Alignment of the gene Family HBG000351 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q676A0_OIKDI Q676A0_OIKDI TGGVQIVSHQTHGIQSSYHFNCTKSKSSQGKSARDQLLEQAHREYQTGDYVSAEIHCRQV Q5BL53_XENTR Q5BL53_XENTR AASVGSVADST------------------------GLAELAHREYQAGDFEAAERHCMQL Q641I4_XENLA Q641I4_XENLA AASVGNVADSTEPTKRMLSF--------------QGLAELAHREYQAGDFEAAERHCMQL OGT1_RAT OGT1_RAT ASSVGNVADST------------------------GLAELAHREYQAGDFEAAERHCMQL OGT1_MOUSE OGT1_MOUSE ASSVGNVADSTEPTKRMLSF--------------QGLAELAHREYQAGDFEAAERHCMQL A5D7G1_BOVIN A5D7G1_BOVIN ASSVGNVADST------------------------GLAELAHREYQAGDFEAAERHCMQL OGT1_HUMAN OGT1_HUMAN ASSVGNVADSTEPTKRMLSF--------------QGLAELAHREYQAGDFEAAERHCMQL OGT1_PIG OGT1_PIG ASSVGNVADSTEPTKRMLSF--------------QGLAELAHREYQAGDFEAAERHCMQL A6QQD9_BOVIN A6QQD9_BOVIN --------------------------------------------------------MISP Q548W1_HUMAN Q548W1_HUMAN -------------------------------------------MLQGHFWLVREGIMISP Q4SJS9_TETNG Q4SJS9_TETNG ATSVGNVADST------------------------GLAELAHREYQSGDFEAAERHCMQL B3DKP3_DANRE B3DKP3_DANRE ASSVGNVADSTEPTKRVLSF--------------QGLAELAHREYQSGDFEAAERHCMQL Q5GA11_DANRE Q5GA11_DANRE ASSVGNVADSTEPTKRVLSF--------------QGLAELAHREYQSGDFEAAERHCMQL Q5GA13_DANRE Q5GA13_DANRE ASSVGNVADSTEPTKRVLSF--------------QGLAELAHREYQSGDFEAAERHCMQL Q5GA10_DANRE Q5GA10_DANRE ASSVGNVADST------------------------GLAELAHREYQSGDFEAAERHCMQL Q5GA12_DANRE Q5GA12_DANRE ASSVGNVADST------------------------GLAELAHREYQSGDFEAAERHCMQL MATCH . CONSENSUS A?SVG?VADST????????????????????????GLAELAHREYQ?GDFEAAERHCMQL

Q676A0_OIKDI Q676A0_OIKDI YQTDPQSPAVLLLLSSIYFQKRLLDDSAYFSREAIRVNPTLAEAYSNLGNVHKEQGDVQQ Q5BL53_XENTR Q5BL53_XENTR WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE Q641I4_XENLA Q641I4_XENLA WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE OGT1_RAT OGT1_RAT WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE OGT1_MOUSE OGT1_MOUSE WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE A5D7G1_BOVIN A5D7G1_BOVIN WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE OGT1_HUMAN OGT1_HUMAN WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE OGT1_PIG OGT1_PIG WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE A6QQD9_BOVIN A6QQD9_BOVIN SSPSPN----------LFF----------FSPLQIFPFPFTSFPSHLL------------ Q548W1_HUMAN Q548W1_HUMAN SSPPPPNL--------------------FFFPLQIFPFPFTSFP---------------- Q4SJS9_TETNG Q4SJS9_TETNG WRQEPDNTAML------------ATRDDFFYTLAIKQNPLLAEAYSNLGNVYKERGQLQE B3DKP3_DANRE B3DKP3_DANRE WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPMLAEAYSNLGNVYKERGQLQE Q5GA11_DANRE Q5GA11_DANRE WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPMLAEAYSNLGNVYKERGQLQE Q5GA13_DANRE Q5GA13_DANRE WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPMLAEAYSNLGNVYKERGQLQE Q5GA10_DANRE Q5GA10_DANRE WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPMLAEAYSNLGNVYKERGQLQE Q5GA12_DANRE Q5GA12_DANRE WRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPMLAEAYSNLGNVYKERGQLQE MATCH * * * * : . CONSENSUS WRQEPDNT?VLLLLSSI?FQ?R?LDRSA?FSTLAIKQNP?LAEAYSNLGNVYKERGQLQE

