Alignment of the gene Family HBG000325 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q28D23_XENTR Q28D23_XENTR ------MTSLQRKLPEWMSVQQKEDSIDDKKKSLWKKNIVEDNLPYLKFNGSIVYSYEGN Q6GPM6_XENLA Q6GPM6_XENLA ------MTSLQRKLPEWMSVKQQEDRIDDAKKSFCKKNILEDNLPFMKFNGSIVYSYESN WRN_XENLA WRN_XENLA ------MTSLQRKLPEWMSVKQQEDRIDDAKKSFCKKNILEDNLPFMKFNGSIVYSYESN WRN_MOUSE WRN_MOUSE ----METTSLQRKFPEWMSMQSQRCATEE-KACV-QKSVLEDNLPFLEFPGSIVYSYEAS Q3TB25_MOUSE Q3TB25_MOUSE ----METTSLQRKFPEWMSMQSQRCATEE-KACV-QKSVLEDNLPFLEFPGSIVYSYEAS Q80YP9_MOUSE Q80YP9_MOUSE ----METTSLQRKFPEWMSMQSQRCATEE-KACV-QKSVLEDNLPFLEFPGSIVYSYEAS Q5RDV4_PONAB Q5RDV4_PONAB SEKKLETTPQQRKCPEWMNAQNKRCAVEERKACV-RKSVFEDDLPFLEFTGSIVYSYDAS Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACV-RKSVFEDDLPFLEFTGSIVYSYDAS MATCH CONSENSUS ???????T??QRK?PEWM????????????K?????K???ED?LP???F?GSIVYSY???

Q28D23_XENTR Q28D23_XENTR DCSLLSEDIRSSLQEEDVLGFDIEWPPIYTKGKTGKVALIQVCVSEKKCYLFHISPMAGF Q6GPM6_XENLA Q6GPM6_XENLA DCSLLSEDIRSSLLEEDVLGFDIEWPPVYTKGKTGKVALIQVCVSEKKCYLFHISPMAGF WRN_XENLA WRN_XENLA DCSLLSEDIRSSLLEEDVLGFDIEWPPVYTKGKTGKVALIQVCVSEKKCYLFHISPMAGF WRN_MOUSE WRN_MOUSE DCSFLSEDISMRLSDGDVVGFDMEWPPIYKPGKRSRVAVIQLCVSENKCYLFHISSMSVF Q3TB25_MOUSE Q3TB25_MOUSE DCSFLSEDISMRLSDGDVVGFDMEWPPIYKPGKRSRVAVIQLCVSESKCYLFHISSMSVF Q80YP9_MOUSE Q80YP9_MOUSE DCSFLSEDISMRLSDGDVVGFDMEWPPIYKPGKRSRVAVIQLCVSESKCYLFHISSMSVF Q5RDV4_PONAB Q5RDV4_PONAB DCSFLSEDISMSLSDGDVVGFDMEWPPLYKKRKLGKVALIQLCVSESKCYLFHISSMSVF Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF MATCH CONSENSUS DCS?LSEDI???L???DV?GFD?EWPP?Y???K???VA?IQ?CVSE?KCYLFH?S?M??F

Q28D23_XENTR Q28D23_XENTR PKGLRRLLEDESVKKVGVGIEGDQWKLMSDYELKLKGFIELSEVANQKLRCKEKWSLNGL Q6GPM6_XENLA Q6GPM6_XENLA PKGLKRLLEDESVRKVGVGIEGDQWKLMSDYELKLKGFIELSEMANQKLRCKEKWSLNGL WRN_XENLA WRN_XENLA PKGLKRLLEDESVRKVGVGIEGDQWKLMSDYELKLKGFIELSEMANQKLRCKEKWTFNGL WRN_MOUSE WRN_MOUSE PQGLKMLLENKSIKKAGVGIEGDQWKLLRDFDVKLESFVELTDVANEKLKCAETWSLNGL Q3TB25_MOUSE Q3TB25_MOUSE PQGLKMLLENKSIKKAGVGIEGDQWKLLRDFDVKLESFVELTDVANEKLKCAETWSLNGL Q80YP9_MOUSE Q80YP9_MOUSE PQGLKMLLENKSIKKAGVGIEGDQWKLLRDFDVKLESFVELTDVANEKLKCAETWSLNGL Q5RDV4_PONAB Q5RDV4_PONAB PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELADVANKKLKCTETWSLNSL Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL MATCH CONSENSUS P?GL??LLE?????K?GVGIEGDQWKL??D???KL??F?EL???AN?KL?C?E?W??N?L

