Alignment of the gene Family HBG000281 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q4SFA6_TETNG Q4SFA6_TETNG ------------------------------------------------------------ B8JHY6_DANRE B8JHY6_DANRE -----MTVVPTALGVA--VPPRVSPIIEVEEDSENPISAPTPGRVFNVNNSNNNEEEEKK Q3I0N0_MORSA Q3I0N0_MORSA --------MTTSTTLPHLTVPPHTATQLVADSEEYSEDDLTAPQSDP------------- Q4SDK7_TETNG Q4SDK7_TETNG ------------------------------------------------------------ CNGA2_BOVIN CNGA2_BOVIN ----MTEKANGVKSSPANNHNHHAPPAIKASGKDDHRASSRPQSAAA-DDTSSELQQLAE B3KXY3_HUMAN B3KXY3_HUMAN ----MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAAD-DDTSSELQRLAD CNGA2_HUMAN CNGA2_HUMAN ----MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAAD-DDTSSELQRLAD CNGA2_RABIT CNGA2_RABIT ----MTEKSNGVKSSPANNHNNHVPATIKANGKDESRTRSRPQSAAD-DDTSSELQRLAE CNGA2_RAT CNGA2_RAT ---MMTEKSNGVKSSPANNHNHHPPPSIKANGKDDHRAGSRPQSVAADDDTSPELQRLAE CNGA2_MOUSE CNGA2_MOUSE ---MMTEKSNGVKSSPANNHNHHPPPSIKANGKDDHRAGSRPQSVAADDDTSSELQRLAE Q80XH6_MOUSE Q80XH6_MOUSE ---MMTEKSNGVKSSPANNHNHHPPPSIKANGKDDHRAGSRPQSVAADDDTSSELQRLAE Q0GFG2_DANRE Q0GFG2_DANRE ------MTCQLLLESMDLSPHRLSVKTSIEDESEPADCTFSRDQSIC-DDTSSELQRVAT CNG_ICTPU CNG_ICTPU ----MTGQAALERSV---SSHRLSVRSRLEGEAERAESAISRTDGD--DDTCSELQRVTA Q4S8S3_TETNG Q4S8S3_TETNG ------------------------------------------------------------ Q3I0N2_MORSA Q3I0N2_MORSA -----MAKVAPSDPSP---ISRLTPPTIVRQDMEEESGEVGVDN---------------- Q804I6_CARAU Q804I6_CARAU ---------------MSARVRPLAPPTFHLEGVDQVAMATEDIIEKKHPDDGNNF----- Q1L4A6_UTAST Q1L4A6_UTAST -MSIMTTKIGVTETHHASSNIHNLALQDRSESTERVKDG--------------------- Q561K9_XENLA Q561K9_XENLA ---------------G--TVPKVSIQDM-DEVLERMENGECRLLGKT-DNIHCSSQSMES CNG3_CHICK CNG3_CHICK ---MKVGVIETHHSHP--IIPSVVVQDT-SEDPGLIEKGENR------------------ CNGA1_MOUSE CNGA1_MOUSE ---MKTNIINTWHSFV--NIPNVIVPAI-EKEIRRMENGACSSFSDDDNGSLSEESENED CNGA1_RAT CNGA1_RAT ---MKTNIINTWHSFV--NIPNVVVPAI-EKEIRRMENGACSSFSDNDNGSLSEESENED CNGA1_HUMAN CNGA1_HUMAN KLSMKNNIINTQQSFV--TMPNVIVPDI-EKEIRRMENGACSSFSEDDDSASTSEESENE Q4W5E3_HUMAN Q4W5E3_HUMAN KLSMKNNIINTQQSFV--TMPNVIVPDI-EKEIRRMENGACSSFSED-DDSASTSEESEN Q9N0H4_PIG Q9N0H4_PIG ---MKNNIINTQQSFV--TMPNVIVPDI-EKEIRRMENGACSSFSED-DDSASTSEESEN CNGA1_BOVIN CNGA1_BOVIN ---MKKVIINTWHSFV--NIPNVVGPDV-EKEITRMENGACSSFSGDDDDSASMFEESET CNGA1_CANFA CNGA1_CANFA ---MKKNIINTWYSFV--NIPNVIVPDI-EKEIRRMENGARSSFSDDDGDDDSASMFEES Q8UVT8_ONCMY Q8UVT8_ONCMY -----MAKICTDQSYPATTRQRPSLCTP-NDNLDSIENGTPRSNSEC-EDTSSEIQGAVS Q4RKX8_TETNG Q4RKX8_TETNG ------------------------------------------------------------ Q4S111_TETNG Q4S111_TETNG ------------------------------------------------------------ CNG1_CHICK CNG1_CHICK -----MAKINTQHSYP--GMHGLSVRTT-DEDIERIENGFIRTHSLC-EDTSSELQRVIS Q1L2P6_UTAST Q1L2P6_UTAST ------------------------------------------------------------ CNGA3_MOUSE CNGA3_MOUSE -----MAKVNTQCSQP--SPTQLSIKNA-DRDLDHVENGLG------------------- Q8CFV6_MOUSE Q8CFV6_MOUSE -----MAKVNTQCSQP--SPTQLSIKNA-DRDLDHVENGLG------------------- Q9ER32_RAT Q9ER32_RAT -----MAKVNTQCSQP--SPRQLSVKDAADRDLDQVENGLG------------------- Q9ER33_RAT Q9ER33_RAT -----MAKVNTQCSQP--SPRQLSVKDAADRDLDQVENGLGRSHSPC-EETSSTVHQGIV Q9QWN7_RAT Q9QWN7_RAT -------------------MHQMETSTMVQDN---------------------------- CNGA3_BOVIN CNGA3_BOVIN -----MAKISTQYSHP--TRTHPSVRTM-DRDLDCIENGLSRTHLPC-EETSSELQEGIA Q6ZNA7_HUMAN Q6ZNA7_HUMAN ETRGLADSGQGSFTGQ--GIARFGRIQK-KSQPEKVVRAASRGRPLI-GWTQWCAEDGGD CNGA3_HUMAN CNGA3_HUMAN -----MAKINTQYSHP--SRTHLKVKTS-DRDLNRAENGLSRAHSSS-EETSSVLQPGIA Q4VAP7_HUMAN Q4VAP7_HUMAN -----MAKINTQYSHP--SRTHLKVKTS-DRDLNRAENGLSRAHSSS-EETSSVLQPGIA CNGA4_HUMAN CNGA4_HUMAN ------------------------------------------------------------ CNGA4_MOUSE CNGA4_MOUSE ------------------------------------------------------------ CNGA4_RAT CNGA4_RAT ------------------------------------------------------------ Q4SZ21_TETNG Q4SZ21_TETNG ------------------------------------------------------------ B0V208_DANRE B0V208_DANRE ------------------------------------------------------------ Q8JFN9_ICTPU Q8JFN9_ICTPU ------------------------------------------------------------ Q8JFP0_ICTPU Q8JFP0_ICTPU ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4SFA6_TETNG Q4SFA6_TETNG ------------------------------------RR---------------------- B8JHY6_DANRE B8JHY6_DANRE K-----------KKEKKEKKEKKEKKEKKEKKEKN-QKNEKQKDNEKEKEKEKEKEKEKE Q3I0N0_MORSA Q3I0N0_MORSA --------------------------ALLNMNNSN-NNEEKEEQEKKENEEKEKKEKEEK Q4SDK7_TETNG Q4SDK7_TETNG ---------------------------------------KKQETEEKEAKEKEAKEKEAK CNGA2_BOVIN CNGA2_BOVIN M----------DAPQQRRGGFRRIARLVGVLREWA-YRNFREEEPRPDSFLERFRGPELH B3KXY3_HUMAN B3KXY3_HUMAN V----------DAPQQGRSGFRRIVRLVGIIREWS-NKNFREEEPRPDSFLERFRGPELQ CNGA2_HUMAN CNGA2_HUMAN V----------DAPQQGRSGFRRIVRLVGIIREWA-NKNFREEEPRPDSFLERFRGPELQ CNGA2_RABIT CNGA2_RABIT M----------DAPQQRRGGFRRIVRLVGVIRQWA-NRNFREEEARPDSFLERFRGPELQ CNGA2_RAT CNGA2_RAT M----------DTPRRGRGGFQRIVRLVGVIRDWA-NKNFREEEPRPDSFLERFRGPELQ CNGA2_MOUSE CNGA2_MOUSE M----------DTPRRGRGGFRRIVRLVGIIRDWA-NKNFREEEPRPDSFLERFRGPELQ Q80XH6_MOUSE Q80XH6_MOUSE M----------DTPRRGRGGFRRIVRLVGIIRDWA-NKNFREEEPRPDSFLERFRGPELQ Q0GFG2_DANRE Q0GFG2_DANRE L------EQQRLNSFRDRGALSRLVNMVVTLREWA-HKSLQEEEERPDSFLERFRGPELQ CNG_ICTPU CNG_ICTPU L---ELPSAEMLEAFTQRRPLARLVNLVLSLREWA-HKSLVETEQRPDSFLERFRGPQAA Q4S8S3_TETNG Q4S8S3_TETNG ----------------------RLVNLVVRLREWA-HKSLLENEERPDSFMERFRGPELR Q3I0N2_MORSA Q3I0N2_MORSA ----------------------RVAQMAGPGVLFN-VNNSNNNDDDEEKKKKKKSKKEKK Q804I6_CARAU Q804I6_CARAU ------------------------------------NNNNNNEDEEKKKKKKEKKKKEKK Q1L4A6_UTAST Q1L4A6_UTAST ------------------------------------------KSSKSDGEREKATVEKVN Q561K9_XENLA Q561K9_XENLA P-KCYSIYSSKNRVHAVTATLHRDQHLLGANADCN-TNNSNNKEEE--EKKKKKKEKKEK CNG3_CHICK CNG3_CHICK --------------------FARQWYLPGAFAQYNINNNSNKDEEKKKKKEKKSKSENKK CNGA1_MOUSE CNGA1_MOUSE S-------FFRSNSYKRRGPSQREQHLPGTMALFN-VNNSSNKDQEPKEKKKKKKEKKSK CNGA1_RAT CNGA1_RAT S-------LFRSNSYRRRGPSQREHYLPGTMALFN-VNNSSNKDQDPKEKKKKKKEKKSK CNGA1_HUMAN CNGA1_HUMAN N--PHARGSFSYKSLRKGGPSQREQYLPGAIALFN-VNNSSNKDQEPEEKKKKKKEKKSK Q4W5E3_HUMAN Q4W5E3_HUMAN E-NPHARGSFSYKSLRKGGPSQREQYLPGAIALFN-VNNSSNKDQEPEEKKKKKKEKKSK Q9N0H4_PIG Q9N0H4_PIG E-NPHARGSFSYKSLRKGGPSQREQYLPGAIALFN-VNNSSNKDQEPEEKKKKKKEKKSK CNGA1_BOVIN CNGA1_BOVIN E-NPHARDSFRSNTHGSGQPSQREQYLPGAIALFN-VNNSSNKEQEPKEKKKKKKEKKSK CNGA1_CANFA CNGA1_CANFA ENETPHARDSCRNNSQRRDPSQREQYLPGAIALFN-VNNSSNKEQEPKEKKKKKKEKKSK Q8UVT8_ONCMY Q8UVT8_ONCMY V-LTSRHPEPHRDSFTGSG---------------A-LARMHREVERPDSFLERFRTPELK Q4RKX8_TETNG Q4RKX8_TETNG ---------------------------------WA-SLRGTPVTERHDSFLERFRGPELK Q4S111_TETNG Q4S111_TETNG ---------------------------------WA-SLRGTPVTERHDSFLERFRGPELK CNG1_CHICK CNG1_CHICK M-EGRHLSGSQTSPFTGRGAMARLSRFVVSLRSWA-TRHLHHEDQRPDSFLERIRGPELV Q1L2P6_UTAST Q1L2P6_UTAST ------------------------------------------------------------ CNGA3_MOUSE CNGA3_MOUSE ----------------------RVSRLIISIRAWA-SRHLHDEDQTPDSFLDRFHGSELK Q8CFV6_MOUSE Q8CFV6_MOUSE ----------------------RVSRLIISIRAWA-SRHLHDEDQTPDSFLDRFHGSELK Q9ER32_RAT Q9ER32_RAT ----------------------RVSRFIISIRAWA-ARHLHHEDPTPDSFLDRFHGAELK Q9ER33_RAT Q9ER33_RAT M-ETGELAGAAQSLFTSQG-PARVSRFIISIRAWA-ARHLHHEDPTPDSFLDRFHGAELK Q9QWN7_RAT Q9QWN7_RAT ----------------------RVSRFIISIRAWA-ARHLHHEDPTPDSFLDRFHGAEPK CNGA3_BOVIN CNGA3_BOVIN M-ETRGLAESRQSSFTSQG-PTRLSRLIISLRAWS-ARHLHQEDQRPDSFLERFRGAELQ Q6ZNA7_HUMAN Q6ZNA7_HUMAN E-SEMALAGSPGCSSGPQG---RLSRLIFLLRRWA-ARHVHHQDQGPDSFPDRFRGAELK CNGA3_HUMAN CNGA3_HUMAN M-ETRGLADSGQGSFTGQG-IARLSRLIFLLRRWA-ARHVHHQDQGPDSFPDRFRGAELK Q4VAP7_HUMAN Q4VAP7_HUMAN M-ETRGLADSGQGSFTGQG-IARLSRLIFLLRRWA-ARHVHHQDQGPDSFPDRFRGAELK CNGA4_HUMAN CNGA4_HUMAN ------------------------------------------------------------ CNGA4_MOUSE CNGA4_MOUSE ------------------------------------------------------------ CNGA4_RAT CNGA4_RAT ------------------------------------------------------------ Q4SZ21_TETNG Q4SZ21_TETNG ------------------------------------------------------------ B0V208_DANRE B0V208_DANRE ------------------------------------------------------------ Q8JFN9_ICTPU Q8JFN9_ICTPU ------------------------------------------------------------ Q8JFP0_ICTPU Q8JFP0_ICTPU ------------------------------MNRWTKLLSLHHTQKDGEAQVAKAEGQKEA MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4SFA6_TETNG Q4SFA6_TETNG ------------------------------------------------------------ B8JHY6_DANRE B8JHY6_DANRE KEKEKEKEKEKEKEKEKEKEKKE------------------------------------- Q3I0N0_MORSA Q3I0N0_MORSA EEKERKEKEEKEKKEKEEKEKKE------------------------------------- Q4SDK7_TETNG Q4SDK7_TETNG EKEAKEKEAKEKEAKEKEAKEKE------------------------------------- CNGA2_BOVIN CNGA2_BOVIN TVTTQQGDGKGDKDGEGKGTK--------------------------------------- B3KXY3_HUMAN B3KXY3_HUMAN TVTTQEGDGKGDKDGEDKGTK--------------------------------------- CNGA2_HUMAN CNGA2_HUMAN TVTTQEGDGKGDKDGEDKGTK--------------------------------------- CNGA2_RABIT CNGA2_RABIT TVTTQQGDGKGDKDGDGKGTK--------------------------------------- CNGA2_RAT CNGA2_RAT TVTTHQGDDKGGKDGEGKGTK--------------------------------------- CNGA2_MOUSE CNGA2_MOUSE TVTPHQGDGKGDKDGEGKGTK--------------------------------------- Q80XH6_MOUSE Q80XH6_MOUSE TVTTHQGDGKGDKDGEGKGTK--------------------------------------- Q0GFG2_DANRE Q0GFG2_DANRE IATSRLSISRHDIQDGNTSAKTK------------------------------------- CNG_ICTPU CNG_ICTPU NDQSAAPADAPKKTFK-------------------------------------------- Q4S8S3_TETNG Q4S8S3_TETNG MAPSRSSNSQPDANGTGGIFR--------------------------------------- Q3I0N2_MORSA Q3I0N2_MORSA EKKEKKEKKEKEKQEKKERKEKK------------------------------------- Q804I6_CARAU Q804I6_CARAU EKKEKKEKEKKNETEEKEKEKEK------------------------------------- Q1L4A6_UTAST Q1L4A6_UTAST KENQKRNKDTPEKKYKEEK----------------------------------------- Q561K9_XENLA Q561K9_XENLA SDHKKEKKKEKEKKKDKEKGEKE------------------------------------- CNG3_CHICK CNG3_CHICK DGERQKNKEKKEKHKNKDKKKGK------------------------------------- CNGA1_MOUSE CNGA1_MOUSE ADDKNENKKDPEKKKKKEKEKEK------------------------------------- CNGA1_RAT CNGA1_RAT ADDKKESKKDPEKKKKKEKEKEK------------------------------------- CNGA1_HUMAN CNGA1_HUMAN SDDKNENKNDPEKKKKKKDKEKK------------------------------------- Q4W5E3_HUMAN Q4W5E3_HUMAN SDDKNENKNDPEKKKKKKDKEKK------------------------------------- Q9N0H4_PIG Q9N0H4_PIG SDNKNENKNDPEKKKKKKDKEKK------------------------------------- CNGA1_BOVIN CNGA1_BOVIN PDDKNENKKDPEKKKKKEKDKDK------------------------------------- CNGA1_CANFA CNGA1_CANFA SGDKNENKKDSEKKKKKEKEKEK------------------------------------- Q8UVT8_ONCMY Q8UVT8_ONCMY EASSRESNTR----SQGYPDRVRKRNQVGQWPLAMYNMNNCNNTDDKKDDKKDEIKKEEK Q4RKX8_TETNG Q4RKX8_TETNG DLN--QDSGIKEMGHSDSLGG--------------------------------------- Q4S111_TETNG Q4S111_TETNG DLN--QDSGIKELGHSDSLGG--------------------------------------- CNG1_CHICK CNG1_CHICK EVSSRQSNIRSFLGIREQPGGVN-----GPWPLARFNVNFSNNTNEDKKEEKKEVK---- Q1L2P6_UTAST Q1L2P6_UTAST ------------------------------------------------------------ CNGA3_MOUSE CNGA3_MOUSE EVSTRESNAQPNPGEQKPPDGGE-----G------------------------------- Q8CFV6_MOUSE Q8CFV6_MOUSE EVSTRESNAQPNPGEQKPPDGGE-----G------------------------------- Q9ER32_RAT Q9ER32_RAT EVSSQERNAQPNPGGQEPPEGGK-----G------------------------------- Q9ER33_RAT Q9ER33_RAT EVSSQERNAQPNPGGQEPPEGGK-----G------------------------------- Q9QWN7_RAT Q9QWN7_RAT EVSSQERNAQPNPGGQEPPEGGK------------------------------------- CNGA3_BOVIN CNGA3_BOVIN EVSSRESHVQFNVGSQEPPDRGR-----SAWPLARNNTNTCNNSEKDDKAKKEE------ Q6ZNA7_HUMAN Q6ZNA7_HUMAN EVSSQESNAQANVGSQEPADRGR-----SAWPLAKCNTNTSNNTEEEKKT---------- CNGA3_HUMAN CNGA3_HUMAN EVSSQESNAQANVGSQEPADRGR-----SAWPLAKCNTNTSNNTEEEKKT---------- Q4VAP7_HUMAN Q4VAP7_HUMAN EVSSQESNAQANVGSQEPADRGR------------------------------------- CNGA4_HUMAN CNGA4_HUMAN --MSQDTKVKTTESSPPAPSK--------------------------------------- CNGA4_MOUSE CNGA4_MOUSE --MSQDSKVKTTESTPPAPTK--------------------------------------- CNGA4_RAT CNGA4_RAT --MSQDGKVKTTESTPPAPTK--------------------------------------- Q4SZ21_TETNG Q4SZ21_TETNG ------------------------------------------------------------ B0V208_DANRE B0V208_DANRE ------------------------------------------------------------ Q8JFN9_ICTPU Q8JFN9_ICTPU ------------------------------------------------------------ Q8JFP0_ICTPU Q8JFP0_ICTPU TKEQKIK----------------------------------------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4SFA6_TETNG Q4SFA6_TETNG ------------------------------------------------------KRCTVM B8JHY6_DANRE B8JHY6_DANRE ------------------------------------------------------GPKEVF Q3I0N0_MORSA Q3I0N0_MORSA ----------------------------------------------------KEKAKELF Q4SDK7_TETNG Q4SDK7_TETNG -------------------------------------------------AKEKDKPREVF CNGA2_BOVIN CNGA2_BOVIN ------------------------------------------------------KKFELF B3KXY3_HUMAN B3KXY3_HUMAN ------------------------------------------------------KKFELF CNGA2_HUMAN CNGA2_HUMAN ------------------------------------------------------KKFELF CNGA2_RABIT CNGA2_RABIT ------------------------------------------------------KKFELF CNGA2_RAT CNGA2_RAT ------------------------------------------------------KKFELF CNGA2_MOUSE CNGA2_MOUSE ------------------------------------------------------KKFELF Q80XH6_MOUSE Q80XH6_MOUSE ------------------------------------------------------KKFELF Q0GFG2_DANRE Q0GFG2_DANRE ------------------------------------------------------KKSDVF CNG_ICTPU CNG_ICTPU ------------------------------------------------------ERWEGF Q4S8S3_TETNG Q4S8S3_TETNG ------------------------------------------------------KRWNLL Q3I0N2_MORSA Q3I0N2_MORSA ----------------------------QKEKEEKEKEKEKEKEKEKEKKAKEEAPKEIQ Q804I6_CARAU Q804I6_CARAU ---------------------------------------------EKEKEKEKEQPKEIQ Q1L4A6_UTAST Q1L4A6_UTAST ------------------------------------------------------EKKEVF Q561K9_XENLA Q561K9_XENLA ---------------------NKVKAKEEKEKEKAKEKAEKEKEKEKEKEKKEEKKKEIF CNG3_CHICK CNG3_CHICK ---------------------------------------------------EEEKKKDIF CNGA1_MOUSE CNGA1_MOUSE -----------------------------------------KKKEEKTKEKKEEEKKEVV CNGA1_RAT CNGA1_RAT ------------------------------------------KKEEKPKEKKEEEKKEVV CNGA1_HUMAN CNGA1_HUMAN ------------------------------------------KKEEKSKDKKEEEKKEVV Q4W5E3_HUMAN Q4W5E3_HUMAN ------------------------------------------KKEEKSKDKKEEEKKEVV Q9N0H4_PIG Q9N0H4_PIG ------------------------------------------KKEEKSKDKKEEEKKEVV CNGA1_BOVIN CNGA1_BOVIN -----------------------------------------KKKEEKGKDKKEEEKKEVV CNGA1_CANFA CNGA1_CANFA -----------------------------------------KNKEEKGKDKKEEEKKEVM Q8UVT8_ONCMY Q8UVT8_ONCMY KQEAQGDEKKEEEKEEKKEEEKEEKKEEEPKKEEPKKEEPKKEEPKKEEKKKEEPPKEIW Q4RKX8_TETNG Q4RKX8_TETNG ------------------------------------------------------KKKEIW Q4S111_TETNG Q4S111_TETNG ------------------------------------------------------KKKEIW CNG1_CHICK CNG1_CHICK -------------------EEKKEEKKEEKKEEKKDDKKDDKKDDKKDDKKKEEQKKEVF Q1L2P6_UTAST Q1L2P6_UTAST ------------------------------------------------------------ CNGA3_MOUSE CNGA3_MOUSE ------------------------------------------------------RKEEPI Q8CFV6_MOUSE Q8CFV6_MOUSE ------------------------------------------------------RKEEPI Q9ER32_RAT Q9ER32_RAT ------------------------------------------------------RKKDPI Q9ER33_RAT Q9ER33_RAT ------------------------------------------------------RKKDPI Q9QWN7_RAT Q9QWN7_RAT -----------------------------------------------------GRKKDPI CNGA3_BOVIN CNGA3_BOVIN ---------------------------------------KEKKEEKKENPKKEEKKKDSV Q6ZNA7_HUMAN Q6ZNA7_HUMAN ------------------------------------------------------KKKDAI CNGA3_HUMAN CNGA3_HUMAN ------------------------------------------------------KKKDAI