLDRLLAHTVPHPKLAPTSRKGGLDRFRAAVQTTCDLMSLVAKAKELHI A2AI90_MOUSE A2AI90_MOUSE A--RCGDEVARYLDRLLAHTVPHPKLAPTSRKGGLDRFRAAVQTTCDLMSLVAKAKELHI A2AI89_MOUSE A2AI89_MOUSE A--RCGDEVARYLDRLLAHTVPHPKLAPTSRKGGLDRFRAAVQTTCDLMSLVAKAKELHI Q8BSV5_MOUSE Q8BSV5_MOUSE A--RCGDEVARYLDRLLAHTVPHPKLAPTSRKGGLDRFRAAVQTTCDLMSLVAKAKELHI Q8CBA7_MOUSE Q8CBA7_MOUSE ------------------------------------------------------------ A2AI91_MOUSE A2AI91_MOUSE ------------------------------------------------------------ KPB1_RABIT KPB1_RABIT A--RCGDEVARYLDHLLAHTAPHPKLAPASQKGGLNRFRAAVQTTCDLMSLVTKAKELHV B7ZL07_HUMAN B7ZL07_HUMAN ------------------------------------------------------------ A6NIT2_HUMAN A6NIT2_HUMAN ------------------------------------------------------------ A6NMN0_HUMAN A6NMN0_HUMAN A--RCGDEVARYLDHLLAHTAPHPKLAPTSQKGGLDRFQAAVQTTCDLMSLVTKAKELHV KPB1_HUMAN KPB1_HUMAN A--RCGDEVARYLDHLLAHTAPHPKLAPTSQKGGLDRFQAAVQTTCDLMSLVTKAKELHV MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q675R7_OIKDI Q675R7_OIKDI -------------------------PITPMRSPKDFHKARIINMNL----DLT-DMTLVP Q4SY00_TETNG Q4SY00_TETNG HGESVPPGRVGGLRRRRSHPPCGLCPDANMYLSNKLFRSAQPALNLNLPDAST-PQDAQL A2AHQ6_MOUSE A2AHQ6_MOUSE -------------------------TFFPMILPTKVLSGHRKSLNL----VDS-PQPLLK KPB2_MOUSE KPB2_MOUSE -------------------------TFFPMILPTKVLSGHRKSLNL----VDS-PQPLLK A2AHQ7_MOUSE A2AHQ7_MOUSE -------------------------TFFPMILPTKVLSGHRKSLNL----VDS-PQPLLK KPB2_HUMAN KPB2_HUMAN -------------------------PFVPMTLPTKVLSAHRKSLNL----VDS-PQPLLE KPB2_RABIT KPB2_RABIT -------------------------PFAPMTLPTKALSVHRKSLNL----VDS-PQPLLK B2GUN6_XENTR B2GUN6_XENTR -------------------------QDIQMYLPSKLFLASQPSFDL----LESAPSYQAS KPB1_RAT KPB1_RAT -------------------------QNVHMYLPTKLFQPSRPSLNL----LDS-PESPQD KPB1_MOUSE KPB1_MOUSE -------------------------QNVHMYIPTKLFQPSRPSLNL----LDS-PESPQD Q3UV91_MOUSE Q3UV91_MOUSE -------------------------NDVHMYLPTKLFQPSRPSLNL----LDS-PESPQD A2AI87_MOUSE A2AI87_MOUSE -------------------------QNVHMYLPTKLFQPSRPSLNL----LDS-PESPQD A2AI88_MOUSE A2AI88_MOUSE -------------------------QNVHMYLPTKLFQPSRPSLNL----LDS-PESPQD A2AI90_MOUSE A2AI90_MOUSE -------------------------QNVHMYLPTKLFQPSRPSLNL----LDS-PESPQD A2AI89_MOUSE A2AI89_MOUSE -------------------------QNVHMYLPTKLFQPSRPSLNL----LDS-PESPQD Q8BSV5_MOUSE Q8BSV5_MOUSE -------------------------QNVHMYLPTKLFQPSRPSLNL----LDS-PESPQD Q8CBA7_MOUSE Q8CBA7_MOUSE -------------------------NDVHMYLPTKLFQPSRPSLNL----LDS-PESPQD A2AI91_MOUSE A2AI91_MOUSE -------------------------NDVHMYLPTKLFQPSRPSLNL----LDS-PESPQD KPB1_RABIT KPB1_RABIT -------------------------QNVHMYLPTKLFQASRPSLNL----LDS-SHPSQE B7ZL07_HUMAN B7ZL07_HUMAN -------------------------HDVHMYLPTKLFQASRPSFNL----LDS-PHPRQE A6NIT2_HUMAN A6NIT2_HUMAN --------------------------DVHMYLPTKLFQASRPSFNL----LDS-PHPRQE A6NMN0_HUMAN A6NMN0_HUMAN -------------------------QNVHMYLPTKLFQASRPSFNL----LDS-PHPRQE KPB1_HUMAN KPB1_HUMAN -------------------------QNVHMYLPTKLFQASRPSFNL----LDS-PHPRQE MATCH * ... ::* : CONSENSUS ?????????????????????????????M?LPTK?????R?S?NL?????DS?P?????