Q28D23_XENTR Q28D23_XENTR VKHLFKKQLLKDSSIRCSNWDIFPLSTDQKLYAASDAYAGLLIYQKLECMDAHEKVSFCV Q6GPM6_XENLA Q6GPM6_XENLA IKHLFKEQLIKESSVRCSNWDIFPLTEDQKLYAATDAYAGLLIYKKLEGMDAHESDSFRV WRN_XENLA WRN_XENLA IKHLFKEQLYKRKSYRCSNWDIFLLTEDQKLYAATDAYAGLLIYKKLEGMDAHESDSFRV WRN_MOUSE WRN_MOUSE VKHVLGKQLLKDKSIRCSNWSNFPLTEDQKLYAATDAYAGLIIYQKLGNLGDTVQV-FAL Q3TB25_MOUSE Q3TB25_MOUSE VKHVLGKQLLKDKSIRCSNWSNFPLTEDQKLYAATDAYAGLIIYQKLGNLGDTAQV-FAL Q80YP9_MOUSE Q80YP9_MOUSE VKHVLGKQLLKDKSIRCSNWSNFPLTEDQKLYAATDAYAGLIIYQKLGNLGDTAQV-FAL Q5RDV4_PONAB Q5RDV4_PONAB VKHPLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQR-FAI Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQR-FAI MATCH CONSENSUS ?KH????QL?K??S?RCSNW??F?L??DQKLYAA?DAYAG??IY??L??????????F??

Q28D23_XENTR Q28D23_XENTR SR-------GIKRQLTDLSNGFMDLVKDVPSSFGHSTGALRAVAILEDLSEKLEELRSIV Q6GPM6_XENLA Q6GPM6_XENLA GREGVADCKGVKRQLTDLSKGLMDLVNQVPNSFGCYTEAVRAVDILEDLSEKLEELRNIM WRN_XENLA WRN_XENLA GREGVADCKGVKRQLTDLSKGLMDLVNQVPNSFGCYTEAVRAVDILEDLSEKLEELRNIM WRN_MOUSE WRN_MOUSE NKAEENLPLEMKKQLNLISEEMRDLANRFPVTCRNLETLQRVPVILKSISENLCSLRKVI Q3TB25_MOUSE Q3TB25_MOUSE NKAEENLPLEMKKQLNSISEEMRDLANRFPVTCRNLETLQRVPVILKSISENLCSLRKVI Q80YP9_MOUSE Q80YP9_MOUSE NKAEENLPLEMKKQLNSISEEMRDLANRFPVTCRNLETLQRVPVILKSISENLCSLRKVI Q5RDV4_PONAB Q5RDV4_PONAB NKEEEILLSNMNKQLTSISEEVMDLAKHLPDAFSKLENPRRVSILLKDISENLYSLRKMI Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN NKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMI MATCH CONSENSUS ?????????????QL???S????DL????P??????????R????L???SE?L??LR???

Q28D23_XENTR Q28D23_XENTR KEASKGE-----GNGLLCHDSEDCSEEDKYQSINLASKELLAE----------------- Q6GPM6_XENLA Q6GPM6_XENLA KEASKAE-----GNGLHFQNSEDCSKKDK-SILHVACKESLAE----------------- WRN_XENLA WRN_XENLA KEASKAE-----GNGLHFQNSEDCSKKDK-SILHVACKESLAE----------------- WRN_MOUSE WRN_MOUSE CGPTNTETRLKPGSSFNLLSSEDSAAAGE-KEKQIGKHSTFAKIKEEPWDPELDSLVKQE Q3TB25_MOUSE Q3TB25_MOUSE CGPTNTETRLKPGSSFNLLSSEDSAAAGE-KEKQIGKHSTFAKIKEEPWDPELDSLVKQE Q80YP9_MOUSE Q80YP9_MOUSE CGPTNTETRLKPGSSFNLLSSEDSAAAGE-KEKQIGKHSTFAKIKEEPWDPELDSLVKQE Q5RDV4_PONAB Q5RDV4_PONAB IGSTNIETELRPSNNLNLLSFEDSTTGRV-QQKQIREHEVLINVEDETWDPTLDHLAKHD Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN IGSTNIETELRPSNNLNLLSFEDSTTGGV-QQKQIREHEVLIHVEDETWDPTLDHLAKHD MATCH CONSENSUS ??????E??????????????ED?????????????????????????????????????