Q4VAP7_HUMAN Q4VAP7_HUMAN --------------------------------------------------RKKTKKKDAI CNGA4_HUMAN CNGA4_HUMAN ------------------------------------------------------ARKLLP CNGA4_MOUSE CNGA4_MOUSE ------------------------------------------------------ARKWLP CNGA4_RAT CNGA4_RAT ------------------------------------------------------ARKWLP Q4SZ21_TETNG Q4SZ21_TETNG -------------------------------------------------------RWKEW B0V208_DANRE B0V208_DANRE ------------------------------------------------------------ Q8JFN9_ICTPU Q8JFN9_ICTPU ------------------------------------------------------------ Q8JFP0_ICTPU Q8JFP0_ICTPU ------------------------------------------------------VNWREW MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4SFA6_TETNG Q4SFA6_TETNG VVSPSDDAYYYWLMVVGSAVLYNWTLLVVRLVTCSPGEGQNEPVSTSLQRRNVLLWLVLD B8JHY6_DANRE B8JHY6_DANRE VINPAGLLYYQWLLIITFPVMYNWTVIIAR------------ACFEELQHEYLLTWFLLD Q3I0N0_MORSA Q3I0N0_MORSA VINPAGSLYYNWLFIITLPVMYNWTMIIAR------------ACFEELQHNFFLYWIVLD Q4SDK7_TETNG Q4SDK7_TETNG IINPAGNLYYNWLFIITLPVMYNWTMIIAR------------ACFEELQHNFIIYWFLLD CNGA2_BOVIN CNGA2_BOVIN VLDPAGDWYYRWLFLIALPVLYNWCLLVAR------------ACFSDLQKGYYIVWLVLD B3KXY3_HUMAN B3KXY3_HUMAN VLDPAGDWYYCWLFVIAMPVLYNWCLLVAR------------ACFSDLQKGYYLVWLVLD CNGA2_HUMAN CNGA2_HUMAN VLDPAGDWYYCWLFVIAMPVLYNWCLLVAR------------ACFSDLQKGYYLVWLVLD CNGA2_RABIT CNGA2_RABIT VLDPAGDWYYRWLFVIAMPVLYNWCLLVAR------------ACFSDLQRGYFLVWLVLD CNGA2_RAT CNGA2_RAT VLDPAGDWYYRWLFVIAMPVLYNWCLLVAR------------ACFSDLQRNYFVVWLVLD CNGA2_MOUSE CNGA2_MOUSE VLDPAGDWYYRWLFVIAMPVLYNWCLLVAR------------ACFSDLQRNYFVVWLVLD Q80XH6_MOUSE Q80XH6_MOUSE VLDPAGDWYYRWLFVIAMPVLYNWCLLVAR------------ACFSDLQRNYFVVWLVLD Q0GFG2_DANRE Q0GFG2_DANRE ILSPADDLYYRWLFVIASAVLYNWCFVVAR------------ACFNELQTRNFILWLFLD CNG_ICTPU CNG_ICTPU VVSQSDDIYYYWLFFIALASLYNWIMLVAR------------ACFDQLQDENFFLWVGLD Q4S8S3_TETNG Q4S8S3_TETNG VVSPSDNAYYRWLFVIAVAVLYNWFLVVAR------------ACFDKLQVENYICWLVLD Q3I0N2_MORSA Q3I0N2_MORSA VIDPAGNTYYYWLAIITMPVMYNWTLIIAR------------ACFEELQTDYLMYWFMLD Q804I6_CARAU Q804I6_CARAU VVDPAGNTYYNWLFVITCPVMYNWVLIIAR------------ACYEELQTDYLMLWFILD Q1L4A6_UTAST Q1L4A6_UTAST VIDPSGNLYYNWLFCITLPVMYNWTMIIAR------------ACFDELQSNNLQMWLIFD Q561K9_XENLA Q561K9_XENLA VIDPSGNLYYNWLFCITMPVMYNWTMIIAR------------ACFDELQQDYLELWFFVD CNG3_CHICK CNG3_CHICK IIDPAGNMYYNWLFCITMPVMYNWTMIIAR------------ACFDELQNDYLAVWFIVD CNGA1_MOUSE CNGA1_MOUSE VIDPSGNTYYNWLFCITLPVMYNWTMIIAR------------ACFDELQSDYLEYWLIFD CNGA1_RAT CNGA1_RAT VIDPSGNMYYNWLFCITLPVMYNWTMIIAR------------ACFDELQSDYLEYWLIFD CNGA1_HUMAN CNGA1_HUMAN VIDPSGNTYYNWLFCITLPVMYNWTMVIAR------------ACFDELQSDYLEYWLILD Q4W5E3_HUMAN Q4W5E3_HUMAN VIDPSGNTYYNWLFCITLPVMYNWTMVIAR------------ACFDELQSDYLEYWLILD Q9N0H4_PIG Q9N0H4_PIG VIDPSGNTYYNWLFCITLPVMYNWTMVIAR------------ACFDELQSDYLEYWLILD CNGA1_BOVIN CNGA1_BOVIN VIDPSGNTYYNWLFCITLPVMYNWTMIIAR------------ACFDELQSDYLEYWLAFD CNGA1_CANFA CNGA1_CANFA VIDPAGNMYYNWLFCITLPVMYNWTMVIAR------------ACFDELQSDYLEYWIIFD Q8UVT8_ONCMY Q8UVT8_ONCMY IMDPSADKYYTWLTIIAAPCFYNLMMLVTR------------ACFNELQNTYTMLWIVLD Q4RKX8_TETNG Q4RKX8_TETNG IMDPAADQYYRWLTVIAAPVFYNLMMIVTR------------ACFNELQDTYTKLWIALD Q4S111_TETNG Q4S111_TETNG IMDPAADQYYRWLTVIAAPVFYNLMMIVTR------------ACFNELQDTYTKLWIALD CNG1_CHICK CNG1_CHICK VIDPSSNMYYNWLTIIAAPVFYNWCMLICR------------ACFDELQIDHIKLWLFLD Q1L2P6_UTAST Q1L2P6_UTAST ------------------------------------------------QMENLTLWLILD CNGA3_MOUSE CNGA3_MOUSE VVDPSSNIYCRWLTAIALPVFYNWCLLVCR------------ACFDELQSEHLTLWLVLD Q8CFV6_MOUSE Q8CFV6_MOUSE VVDPSSNIYYRWLTAIALPVFYNWCLLVCR------------ACFDELQSEHLTLWLVLD Q9ER32_RAT Q9ER32_RAT VVDPSSNIYYRWLTAIALPVFYNWCLLVCR------------ACFDELQSEHLTLWLVLD Q9ER33_RAT Q9ER33_RAT VVDPSSNIYYRWLTAIALPVFYNWCLLVCR------------ACFDELQSEHLTLWLVLD Q9QWN7_RAT Q9QWN7_RAT VVDPSSNIYYRWLTAIALPVFYNWCLLVCR------------ACFDELQSEHLTLWLVLD CNGA3_BOVIN CNGA3_BOVIN VMDPSSNMYYHWLTVIAVPVFYNWCLLVCR------------ACFDELQSEHLMLWLVLD Q6ZNA7_HUMAN Q6ZNA7_HUMAN VVDPSSNLYYRWLTAIALPVFHNWYLLICR------------ACFDELQSEYLMLWLVLD CNGA3_HUMAN CNGA3_HUMAN VVDPSSNLYYRWLTAIALPVFYNWYLLICR------------ACFDELQSEYLMLWLVLD Q4VAP7_HUMAN Q4VAP7_HUMAN VVDPSSNLYYRWLTAIALPVFYNWYLLICR------------ACFDELQSEYLMLWLVLD CNGA4_HUMAN CNGA4_HUMAN VLDPSGDYYYWWLNTMVFPVMYNLIILVCR------------ACFPDLQHGYLVAWLVLD CNGA4_MOUSE CNGA4_MOUSE VLDPSGDYYYWWLNTMVFPIMYNLIIVVCR------------ACFPDLQHSYLVAWFVLD CNGA4_RAT CNGA4_RAT VLDPSGDYYYWWLNTMVFPIMYNLIIVVCR------------ACFPDLQHSYLVAWFVLD Q4SZ21_TETNG Q4SZ21_TETNG LVDPAEQFYYIWLQVMILPIVYNSVIIILR------------TCFTTIALSYLPVWLTLD B0V208_DANRE B0V208_DANRE --------------------------IVKR------------TCFYTIEEAYVATWLTLD Q8JFN9_ICTPU Q8JFN9_ICTPU ---------------MVFPIIYNWVVIILR------------ICFYEVDQKFQAVWYTLD Q8JFP0_ICTPU Q8JFP0_ICTPU VIDPSEEFYYGWLQVMVFPIIYNWVVIILR------------ICFYEVDQKFQAVWYTLD MATCH * .* CONSENSUS ???P????YY?WL??I??PV?YNW?????R????????????ACF??LQ??????W??LD

Q4SFA6_TETNG Q4SFA6_TETNG YLCDGVYILDVVVRLHT--------------------------------GFLEQGLMVKD B8JHY6_DANRE B8JHY6_DANRE YTSDLLYLADMAFRART--------------------------------GYLEQGLLVKD Q3I0N0_MORSA Q3I0N0_MORSA YTSDVMYLADMFFRTRT--------------------------------GYLEQGLMIKD Q4SDK7_TETNG Q4SDK7_TETNG FTSDLIYVADMFVRTRTGTASPCQPVLSVQTNVIVREGPLECFLSLPSAGYLEQGLLVKD CNGA2_BOVIN CNGA2_BOVIN YVSDVVYIADLFIRLRT--------------------------------GFLEQGLLVKD B3KXY3_HUMAN B3KXY3_HUMAN YVSDVVYIADLFIRLRT--------------------------------GFLEQGLLVKD CNGA2_HUMAN CNGA2_HUMAN YVSDVVYIADLFIRLRT--------------------------------GFLEQGLLVKD CNGA2_RABIT CNGA2_RABIT YFSDVVYIADLFIRLRT--------------------------------GFLEQGLLVKD CNGA2_RAT CNGA2_RAT YFSDTVYIADLIIRLRT--------------------------------GFLEQGLLVKD CNGA2_MOUSE CNGA2_MOUSE YFSDTVYIADLIIRLRT--------------------------------GFLEQGLLVKD Q80XH6_MOUSE Q80XH6_MOUSE YFSDTVYIADLIIRLRT--------------------------------GFLEQGLLVKD Q0GFG2_DANRE Q0GFG2_DANRE YLSDVIYILDTCVRLRT--------------------------------GFLEQGLLVKD CNG_ICTPU CNG_ICTPU YLCDVIYILDTCIRLRT--------------------------------GYLEQGLLVKD Q4S8S3_TETNG Q4S8S3_TETNG YLSDLIYLLDTGVRLRT--------------------------------GFLEQGLLVKD Q3I0N2_MORSA Q3I0N2_MORSA LFSDLIYIADMIFRTRT--------------------------------GYLEQGLLVKD Q804I6_CARAU Q804I6_CARAU FLSDLVYVLDMVFRTRT--------------------------------GYLEQGLLVKD Q1L4A6_UTAST Q1L4A6_UTAST YISDVIYVADMFVRTRT--------------------------------GYLEQGLLVKE Q561K9_XENLA Q561K9_XENLA YISDAIYIADMFARTRT--------------------------------GYLEQGLLVRD CNG3_CHICK CNG3_CHICK YVSDVIYIADMFVRTRT--------------------------------GYLEQGLLVKE CNGA1_MOUSE CNGA1_MOUSE YVSDVVYLADMFVRTRT--------------------------------GYLEQGLLVKD CNGA1_RAT CNGA1_RAT YVSDVVYLADMFVRTRT--------------------------------GYLEQGLLVKD CNGA1_HUMAN CNGA1_HUMAN YVSDIVYLIDMFVRTRT--------------------------------GYLEQGLLVKE Q4W5E3_HUMAN Q4W5E3_HUMAN YVSDIVYLIDMFVRTRT--------------------------------GYLEQGLLVKE Q9N0H4_PIG Q9N0H4_PIG YVSDIVYLIDMFVRTRT--------------------------------GYLEQGLLVKE CNGA1_BOVIN CNGA1_BOVIN YLSDVVYLLDMFVRTRT--------------------------------GYLEQGLLVKE CNGA1_CANFA CNGA1_CANFA YLSDIVYLLDMFVRTRT--------------------------------GYLEQGLLVRE Q8UVT8_ONCMY Q8UVT8_ONCMY YTSDLVYYADTFVRSRT--------------------------------GYLEQGLLVKD Q4RKX8_TETNG Q4RKX8_TETNG YTADFIYYADTFVRSRT--------------------------------GYLEQGLLVKD Q4S111_TETNG Q4S111_TETNG YTADFIYYADTFVRSRT--------------------------------GYLEQGLLVKD CNG1_CHICK CNG1_CHICK YCSDIIYVFDMFVRFRT--------------------------------GFLEQGLLVKD Q1L2P6_UTAST Q1L2P6_UTAST YSSDVIYIIDTFVRFRT--------------------------------GFLEQGLLVRD CNGA3_MOUSE CNGA3_MOUSE YSADVLYVLDMLVRART--------------------------------GFLEQGLMVRD Q8CFV6_MOUSE Q8CFV6_MOUSE YSADVLYVLDMLVRART--------------------------------GFLEQGLMVRD Q9ER32_RAT Q9ER32_RAT YSADALYVVDMLVRART--------------------------------GFLEQGLMVRD Q9ER33_RAT Q9ER33_RAT YSADALYVVDMLVRART--------------------------------GFLEQGLMVRD Q9QWN7_RAT Q9QWN7_RAT YSADALYVVDMLVRART--------------------------------GFLEQGLMVRD CNGA3_BOVIN CNGA3_BOVIN YSADILYGMDMLVRART--------------------------------GFLEQGLMVMD Q6ZNA7_HUMAN Q6ZNA7_HUMAN YSADVLYVLDVLVRART--------------------------------GFLEQGLMVSD CNGA3_HUMAN CNGA3_HUMAN YSADVLYVLDVLVRART--------------------------------GFLEQGLMVSD Q4VAP7_HUMAN Q4VAP7_HUMAN YSADVLYVLDVLVRART--------------------------------GFLEQGLMVSD CNGA4_HUMAN CNGA4_HUMAN YTSDLLYLLDMVVRFHT--------------------------------GFLEQGILVVD CNGA4_MOUSE CNGA4_MOUSE YTSDLLYLLDIGVRFHT--------------------------------GFLEQGILVVD CNGA4_RAT CNGA4_RAT YTSDLLYLLDIGVRFHT--------------------------------GFLEQGILVVD Q4SZ21_TETNG Q4SZ21_TETNG YLSDLMYIFDMIITVHT-------------------------------------GILVKD B0V208_DANRE B0V208_DANRE YLCDLVYVLDTIIGFRT--------------------------------GFLEQGILVRD Q8JFN9_ICTPU Q8JFN9_ICTPU YISDLAYVADIFIKVRT--------------------------------GYLEQGSLVRD Q8JFP0_ICTPU Q8JFP0_ICTPU YISDLAYVADIFIKVRT--------------------------------GYLEQGSLVRD MATCH .