Q676A0_OIKDI Q676A0_OIKDI ALEFYKYAVGLKPDFIDGYVNLAAALTSIQDYEGAIKAHMEALQINPNLYGVRSDLGNIF Q5BL53_XENTR Q5BL53_XENTR AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL Q641I4_XENLA Q641I4_XENLA AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL OGT1_RAT OGT1_RAT AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL OGT1_MOUSE OGT1_MOUSE AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL A5D7G1_BOVIN A5D7G1_BOVIN AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL OGT1_HUMAN OGT1_HUMAN AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL OGT1_PIG OGT1_PIG AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL A6QQD9_BOVIN A6QQD9_BOVIN --------LSLTP----------------------------------------------- Q548W1_HUMAN Q548W1_HUMAN -----SHLLSLTP----------------------------------------------- Q4SJS9_TETNG Q4SJS9_TETNG AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL B3DKP3_DANRE B3DKP3_DANRE AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL Q5GA11_DANRE Q5GA11_DANRE AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL Q5GA13_DANRE Q5GA13_DANRE AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL Q5GA10_DANRE Q5GA10_DANRE AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL Q5GA12_DANRE Q5GA12_DANRE AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL MATCH : *.* CONSENSUS AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL

Q676A0_OIKDI Q676A0_OIKDI KSLGRLEEAE-------------ECYQKAXQCNSTXAVAYSNLGCVYNKRGDIWLAIHNF Q5BL53_XENTR Q5BL53_XENTR KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF Q641I4_XENLA Q641I4_XENLA KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF OGT1_RAT OGT1_RAT KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF OGT1_MOUSE OGT1_MOUSE KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF A5D7G1_BOVIN A5D7G1_BOVIN KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF OGT1_HUMAN OGT1_HUMAN KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF OGT1_PIG OGT1_PIG KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF A6QQD9_BOVIN A6QQD9_BOVIN --------PK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF Q548W1_HUMAN Q548W1_HUMAN --------PK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF Q4SJS9_TETNG Q4SJS9_TETNG KALGRLEEAKPAAATSLTKSKNMACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF B3DKP3_DANRE B3DKP3_DANRE KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF Q5GA11_DANRE Q5GA11_DANRE KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF Q5GA13_DANRE Q5GA13_DANRE KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF Q5GA10_DANRE Q5GA10_DANRE KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF Q5GA12_DANRE Q5GA12_DANRE KALGRLEEAK-------------ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF MATCH .: ** ** : :.. ***:******:* :*:******:* CONSENSUS KALGRLEEAK?????????????ACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF

Q676A0_OIKDI Q676A0_OIKDI EKAVKLDVTFLDAFINLGNMFKEARIFDRAVSAYQRALALNVGHAVVHGNLASVYYEQGR Q5BL53_XENTR Q5BL53_XENTR EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL Q641I4_XENLA Q641I4_XENLA EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL OGT1_RAT OGT1_RAT EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL OGT1_MOUSE OGT1_MOUSE EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL A5D7G1_BOVIN A5D7G1_BOVIN EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL OGT1_HUMAN OGT1_HUMAN EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL OGT1_PIG OGT1_PIG EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL A6QQD9_BOVIN A6QQD9_BOVIN EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL Q548W1_HUMAN Q548W1_HUMAN EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL Q4SJS9_TETNG Q4SJS9_TETNG EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAGYLRALSLSPNHAVVHGNLACVYYEQGL B3DKP3_DANRE B3DKP3_DANRE EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAGYLRALSLSPNHAVVHGNLACVYYEQGL Q5GA11_DANRE Q5GA11_DANRE EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAGYLRALSLSPNHAVVHGNLACVYYEQGL Q5GA13_DANRE Q5GA13_DANRE EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAGYLRALSLSPNHAVVHGNLACVYYEQGL Q5GA10_DANRE Q5GA10_DANRE EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAGYLRALSLSPNHAVVHGNLACVYYEQGL Q5GA12_DANRE Q5GA12_DANRE EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAGYLRALSLSPNHAVVHGNLACVYYEQGL MATCH ****.** .****:*****::**********:.* ***:*. .*********.****** CONSENSUS EKAVTLDPNFLDAYINLGNVLKEARIFDRAVA?YLRALSLSPNHAVVHGNLACVYYEQGL