Q28D23_XENTR Q28D23_XENTR ------NKIDYKNAESKNNKDVDCCQNENMKQDFL---GISEEELYMMERKDDENQIKP- Q6GPM6_XENLA Q6GPM6_XENLA ------HKMDCKNADSQNNKDIDSCQNENRDEDFFMTLGISEEELYMMEREDDKKQTNP- WRN_XENLA WRN_XENLA ------HKMDCKNADSQNNKDIDSCQNENRDEDFFMTLGISEEELYMMEREDDKKQTNP- WRN_MOUSE WRN_MOUSE EVDVFRNQVKQEKGESENEIE-DNLLREDMERTCVIP-SISENELQDLEQQAKEEKYNDV Q3TB25_MOUSE Q3TB25_MOUSE EVDVFRNQVKQEKGESENEIE-DNLLREDMERTCVIP-SISENELQDLEQQAKEEKYNDV Q80YP9_MOUSE Q80YP9_MOUSE EVDVFRNQVKQEKGESENEIE-DNLLREDMERTCVIP-SISENELQDLEQQAKEEKYNDV Q5RDV4_PONAB Q5RDV4_PONAB GEDVLGNKVERKEDGFEDGVE-DNKLKENTERACLMSLDITEHELQILEQQAQEEYLSDI Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN GEDVLGNKVERKEDGFEDGVE-DNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDI MATCH CONSENSUS ??????????????????????D????E???????????I?E?EL???E???????????

Q28D23_XENTR Q28D23_XENTR GQKSNEHLYDTNEEKNMSY----------------------------------------- Q6GPM6_XENLA Q6GPM6_XENLA DYKLNKDSCDTNEEKDMSY----------------------------------------- WRN_XENLA WRN_XENLA DYKLNKDSCDTNEEKDMSY----------------------------------------- WRN_MOUSE WRN_MOUSE SHQLSEHLSPNDDENDSSY----------------------------------------- Q3TB25_MOUSE Q3TB25_MOUSE SHQLSEHLSPNDDENDSSY----------------------------------------- Q80YP9_MOUSE Q80YP9_MOUSE SHQLSEHLSPNDDENDSSY----------------------------------------- Q5RDV4_PONAB Q5RDV4_PONAB AYKSTEHLSPNNNENDTSYVIESDEDLEMEMLKHLSPNNNENDTSYVIESDEDLEMEMLK Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN AYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSY-------------- MATCH CONSENSUS ?????????????E???SY?????????????????????????????????????????

Q28D23_XENTR Q28D23_XENTR ----------------------------------------IIESDEEFESEIIKSLEDLD Q6GPM6_XENLA Q6GPM6_XENLA ----------------------------------------VIESDEDFDSEIIKSLEDLD WRN_XENLA WRN_XENLA ----------------------------------------VIESDEDFDSEIIKSLEDLD WRN_MOUSE WRN_MOUSE ----------------------------------------IIESDEDLEMEMLKSLENLN Q3TB25_MOUSE Q3TB25_MOUSE ----------------------------------------IIESDEDLEMEMLKSLENLN Q80YP9_MOUSE Q80YP9_MOUSE ----------------------------------------IIESDEDLEMEMLKSLENLN Q5RDV4_PONAB Q5RDV4_PONAB HLSPNNNENDTSHVIESDEDLEMEMLKHLSPNNNENDTSHVIESDEDLEMEMLKSLENLN Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN ----------------------------------------VIESDEDLEMEMLKSLENLN MATCH CONSENSUS ?????????????????????????????????????????IESDE????E??KSLE?L?

Q28D23_XENTR Q28D23_XENTR NSIEEAIGTS---VHQTGLIPAKSVDTVADEEEDEGIEEEDDDDDWDPSIPEPNAEQVSC Q6GPM6_XENLA Q6GPM6_XENLA NSTEEALGTG---VPQAGLIPAKSVDTVADEEEDEGIEEEDDDDDWDPSMPEPSAQHISC WRN_XENLA WRN_XENLA NSTEEALGTG---VPQAGLIPAKSVDTVADEEEDEGIEEEDDDDDWDPSMPEPSAQHISC WRN_MOUSE WRN_MOUSE SDMVEPTHSKWLEMGTNGCLPPEE----EDGHGNEAIKEEQEEEDH--LLPEPNAKQINC Q3TB25_MOUSE Q3TB25_MOUSE SDVVEPTHSTWLEMGTNGRLPPEE----EDGHGNEAIKEEQEEEDH--LLPEPNAKQINC Q80YP9_MOUSE Q80YP9_MOUSE SDVVEPTHSTWLEMGTNGRLPPEE----EDGHGNEAIKEEQEEEDH--LLPEPNAKQINC Q5RDV4_PONAB Q5RDV4_PONAB SGTVEPTHSKCLKMERNLGLPTKE----EEDDDENEANEEEKDDDKDSLLPAPNEEQVTC Q59F09_HUMAN Q59F09_HUMAN ------------------------------------------------------------ WRN_HUMAN WRN_HUMAN SGTVEPTHSKCLKMERNLGLPTKE----EEEDDENEANEGEEDDDKDFLWPAPNEEQVTC MATCH CONSENSUS ????E???????????????P?????????????????E?????D?????P?P??????C