* * * :* * :: : CONSENSUS Y??D??Y??D???R?RT????????????????????????????????G?LEQGL?V?D

Q4SFA6_TETNG Q4SFA6_TETNG LKRLRQTYVRTLLCKLDLCSILPTDLLCLTTGLGYTPLLRFNRLLRLYRLFELFERTETR B8JHY6_DANRE B8JHY6_DANRE EKLLLKRYTDSLQFRLDVISMLPTDIFYFILGLDY-PEIRINKLLRLNRMFEFFKISETM Q3I0N0_MORSA Q3I0N0_MORSA KKLLRDRYLDSFQFRLDFISMLPTDIFYFYYGFDY-PEIRLNKLLRIGRLMEFFTKTETK Q4SDK7_TETNG Q4SDK7_TETNG EKLLRDGYVASFQFRLDVVSMLPTDILYLCFGLDY-PEIRINKLLRIGRMMEFFTRTETK CNGA2_BOVIN CNGA2_BOVIN TKKLRDNYIHTMQFKLDVASIIPTDLIYFAVGIHN-PEVRFNRLLHFARMFEFFDRTETR B3KXY3_HUMAN B3KXY3_HUMAN TKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHS-PEVRFNRLLHFARMFEFFDRTETR CNGA2_HUMAN CNGA2_HUMAN TKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHS-PEVRFNRLLHFARMFEFFDRTETR CNGA2_RABIT CNGA2_RABIT PKKLRDNYIHTLQFKLDVASIIPTDLIYFAVGIHN-PELRFNRLLHFARMFEFFDRTETR CNGA2_RAT CNGA2_RAT PKKLRDNYIHTLQFKLDVASIIPTDLIYFAVGIHS-PEVRFNRLLHFARMFEFFDRTETR CNGA2_MOUSE CNGA2_MOUSE PKKLRDNYIHTLQFKLDVASIIPTDLIYFAVGIHS-PEVRFNRLLHFARMFEFFDRTETR Q80XH6_MOUSE Q80XH6_MOUSE PKKLRDNYIHTLQFKLDVASIIPTDLIYFAVGIHS-PEVRFNRLLHFARMFEFFDRTETR Q0GFG2_DANRE Q0GFG2_DANRE LIKLRESYFHTLQFKLDLLSIIPTDLGYIVIGIHV-PELRLNRLMRFSRLFEFFDRTETR CNG_ICTPU CNG_ICTPU LAKLRDNYIRTLQFKLDFLSILPTELLFFVTGYV--PQLRFNRLLRFSRMFEFFDRTETR Q4S8S3_TETNG Q4S8S3_TETNG QAKLWASYVRTLQFKLDLLSILPTDLAYISTGIHT-PQLRFNRLLRFPRMFEFFDRTETR Q3I0N2_MORSA Q3I0N2_MORSA EQKLRERYMKSFQFKLDLISMIPTDLLYLVFGITY-PEIRLNKLFRFNRMLEFFQRTETR Q804I6_CARAU Q804I6_CARAU EKKLRDRYMQSIQFKLDLASMIPTDILYFYFGLNY-PEIRMNKLLRVNRLFEFFQRTETR Q1L4A6_UTAST Q1L4A6_UTAST EVKLKKRYKGTVQFKLDILSIIPTDLLYFKLGLNY-PEIRINRLLRISRLFEFFQQTETR Q561K9_XENLA Q561K9_XENLA EVKLRDKYKKTSQFKLDVLSIIPTDILYFQFGLNY-PELRLNKLLRISRMFEFFQRTETR CNG3_CHICK CNG3_CHICK EQKLKEKYKSSLQFKLDFLSIIPTDLLYFKLGLNY-PELRINRLLRVARMFEFFQRTETR CNGA1_MOUSE CNGA1_MOUSE RMKLIEKYKANLQFKLDVLSVIPTDLLYIKFGWNY-PEIRLNRLLRISRMFEFFQRTETR CNGA1_RAT CNGA1_RAT ELKLIEKYKANLQFKLDVLSVIPTDLLYFKFGWNY-PEIRLNRLLRISRMFEFFQRTETR CNGA1_HUMAN CNGA1_HUMAN ELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNY-PEIRLNRLLRFSRMFEFFQRTETR Q4W5E3_HUMAN Q4W5E3_HUMAN ELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNY-PEIRLNRLLRFSRMFEFFQRTETR Q9N0H4_PIG Q9N0H4_PIG ELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNY-PEIRLNRLLRFSRMFEFFQRTETR CNGA1_BOVIN CNGA1_BOVIN ERKLIDKYKSTFQFKLDVLSVIPTDLLYIKFGWNY-PEIRLNRLLRISRMFEFFQRTETR CNGA1_CANFA CNGA1_CANFA EAKLIEKYKSNLQFKLDFLSVIPTDLLYFKLGWNY-PEIRLNRLLRISRMFEFFQRTETR Q8UVT8_ONCMY Q8UVT8_ONCMY KQKLLDKYRQTAQFKWDVISMIPTDLLFLKVGINN-PELRLNRLTKMNRLFEYFDRTETR Q4RKX8_TETNG Q4RKX8_TETNG AKKLRDKYRTTPQFKYDMISMIPTDLLFLNYGYNN-PEFRFNRLCKISRLFEFFERTETR Q4S111_TETNG Q4S111_TETNG AKKLRDKYRTTPQFKYDMISMIPTDLLFLNYGYNN-PEFRFNRLCKISRLFEFFERTETR CNG1_CHICK CNG1_CHICK EKKLRDHYTQTVQFKLDVLSLLPTDLAYLKLGLNY-PELRFNRLLRIARLFEFFDRTETR Q1L2P6_UTAST Q1L2P6_UTAST EKKLRLNYQSTTQFKLDLLSLLPTDLGYLKFGLNY-PELRFNRLLRLARLFEFFDRTETR CNGA3_MOUSE CNGA3_MOUSE TKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGVNY-PELRFNRLLKFSRLFEFFDRTETR Q8CFV6_MOUSE Q8CFV6_MOUSE TKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGVNY-PELRFNRLLKFSRLFEFFDRTETR Q9ER32_RAT Q9ER32_RAT TKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGMNY-PELRFNRLLRFSRLFEFFDRTETR Q9ER33_RAT Q9ER33_RAT TKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGMNY-PELRFNRLLRFSRLFEFFDRTETR Q9QWN7_RAT Q9QWN7_RAT TKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGMNY-PELRFNRLLRFSRLFEFFDRTETR CNGA3_BOVIN CNGA3_BOVIN ASRLWKHYTQTLHFKLDVLSLVPTDLAYFKLGMNY-PELRFNRLLKLARLFEFFDRTETR Q6ZNA7_HUMAN Q6ZNA7_HUMAN TNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNY-PEVRFNRLLKFSRLFEFFDRTETR CNGA3_HUMAN CNGA3_HUMAN TNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNY-PEVRFNRLLKFSRLFEFFDRTETR Q4VAP7_HUMAN Q4VAP7_HUMAN TNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNY-PEVRFNRLLKFSRLFEFFDRTETR CNGA4_HUMAN CNGA4_HUMAN KGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHT-PTLRLNRFLRAPRLFEAFDRTETR CNGA4_MOUSE CNGA4_MOUSE KSMIASRYVRTWSFLLDLASLVPTDAAYVQLGPHI-PTLRLNRFLRVPRLFEAFDRTETR CNGA4_RAT CNGA4_RAT KGMIASRYVRTWSFLLDLASLVPTDAAYVQLGPHI-PTLRLNRFLRVPRLFEAFDRTETR Q4SZ21_TETNG Q4SZ21_TETNG LNQLKKRYLHSKDFLRDLASLLPTDLLYFVFGFQT-PLVRINRLLRMPRLNEALDRMETR B0V208_DANRE B0V208_DANRE LSRLKTRYLRSSRFKWDMTSLLPTDLLYLQLGIHT-PLVRVNRFLRTGRLNEALDRMETR Q8JFN9_ICTPU Q8JFN9_ICTPU MSRLKKRYLHSSQFLLDVLSQLPTDLLYLSDFFKT-PVVRINRFLRSPRLSEALERMETR Q8JFP0_ICTPU Q8JFP0_ICTPU MSRLKKRYLHSSQFLLDVLSQLPTDLLYLSDFFKT-PVVRINRFLRSPRLSEALERMETR MATCH : * . *. * :**: . * .*.*:: : *: * : ** CONSENSUS ???L???Y?????FKLD??S??PTDL?Y???G????P??R?NRLL???R?FEFF?RTETR

Q4SFA6_TETNG Q4SFA6_TETNG TGYPNAFRIWKLVLYILVIIHWNACGYYSFSKVLGLGSDSWVYPNASDPA---FGSLRQR B8JHY6_DANRE B8JHY6_DANRE TNYPNIFRICTLVMYIIIIIHWNACLYFSFSKSIGFGSDAWVYPALTEPE---FGELMRK Q3I0N0_MORSA Q3I0N0_MORSA TNYPNIFRIGNLIMYILIIIHWNACFFFSFSKYIGFGADDWVYPALDDPDEPAFGEPMRK Q4SDK7_TETNG Q4SDK7_TETNG TNYPNIFRIANLIMYILIIIHWNACFYFSFSKSIGFGADEWVYPALDDPDEPAFGEAMRK CNGA2_BOVIN CNGA2_BOVIN TSYPNIFRISNLILYILIIIHWNACIYYAISKSIGFGVDTWVYPNITDPE---YGYLSRE B3KXY3_HUMAN B3KXY3_HUMAN TNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPE---YGYLARE CNGA2_HUMAN CNGA2_HUMAN TNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPE---YGYLARE CNGA2_RABIT CNGA2_RABIT TSYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPE---YGYLARE CNGA2_RAT CNGA2_RAT TSYPNIFRISNLVLYILVIIHWNACIYYVISKSIGFGVDTWVYPNITDPE---YGYLARE CNGA2_MOUSE CNGA2_MOUSE TSYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPE---YGYLARE Q80XH6_MOUSE Q80XH6_MOUSE TSYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPE---YGYLARE Q0GFG2_DANRE Q0GFG2_DANRE TSYPNLFRICNLVLYILVIIHWNACIYFAISKSLGFGSDQWVYPNISDPK---FGTLTRG CNG_ICTPU CNG_ICTPU TNYPNAFRICNLILYILVIIHWNACIYYAISKALGLSSDTWVYSG----Q---NKTLSFC Q4S8S3_TETNG Q4S8S3_TETNG TNYPNIFRICNLVLYILVIIHWNACIYYAISKSLGFGSDTWVFPNISIPE---YSSLTRS Q3I0N2_MORSA Q3I0N2_MORSA TNYPNALRISNLVMYIVIIIHWNACLYYSFSKAIGFGSDRFVYPDPADPE---FGRLVRK Q804I6_CARAU Q804I6_CARAU TNFPNVFRISNLVMYIVIIIHWNACMYYSFSKAMGFGTDPFVYPDTSDPE---FGRLVRK Q1L4A6_UTAST Q1L4A6_UTAST TSYPNIFRISNLGMYIIIIIHWNACIYFSISKAIGFGTDTWVYPNITHPE---FGRLARK Q561K9_XENLA Q561K9_XENLA TNYPNIFRISNLIMYIVIIIHWNACVYYSISKAIGFGEDTWVYPNTTDPE---YGRLARK CNG3_CHICK CNG3_CHICK TNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGADTWVYPNTSHPE---FARLTRK CNGA1_MOUSE CNGA1_MOUSE TNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPE---FGRLARK CNGA1_RAT CNGA1_RAT TNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPE---FGRLARK CNGA1_HUMAN CNGA1_HUMAN TNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPE---FGRLARK Q4W5E3_HUMAN Q4W5E3_HUMAN TNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPE---FGRLARK Q9N0H4_PIG Q9N0H4_PIG TNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPE---FGRLARK