Q676A0_OIKDI Q676A0_OIKDI LDLAIETYRIAIRLQPNFPDAYCNLANALKDRLLVSEAESCYEQALKLHPEHADSLNNLA Q5BL53_XENTR Q5BL53_XENTR IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVVDAEECYNTALRLCPTHADSLNNLA Q641I4_XENLA Q641I4_XENLA IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVVDAEECYNTALRLCPTHADSLNNLA OGT1_RAT OGT1_RAT IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA OGT1_MOUSE OGT1_MOUSE IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA A5D7G1_BOVIN A5D7G1_BOVIN IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA OGT1_HUMAN OGT1_HUMAN IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA OGT1_PIG OGT1_PIG IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA A6QQD9_BOVIN A6QQD9_BOVIN IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA Q548W1_HUMAN Q548W1_HUMAN IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA Q4SJS9_TETNG Q4SJS9_TETNG IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGNVSEAEECYNTALRLCPTHADSLNNLA B3DKP3_DANRE B3DKP3_DANRE IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGNVSEAEECYNTALRLCPTHADSLNNLA Q5GA11_DANRE Q5GA11_DANRE IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGNVSEAEECYNTALRLCPTHADSLNNLA Q5GA13_DANRE Q5GA13_DANRE IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGNVSEAEECYNTALRLCPTHADSLNNLA Q5GA10_DANRE Q5GA10_DANRE IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGNVSEAEECYNTALRLCPTHADSLNNLA Q5GA12_DANRE Q5GA12_DANRE IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGNVSEAEECYNTALRLCPTHADSLNNLA MATCH :****:*** **.***:*************:: * :**.**: **:* * ********* CONSENSUS IDLAIDTYRRAIELQPHFPDAYCNLANALKEKG?V?EAE?CYNTALRLCPTHADSLNNLA

Q676A0_OIKDI Q676A0_OIKDI NIKREQNRTHEAMELYQRALKAKPDFPAAHSNLASILQQQGRHHDAIEHYKQAIRIFPQF Q5BL53_XENTR Q5BL53_XENTR NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF Q641I4_XENLA Q641I4_XENLA NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF OGT1_RAT OGT1_RAT NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF OGT1_MOUSE OGT1_MOUSE NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF A5D7G1_BOVIN A5D7G1_BOVIN NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF OGT1_HUMAN OGT1_HUMAN NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF OGT1_PIG OGT1_PIG NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF A6QQD9_BOVIN A6QQD9_BOVIN NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF Q548W1_HUMAN Q548W1_HUMAN NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF Q4SJS9_TETNG Q4SJS9_TETNG NIKREQGNIEEAIQLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF B3DKP3_DANRE B3DKP3_DANRE NIKREQGNIEEAVQLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF Q5GA11_DANRE Q5GA11_DANRE NIKREQGNIEEAVQLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF Q5GA13_DANRE Q5GA13_DANRE NIKREQGNIEEAVQLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF Q5GA10_DANRE Q5GA10_DANRE NIKREQGNIEEAVQLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF Q5GA12_DANRE Q5GA12_DANRE NIKREQGNIEEAVQLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF MATCH ******.. .**:.**::**:. *:*.********:*****: ::*: ***:**** * * CONSENSUS NIKREQGNIEEAV?LYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF

Q676A0_OIKDI Q676A0_OIKDI ADAYSNMGNTYKEMARNQEAIQCYQSAISINPNFADAFSNLASLHKDCGNTEEAIQYFDF Q5BL53_XENTR Q5BL53_XENTR ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT Q641I4_XENLA Q641I4_XENLA ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT OGT1_RAT OGT1_RAT ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT OGT1_MOUSE OGT1_MOUSE ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT A5D7G1_BOVIN A5D7G1_BOVIN ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT OGT1_HUMAN OGT1_HUMAN ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT OGT1_PIG OGT1_PIG ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT A6QQD9_BOVIN A6QQD9_BOVIN ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT Q548W1_HUMAN Q548W1_HUMAN ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT Q4SJS9_TETNG Q4SJS9_TETNG ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT B3DKP3_DANRE B3DKP3_DANRE ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT Q5GA11_DANRE Q5GA11_DANRE ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT Q5GA13_DANRE Q5GA13_DANRE ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT Q5GA10_DANRE Q5GA10_DANRE ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT Q5GA12_DANRE Q5GA12_DANRE ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT MATCH ********** *** * *:*** **.*** ****.*****:***.** *** : CONSENSUS ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT

Q676A0_OIKDI Q676A0_OIKDI ALRVRPNFPEAFCARAHCHQYICDWNDYSSRNVKIVEIVDEQLKKARLPSVHPHHSMLYP Q5BL53_XENTR Q5BL53_XENTR ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP Q641I4_XENLA Q641I4_XENLA ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAEQLEKNRLPSVHPHHSMLYP OGT1_RAT OGT1_RAT ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAEQLEKNRLPSVHPHHSMLYP OGT1_MOUSE OGT1_MOUSE ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAEQLEKNRLPSVHPHHSMLYP A5D7G1_BOVIN A5D7G1_BOVIN ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP OGT1_HUMAN OGT1_HUMAN ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP OGT1_PIG OGT1_PIG ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP A6QQD9_BOVIN A6QQD9_BOVIN ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP Q548W1_HUMAN Q548W1_HUMAN ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP Q4SJS9_TETNG Q4SJS9_TETNG ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVTIVADQLDKNRLPSVHPHHSMLYP B3DKP3_DANRE B3DKP3_DANRE ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP Q5GA11_DANRE Q5GA11_DANRE ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP Q5GA13_DANRE Q5GA13_DANRE ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP Q5GA10_DANRE Q5GA10_DANRE ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP Q5GA12_DANRE Q5GA12_DANRE ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYP MATCH **:::*:**:*:* *** * :***.**..* *:* ** :**.* ************** CONSENSUS ALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVA?QLEKNRLPSVHPHHSMLYP

Q676A0_OIKDI Q676A0_OIKDI LSHYQRRAIAGKHAQYCKDKVAHHGIATKFAPRN---KNRRIRIGYVSSDFGNHPTAHLM Q5BL53_XENTR Q5BL53_XENTR LSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKASDGRLRVGYVSSDFGNHPTSHLM Q641I4_XENLA Q641I4_XENLA LSHAFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKASDGRLRVGYVSSDFGNHPTSHLM OGT1_RAT OGT1_RAT LSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLM OGT1_MOUSE OGT1_MOUSE LSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLM A5D7G1_BOVIN A5D7G1_BOVIN LSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLM OGT1_HUMAN OGT1_HUMAN LSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLM OGT1_PIG OGT1_PIG LSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLM A6QQD9_BOVIN A6QQD9_BOVIN LSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLM Q548W1_HUMAN Q548W1_HUMAN LSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLM Q4SJS9_TETNG Q4SJS9_TETNG LSHGFRKAIAERHGNLCLDKINALHKPPYEHPKDLKASGGRLRVGYVSSDFGNHPTSHLM B3DKP3_DANRE B3DKP3_DANRE LSHGFRKAIAERHGNLCLDKINALHKPAYEHPKDLKASSGRLRVGYISSDFGNHPTSHLM Q5GA11_DANRE Q5GA11_DANRE LSHGFRKAIAERHGNLCLDKINALHKPAYEHPKDLKASSGRLRVGYISSDFGNHPTSHLM Q5GA13_DANRE Q5GA13_DANRE LSHGFRKAIAERHGNLCLDKINALHKPAYEHPKDLKASSGRLRVGYISSDFGNHPTSHLM Q5GA10_DANRE Q5GA10_DANRE LSHGFRKAIAERHGNLCLDKINALHKPAYEHPKDLKASSGRLRVGYISSDFGNHPTSHLM Q5GA12_DANRE Q5GA12_DANRE LSHGFRKAIAERHGNLCLDKINALHKPAYEHPKDLKASSGRLRVGYISSDFGNHPTSHLM MATCH *** *:*** :*.: * **: .. *:: .. *:*:**:*********:*** CONSENSUS LSHGFRKAIAERHGNLCLDKIN?LHKP?YEHPKDLK?S?GRLRVGY?SSDFGNHPTSHLM

Q676A0_OIKDI Q676A0_OIKDI QSVPGMHDNTKVEVFCYALTPDDGTAYFKKISSEAEHFTDLSQFIDNAQAAEKIKSDGID Q5BL53_XENTR Q5BL53_XENTR QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFVDLSQIPCNGKAADRIHQDGVH Q641I4_XENLA Q641I4_XENLA QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFVDLSQIPCNGKAADRIHQDGIH OGT1_RAT OGT1_RAT QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIH OGT1_MOUSE OGT1_MOUSE QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIH A5D7G1_BOVIN A5D7G1_BOVIN QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIH OGT1_HUMAN OGT1_HUMAN QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIH OGT1_PIG OGT1_PIG QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIH A6QQD9_BOVIN A6QQD9_BOVIN QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIH Q548W1_HUMAN Q548W1_HUMAN QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIH Q4SJS9_TETNG Q4SJS9_TETNG QSIPGMHNPEKFEVFCYALSPDDSTNFRVKVVAEAHHFVDLSQISCNGKAADRIHQDGVH B3DKP3_DANRE B3DKP3_DANRE QSIPGMHNSEKFEVFCYALSPDDGTNFRVKVMAEAHHFIDLSQIPCNGKAADRIHQDGIH Q5GA11_DANRE Q5GA11_DANRE QSIPGMHNSEKFEVFCYALSPDDGTNFRVKVMAEAHHFIDLSQIPCNGKAADRIHQDGIH Q5GA13_DANRE Q5GA13_DANRE QSIPGMHNSEKFEVFCYALSPDDGTNFRVKVMAEAHHFIDLSQIPCNGKAADRIHQDGIH Q5GA10_DANRE Q5GA10_DANRE QSIPGMHNSEKFEVFCYALSPDDGTNFRVKVMAEAHHFIDLSQIPCNGKAADRIHQDGIH Q5GA12_DANRE Q5GA12_DANRE QSIPGMHNSEKFEVFCYALSPDDGTNFRVKVMAEAHHFIDLSQIPCNGKAADRIHQDGIH MATCH **:****: *.*******:***.* : *: :**.** ****: *.:**::*:.**:. CONSENSUS QSIPGMHN??KFEVFCYALSPDDGTNFRVKVMAEA?HF?DLSQIPCNGKAADRIHQDGIH