Q28D23_XENTR Q28D23_XENTR LKTYFGHSSFKPVQWKVIHSVLRERRDNLVVMATGYGKSLCYQFAPVYTSGIGIVICPLI Q6GPM6_XENLA Q6GPM6_XENLA LKTYFGHSSFKPVQWKVVHSVLRERRDNLVVMATGYGKSLCYQFAPVYTSGIGIVICPLI WRN_XENLA WRN_XENLA LKTYFGHSSFKPVQWKVVHSVLRERRDNLVVMATGYGKSLCYQFAPVYTSGIGIVICPLI WRN_MOUSE WRN_MOUSE LKTYFGHSSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYTGKIGIVISPLI Q3TB25_MOUSE Q3TB25_MOUSE LKTYFGHSSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYTGKIGIVISPLI Q80YP9_MOUSE Q80YP9_MOUSE LKTYFGHSSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPVYTGKIGIVISPLI Q5RDV4_PONAB Q5RDV4_PONAB LKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLI Q59F09_HUMAN Q59F09_HUMAN ---------------------------------------------------IGLVISPLI WRN_HUMAN WRN_HUMAN LKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLI MATCH **:**.*** CONSENSUS LK?YFGHSSFKPVQWKV?HSVL?ERRDN??VMATGYGKSLC?Q??PVY???IG?VI?PLI

Q28D23_XENTR Q28D23_XENTR SLMEDQVLQLEMSNIPSCFLGSAQSKNVLQDVKAGRMRVIYMTPEFCSGGISLLQDLDNR Q6GPM6_XENLA Q6GPM6_XENLA SLMEDQVLQLEMSNISSCFLGSAQSKNVLQDVKDGKMRVIYMTPEFCSRGISLLQDLDNR WRN_XENLA WRN_XENLA SLMEDQVLQLEMSNISSCFLGSAQSKNVLQDVKDGKMRVIYMTPEFCSRGISLLQDLDNR WRN_MOUSE WRN_MOUSE SLMEDQVLQLELSNVPACLLGSAQSKNILGDVKLGKYRVIYITPEFCSGNLDLLQKLDSS Q3TB25_MOUSE Q3TB25_MOUSE SLMEDQVLQLELSNVPACLLGSAQSKNILGDVKLGKYRVIYITPEFCSGNLDLLQQLDSS Q80YP9_MOUSE Q80YP9_MOUSE SLMEDQVLQLELSNVPACLLGSAQSKNILGDVKLGKYRVIYITPEFCSGNLDLLQQLDSS Q5RDV4_PONAB Q5RDV4_PONAB SLMEDQVLQLKMSNVPACFLGSAQSENVLTDIKLGKYRIVYITPEYCSGNMGLLQQLEAD Q59F09_HUMAN Q59F09_HUMAN SLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEAD WRN_HUMAN WRN_HUMAN SLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEAD MATCH **********::**:.:*:******:*:* *:* *: *::*:***:** .:.***.*: CONSENSUS SLMEDQVLQL??SN???C?LGSAQS?N?L?D?K?GK?R??Y?TPE?CS????LLQ?L???

Q28D23_XENTR Q28D23_XENTR YGITLIAIDEAHCISEWGHDFRSAYRSLGSLKRMLPTVPIVALTATASPSIREDISKSLS Q6GPM6_XENLA Q6GPM6_XENLA YGITLIAIDEAHCISEWGHDFRSAYRSLGSLKRMLPNVPIVALTATASPSIREDITKSLN WRN_XENLA WRN_XENLA YGITLIAIDEAHCISEWGHDFRSAYRSLGSLKRMLPNVPIVALTATASPSIREDITKSLN WRN_MOUSE WRN_MOUSE IGITLIAVDEAHCISEWGHDFRSSFRMLGSLKTALPLVPVIALSATASSSIREDIISCLN Q3TB25_MOUSE Q3TB25_MOUSE IGITLIAVDEAHCISEWGHDFRSSFRMLGSLKTALPLVPVIALSATASSSIREDIISCLN Q80YP9_MOUSE Q80YP9_MOUSE IGITLIAVDEAHCISEWGHDFRSSFRMLGSLKTALPLVPVIALSATASSSIREDIISCLN Q5RDV4_PONAB Q5RDV4_PONAB IGITLIAVDEAHCISEWGHDFRNSFRKLGSLKTALPMVPIVALTATASSSIQEDIVRCLN Q59F09_HUMAN Q59F09_HUMAN IGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLN WRN_HUMAN WRN_HUMAN IGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLN MATCH ******:**************.::* ***** ** **::**:****.**:*** .*. CONSENSUS ?GITLIA?DEAHCISEWGHDFR???R?LGSLK??LP?VP??AL?ATAS?SIREDI???LN