CNGA1_BOVIN CNGA1_BOVIN TNYPNIFRISNLVMYIIIIIHWNACVYFSISKAIGFGNDTWVYPDVNDPD---FGRLARK CNGA1_CANFA CNGA1_CANFA TNYPNIFRISNLVMYIVIIIHWNACVYFSISKAIGFGNDTWVYPDVNDPE---FGRLARK Q8UVT8_ONCMY Q8UVT8_ONCMY TSFPTFSESATWYFYILIIIHWNACIFFAIFKIIGFGSDTWVYPTSVTLS---TAAFPGS Q4RKX8_TETNG Q4RKX8_TETNG TSFPNMFRISNLVLYILVIIHWNACLFFALSKTIGFGSDTWVYPNISHPE---HGRLARK Q4S111_TETNG Q4S111_TETNG TSFPNMFRISNLVLYILVIIHWNACLFFALSKTIGFGSDTWVYPNISHPE---HGRLARK CNG1_CHICK CNG1_CHICK TNYPNMFRIGNLVLYILIIIHWNACIYFAISKVIGFGTDSWVYPNVSIPE---YGRLSRK Q1L2P6_UTAST Q1L2P6_UTAST TNYPNMFRIGNLVLYILIIIHWNACIFFAISKQIGFGSDTWVYPNISHPE---YGRLARK CNGA3_MOUSE CNGA3_MOUSE TNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPE---YARLSRK Q8CFV6_MOUSE Q8CFV6_MOUSE TNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPE---YARLSRK Q9ER32_RAT Q9ER32_RAT TNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPE---YGRLSRK Q9ER33_RAT Q9ER33_RAT TNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPE---YGRLSRK Q9QWN7_RAT Q9QWN7_RAT TNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPE---YGRLSRK CNGA3_BOVIN CNGA3_BOVIN TNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNVSNPE---YGRLSRK Q6ZNA7_HUMAN Q6ZNA7_HUMAN TNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPE---HGRLSRK CNGA3_HUMAN CNGA3_HUMAN TNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPE---HGRLSRK Q4VAP7_HUMAN Q4VAP7_HUMAN TNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPE---HGRLSRK CNGA4_HUMAN CNGA4_HUMAN TAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPG---FERLRRQ CNGA4_MOUSE CNGA4_MOUSE TAYPNAFRIAKLMIYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPG---FERLRRQ CNGA4_RAT CNGA4_RAT TAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPG---FERLRRQ Q4SZ21_TETNG Q4SZ21_TETNG TSYPNTFRISKLMIYIFVLIHWNGCLYFALSSYIGFGSDRWVYPNITDPA---FASLRRQ B0V208_DANRE B0V208_DANRE TSFPNAFRVAKLMLYIFVLIHWNACIYFSLSNYIGFGADPWVYPNISHPE---FASMRRQ Q8JFN9_ICTPU Q8JFN9_ICTPU TAYPNIFRISKLMILIFILIHWNACLYFALSKYIGLGSDDWVYPDTTDIE---FNSTRRQ Q8JFP0_ICTPU Q8JFP0_ICTPU TAYPNIFRISKLMILIFILIHWNACLYFALSKYIGLGSDDWVYPDTTDIE---FNSTRRQ MATCH * :*. . . : .::****.* :: : :*:. * :*:. CONSENSUS T?YPN?FRI??L??YI??IIHWNAC?Y???SK?IGFG?D?WVYP????P???????L?R?

Q4SFA6_TETNG Q4SFA6_TETNG YIYCLYWSTLTLTTIGETPPPVRDEEYLFMIFDFLVGVLIFASIVGNIGAMISNMNATRA B8JHY6_DANRE B8JHY6_DANRE YSFSLYWSTLTLTTIGETPSPELDSEFFFHVVDFLVGVLIFATIVGNIATMISNMNAAQA Q3I0N0_MORSA Q3I0N0_MORSA YAFSLYWSTLTLTTIGETPSPALDSEFFFHVVDFLVGVLVFATIVGNIATMISNMNAAQA Q4SDK7_TETNG Q4SDK7_TETNG YSFSLYWSTLTLTTIGETPPPALDSEFLFHVIDFLVGVLIFATIVGNIATMISNMNAAQA CNGA2_BOVIN CNGA2_BOVIN YIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRA B3KXY3_HUMAN B3KXY3_HUMAN YIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRA CNGA2_HUMAN CNGA2_HUMAN YIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRA CNGA2_RABIT CNGA2_RABIT YIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRA CNGA2_RAT CNGA2_RAT YIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRA CNGA2_MOUSE CNGA2_MOUSE YIYCLYWSTLTLTTIGETPPPVKDEEYLFFIFDFLIGVLIFATIVGNVGSMISNMNATRA Q80XH6_MOUSE Q80XH6_MOUSE YIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRA Q0GFG2_DANRE Q0GFG2_DANRE YVYCLYWSTLTLTTIGEMPAPVQDEEYLFVVFDFLVGVLIFATIVGNVGAMISNMNATRA CNG_ICTPU CNG_ICTPU YVYCFYWSTLTLTTIGEMPPPVKDEEYVFVVFDFLVGVLIFATIVGNVGSMIANMNATRA Q4S8S3_TETNG Q4S8S3_TETNG YVYCLYWSTLTLTTIGEMPAPVRDEEYLFVVFDFLVGVLIFATIVGNVGSMIANMNATRA Q3I0N2_MORSA Q3I0N2_MORSA YAYSMYWSTLTLTTIGETPPPVENSEYFFVVTDFLVGVLIFATIVGNVGSMITNMNAARA Q804I6_CARAU Q804I6_CARAU YAYSMYWSTLTLTTIGETPPPVKNAEYYFVVMDFLVGVLIFATIVGNVGSMITNANAARA Q1L4A6_UTAST Q1L4A6_UTAST YVYSLYWSTLTLTTIGETPPPVRDVEYVFVVVDFLVGVLIFATIVGNIGSMISNMNAARE Q561K9_XENLA Q561K9_XENLA YVYSLYWSTLTLTTIGETPPPVQDSEFWFVVADFLVGVLIFATIVGNVGSMISNMNAARA CNG3_CHICK CNG3_CHICK YVYSLYWSTLTLTTIGETPPPVRDSEYFFVVVDFLVGVLIFATIVGNVGSMISNMNAARA CNGA1_MOUSE CNGA1_MOUSE YVYSLYWSTLTLTTIGETPPPVLDSEYIFVVVDFLIGVLIFATIVGNIGSMISNMNAARA CNGA1_RAT CNGA1_RAT YVYSLYWSTLTLTTIGETPPPVLDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARA CNGA1_HUMAN CNGA1_HUMAN YVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARA Q4W5E3_HUMAN Q4W5E3_HUMAN YVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARA Q9N0H4_PIG Q9N0H4_PIG YVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARA CNGA1_BOVIN CNGA1_BOVIN YVYSLYWSTLTLTTIGETPPPVRDSEYFFVVADFLIGVLIFATIVGNIGSMISNMNAARA CNGA1_CANFA CNGA1_CANFA YVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARA Q8UVT8_ONCMY Q8UVT8_ONCMY IIYCLYWSTLTLTTIGETPPPVRDFEYLFVVADFLIGVLIFATIVGNVGAMISNMNKNRA Q4RKX8_TETNG Q4RKX8_TETNG YIYSLYWSTLTLTTIGETPAPVKDIEYLFVISDFLTGVLIFASIVGNVGAMISNMNASRA Q4S111_TETNG Q4S111_TETNG YIYSLYWSTLTLTTIGETPAPVKDIEYLFVISDFLTGVLIFASIVGNVGAMISNMNASRA CNG1_CHICK CNG1_CHICK YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRA Q1L2P6_UTAST Q1L2P6_UTAST YIYSLYWSTLTLTTIGETPPPVKDIEYLFVVMDFLVGVLIFATIVGNVGSMISNMNASRA CNGA3_MOUSE CNGA3_MOUSE YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGILIFATIVGNVGSMISNMNAPRV Q8CFV6_MOUSE Q8CFV6_MOUSE YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGILIFATIVGNVGSMISNMNAPRV Q9ER32_RAT Q9ER32_RAT YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRA Q9ER33_RAT Q9ER33_RAT YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRA Q9QWN7_RAT Q9QWN7_RAT YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRA CNGA3_BOVIN CNGA3_BOVIN YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRA Q6ZNA7_HUMAN Q6ZNA7_HUMAN YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRA CNGA3_HUMAN CNGA3_HUMAN YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRA Q4VAP7_HUMAN Q4VAP7_HUMAN YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRA CNGA4_HUMAN CNGA4_HUMAN YLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADA CNGA4_MOUSE CNGA4_MOUSE YLYSFYFSTLILTTVGDTPLPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADA CNGA4_RAT CNGA4_RAT YLYSFYFSTLILTTVGDTPLPDREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADA Q4SZ21_TETNG Q4SZ21_TETNG YIYCFWFSAQIFTTVGDTPLPKREDEYLFMIADLLIAVLVFASIVGNVGNVITNLRDRDN B0V208_DANRE B0V208_DANRE YFYCFWFSTLILTTVGDTPTPEREEEYMFLIADMLIAVLVFASVVGSMGDVISSLRDRDN Q8JFN9_ICTPU Q8JFN9_ICTPU YFYSFWFSTLILTTVGDTPQPTREEEFLFMIADLLIAVLVFASVVGSVGSVIMNLRNRDN Q8JFP0_ICTPU Q8JFP0_ICTPU YFYSFWFSTLILTTVGDTPQPTREEEFLFMIADLLIAVLVFASVVGSVGSVIMNLRNRDN MATCH :.:::*: :**:*: * * : *: * : *:* .:: **:::*.:. :* . . CONSENSUS Y?Y??YWSTLTLTTIGETP?P??D?EY?F???DFL?GVLIFATIVGN?G?MI?NMNA??A

Q4SFA6_TETNG Q4SFA6_TETNG AFHNRVDVLKHYMQFRHVSKGLEQRIICWLDYIWTNQKTVDEQDVFRSLPTKLRAEIAIN B8JHY6_DANRE B8JHY6_DANRE QFQARIDNIKQYMHARHVSKELEDRVIKWFDYLWTNKKAQDEREVLRYLPDKLRAEIGMN Q3I0N0_MORSA Q3I0N0_MORSA QFQARIDNIKQYMQVRKVSKDLELRVIKWFDYLWNNGKAQDEREVLRYLPDKLKAEIAIQ Q4SDK7_TETNG Q4SDK7_TETNG QFQARIDNIKHYMQARKVSKDLELRVIKWFDYLWNNGKAQDEREVLRYLPDKLKAEIAIQ CNGA2_BOVIN CNGA2_BOVIN EFQAKIDAVKHYMQFRKVSKEMEAKVIRWFDYLWTNKKSVDEREVLKNLPAKLRAEIAIN B3KXY3_HUMAN B3KXY3_HUMAN EFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAIN CNGA2_HUMAN CNGA2_HUMAN EFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAIN CNGA2_RABIT CNGA2_RABIT EFQAKIDAVKHYMQFRKVSKEMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAIN CNGA2_RAT CNGA2_RAT EFQAKIDAVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAIN CNGA2_MOUSE CNGA2_MOUSE EFQAKIDAVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAIN Q80XH6_MOUSE Q80XH6_MOUSE EFQAKIDAVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAIN Q0GFG2_DANRE Q0GFG2_DANRE EFQGQIDAIKHYMKFRKVSKELEARVIKWFDYLWTNKKTIDEQDVLKNLPNKLRAEIAIN CNG_ICTPU CNG_ICTPU EFQTRIDAIKHYMHFRKVNRTLETRVIKWFDYLWTNKKTVDEQEVLKNLPDKLRAEIAIN Q4S8S3_TETNG Q4S8S3_TETNG EFQARIDAIKHYMHFRKVNKELETRVIKWFDYLWTNKKAVDEQEVLKNLPNKLRAEIAIN Q3I0N2_MORSA Q3I0N2_MORSA SFQARIDAIKQYMSFRKVTKDLEKRVIKWFDFLWTNKKAVDEREVLKYLPDKLRAEIAIN Q804I6_CARAU Q804I6_CARAU DFQARIDAIKQYMSFRKVTKDLEKRVIKWFDYLWTNKKAVDEREVLKYLPDKLRAEIAIN Q1L4A6_UTAST