Q676A0_OIKDI Q676A0_OIKDI ILLNMNGYTKGARNEIFALRPAPIQVMWLGYPGTSGADFMDYILTDDQTSPMSCVEQYSE Q5BL53_XENTR Q5BL53_XENTR ILINMNGYTKGARNELFALKAAPIQAMWLGYPGTSGASFMDYIISDIETSPVDVAEQYSE Q641I4_XENLA Q641I4_XENLA ILVNMNGYTKGARNELFALKAAPIQAMWLGYPGTSGAPFMDYIISDKETSPIDVAEQYSE OGT1_RAT OGT1_RAT ILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSE OGT1_MOUSE OGT1_MOUSE ILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSE A5D7G1_BOVIN A5D7G1_BOVIN ILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSE OGT1_HUMAN OGT1_HUMAN ILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSE OGT1_PIG OGT1_PIG ILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSE A6QQD9_BOVIN A6QQD9_BOVIN ILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSE Q548W1_HUMAN Q548W1_HUMAN ILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSE Q4SJS9_TETNG Q4SJS9_TETNG ILVNMNGYTKGARNELFALRPAPVQAMWLGYPGTSGAPFMDYIISDKETSPIEVAEQYSE B3DKP3_DANRE B3DKP3_DANRE ILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGAPFMDYIVSDKATSPIEVAEQYSE Q5GA11_DANRE Q5GA11_DANRE ILVNMNGYTKGARNELFALRPAPIQAMWLAYPGTSGAPFMDYIVSDKATSPIEVAEQYSE Q5GA13_DANRE Q5GA13_DANRE ILVNMNGYTKGARNELFALRPAPIQAMWLAYPGTSGAPFMDYIVSDKATSPIEVAEQYSE Q5GA10_DANRE Q5GA10_DANRE ILVNMNGYTKGARNELFALRPAPIQAMWLAYPGTSGAPFMDYIVSDKATSPIEVAEQYSE Q5GA12_DANRE Q5GA12_DANRE ILVNMNGYTKGARNELFALRPAPIQAMWLAYPGTSGAPFMDYIVSDKATSPIEVAEQYSE MATCH **:************:***:.**:*.***.******* *****::* *** . .***** CONSENSUS ILVNMNGYTKGARNELFALRPAPIQAMWL?YPGTSGA?FMDYI??D??TSP?EVAEQYSE

Q676A0_OIKDI Q676A0_OIKDI KLAYMGRTFFIGDHAQMFSHMKSKILLSVGRT-----TTAVINYEDSETLSRLMGSMRLQ Q5BL53_XENTR Q5BL53_XENTR KLAYMPNTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLESLPDVKIV Q641I4_XENLA Q641I4_XENLA KLAYMPNTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLESLPDVKIV OGT1_RAT OGT1_RAT KLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIV OGT1_MOUSE OGT1_MOUSE KLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIV A5D7G1_BOVIN A5D7G1_BOVIN KLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIV OGT1_HUMAN OGT1_HUMAN KLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIV OGT1_PIG OGT1_PIG KLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIV A6QQD9_BOVIN A6QQD9_BOVIN KLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIV Q548W1_HUMAN Q548W1_HUMAN KLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIV Q4SJS9_TETNG Q4SJS9_TETNG KLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIFDNRIVLNGIDLKAFLDSLPDVKVI B3DKP3_DANRE B3DKP3_DANRE KLAYMPNTFFIGDHANMFPHLKKKAVIDFKSNGHIFDNRIVLNGIDLKAFLESLPDVKVV Q5GA11_DANRE Q5GA11_DANRE KLAYMPNTFFIGDHANMFPHLKKKAVIDFKSNGHIFDNRIVLNGIDLKAFLESLPDVKVV Q5GA13_DANRE Q5GA13_DANRE KLAYMPNTFFIGDHANMFPHLKKKAVIDFKSNGHIFDNRIVLNGIDLKAFLESLPDVKVV Q5GA10_DANRE Q5GA10_DANRE KLAYMPNTFFIGDHANMFPHLKKKAVIDFKSNGHIFDNRIVLNGIDLKAFLESLPDVKVV Q5GA12_DANRE Q5GA12_DANRE KLAYMPNTFFIGDHANMFPHLKKKAVIDFKSNGHIFDNRIVLNGIDLKAFLESLPDVKVV MATCH ***** .********:**.*:*.* ::.. . . *:* * ::: : .::: CONSENSUS KLAYMP?TFFIGDHANMFPHLKKKAVIDFKSNGHI?DNRIVLNGIDLKAFL?SLPDVK?V