Q28D23_XENTR Q28D23_XENTR LHNPQITCTSFDRPNLYLDVAKKTTNISTDLQQFLIKK-QGSGWEFEGATIVYCPTRKTS Q6GPM6_XENLA Q6GPM6_XENLA LHNPQVTCTSFDRPNLYLDVARKTTNISIDLRQFLIKKQQGSGWEFEGATIVYCPTRKTS WRN_XENLA WRN_XENLA LHNPQVTCTSFDRPNLYLDVARKTTNISIDLRQFLIKKQQGSGWEFEGATIVYCPTRKTS WRN_MOUSE WRN_MOUSE LKDPQITCTGFDRPNLYLEVGRKTGNILQDLKPFLVRK-ASSAWEFEGPTIIYCPSRKMT Q3TB25_MOUSE Q3TB25_MOUSE LKDPQITCTGFDRPNLYLEVGRKTGNILQDLKPFLVRK-ASSAWEFEGPTIIYCPSRKMT Q80YP9_MOUSE Q80YP9_MOUSE LKDPQITCTGFDRPNLYLEVGRKTGNILQDLKPFLVRK-ASSAWEFEGPTIIYCPSRKMT Q5RDV4_PONAB Q5RDV4_PONAB LRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVK--TSSHWEFEGPTIIYCPSRKMT Q59F09_HUMAN Q59F09_HUMAN LRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVK--TSSHWEFEGPTIIYCPSRKMT WRN_HUMAN WRN_HUMAN LRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVK--TSSHWEFEGPTIIYCPSRKMT MATCH *::**:***.********:* :** ** **: **:: .* *****.**:***:** : CONSENSUS L??PQ?TCT?FDRPNLYL?V?RKT?NI??DL??FL??????S?WEFEG?TI?YCP?RK??

Q28D23_XENTR Q28D23_XENTR EQVTAELTKLGIACGTYHAGMGIKQRRDVHHRFMRDEIQCVVATVAFGMGINKPDIRKVI Q6GPM6_XENLA Q6GPM6_XENLA EQVTAELIKLGIACGTYHAGMGIKQRREVHHRFMRDEIQCVVATVAFGMGINKPDIRKVI WRN_XENLA WRN_XENLA EQVTAELIKLGIACGTYHAGMGIKQRREVHHRFMRDEIHCVVATVAFGMGINKPDIRKVI WRN_MOUSE WRN_MOUSE EQVTAELGKLNLACRTYHAGMKISERKDVHHRFLRDEIQCVVATVAFGMGINKADIRKVI Q3TB25_MOUSE Q3TB25_MOUSE EQVTAELGKLNLACRTYHAGMKISERKDVHHRFLRDEIQCVVATVAFGMGINKADIRKVI Q80YP9_MOUSE Q80YP9_MOUSE EQVTAELGKLNLACRTYHAGMKISERKDVHHRFLRDEIQCVVATVAFGMGINKADIRKVI Q5RDV4_PONAB Q5RDV4_PONAB EQVTAELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVI Q59F09_HUMAN Q59F09_HUMAN QQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVI WRN_HUMAN WRN_HUMAN QQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVI MATCH :***.** **.::* ****** :. *:::****:****:**:**:********.***:** CONSENSUS ?QVT?EL?KL???C?TYHAGM????R???HHRF?RDEIQCV?AT?AFGMGINK?DIR?VI

Q28D23_XENTR Q28D23_XENTR HYGAPKEMESYYQEIGRAGRDGLPSCCHALWTQADINFNRHMLGEIPNNSFREYKLKMLT Q6GPM6_XENLA Q6GPM6_XENLA HYGAPKEMESYYQEIGRAGRDGLPSCCHALWTQADMNFNRHMLGEIPNKGFREYKLKMLT WRN_XENLA WRN_XENLA HYGAPKEMESYYQEIGRAGRDGLPSCCHALWAQADMNFNRHMLGEIPNKGFREYKLKMLT WRN_MOUSE WRN_MOUSE HYGAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTSRNLLIEIHDEKFRLYKLKMMV Q3TB25_MOUSE Q3TB25_MOUSE HYGAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTSRNLLIEIHDEKFRLYKLKMMV Q80YP9_MOUSE Q80YP9_MOUSE HYGAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTSRNLLIEIHDEKFRLYKLKMMV Q5RDV4_PONAB Q5RDV4_PONAB HYGAPKEMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMA Q59F09_HUMAN Q59F09_HUMAN HYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMA WRN_HUMAN WRN_HUMAN HYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMA MATCH ******:**************** *.** **: **:* .*::* ** :: ** *****:. CONSENSUS HYGAPK?MESYYQEIGRAGRDGL?S?CH?LW??AD?N??R??L?EI????FR?YKLKM??