Q675R7_OIKDI Q675R7_OIKDI KVNRRRSESVAF-------SSTRSGRDDSYTILT----AKCLVDQAGVLIEISEATDGNY Q4SY00_TETNG Q4SY00_TETNG SSRASRRCRRWWSARKSGIPRDAGGAFDYLALAHCLRDTQSLQDQADILYILFKDKAMDW A2AHQ6_MOUSE A2AHQ6_MOUSE T---TPEYDYQW-------PRDDHDEVDCEKLVGQLKDCSNLQDQADILYILYVMKGPRW KPB2_MOUSE KPB2_MOUSE T---TPEYDYQW-------PRDDHDEVDCEKLVGQLKDCSNLQDQADILYILYVMKGPRW A2AHQ7_MOUSE A2AHQ7_MOUSE T---TPEYDYQW-------PRDDHDEVDCEKLVGQLKDCSNLQDQADILYILYVMKGPRW KPB2_HUMAN KPB2_HUMAN K---VPESDFQW-------PRDDHGDVDCEKLVEQLKDCSNLQDQADILYILYVIKGPSW KPB2_RABIT KPB2_RABIT R----ILKRLHW-------PKDERGDVDCEKLVEQLKDCCTLQDQADILYILYVLKGPSW B2GUN6_XENTR B2GUN6_XENTR GRIPTIHAELHL-------PKDTEGQVDYAAMVDHLRETNNLQEQADILYLLYTMKGGDW KPB1_RAT KPB1_RAT SQVPSVRVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYTMKGPDW KPB1_MOUSE KPB1_MOUSE SQVPSVHVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMKGPDW Q3UV91_MOUSE Q3UV91_MOUSE SQVPSVHVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMKGPDW A2AI87_MOUSE A2AI87_MOUSE SQVPSVHVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMKGPDW A2AI88_MOUSE A2AI88_MOUSE SQVPSVHVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMKGPDW A2AI90_MOUSE A2AI90_MOUSE SQVPSVHVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMKGPDW A2AI89_MOUSE A2AI89_MOUSE SQVPSVHVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMKGPDW Q8BSV5_MOUSE Q8BSV5_MOUSE SQVPSVHVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMK---- Q8CBA7_MOUSE Q8CBA7_MOUSE SQVPSVHVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMKGPDW A2AI91_MOUSE A2AI91_MOUSE SQVPSVHVEVHL-------PRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMKGPDW KPB1_RABIT KPB1_RABIT DQVPTVRVEVHL-------PRDQSGEVDFQALVLQLKETSSLQEQADILYMLYTMKGPDW B7ZL07_HUMAN B7ZL07_HUMAN NQVPSVRVEIHL-------PRDQSGEVDFKALVLQLKETSSLQEQADILYMLYTMKGPDW A6NIT2_HUMAN A6NIT2_HUMAN NQVPSVRVEIHL-------PRDQSGEVDFKALVLQLKETSSLQEQADILYMLYTMKGPDW A6NMN0_HUMAN A6NMN0_HUMAN NQVPSVRVEIHL-------PRDQSGEVDFKALVLQLKETSSLQEQADILYMLYTMKGPDW KPB1_HUMAN KPB1_HUMAN NQVPSVRVEIHL-------PRDQSGEVDFKALVLQLKETSSLQEQADILYMLYTMKGPDW MATCH . . * : * :**.:* : . CONSENSUS ???????????????????PRD??G?VD???LV?QLK??S?LQ?QADILY?LY?MKGP?W