Q676A0_OIKDI Q676A0_OIKDI MNEEYRSNDDGLDCDSEDVAEYAALDQNHDTSIALQNMVIKGQQCLQIGDIKIINGLCLP Q5BL53_XENTR Q5BL53_XENTR ---KMKGPDSGDNVDN-NSALNMPVIPMSSIAEAVIEMINRGQIQITINGFNISNGLATT Q641I4_XENLA Q641I4_XENLA ---KMKGPDSGDNVDN-NSALSMPVIPMSSIAEAVIEMINRGQIQITINGFNISNGLATT OGT1_RAT OGT1_RAT ---KMKCPDGGDNADTTNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATT OGT1_MOUSE OGT1_MOUSE ---KMKCPDGGDNPDSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATT A5D7G1_BOVIN A5D7G1_BOVIN ---KMKCPDGGDNVDSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATT OGT1_HUMAN OGT1_HUMAN ---KMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATT OGT1_PIG OGT1_PIG ---KMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATT A6QQD9_BOVIN A6QQD9_BOVIN ---KMKCPDGGDNVDSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATT Q548W1_HUMAN Q548W1_HUMAN ---KMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATT Q4SJS9_TETNG Q4SJS9_TETNG ---KMKCDNNQEPSADTNGALSMPVIPMNTAAEAIINMINQGQIQVTINGFTVSNGLATT B3DKP3_DANRE B3DKP3_DANRE ---KMEC--DGQEVADSNGALSMPIIPMNTAAEAIINMINQGQIQVTINGFTVSNGLATT Q5GA11_DANRE Q5GA11_DANRE ---KMEC--DGQEVADSNGALSMPIIPMNTAAEAIINMINQGQIQVTINGFTVSNGLATT Q5GA13_DANRE Q5GA13_DANRE ---KMEC--DGQEVADSNGALSMPIIPMNTAAEAIINMINQGQIQVTINGFTVSNGLATT Q5GA10_DANRE Q5GA10_DANRE ---KMEC--DGQEVADSNGALSMPIIPMNTAAEAIINMINQGQIQVTINGFTVSNGLATT Q5GA12_DANRE Q5GA12_DANRE ---KMEC--DGQEVADSNGALSMPIIPMNTAAEAIINMINQGQIQVTINGFTVSNGLATT MATCH : . . : * .: : *: :*: :** : *..:.: ***. . CONSENSUS ???KM?C???G??????N?AL?MP?IPMNT?AEA?I?MIN?GQIQ?TINGF??SNGLATT

Q676A0_OIKDI Q676A0_OIKDI ----------------AFEAQASQGEAKIQNAVYTSRRQYGLPDDAIVYCNFNQLYKLDP Q5BL53_XENTR Q5BL53_XENTR ----------------QINNKAATGEEVPRTIIVTTRSQYGLPEDAVVYCNFNQLYKIDP Q641I4_XENLA Q641I4_XENLA ----------------QINNKAATGEEVPRTIIVTTRSQYGLPEDAVVYCNFNQLYKIDP OGT1_RAT OGT1_RAT ----------------QINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDP OGT1_MOUSE OGT1_MOUSE ----------------QINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDP A5D7G1_BOVIN A5D7G1_BOVIN ----------------QINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDP OGT1_HUMAN OGT1_HUMAN ----------------QINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDP OGT1_PIG OGT1_PIG ----------------QINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDP A6QQD9_BOVIN A6QQD9_BOVIN ----------------QINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDP Q548W1_HUMAN Q548W1_HUMAN ----------------QINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDP Q4SJS9_TETNG Q4SJS9_TETNG ----------------QITNKAATGEEVLRTVVVTTRSQYGLPEDAIVYCNFNQLYKIDP B3DKP3_DANRE B3DKP3_DANRE ----------------QINNKAATGEEVPRTIVVTTRSQYGLPEDSIVYCNFNQLYKIDP Q5GA11_DANRE Q5GA11_DANRE ----------------QINNKAATGEEVPRTIVVTTRSQYGLPEDSIVYCNFNQLYKIDP Q5GA13_DANRE Q5GA13_DANRE QIFTVEEVVVSGTVALQINNKAATGEEVPRTIVVTTRSQYGLPEDSIVYCNFNQLYKIDP Q5GA10_DANRE Q5GA10_DANRE ----------------QINNKAATGEEVPRTIVVTTRSQYGLPEDSIVYCNFNQLYKIDP Q5GA12_DANRE Q5GA12_DANRE QIFTVEEVVVSGTVALQINNKAATGEEVPRTIVVTTRSQYGLPEDSIVYCNFNQLYKIDP MATCH : :*: ** :. : *:* *****:*::**********:** CONSENSUS ????????????????QINNKAATGEEVPRTI?VTTRSQYGLPED?IVYCNFNQLYKIDP