Q28D23_XENTR Q28D23_XENTR KMEKYLNSSNCRRKIILSHFEDKQLRKASSGIMGTEKCCDNCKTRLRFNISINDTEDNLQ Q6GPM6_XENLA Q6GPM6_XENLA KMEKYLNSSTCRRKIILSHFEDKQLRKASSGIMGTEKCCDNCKTRLICNISINDTEDNLQ WRN_XENLA WRN_XENLA KMEKYLNSSTCRRKIILSHFEDKQLRKASSGIMGTEKCCDNCKTRLICNISINDTEDNLQ WRN_MOUSE WRN_MOUSE KMEKYLHSSQCRRRIILSHFEDKCLQKASLDIMGTEKCCDNCRPRLNHCLTANNSEDASQ Q3TB25_MOUSE Q3TB25_MOUSE ------------------------------------------------------------ Q80YP9_MOUSE Q80YP9_MOUSE KMEKYLHSSQCRRRIILSHFEDKCLQKASLDIMGTEKCCDNCRPRLNHCLTANNSEDASQ Q5RDV4_PONAB Q5RDV4_PONAB KMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDNYYSMDDSEDTSW Q59F09_HUMAN Q59F09_HUMAN KMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSW WRN_HUMAN WRN_HUMAN KMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSW MATCH CONSENSUS KMEKYL?SS?CRR?IILSHFEDK???KAS??IMGTEKCCDNC??RL?????????ED???

Q28D23_XENTR Q28D23_XENTR EFGQQAYKFISAVDILGQKFGTGVPVLFLRGSTSQRLPDRFRHHPLFSCGKDQTEAFWKV Q6GPM6_XENLA Q6GPM6_XENLA DFGPQAYKFISAVDVLGQKFGTGVPVLFLRGSTSQRVPDRFRNHSLFSSGKDQTEAFWKV WRN_XENLA WRN_XENLA DFGPQAYKFISAVDVLGQKFGTGVPVLFLRGSTSQRVPDRFRNHSLFSSGKDQTEAFWKV WRN_MOUSE WRN_MOUSE DFGPQAFQLLSAVDILQEKFGIGIPILFLRGSNSQRLPDKYRGHRLFGAGKEQAESWWKT Q3TB25_MOUSE Q3TB25_MOUSE ------------------------------------------------------------ Q80YP9_MOUSE Q80YP9_MOUSE DFGPQAFQLLSAVDILQEKFGIGIPILFLRGSNSQRLPDKYRGHRLFGAGKEQAESWWKT Q5RDV4_PONAB Q5RDV4_PONAB DFGPQAFKLLSAVDILEEKFGIGLPILFLRGSNSRRLADQYRRHSLFGTGKDQTESWWKA Q59F09_HUMAN Q59F09_HUMAN DFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKA WRN_HUMAN WRN_HUMAN DFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKA MATCH CONSENSUS ?FG?QA????SAVD?L??KFG?G?P?LFLRGS?S?R??D??R?H?LF??GK?Q?E??WK?

Q28D23_XENTR Q28D23_XENTR LARQLISEGYLQESSGHTKFSTICGLTSKGTNWLMKASNQQHPSLLLPSNDELCLRRTTV Q6GPM6_XENLA Q6GPM6_XENLA LARQLITEGYLQESSGQTKFSTICGLTSKGSNWLIKANNEQCPSLLLPSNNELCLQRTRV WRN_XENLA WRN_XENLA LARQLITEGYLQESSGQTKFSTICGLTSKGSNWLIKANNEQCPSLLLPSNNELCLQRTRV WRN_MOUSE WRN_MOUSE LSHHLIAEGFLVEVPKENKYIKTCSLTKKGRKWLGEASLQSPPSLLLQANEEMFPRKVLL Q3TB25_MOUSE Q3TB25_MOUSE ------------------------------------------------------------ Q80YP9_MOUSE Q80YP9_MOUSE LSHHLIAEGFLVEVPKENKYIKTCSLTKKGRKWLGEASSQSPPSLLLQANEEMFPRKVLL Q5RDV4_PONAB Q5RDV4_PONAB FSRQLITEGFLVEVPGYNKFVKICTLTRKGRNWLHKANTES-QSLILQANEELCPKKFLL Q59F09_HUMAN Q59F09_HUMAN FSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTES-QSLILQANEELCPKKLLL WRN_HUMAN WRN_HUMAN FSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTES-QSLILQANEELCPKKFLL MATCH CONSENSUS ????LI?EG?L?E?????K????C?LT?KG??WL??A??????SL?L??N?E????????