Q675R7_OIKDI Q675R7_OIKDI RVQIPSVGPVQIGPLLEEVFDRACREQQWLLARELAGYLNKPLPGLDQAVTDILVRQKSI Q4SY00_TETNG Q4SY00_TETNG DTRLHG-RGSTVRSLLTELYDKAGELKHWSLIRMTSGMLRKKVEELDSACSDLLAHQKHL A2AHQ6_MOUSE A2AHQ6_MOUSE DTNLFGQHGVTVHSLLSELYGKAGLNQEWSLIRYISGLLRKKVEVLAEACADLLSHQKQL KPB2_MOUSE KPB2_MOUSE DTNLFGQHGVTVHSLLSELYGKAGLNQEWSLIRYISGLLRKKVEVLAEACADLLSHQKQL A2AHQ7_MOUSE A2AHQ7_MOUSE DTNLFGQHGVTVHSLLSELYGKAGLNQEWSLIRYISGLLRKKVEVLAEACADLLSHQKQL KPB2_HUMAN KPB2_HUMAN DTNLSGQHGVTVQNLLGELYGKAGLNQEWGLIRYISGLLRKKVEVLAEACTDLLSHQKQL KPB2_RABIT KPB2_RABIT DTALSGQHGVTVHNLLSELYGKAGLNQEWGLIRYISGLLRKKVEVLAEACADLLSHQKQL B2GUN6_XENTR B2GUN6_XENTR DTKIYGQPGVTVKDLLKDLYGKVGSMRQWALIRGISGILKKKVEALDEACTDLLSHQKQL KPB1_RAT KPB1_RAT NTELYEEGGSTVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHL KPB1_MOUSE KPB1_MOUSE NTELYEEGGATVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHL Q3UV91_MOUSE Q3UV91_MOUSE NTELYEEGGATVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHL A2AI87_MOUSE A2AI87_MOUSE NTELYEEGGATVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHL A2AI88_MOUSE A2AI88_MOUSE NTELYEEGGATVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHL A2AI90_MOUSE A2AI90_MOUSE NTELYEEGGATVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHL A2AI89_MOUSE A2AI89_MOUSE NTELYEEGGATVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHL Q8BSV5_MOUSE Q8BSV5_MOUSE ------------------------------------------------------------ Q8CBA7_MOUSE Q8CBA7_MOUSE NTELYEEGGATVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHL A2AI91_MOUSE A2AI91_MOUSE NTELYEEGGATVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHL KPB1_RABIT KPB1_RABIT DTELYEEGSATVRELLTELYGKVGKIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHL B7ZL07_HUMAN B7ZL07_HUMAN NTELYNERSATVRELLTELYGKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHL A6NIT2_HUMAN A6NIT2_HUMAN NTELYNERSATVRELLTELYGKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHL A6NMN0_HUMAN A6NMN0_HUMAN NTELYNERSATVRELLTELYGKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHL KPB1_HUMAN KPB1_HUMAN NTELYNERSATVRELLTELYGKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSHQKHL MATCH CONSENSUS ?T?L??????TV??LL?ELY?K?G????W?LIRYISG?LRKKVE?L?EAC?DLLS?QK?L

Q675R7_OIKDI Q675R7_OIKDI TVGLPPDSRETTIDKPLQSGEIEAMILEACG-DGDVAILQQE---YLAMLIRGQPTLFND Q4SY00_TETNG Q4SY00_TETNG TVGLPPEPREKTITAPIPPDQLAALIDEASDSNISVAILTQEIMVYLAMSIRTQPSLFSE A2AHQ6_MOUSE A2AHQ6_MOUSE TVGLPPEPREKTISTPLPPEELTELIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLFAE KPB2_MOUSE KPB2_MOUSE TVGLPPEPREKTISTPLPPEELTELIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLFAE A2AHQ7_MOUSE A2AHQ7_MOUSE TVGLPPEPREKTISTPLPPEELTELIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLFAE KPB2_HUMAN KPB2_HUMAN TVGLPPEPREKIISAPLPPEELTKLIYEASGQDISIAVLTQEIVVYLAMYVRAQPSLFVE KPB2_RABIT KPB2_RABIT TVGLPPEPREKTISAPLPPEELTELIYEASGEDISIAVLTQEIVVYLAMYVRAQPALFVE