Q676A0_OIKDI Q676A0_OIKDI NTMSAWCNILKKVPDAVIWLLRFPALGERHVHDWCWRLVSIIFTKPLTNYSCSHHNIPKE Q5BL53_XENTR Q5BL53_XENTR STLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM-----------------GLPQS Q641I4_XENLA Q641I4_XENLA STLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM-----------------GLPQS OGT1_RAT OGT1_RAT STLQMGANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM-----------------GLPQN OGT1_MOUSE OGT1_MOUSE STLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM-----------------GLPQN A5D7G1_BOVIN A5D7G1_BOVIN STLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM-----------------GLPQN OGT1_HUMAN OGT1_HUMAN STLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM-----------------GLPQN OGT1_PIG OGT1_PIG STLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM-----------------GLPQN A6QQD9_BOVIN A6QQD9_BOVIN STLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM-----------------GLPQN Q548W1_HUMAN Q548W1_HUMAN STLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM-----------------GLPQN Q4SJS9_TETNG Q4SJS9_TETNG PTLQMWANILTRVPNSVLWLLRFPAVGEPNIQQYAQKV-----------------GLPAS B3DKP3_DANRE B3DKP3_DANRE PTLQMWANILKRVPNSVIWLLRFPAVGEPNIQQYAQNL-----------------GLPAS Q5GA11_DANRE Q5GA11_DANRE PTLQMWANILKRVPNSVIWLLRFPAVGEPNIQQYAQNL-----------------GLPAS Q5GA13_DANRE Q5GA13_DANRE PTLQMWANILKRVPNSVIWLLRFPAVGEPNIQQYAQNL-----------------GLPAS Q5GA10_DANRE Q5GA10_DANRE PTLQMWANILKRVPNSVIWLLRFPAVGEPNIQQYAQNL-----------------GLPAS Q5GA12_DANRE Q5GA12_DANRE PTLQMWANILKRVPNSVIWLLRFPAVGEPNIQQYAQNL-----------------GLPAS MATCH *:. .***.:**::*:*******:** :::::. .: .:* . CONSENSUS ?TLQMWANILKRVPNSV?WLLRFPAVGEPNIQQYAQN??????????????????GLP??

Q676A0_OIKDI Q676A0_OIKDI RIIFSPVAAKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGCPMVTLP----------- Q5BL53_XENTR Q5BL53_XENTR RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- Q641I4_XENLA Q641I4_XENLA RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGKESAESLGLH OGT1_RAT OGT1_RAT RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- OGT1_MOUSE OGT1_MOUSE RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- A5D7G1_BOVIN A5D7G1_BOVIN RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- OGT1_HUMAN OGT1_HUMAN RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- OGT1_PIG OGT1_PIG RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- A6QQD9_BOVIN A6QQD9_BOVIN RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- Q548W1_HUMAN Q548W1_HUMAN RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- Q4SJS9_TETNG Q4SJS9_TETNG RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- B3DKP3_DANRE B3DKP3_DANRE RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- Q5GA11_DANRE Q5GA11_DANRE RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- Q5GA13_DANRE Q5GA13_DANRE RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- Q5GA10_DANRE Q5GA10_DANRE RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- Q5GA12_DANRE Q5GA12_DANRE RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP----------- MATCH ********.********************************* ****:* CONSENSUS RIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP???????????