Q28D23_XENTR Q28D23_XENTR SNSISRVPSHSSMIPHASPNTRSSIPKAGPEKISLKEKFSYQEAGKLSTAVDVSKSSLKL Q6GPM6_XENLA Q6GPM6_XENLA SN-FSSAQAHSSMVPHASSNTRSSMPKAGPEKMELKDKFSYQEAERLSKAAGVSKSSFKL WRN_XENLA WRN_XENLA SN-FSSAQAHSSMVPHASSNTRSSMPKAGPEKMELKDKFSYQEAERLSKAAGVSKSSFKL WRN_MOUSE WRN_MOUSE PS---SNPVSPETTQHSSNQNPAGLTT---KQSNLERTHSYKVPEKVSSGTNIPKKSAVM Q3TB25_MOUSE Q3TB25_MOUSE ------------------------------------------------------------ Q80YP9_MOUSE Q80YP9_MOUSE PS---SNPVSPETTQHSSNQNPAGLTT---KQSNLERTHSYKVPEKVSSGTNIPKKSAVM Q5RDV4_PONAB Q5RDV4_PONAB PS---WKTVSSGTKEHYYNQVPVELTTE--KKSNLEKLYSYKPCDKISSGSNISKKSIMV Q59F09_HUMAN Q59F09_HUMAN PS---SKTVSSGTKEHCYNQVPVELSTE--KKSNLEKLYSYKPCDKISSGSNISKKSIMV WRN_HUMAN WRN_HUMAN PS---SKTVSSGTKEHCYNQVPVELSTE--KKSNLEKLYSYKPCDKISSGSNISKKSIMV MATCH CONSENSUS ???????????????H??????????????????L????SY??????S??????K?S???

Q28D23_XENTR Q28D23_XENTR QTPCKPLQAAEPDVSPKEMELQTALYGRLVVARQKIASERDIPPAVLATNKVLVDMAKLR Q6GPM6_XENLA Q6GPM6_XENLA QTPCKLSRPPEPEVSPREMELQTTLYGRLVVARQKIASERDIPPAVLATNKVLVDMAKLR WRN_XENLA WRN_XENLA QTPCKLSRPPEPEVSPRERELQTTLYGRLVVARQKIASERDILPAVLATNKVLVDMAKLR WRN_MOUSE WRN_MOUSE PSPGTSSSPLEPAISAQELDARTGLYARLVEARQKHANKMDVPPAILATNKVLLDMAKMR Q3TB25_MOUSE Q3TB25_MOUSE ------------------------------------------------------------ Q80YP9_MOUSE Q80YP9_MOUSE PSPGTSSSPLEPAISAQELDARTGLYARLVEARQKHANKMDVPPAILATNKVLLDMAKMR Q5RDV4_PONAB Q5RDV4_PONAB QSPEKSYSSSEPAISSQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMR Q59F09_HUMAN Q59F09_HUMAN QSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMR WRN_HUMAN WRN_HUMAN QSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMR MATCH CONSENSUS ??P????????P??S??E??????LY??LV?ARQK?A???D??PA?LATNK?L?DMAK?R

Q28D23_XENTR Q28D23_XENTR PTTIENMKKLDGVSEAKSAMLAPLVEVVKEFCIANSLKMDI------------------- Q6GPM6_XENLA Q6GPM6_XENLA PTTSENMKKLDGVSEAKSAMLAPLLEVVKEFCIANSLKVDVFSGSVSQSESTFFTPREQE WRN_XENLA WRN_XENLA PTTSENMKKLDGVSEAKSAMLAPLLEVVKEFCIANSLKVDVFSGSVSQSESTFFTPREQE WRN_MOUSE WRN_MOUSE PTTVENMKQIDGVSEGKAALLAPLVGVIKHFCQVTSVQTDLLSSAKPHKEQEKSQEMEKK Q3TB25_MOUSE Q3TB25_MOUSE ------------------------------------------------------------ Q80YP9_MOUSE Q80YP9_MOUSE PTTVENMKQIDGVSEGKAALLAPLLEVIKHFCQVTSVQTDLLSSAKPHKEQEKSQEMEKK Q5RDV4_PONAB Q5RDV4_PONAB PTTVENIKRIDGVSEGKAAMLAPPLEVIKHFCQTNNVQTDLFSSTKPQEEQKTSLVAKKK Q59F09_HUMAN Q59F09_HUMAN PTTVENVKRIDGVSEGKAAMLAPLWEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNK WRN_HUMAN WRN_HUMAN PTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNK MATCH CONSENSUS PTT?EN?K??DGVSE?K?A?LAP???V?K?FC???????D????????????????????