B2GUN6_XENTR B2GUN6_XENTR TVGLPPEPREIAITAPLPYEKLIRLIDEASEQNRTISILTQEIMVYLAMYMRTQPSLFAE KPB1_RAT KPB1_RAT TVGLPPEPREKTISAPLPYEALTKLIDEASEGDMNISTLTQEIMVYLAMYMRTQPGLFAE KPB1_MOUSE KPB1_MOUSE TVGLPPEPREKTISAPLPYEALTKLIDEASEGDMSISTLTQEIMVYLAMYMRTQPGLFAE Q3UV91_MOUSE Q3UV91_MOUSE TVGLPPEPREKTISAPLPYEALTKLIDEASEGDMSISTLTQEIMVYLAMYMRTQPGLFAE A2AI87_MOUSE A2AI87_MOUSE TVGLPPEPREKTISAPLPYEALTKLIDEASEGDMSISTLTQEIMVYLAMYMRTQPGLFAE A2AI88_MOUSE A2AI88_MOUSE TVGLPPEPREKTISAPLPYEALTKLIDEASEGDMSISTLTQEIMVYLAMYMRTQPGLFAE A2AI90_MOUSE A2AI90_MOUSE TVGLPPEPREKTISAPLPYEALTKLIDEASEGDMSISTLTQEIMVYLAMYMRTQPGLFAE A2AI89_MOUSE A2AI89_MOUSE TVGLPPEPREKTISAPLPYEALTKLIDEASEGDMSISTLTQEIMVYLAMYMRTQPGLFAE Q8BSV5_MOUSE Q8BSV5_MOUSE ------------------------------------------------------------ Q8CBA7_MOUSE Q8CBA7_MOUSE TVGLPPEPREKTISAPLPYEALTKLIDEASEGDMSISTLTQEIMVYLAMYMRTQPGLFAE A2AI91_MOUSE A2AI91_MOUSE TVGLPPEPREKTISAPLPYEALTKLIDEASEGDMSISTLTQEIMVYLAMYMRTQPGLFAE KPB1_RABIT KPB1_RABIT TVGLPPEPREKTISAPLPYEALTRLIEEACEGDMNISILTQEIMVYLAMYMRTQPGLFAE B7ZL07_HUMAN B7ZL07_HUMAN TVGLPPEPREKTISAPLPYEALTQLIDEASEGDMSISILTQEIMVYLAMYMRTQPGLFAE A6NIT2_HUMAN A6NIT2_HUMAN TVGLPPEPREKTISAPLPYEALTQLIDEASEGDMSISILTQEIMVYLAMYMRTQPGLFAE A6NMN0_HUMAN A6NMN0_HUMAN TVGLPPEPREKTISAPLPYEALTQLIDEASEGDMSISILTQEIMVYLAMYMRTQPGLFAE KPB1_HUMAN KPB1_HUMAN TVGLPPEPREKTISAPLPYEALTQLIDEASEGDMSISILTQEIMVYLAMYMRTQPGLFAE MATCH CONSENSUS TVGLPPEPREKTIS?PLP?E?LT?LI?EAS??D??I??LTQEI?VYLAMY?R?QP?LF?E

Q675R7_OIKDI Q675R7_OIKDI LLRLRVGLIVQVLASELARLFNCS--------------------------GQEASSCLLA Q4SY00_TETNG Q4SY00_TETNG MFRLRIGLIIQVMATELAQSLNCSGSSSPWALRRGLFARLLSLIRRVPPPGEEATETLMS A2AHQ6_MOUSE A2AHQ6_MOUSE MLRLRIGLIIQVMATELARSLNCS--------------------------GKEASESLMN KPB2_MOUSE KPB2_MOUSE MLRLRIGLIIQVMATELARSLNCS--------------------------GKEASESLMN A2AHQ7_MOUSE A2AHQ7_MOUSE MLRLRIGLIIQVMATELARSLNCS--------------------------GKEASESLMN KPB2_HUMAN KPB2_HUMAN MLRLRIGLIIQVMATELARSLNCS--------------------------GEEASESLMN KPB2_RABIT KPB2_RABIT MLRLRIGLIIQVMATELARSLNCS--------------------------GEEASESLMN B2GUN6_XENTR B2GUN6_XENTR MFRLRIGLIIQVMATELSHSLRCS--------------------------AEEATESLMN KPB1_RAT KPB1_RAT MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN KPB1_MOUSE KPB1_MOUSE MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN Q3UV91_MOUSE Q3UV91_MOUSE MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN A2AI87_MOUSE A2AI87_MOUSE MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN A2AI88_MOUSE A2AI88_MOUSE MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN A2AI90_MOUSE A2AI90_MOUSE MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN A2AI89_MOUSE A2AI89_MOUSE MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN Q8BSV5_MOUSE Q8BSV5_MOUSE ------------------------------------------------------------ Q8CBA7_MOUSE Q8CBA7_MOUSE MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN A2AI91_MOUSE A2AI91_MOUSE MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN KPB1_RABIT KPB1_RABIT MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN B7ZL07_HUMAN B7ZL07_HUMAN MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN A6NIT2_HUMAN A6NIT2_HUMAN MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN A6NMN0_HUMAN A6NMN0_HUMAN MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN KPB1_HUMAN KPB1_HUMAN MFRLRIGLIIQVMATELAHSLRCS--------------------------AEEATEGLMN MATCH CONSENSUS M?RLRIGLIIQVMATELA?SL?CS????????????????????????????EA?E?LMN

Q675R7_OIKDI Q675R7_OIKDI LPPSELKDRAVLLIFQSCHLARSMLTLLHSLLSGHEIAIAQDGKKGI--RARSNSRTRRG Q4SY00_TETNG Q4SY00_TETNG LSPSELKNLLHHILSGKEFGVQRSVRDLDAGV-SPAISIHHLGNVGATKSERAGISKLKS A2AHQ6_MOUSE A2AHQ6_MOUSE LSPFDMKSLLHHILSGKEFGVERSVRPIHSSMSSPAISIHEVGHTGATKTERSGITRLRS KPB2_MOUSE KPB2_MOUSE LSPFDMKSLLHHILSGKEFGVERSVRPIHSSMSSPAISIHEVGHTGATKTERSGITRLRS A2AHQ7_MOUSE A2AHQ7_MOUSE LSPFDMKSLLHHILSGKEFGVERSVRPIHSSMSSPAISIHEVGHTGATKTERSGITRLRS KPB2_HUMAN KPB2_HUMAN LSPFDMKNLLHHILSGKEFGVERSVRPIHSSTSSPTISIHEVGHTGVTKTERSGINRLRS KPB2_RABIT KPB2_RABIT LSPFDMKNLLHHILSGKEFGVERSMRPIHSSASSPAISIHEVGHTGVTKTERSGINRLRS B2GUN6_XENTR B2GUN6_XENTR LSPSDMKNLLHHILSGKEFGVERSVRGGEPWV-SPAISIHELGAVGATKSERAGITRLKS KPB1_RAT KPB1_RAT LSPSAMRNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS KPB1_MOUSE KPB1_MOUSE LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS Q3UV91_MOUSE Q3UV91_MOUSE LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS A2AI87_MOUSE A2AI87_MOUSE LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS A2AI88_MOUSE A2AI88_MOUSE LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS A2AI90_MOUSE A2AI90_MOUSE LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS A2AI89_MOUSE A2AI89_MOUSE LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS Q8BSV5_MOUSE Q8BSV5_MOUSE ------------------------------------------------------------ Q8CBA7_MOUSE Q8CBA7_MOUSE LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS A2AI91_MOUSE A2AI91_MOUSE LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS KPB1_RABIT KPB1_RABIT LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS B7ZL07_HUMAN B7ZL07_HUMAN LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS A6NIT2_HUMAN A6NIT2_HUMAN LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS A6NMN0_HUMAN A6NMN0_HUMAN LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS KPB1_HUMAN KPB1_HUMAN LSPSAMKNLLHHILSGKEFGVERSVRPTDSNV-SPAISIHEIGAVGATKTERTGIMQLKS MATCH CONSENSUS LSP??MK?LLHHILSGKEFGVERSVRP??S???SPAISIHE?G??GATKTER?GI??L?S

Q675R7_OIKDI Q675R7_OIKDI SIVSPFTERGRMLNEAYSSNRARSGDRLSRQDSTHQSLMLTLGGI-NSEIVVEDP---GQ Q4SY00_TETNG Q4SY00_TETNG DMKM--VERRESL---------PTSVQLDHSSPCRRKSMRSHSLEIEGIESGVKISQSSS A2AHQ6_MOUSE A2AHQ6_MOUSE EMKQ--MNRRASADEQFFPLGQTMSNSLHSIKSVRSSTPSSPTGT-SSTDSGGQHLGWGE KPB2_MOUSE KPB2_MOUSE EMKQ--MNRRASADEQFFPLGQTMSNSLHSIKSVRSSTPSSPTGT-SSTDSGGQHLGWGE A2AHQ7_MOUSE A2AHQ7_MOUSE EMKQ--MNRRASADEQFFPLGQTMSNSLHSIKSVRSSTPSSPTGT-SSTDSGGQHLGWGE KPB2_HUMAN KPB2_HUMAN EMKQ--MTRRFSADEQFFSVGQAASSSAHSSKSARSSTPSSPTGT-SSSDSGGHHIGWGE KPB2_RABIT KPB2_RABIT EMKQ--MTRRFSADEQFFPVSQTVSSSAYS-KSVRSSTPSSPTGT-SSSDSGGHHISWGE B2GUN6_XENTR B2GUN6_XENTR EIK--------------------LDMDLSSGMSLKPGDSLSVSGDLSTSTISDSDSANDS KPB1_RAT KPB1_RAT EIKQVEFRRLSVSPESQTSGGHPSSIDLMSPTFLSPAACISASSG-SFPTVCEPQTSKDS KPB1_MOUSE KPB1_MOUSE EIKQVEFRRLSVSMESQTSGGHPSGVDLMSPSFLSPAACIAASSG-SFPTVCDHQTSKDS Q3UV91_MOUSE Q3UV91_MOUSE EIKQVEFRRLSVSMESQTSGGHPSGVDLMSPSFLSPAACIAASSG-SFPTVCDHQTSKDS A2AI87_MOUSE A2AI87_MOUSE EIKQVEFHRLSVSTESQTSGGHPSGVDLMSPSFLSPAACIAASSG-SFPTVCDHQTSKDS A2AI88_MOUSE A2AI88_MOUSE EIKQVEFHRLSVSTESQ-----------------SPAACIAASSG-SFPTVCDHQTSKDS A2AI90_MOUSE A2AI90_MOUSE EIKQVEFRRLSVSMESQTSGGHPSGVDLMSPSFLSPAACIAASSG-SFPTVCDHQTSKDS A2AI89_MOUSE A2AI89_MOUSE EIKQ------------------------------SPAACIAASSG-SFPTVCDHQTSKDS Q8BSV5_MOUSE Q8BSV5_MOUSE ------------------------------------------------------------ Q8CBA7_MOUSE Q8CBA7_MOUSE EIKQVEFRRLSVSMESQTSGGHPSGVDLMSPSFLSPAACIAASSG-SFPTVCDHQTSKDS A2AI91_MOUSE A2AI91_MOUSE EIKQVEFRRLSVSMESQTSGGHPSGVDLMSPSFLSPAACIAASSG-SFPTVCDHQTSKDS KPB1_RABIT KPB1_RABIT EIKQVEFRRLSISTESQPNGGHSLGADLMSPSFLSPGTSVTPSSG-SFP---GHHTSKDS B7ZL07_HUMAN B7ZL07_HUMAN EIKQ------------------------------SPGTSMTPSSG-SFPSAYDQQSSKDS A6NIT2_HUMAN A6NIT2_HUMAN EIKQVEFRRLSISAESQSNGGHPLGIDLMSPSFMSPGTSMTPSSG-SFPSAYDQQSSKDS A6NMN0_HUMAN A6NMN0_HUMAN EIKQVEFRRLSISAESQSNGGHPLGIDLMSPSFMSPGTSMTPSSG-SFPSAYDQQSSKDS KPB1_HUMAN KPB1_HUMAN EIKQVEFRRLSISAESQ-----------------SPGTSMTPSSG-SFPSAYDQQSSKDS MATCH CONSENSUS E?KQ????R?????????????????????????????????????S?????????????