Q676A0_OIKDI Q676A0_OIKDI -------LESFASRVASSQMKTLGLDELIADDYESYESIAIRLGRDVDYRRSIRSRLYNF Q5BL53_XENTR Q5BL53_XENTR -------GDTLASRVAASQLTCLGCPELIAKGRQDYEDTAVKLGTDLEYLKKIRSKVWKQ Q641I4_XENLA Q641I4_XENLA NKDCFLSGDTLASRVAASQLTCLGCPELIAKSRQDYEDIAVKLGTDLEYLKKIRAKVWKQ OGT1_RAT OGT1_RAT -------GETLASRVAASQLTCLGCLELIAKSRQEYEDIAVKLGTDLEYLKKIRGKVWKQ OGT1_MOUSE OGT1_MOUSE -------GETLASRVAASQLTCLGCLELIAKSRQEYEDIAVKLGTDLEYLKKIRGKVWKQ A5D7G1_BOVIN A5D7G1_BOVIN -------GETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKIRGKVWKQ OGT1_HUMAN OGT1_HUMAN -------GETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQ OGT1_PIG OGT1_PIG -------GETLASRVAASQLTCLGCLELIAKNRQEFEDIAVKLGTDLEYLKKIRGKVWKQ A6QQD9_BOVIN A6QQD9_BOVIN -------GETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKIRGKVWKQ Q548W1_HUMAN Q548W1_HUMAN -------GETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQ Q4SJS9_TETNG Q4SJS9_TETNG -------GETLASRVATSQLSCLGCPELIAQSHEEYEDIAVKLGSDMEYLKMVRARVWKQ B3DKP3_DANRE B3DKP3_DANRE -------GETLASRVAASQLTCLGCPELIAQSRQEYEDVAVKLGTDMEFLKKVRARVWKQ Q5GA11_DANRE Q5GA11_DANRE -------GETLASRVAASQLTCLGCPELIAQSRQEYEDVAVKLGTDMEFLKKVRARVWKQ Q5GA13_DANRE Q5GA13_DANRE -------GETLASRVAASQLTCLGCPELIAQSRQEYEDVAVKLGTDMEFLKKVRARVWKQ Q5GA10_DANRE Q5GA10_DANRE -------GETLASRVAASQLTCLGCPELIAQSRQEYEDVAVKLGTDMEFLKKVRARVWKQ Q5GA12_DANRE Q5GA12_DANRE -------GETLASRVAASQLTCLGCPELIAQSRQEYEDVAVKLGTDMEFLKKVRARVWKQ MATCH :::*****:**:. ** ****.. :.:*. *::** *::: : :*.:::: CONSENSUS ???????GETLASRVAASQLTCLGC?ELIA??RQEYED?AVKLGTD?E?LKK?R??VWKQ

Q676A0_OIKDI Q676A0_OIKDI RKSSRLFSVKDYATSMERVYKKMFERFNDGRQPEHIFEQHLLDN---- Q5BL53_XENTR Q5BL53_XENTR RISSPLFNTKQYTIDLERLYLQMWEHYSAGNKTDHLIK--TVESTESA Q641I4_XENLA Q641I4_XENLA RISSPLFNTKQYTMDLERLYLEMWEHFAAGNKRDHLIK--PVESTESA OGT1_RAT OGT1_RAT RISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK--PVEVTESA OGT1_MOUSE OGT1_MOUSE RISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK--PVEVTESA A5D7G1_BOVIN A5D7G1_BOVIN RISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK--PVEVTESA OGT1_HUMAN OGT1_HUMAN RISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK--PVEVTESA OGT1_PIG OGT1_PIG RISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK--PVEVTESA A6QQD9_BOVIN A6QQD9_BOVIN RISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK--PVEVTESA Q548W1_HUMAN Q548W1_HUMAN RISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK--PVEVTESA Q4SJS9_TETNG Q4SJS9_TETNG RICSPLFNTKQYTMDLEKLYLRMWEHYSKGNKPEHLVQ--TVEASENA B3DKP3_DANRE B3DKP3_DANRE RICSPLFNTKQYTMDLEKLYLQMWENHASGGKPDHLVKMQSLETSEST Q5GA11_DANRE Q5GA11_DANRE RICSPLFNTKQYTMDLEKLYLQMWENHASGGKPDHLVKMQSLETSEST Q5GA13_DANRE Q5GA13_DANRE RICSPLFNTKQYTMDLEKLYLQMWENHASGGKPDHLVKMQSLETSEST Q5GA10_DANRE Q5GA10_DANRE RICSPLFNTKQYTMDLEKLYLQMWENHASGGKPDHLVKMQSLETSEST Q5GA12_DANRE Q5GA12_DANRE RICSPLFNTKQYTMDLEKLYLQMWENHASGGKPDHLVKMQSLETSEST MATCH * .* **..*:*: .:*::* .*:*.. * : :*:.: :: CONSENSUS RI?SPLFNTKQYTM?LE?LYLQMWE??A?G?KPDH??K????E??ES?


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