Q1L4A6_UTAST EFQARIDAIKQYMQFRNVSKDLEKRVIKWFDYLWTNKKAVDERKVLKFLPDKLRAEIAIN Q561K9_XENLA Q561K9_XENLA EFQGRIDAIKQYMHFRKVSKDLEKRVIKWFDYLWTNKKAVDEREVLKYLPDKLRAEIAIN CNG3_CHICK CNG3_CHICK EFQAKIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKAVDEREVLKYLPDKLRAEIAIN CNGA1_MOUSE CNGA1_MOUSE EFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAIN CNGA1_RAT CNGA1_RAT EFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAIN CNGA1_HUMAN CNGA1_HUMAN EFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAIN Q4W5E3_HUMAN Q4W5E3_HUMAN EFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAIN Q9N0H4_PIG Q9N0H4_PIG EFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAIN CNGA1_BOVIN CNGA1_BOVIN EFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLKYLPDKLRAEIAIN CNGA1_CANFA CNGA1_CANFA EFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAIN Q8UVT8_ONCMY Q8UVT8_ONCMY DFQAKIDSIKQFMQFRKVSKDLEARVIKWFDYLWTEKKTCDEKEVLKNLPDKLKAEIAID Q4RKX8_TETNG Q4RKX8_TETNG EFQAKIDSIKQYMQFRKVSKELEARVIKWFDYLWTEKKTCDEKEVLKNLPDKLKAEIAVN Q4S111_TETNG Q4S111_TETNG EFQAKIDSIKQYMQFRKVSKELEARVIKWFDYLWTEKKTCDEKEVLKNLPDKLKAEIAVN CNG1_CHICK CNG1_CHICK EFQAKVDSIKQYMHFRKVTKDLEARVIKWFDYLWTNKKTVDEKEVLKNLPDKLKAEIAIN Q1L2P6_UTAST Q1L2P6_UTAST EFQAKVDSIKQYLHFRKVTKDLEARVIKWFDYLWTNKKTVEEKEVLKYLPDKLKAEIAIN CNGA3_MOUSE CNGA3_MOUSE EFQAKIDSVKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAIN Q8CFV6_MOUSE Q8CFV6_MOUSE EFQAKIDSVKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAIN Q9ER32_RAT Q9ER32_RAT EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAIN Q9ER33_RAT Q9ER33_RAT EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAIN Q9QWN7_RAT Q9QWN7_RAT EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAIN CNGA3_BOVIN CNGA3_BOVIN EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAIN Q6ZNA7_HUMAN Q6ZNA7_HUMAN EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAIN CNGA3_HUMAN CNGA3_HUMAN EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAIN Q4VAP7_HUMAN Q4VAP7_HUMAN EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAIN CNGA4_HUMAN CNGA4_HUMAN AFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVS CNGA4_MOUSE CNGA4_MOUSE AFYPDHALVKKYMKLQHVNRRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVS CNGA4_RAT CNGA4_RAT AFYPDHALVKKYMKLQHVNKRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVS Q4SZ21_TETNG Q4SZ21_TETNG VFFPNHELVKAYLSSHHISKELRQRIDNWYQHLHINKKIIRENEILQELPLHLRTEIAVS B0V208_DANRE B0V208_DANRE VFFPDHELVKGYLRSHRISKELQKRVNDWYQHLHINKKITRENEILQHLPMTLQTATAVS Q8JFN9_ICTPU Q8JFN9_ICTPU VFFPNHELVRSYLRSRRINKALHNRVNTWYQHLHINKKITRENEILQQLPVTLQTAIAVS Q8JFP0_ICTPU Q8JFP0_ICTPU VFFPNHELVRSYLRSRRINKALHNRVNTWYQHLHINKKITRENEILQQLPVTLQTAIAVS MATCH * :: :: :.:.: :. :: * :.: : * * ::: ** *:: .:. CONSENSUS ?FQ???D??K?YM??R?V?K??E?RVI?WFDYLW?NKK??DE?EVL??LP?KL?AEIA??

Q4SFA6_TETNG Q4SFA6_TETNG VHLDTLKKVWIFQDWEAGLLVELVLKLQLQVFSPGDYICRKGDVGKEMYIIKDGKLAVVA B8JHY6_DANRE B8JHY6_DANRE VHLDTLKKVRIFADCEAGLLIELVLKLRPQVFSPGDYICRKGDIGREMYIIKDGKLAVVA Q3I0N0_MORSA Q3I0N0_MORSA VHMDTLKKVRIFADCEAGLLIELVLKLRPQVFSPGDYICKKGDIGREMYIIKDGKLAVVA Q4SDK7_TETNG Q4SDK7_TETNG VHMDTLKKVRIFSDCEAGLLIELVLKLRPQVFSPGDYICKKGDIGREMYIIKDGKLAVVA CNGA2_BOVIN CNGA2_BOVIN VHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVA B3KXY3_HUMAN B3KXY3_HUMAN VHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVA CNGA2_HUMAN CNGA2_HUMAN VHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVA CNGA2_RABIT CNGA2_RABIT VHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVA CNGA2_RAT CNGA2_RAT VHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVA CNGA2_MOUSE CNGA2_MOUSE VHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVA Q80XH6_MOUSE Q80XH6_MOUSE VHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVA Q0GFG2_DANRE Q0GFG2_DANRE VHLETLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGCLAVVA CNG_ICTPU CNG_ICTPU VHLDTLKKVRIFQDCEAGLLVELVLKLRPQVYSPGDYICRKGDIGKEMYIIKEGQLAVVA Q4S8S3_TETNG Q4S8S3_TETNG VHLETLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVA Q3I0N2_MORSA Q3I0N2_MORSA VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA Q804I6_CARAU Q804I6_CARAU VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA Q1L4A6_UTAST Q1L4A6_UTAST VHLETLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYVCRKGDIGREMYIIKEGKLAVVA Q561K9_XENLA Q561K9_XENLA VHLDTLKKVRIFADCEAGLLIELVLKLQPQVYSPGDYICRKGDIGREMYIIKEGKLAVVA CNG3_CHICK CNG3_CHICK VHLETLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICRKGDIGREMYIIKEGKLAVVA CNGA1_MOUSE CNGA1_MOUSE VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA CNGA1_RAT CNGA1_RAT VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA CNGA1_HUMAN CNGA1_HUMAN VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA Q4W5E3_HUMAN Q4W5E3_HUMAN VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA Q9N0H4_PIG Q9N0H4_PIG VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA CNGA1_BOVIN CNGA1_BOVIN VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA CNGA1_CANFA CNGA1_CANFA VHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVA Q8UVT8_ONCMY Q8UVT8_ONCMY VHLDTLKKVKIFQECEAGLLIELVMKLQPQVFSPGDYICKKGDIGREMYIIKEGKLAVVA Q4RKX8_TETNG Q4RKX8_TETNG VHLDTLKKVRIFQDCEAGLLIELVLKLQPQVFSPGDYICKKGDIGREMYIIKEGKLAVVA Q4S111_TETNG Q4S111_TETNG VHLDTLKKVRIFQDCEAGLLIELVLKLQPQVFSPGDYICKKGDIGREMYIIKEGKLAVVA CNG1_CHICK CNG1_CHICK VHLDTLKKVRIFQDCEAGLLIELVLKLKPTVFSPGDYICKKGDIGREMYIIKEGKLAVVA Q1L2P6_UTAST Q1L2P6_UTAST VHLDTLRKVRIFQDCEAGLLIELVLKLRPTVFSPGDYICKKGDIGREMYIIKEGKLAVVA CNGA3_MOUSE CNGA3_MOUSE VHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGREMYIIKEGKLAVVA Q8CFV6_MOUSE Q8CFV6_MOUSE VHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGREMYIIKEGKLAVVA Q9ER32_RAT Q9ER32_RAT VHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYIIKEGKLAVVA Q9ER33_RAT Q9ER33_RAT VHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYIIKEGKLAVVA Q9QWN7_RAT Q9QWN7_RAT VHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYIIKEGKLAVVA CNGA3_BOVIN CNGA3_BOVIN VHLDTLRKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYIIKEGKLAVVA Q6ZNA7_HUMAN Q6ZNA7_HUMAN VHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVA CNGA3_HUMAN CNGA3_HUMAN VHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVA Q4VAP7_HUMAN Q4VAP7_HUMAN VHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVA CNGA4_HUMAN CNGA4_HUMAN VHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVA CNGA4_MOUSE CNGA4_MOUSE VHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAVVA CNGA4_RAT CNGA4_RAT VHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAVVA Q4SZ21_TETNG Q4SZ21_TETNG VHLSTLSKVTIFHNCDRSLLEELVLKLTPQVFSPGEYVCKKGDVGHEMYIIKEGKLAVVA B0V208_DANRE B0V208_DANRE VHLPTLSKVTIFQNCENSLLEQLVLKLTPQVYSPGEYVCKKGDVGHEMYIIKEGKLAVVA Q8JFN9_ICTPU Q8JFN9_ICTPU VHLPILSKVTIFQNCESSLLEELVLKLTPQVYNPGEYVCRKGDVGHEMYIIKEGKLAVVA Q8JFP0_ICTPU Q8JFP0_ICTPU VHLPILSKVTIFQNCESSLLEELVLKLTPQVYNPGEYVCRKGDVGHEMYIIKEGKLAVVA MATCH **: * :* ** : : .** :**:** .:.**:*:*:***:*:*****.:* ***** CONSENSUS VHL?TLKKVRIF?DCEAGLL?ELVLKL?P?V?SPGDYIC?KGDIG?EMYIIKEGKLAVVA