Q675R7_OIKDI Q675R7_OIKDI RAGSWLRRRQLDGALNRVATDFYSRVWQVLDRCHGLQIGGRLIQGTVTREMTSSELKFAL Q4SY00_TETNG Q4SY00_TETNG ILSPLFQRRSLSLSSLLLPFRVSRFVHRRLPPSF------FNHQRGSGVQMTPGEIKFSV A2AHQ6_MOUSE A2AHQ6_MOUSE QQGQWLRRRRLDGAINRVPVGFYQKVWKILQKCHGLSIDGYVLPSSTTQEMTPCEIKFAV KPB2_MOUSE KPB2_MOUSE QQGQWLRRRRLDGAINRVPVGFYQKVWKILQKCHGLSIDGYVLPSSTTQEMTPCEIKFAV A2AHQ7_MOUSE A2AHQ7_MOUSE QQGQWLRRRRLDGAINRVPVGFYQKVWKILQKCHGLSIDGYVLPSSTTQEMTPCEIKFAV KPB2_HUMAN KPB2_HUMAN RQGQWLRRRRLDGAINRVPVGFYQRVWKILQKCHGLSIDGYVLPSSTTREMTPHEIKFAV KPB2_RABIT KPB2_RABIT RQGQWLRRRRLDGAINRVPVGFYQRVWKILQKCHGLSIDGYVLPSSTTREMTPQEIKFAV B2GUN6_XENTR B2GUN6_XENTR RQGQWLRRRRLDGALNRVPIGFYQKVWLILQKCHGLSVEGFVLPSSSTREMTPGELKFSA KPB1_RAT KPB1_RAT RQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSSTREMTPGEIKFSV KPB1_MOUSE KPB1_MOUSE RQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSTTREMTPGEIKFSV Q3UV91_MOUSE Q3UV91_MOUSE RQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSTTREMTPGEIKFSV A2AI87_MOUSE A2AI87_MOUSE RQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSTTREMTPGEIKFSV A2AI88_MOUSE A2AI88_MOUSE RQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSTTREMTPGEIKFSV A2AI90_MOUSE A2AI90_MOUSE RQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSTTREMTPGEIKFSV A2AI89_MOUSE A2AI89_MOUSE RQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSTTREMTPGEIKFSV Q8BSV5_MOUSE Q8BSV5_MOUSE ------------------------------------------------------------ Q8CBA7_MOUSE Q8CBA7_MOUSE RQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSTTREMTPGEIKFSV A2AI91_MOUSE A2AI91_MOUSE RQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSTTREMTPGEIKFSV KPB1_RABIT KPB1_RABIT RQGQWQRRRRLDGALNRVPIGFYQKVWKVLQKCHGLSVEGFVLPSSTTREMTPGEIKFSV B7ZL07_HUMAN B7ZL07_HUMAN RQGQWQRRRRLDGALNRVPVGFYQKVWKVLQ