Q28D23_XENTR Q28D23_XENTR ------------------------------------------------------------ Q6GPM6_XENLA Q6GPM6_XENLA RISLPESQRMSYSLFQEQNLSLKKIADVRCLSMAVVGMHLWQALKAGYSFDVQRAGLTPE WRN_XENLA WRN_XENLA RISLPESQRMSYSLFQEQNLSLKKIADVRCLSMAVVGMHLWQALKAGYSFDVQRAGLTPE WRN_MOUSE WRN_MOUSE DCSLPQSVAVTYTLFQEKKMPLHSIAENRLLPLTAVGMHLAQAVKAGYPLDMERAGLTPE Q3TB25_MOUSE Q3TB25_MOUSE ------------------------------------------------------------ Q80YP9_MOUSE Q80YP9_MOUSE DCSLPQSVAVTYTLFQEKKMPLHSIAENRLLPLTAAGMHLAQAVKAGYPLDMERAGLTPE Q5RDV4_PONAB Q5RDV4_PONAB ICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPE Q59F09_HUMAN Q59F09_HUMAN ICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPE WRN_HUMAN WRN_HUMAN ICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPE MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q28D23_XENTR Q28D23_XENTR ------------------------------------------------------------ Q6GPM6_XENLA Q6GPM6_XENLA MKKLITDAIKKPPINSDLSSFKAIREYVPANIDGYLIRMVISLLEKEGSSGAQGQPEFPT WRN_XENLA WRN_XENLA MKKLITYAIKKPPINSDLSSFKAIREYVPANIDGYPIRMVISLLEKEGSSGAQGQPEFPT WRN_MOUSE WRN_MOUSE TWKIIMDVIRNPPINSDMYKVKLIRMLVPENIDTYLIHMAIEILQSGSDSRTQPPCDSSR Q3TB25_MOUSE Q3TB25_MOUSE ------------------------------------------------------------ Q80YP9_MOUSE Q80YP9_MOUSE TWKIIMDVIRNPPINSDMYKVKLIRMLVPENLDTYLIHMAIEILQSGSDSRTQPPCDSSR Q5RDV4_PONAB Q5RDV4_PONAB VQKIIADVIRNPPVNSDMSKINLIRMLVPENIDTYLIHMAIEILKHGPDSRLQPSCDVNK Q59F09_HUMAN Q59F09_HUMAN VQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSRDVNK WRN_HUMAN WRN_HUMAN VQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNK MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q28D23_XENTR Q28D23_XENTR ------------------------------------------------------------ Q6GPM6_XENLA Q6GPM6_XENLA QKTLIQTEENPKNVSVQNTKHKVTMGKSMWIEKKPTQPATAELEVTKGKALAPIMLASWN WRN_XENLA WRN_XENLA QKTLIQTEENPKNVSVQNTKHKVTMGKSMWIEKKPTQPATAELEVTKGKALAPIMLASWN WRN_MOUSE WRN_MOUSE KRRFPSSAESC------------------------------------------------- Q3TB25_MOUSE Q3TB25_MOUSE ------------------------------------------------------------ Q80YP9_MOUSE Q80YP9_MOUSE KRRFPSSAESC------------------------------------------------- Q5RDV4_PONAB Q5RDV4_PONAB RRCFPSSEEIC------------------------------------------------- Q59F09_HUMAN Q59F09_HUMAN RRCFPGSEEIC------------------------------------------------- WRN_HUMAN WRN_HUMAN RRCFPGSEEIC------------------------------------------------- MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q28D23_XENTR Q28D23_XENTR --------------------------------------------------------- Q6GPM6_XENLA Q6GPM6_XENLA EASLDADTEELFSESQSSTTTPKRKLPEWFGSTKGNAATNAFKKAKP-GKKKG-LFD WRN_XENLA WRN_XENLA EASLDADTEELFSESQSSTTRPRRRLPEWFGSTKGNAATRCIQESKNLGEEKGSFFD WRN_MOUSE WRN_MOUSE -ESCKESKEVV-TETKASSSESKRKLPEWFAKGNVPSADTGSSSSMAKTKKKG-LFS Q3TB25_MOUSE Q3TB25_MOUSE --------------------------------------------------------- Q80YP9_MOUSE Q80YP9_MOUSE -ESCKESKEAV-TETKASSSESKRKLPEWFAKGNVPSADTGSSSSMAKTKKKG-LFS Q5RDV4_PONAB Q5RDV4_PONAB -SSSKRSKEEVGINTETSSAERKRRLPVWFAKGS-----DTSKKLMDKTKRGG-LFS Q59F09_HUMAN Q59F09_HUMAN -SSSKRSKEEVGINTETSSAERKRRLPVWFAKGS-----DTSKKLMDKTKRGG-LFS WRN_HUMAN WRN_HUMAN -SSSKRSKEEVGINTETSSAERKRRLPVWFAKGS-----DTSKKLMDKTKRGG-LFS MATCH CONSENSUS ?????????????????????????????????????????????????????????


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