Q4SFA6_TETNG Q4SFA6_TETNG EDGVTQLAVLTSGSCFGEISILNISGSKMGNRRTASIRSLGYSDLFCLSKHNLMDTLQEF B8JHY6_DANRE B8JHY6_DANRE DDGVTQFVVLGDGSYFGEISILNIKGSKAGNRRTANIRSIGYSDLFCLSKDDLMEALTEY Q3I0N0_MORSA Q3I0N0_MORSA DDGVAQFVVLGSGSYFGEISILNIKGSKAGNRRTANIRSIGYSDLFCLSKDDLMESLVEY Q4SDK7_TETNG Q4SDK7_TETNG DDGVTQFVVLGSGSYFGEISILNIKGSKAGNRRTANIRSIGYSDLFCLSKDDLMESLLEY CNGA2_BOVIN CNGA2_BOVIN DDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY B3KXY3_HUMAN B3KXY3_HUMAN DDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY CNGA2_HUMAN CNGA2_HUMAN DDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY CNGA2_RABIT CNGA2_RABIT DDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY CNGA2_RAT CNGA2_RAT DDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY CNGA2_MOUSE CNGA2_MOUSE DDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTGTIRSLGYSDLFCLSKDDLMEAVTEY Q80XH6_MOUSE Q80XH6_MOUSE DDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY Q0GFG2_DANRE Q0GFG2_DANRE DDGVTQYAHLTAGSCFGEISILNIRGSKMGNRRTANIRSIGYSDLFCLSKGDLMEAVMEY CNG_ICTPU CNG_ICTPU DDGVTQFALLTAGGCFGEISILNIQGSKMGNRRTANIRSIGYSDLFCLSKDDLMEAVAEY Q4S8S3_TETNG Q4S8S3_TETNG DDGVTQYALLTAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY Q3I0N2_MORSA Q3I0N2_MORSA DDGIKQFVVLSDGSYFGEISILAIKGSKAGNRRTANIRSIGYSDLFCLSKDDLMEALTEY Q804I6_CARAU Q804I6_CARAU DDGVTQFVVLSDGSYFGEISILNIKGSRAGNRRTANIRSIGYSDLFCLSKDDLMEALTEY Q1L4A6_UTAST Q1L4A6_UTAST DDGVTQYVVLSDGSYFGEISILNIKGSKAGNRRTANIRSIGYSDLFCLYKDDLMEALTEY Q561K9_XENLA Q561K9_XENLA DDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY CNG3_CHICK CNG3_CHICK DDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIRSIGYSDLFCLSKDDLMEALTEY CNGA1_MOUSE CNGA1_MOUSE DDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY CNGA1_RAT CNGA1_RAT DDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY CNGA1_HUMAN CNGA1_HUMAN DDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY Q4W5E3_HUMAN Q4W5E3_HUMAN DDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY Q9N0H4_PIG Q9N0H4_PIG DDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY CNGA1_BOVIN CNGA1_BOVIN DDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY CNGA1_CANFA CNGA1_CANFA DDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY Q8UVT8_ONCMY Q8UVT8_ONCMY EDGVTQWCVLSDGAYFGEISILGIKGSKAGNRRTANIRSVGYSDLFALSKDDLMEALTEY Q4RKX8_TETNG Q4RKX8_TETNG DDGVTQFVVLSDGAYFGEISILGIKGSKAGNRRTANIRSVGYSDLFALSKDDLMEALTEY Q4S111_TETNG Q4S111_TETNG DDGVTQFVVLSDGAYFGEISILGIKGSKAGNRRTANIRSVGYSDLFALSKDDLMEALTEY CNG1_CHICK CNG1_CHICK DDGITQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY Q1L2P6_UTAST Q1L2P6_UTAST DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIKSIGYSDLFCLSKDDLMEALTEY CNGA3_MOUSE CNGA3_MOUSE DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY Q8CFV6_MOUSE Q8CFV6_MOUSE DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY Q9ER32_RAT Q9ER32_RAT DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMETLTEY Q9ER33_RAT Q9ER33_RAT DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMETLTEY Q9QWN7_RAT Q9QWN7_RAT DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMETLTEY CNGA3_BOVIN CNGA3_BOVIN EDGITQFVVLGDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY Q6ZNA7_HUMAN Q6ZNA7_HUMAN DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY CNGA3_HUMAN CNGA3_HUMAN DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY Q4VAP7_HUMAN Q4VAP7_HUMAN DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY CNGA4_HUMAN CNGA4_HUMAN DDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEY CNGA4_MOUSE CNGA4_MOUSE DDGVTQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEY CNGA4_RAT CNGA4_RAT DDGVTQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEY Q4SZ21_TETNG Q4SZ21_TETNG DDGVTEFAVLSDGNFFGEISIINIKGNKSGNRRTANIRSIGHSDLFSLSKEDLTDVLSEF B0V208_DANRE B0V208_DANRE DDGVTQFAVLGDGNFFGEISILNIKGNKSGNRRTANIRSIGYSDLFSLSKEDLTETLLEY Q8JFN9_ICTPU Q8JFN9_ICTPU DDGVTQFAVLGDGNFFGEISILNIKGNKSGNRRTANIRSIGYSDLFSLSKEDLTDTLSEF Q8JFP0_ICTPU Q8JFP0_ICTPU DDGVTQFAVLGDGNFFGEISILNIKGNKSGNRRTANIRSIGYSDLFSLSKEDLTDTLSEF MATCH :**: : * * ******: * *. *****..*:*:*:****.* * :* : : *: CONSENSUS DDGVTQ???L??G??FGEISILNIKGSK?GNRRTANI?S?GYSDLFCLSKDDLME???EY

Q4SFA6_TETNG Q4SFA6_TETNG PEARAQLEQRGQDILQKEGLLENVNLTAGED----LEEKLEKLETSLDQLQTHVARLQSE B8JHY6_DANRE B8JHY6_DANRE PDAKAMLEEKGRQILLKDGLLELDPSKLKPDERD-LEDRVNRMYSTLQLMQTKVNKLLAQ Q3I0N0_MORSA Q3I0N0_MORSA PDAKGMLEEKGRQILMKDGLIDLDPANIMPEAKE-LEERVNKLYYTMELMQSKLKKILGN Q4SDK7_TETNG Q4SDK7_TETNG PDAKAMLEEKGRQILMKDGLLDLDPANIKPEAKE-LEEKVSKLYSTMELMQIKLKKILGK CNGA2_BOVIN CNGA2_BOVIN PDAKRVLEERGREILMKEGLLDENEVAASMEV-D-VQEKLEQLETNMDTLYTRFARLLAE B3KXY3_HUMAN B3KXY3_HUMAN PDAKKVLEERGREILMKEGLLDENEVATSMEV-D-VQEKLGQLETNMETLYTRFGRLLAE CNGA2_HUMAN CNGA2_HUMAN PDAKKVLEERGREILMKEGLLDENEVATSMEV-D-VQEKLGQLETNMETLYTRFGRLLAE CNGA2_RABIT CNGA2_RABIT PDAKKVLEERGREILMKEGLLDENEVAASMEV-D-VQEKLKQLETNMETLYTRFGRLLAE CNGA2_RAT CNGA2_RAT PDAKKVLEERGREILMKEGLLDENEVAASMEV-D-VQEKLEQLETNMDTLYTRFARLLAE CNGA2_MOUSE CNGA2_MOUSE PDAKKVLEERGREILMKEGLLDENEVAASMEV-D-VQEKLEQLETNMETLYTRFARLLAE Q80XH6_MOUSE Q80XH6_MOUSE PDAKKVLEERGREILMKEGLLDENEVAASMEV-D-VQEKLEQLETNMETLYTRFARLLAE Q0GFG2_DANRE Q0GFG2_DANRE PDAKKVLEEKGRQILIKEGLLEE-VEADGIGVED-IEKRVERMEDTIEILQTRFARLLAQ CNG_ICTPU CNG_ICTPU PDAQKVLEERGREILRKQGLLDESVAAGGLGVID-TEEKVERLDASLDILQTRFARLLGE Q4S8S3_TETNG Q4S8S3_TETNG PDAKTVLEERGRDILIKEGLLDENAESGGLQKED-TEEKVERLESSLDTLQTRFSRLLSE Q3I0N2_MORSA Q3I0N2_MORSA PDAKALLEEKGRQILMKDGLLDLEVAAQGPDPKE-IEEKVERMTSMLDVLQTRYARLLAQ Q804I6_CARAU Q804I6_CARAU LDAKAMLEEKGRQILMKDNLLDLELAKQGPDPKV-MEEKVIKIGSVLDDLQTRFARLLAE Q1L4A6_UTAST Q1L4A6_UTAST PDAKAMLEAKGKEILMKDGLLDLEAASGGRDPKD-IEEKVNHMEIMLDNLQVRFARLLAE Q561K9_XENLA Q561K9_XENLA PDAKAMLEEKGRQILMKDGLLDLDIANSGADPKD-IEEKVIHMEGLVENLQTKFARLLAE CNG3_CHICK CNG3_CHICK PDAKAMLEEKGKQILMKDGLLDIEVANLGSDPKD-LEEKVAYMEGSMDRLQTKFARLLAE CNGA1_MOUSE CNGA1_MOUSE PDAKTMLEEKGRQILMKDGLLDINIANMGSDPKD-LEEKVTRMEGSVDLLQTRFARILAE CNGA1_RAT CNGA1_RAT PDAKTMLEEKGRQILMKDGLLDINIANLGSDPKD-LEEKVTRMEGSVDLLQTRFARILAE CNGA1_HUMAN CNGA1_HUMAN PDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKD-LEEKVTRMEGSVDLLQTRFARILAE Q4W5E3_HUMAN Q4W5E3_HUMAN PDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKD-LEEKVTRMEGSVDLLQTRFARILAE Q9N0H4_PIG Q9N0H4_PIG PDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKD-LEEKVTRMEGSVDLLQTRFARILAE CNGA1_BOVIN CNGA1_BOVIN PDAKGMLEEKGKQILMKDGLLDINIANAGSDPKD-LEEKVTRMESSVDLLQTRFARILAE CNGA1_CANFA CNGA1_CANFA PDAKTMLEEKGKQILMKDGLLDINIANAGSDPKD-LEEKVTRMEGSVDLLQTRFARILAE Q8UVT8_ONCMY Q8UVT8_ONCMY PEAKKILEEKGKATLMKDNMIDEEIANAGADPKD-MEEKILRLESNMEIMTSKLAKIMAE Q4RKX8_TETNG Q4RKX8_TETNG PEAKKVLEEKGKAILMKDNLIDEAVANAGADPKD-TEEKIAKLQSNLDDMQNKLAKLMAE Q4S111_TETNG Q4S111_TETNG PEAKKVLEEKGKAILMKDNLIDEAVANAGADPKD-TEEKIAKLQSNLDDMQNKLAKLMAE CNG1_CHICK CNG1_CHICK PEAKKALEEKGRQILMKDNLIDEEAAKAGADPKD-LEEKIDRLETALDTLQTRFARLLAE Q1L2P6_UTAST Q1L2P6_UTAST PEAKKALEEKGRQILMKDNLIDEEAAKAGADPKD-LEEKIEKLESALDILQTRFARLLAE CNGA3_MOUSE CNGA3_MOUSE PDAKRALEEKGRQILMKDNLIDEDLVAARVDTRD-VEEKVEYLESSLDILQTRFARLLAE Q8CFV6_MOUSE Q8CFV6_MOUSE PDAKRALEEKGRQILMKDNLIDEDLVAARVDTRD-VEEKVEYLESSLDILQTRFARLLAE Q9ER32_RAT Q9ER32_RAT PDAKRALEEKGRQILMKDNLIDDDLVTARADARN-IEEKVEYLESSLDGLQTRFARLLAE Q9ER33_RAT Q9ER33_RAT PDAKRALEEKGRQILMKDNLIDDDLVTARADARN-IEEKVEYLESSLDGLQTRFARLLAE Q9QWN7_RAT Q9QWN7_RAT PDAKRALEEKGRQILMKDNLIDDDLVTARADARN-IEEKVEYLESSLDGLQTRFARLLAE CNGA3_BOVIN CNGA3_BOVIN PEAKKALEEKGRQILMKDNLIDEELAKAGADPKD-IEEKVEHLETSLDSLQTRFARLLAE Q6ZNA7_HUMAN Q6ZNA7_HUMAN PEAKKALEEKGRQILMKDNLIDEELARAGADPKD-LEEKVEQLGSSLDTLQTRFARLLAE CNGA3_HUMAN CNGA3_HUMAN PEAKKALEEKGRQILMKDNLIDEELARAGADPKD-LEEKVEQLGSSLDTLQTRFARLLAE Q4VAP7_HUMAN Q4VAP7_HUMAN PEAKKALEEKGRQILMKDNLIDEELARAGADPKD-LEEKVEQLGSSLDTLQTRFARLLAE CNGA4_HUMAN CNGA4_HUMAN PQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLDDLQTKFARLLAE CNGA4_MOUSE CNGA4_MOUSE PQAQAVMEEKGREILLKMNKLDVNAEAAEIALQEATESRLKGLDQQLDDLQTKFARLLAE CNGA4_RAT CNGA4_RAT PQAQAVMEEKGREILLKMNKLDVNAEAAEIALQEATESRLKGLDQQLDDLQTKFARLLAE Q4SZ21_TETNG Q4SZ21_TETNG PAAKRHLKEKGRQILTKMGMLEYNGEVGEGEAAT-VETKINNLQSNLESLHTKLARLMVE B0V208_DANRE B0V208_DANRE PAAKRLLEEKGRQILTKMGMLEEAVEGEG-EVEK-TEDKVNRLEGILEMLQTKLARLIAE Q8JFN9_ICTPU Q8JFN9_ICTPU PAAKRLLEEKGRQILTKMGMLE--ISDEGEEEKEKLEDKVERIESSLETLQTKLARLMVE Q8JFP0_ICTPU Q8JFP0_ICTPU PAAKRLLEEKGRQILTKMGMLE--ISDEGEEEKEKLEDKVERIESSLETLQTKLARLMVE MATCH *: :: :*: * * . :: : :: : :: : : :: : CONSENSUS P?AK??LEE?G??IL?K??L?D??????????????EEK??????????LQT??AR?LAE

Q4SFA6_TETNG Q4SFA6_TETNG FASSQLQLKQRISVLENN------------------------------------------ B8JHY6_DANRE B8JHY6_DANRE QEETRKSIRRRIIEIERFVGEVVEDEEEEEKEETEAE----------KKEEEPEKERIEE Q3I0N0_MORSA Q3I0N0_MORSA YKKSDKVLRHRIHDLEELTGEEVEDEDDEEEEVKKEEKVVEEEKKEDEEMKEKEEEEKGE Q4SDK7_TETNG Q4SDK7_TETNG HKDADKVLKQRIADLERRL----------------------------------------- CNGA2_BOVIN CNGA2_BOVIN YTGAQQKLKQRITVLETKMKQNNEDDSLS------------------DGMNSPEPPAEKP B3KXY3_HUMAN B3KXY3_HUMAN YTGAQQKLKQRITVLETKMKQNNEDDYLS------------------DGMNSPELAAADE CNGA2_HUMAN CNGA2_HUMAN YTGAQQKLKQRITVLETKMKQNNEDDYLS------------------DGMNSPELAAADE CNGA2_RABIT CNGA2_RABIT YTGAQQKLKQRITVLEVKMKQNTEDDYLS------------------DGMNSPEPAAAEQ CNGA2_RAT CNGA2_RAT YTGAQQKLKQRITVLETKMKQNHEDDYLS------------------DGINTPEPTAAE- CNGA2_MOUSE CNGA2_MOUSE YTGAQQKLKQRITVLETKMKQNHEDDYLS------------------DGINTPEPAVAE- Q80XH6_MOUSE Q80XH6_MOUSE YTGAQQKLKQRITVLETKMKQNHEDDYLS------------------DGINTPEPAVAE- Q0GFG2_DANRE Q0GFG2_DANRE YTATQQHLKQRLTTLECRTNHSGSGFLSDGN----------------ESTIDGDGTNSEV CNG_ICTPU CNG_ICTPU FTSTQRRLKQRITALERQLCHTGLGLLSDNEA---------------EGEHAGVPTHTHA Q4S8S3_TETNG Q4S8S3_TETNG YTHTQQRLKQRITLLERQLNQTDC------------------------------------ Q3I0N2_MORSA Q3I0N2_MORSA HDATHSKLKHRVARLEKKLV---------------------------PPPPTPETQMGE- Q804I6_CARAU Q804I6_CARAU HEAAQGKLKKRITKLEKKITDSSGVALS-------------------EMLDPELVTAKKE Q1L4A6_UTAST Q1L4A6_UTAST YDAAQQKLKTRLTEVENILKPPTDFDF--------------------SNLEEAEIVPGQ- Q561K9_XENLA Q561K9_XENLA YDSAQQKLKQRVSKIEKIIKPETEAVETAMEETK-------------DEAEAPPPSKE-- CNG3_CHICK CNG3_CHICK YDAAQQKLKKRLTQIEKILKPVMEQEFLDF-----------------EEADPPTDKPGVT CNGA1_MOUSE CNGA1_MOUSE YESMQQKLKQRLTKVEKFLKPLIETEFSALEEP--------------GGESELTESLQD- CNGA1_RAT CNGA1_RAT YESMQQKLKQRLTKVEKFLKPLIETEFSALEEP--------------GGESEPTESLQG- CNGA1_HUMAN CNGA1_HUMAN YESMQQKLKQRLTKVEKFLKPLIDTEFSSI-----------------EGPGAESGPIDST Q4W5E3_HUMAN Q4W5E3_HUMAN YESMQQKLKQRLTKVEKFLKPLIDTEFSSI-----------------EGPGAESGPIDST Q9N0H4_PIG Q9N0H4_PIG YESMQQKLKQRLTKVEKFLKPLIDTEFSSI-----------------EGPGAESGPIDST CNGA1_BOVIN CNGA1_BOVIN YESMQQKLKQRLTKVEKFLKPLIDTEFSAI-----------------EGSGTESGPTDST CNGA1_CANFA CNGA1_CANFA YESMQQKLKQRLTKVERFLKPIIDTEFSAL-----------------EGTGDESRPLDST Q8UVT8_ONCMY Q8UVT8_ONCMY FTSGQGKIKQRITDMESTVKSV-------------------------RPEDISEVVADK- Q4RKX8_TETNG Q4RKX8_TETNG MTSNHTRIKQRVTQMEAKVKS--------------------------------------- Q4S111_TETNG Q4S111_TETNG MTSNHTRIKQRVTQMEAKVKS--------------------------------------- CNG1_CHICK CNG1_CHICK YSSSQQKVKQRLARVETRVKKYGSGSLS-------------------VGEPEPEKPEEQK Q1L2P6_UTAST Q1L2P6_UTAST YTAAQSKVKQRLVKVETKVKKYGSGNLSG------------------DEEKPAEEKKD-- CNGA3_MOUSE CNGA3_MOUSE YSASQMKLKQRLTRLESQMNRRCCGFSP-------------------DRENSEDASKTD- Q8CFV6_MOUSE Q8CFV6_MOUSE YSASQMKLKQRLTRLESQMNRRCCGFSP-------------------DRENSEDASKTD- Q9ER32_RAT Q9ER32_RAT YSASQMKLKQRLSQLESQMTRRGHGFSP-------------------DRENSEDASKAD- Q9ER33_RAT Q9ER33_RAT YSASQMKLKQRLSQLESQMTRRGHGFSP-------------------DRENSEDASKAD- Q9QWN7_RAT Q9QWN7_RAT YSASQMKLKQRLSQLESQMTRRGHGFSP-------------------DRENSEDASKAD- CNGA3_BOVIN CNGA3_BOVIN YNATQMKVKQRLSQLESQVKMGLPP----------------------DGDAPQTEASQP- Q6ZNA7_HUMAN Q6ZNA7_HUMAN YNATQMKMKQRLSQLESQVKGGGDKPLA-------------------DGEVPGDATKTED CNGA3_HUMAN CNGA3_HUMAN YNATQMKMKQRLSQLESQVKGGGDKPLA-------------------DGEVPGDATKTED Q4VAP7_HUMAN Q4VAP7_HUMAN YNATQMKMKQRLSQLESQVKGGGDKPLA-------------------DGEVPGDATKTED CNGA4_HUMAN CNGA4_HUMAN LESSALKIAYRIERLEWQTREWPMPEDLAEAD---------------DEGVPEEGTSKDE CNGA4_MOUSE CNGA4_MOUSE LESSALKIAYRIERLEWQTREWPMPDDMGEAD---------------DEAEPGEGTSKDG CNGA4_RAT CNGA4_RAT LESSALKIAYRIERLEWQTREWPMPEDMGEAD---------------DEAEPGEGTSKDG Q4SZ21_TETNG Q4SZ21_TETNG LESSNVKMQARVEQLELEVA---------------------------------------- B0V208_DANRE B0V208_DANRE LESSARKMMQRVDQLELQTEGWEGIVAEGAQVEIEERAKIKEREIG-DGEGEGEREKEDK Q8JFN9_ICTPU Q8JFN9_ICTPU LESSVRKMMGRVEQLELQTDGWEGIVAEGAGSESDDETERKRDVGDGEGEQEEEPQEERG Q8JFP0_ICTPU Q8JFP0_ICTPU LESSVRKMMGRVEQLELQTDGWEGIVAEGAGSESDDETERKRDVGDGEGEQEEEPQEERG MATCH : *: :* CONSENSUS ??????K?K?R????E????????????????????????????????????????????

Q4SFA6_TETNG Q4SFA6_TETNG ------------------------------------------------------- B8JHY6_DANRE B8JHY6_DANRE EKEKEEKKEEEKTKEVTGEEEKREEP----------------------------- Q3I0N0_MORSA Q3I0N0_MORSA ETKDEEGMGEEAKEEEKKDEEK--------------------------------- Q4SDK7_TETNG Q4SDK7_TETNG ------------------------------------------------------- CNGA2_BOVIN CNGA2_BOVIN ------------------------------------------------------- B3KXY3_HUMAN B3KXY3_HUMAN P------------------------------------------------------ CNGA2_HUMAN CNGA2_HUMAN P------------------------------------------------------ CNGA2_RABIT CNGA2_RABIT P------------------------------------------------------ CNGA2_RAT CNGA2_RAT ------------------------------------------------------- CNGA2_MOUSE CNGA2_MOUSE ------------------------------------------------------- Q80XH6_MOUSE Q80XH6_MOUSE ------------------------------------------------------- Q0GFG2_DANRE Q0GFG2_DANRE NIHL--------------------------------------------------- CNG_ICTPU CNG_ICTPU DIHAQPETHTRTSAETNSEEET--------------------------------- Q4S8S3_TETNG Q4S8S3_TETNG ------------------------------------------------------- Q3I0N2_MORSA Q3I0N2_MORSA ------------------------------------------------------- Q804I6_CARAU Q804I6_CARAU EKE---------------------------------------------------- Q1L4A6_UTAST Q1L4A6_UTAST ------------------------------------------------------- Q561K9_XENLA Q561K9_XENLA ------------------------------------------------------- CNG3_CHICK CNG3_CHICK KTE---------------------------------------------------- CNGA1_MOUSE CNGA1_MOUSE ------------------------------------------------------- CNGA1_RAT CNGA1_RAT ------------------------------------------------------- CNGA1_HUMAN CNGA1_HUMAN ------------------------------------------------------- Q4W5E3_HUMAN Q4W5E3_HUMAN ------------------------------------------------------- Q9N0H4_PIG Q9N0H4_PIG ------------------------------------------------------- CNGA1_BOVIN CNGA1_BOVIN QD----------------------------------------------------- CNGA1_CANFA CNGA1_CANFA QD----------------------------------------------------- Q8UVT8_ONCMY Q8UVT8_ONCMY ------------------------------------------------------- Q4RKX8_TETNG Q4RKX8_TETNG ------------------------------------------------------- Q4S111_TETNG Q4S111_TETNG ------------------------------------------------------- CNG1_CHICK CNG1_CHICK KD----------------------------------------------------- Q1L2P6_UTAST Q1L2P6_UTAST ------------------------------------------------------- CNGA3_MOUSE CNGA3_MOUSE ------------------------------------------------------- Q8CFV6_MOUSE Q8CFV6_MOUSE ------------------------------------------------------- Q9ER32_RAT Q9ER32_RAT ------------------------------------------------------- Q9ER33_RAT Q9ER33_RAT ------------------------------------------------------- Q9QWN7_RAT Q9QWN7_RAT ------------------------------------------------------- CNGA3_BOVIN CNGA3_BOVIN ------------------------------------------------------- Q6ZNA7_HUMAN Q6ZNA7_HUMAN KQQ---------------------------------------------------- CNGA3_HUMAN CNGA3_HUMAN KQQ---------------------------------------------------- Q4VAP7_HUMAN Q4VAP7_HUMAN KQQ---------------------------------------------------- CNGA4_HUMAN CNGA4_HUMAN EGRASQEGPPGPE------------------------------------------ CNGA4_MOUSE CNGA4_MOUSE EEKAGQEGPSGLE------------------------------------------ CNGA4_RAT CNGA4_RAT EGKAGQAGPSGIE------------------------------------------ Q4SZ21_TETNG Q4SZ21_TETNG ------------------------------------------------------- B0V208_DANRE B0V208_DANRE EEPLVEGERGEGDGGEESLGEKDKNVGGNEINEEEKEEKEIIKTETQQDEKEDEK Q8JFN9_ICTPU Q8JFN9_ICTPU EGDGGEEDKDEGKDVK--------------------------------------- Q8JFP0_ICTPU Q8JFP0_ICTPU EGDGGEEDKDEGKDVK--------------------------------------- MATCH CONSENSUS ???????????????????????????????????????????????????????


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