Alignment of the gene Family HBG000511 of HOVERGEN

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Isoforms are ON
Q7ZV57_DANRE Q7ZV57_DANRE -------------------------------MKFVRFMMRNAAMLN-------------- Q4T5D1_TETNG Q4T5D1_TETNG ---------------------------MSSRMKLVRSLMKTAALAN-------------- A6QR49_BOVIN A6QR49_BOVIN -------------------------------MKAARFVMRSAGTL--------------- PDK4_SPETR PDK4_SPETR -------------------------------MKAARFAMHSARSLSSVGL---------- PDK4_MOUSE PDK4_MOUSE -------------------------------MKAARFVMRSASSLSSASL---------- Q544J2_MOUSE Q544J2_MOUSE -------------------------------MKAARFVMRSASSLSSASL---------- PDK4_RAT PDK4_RAT -------------------------------MKAARFVMRSASSLGNAGL---------- PDK4_RHIFE PDK4_RHIFE -------------------------------MKAARFVMRSARSLSSAGL---------- B3KUX1_HUMAN B3KUX1_HUMAN -------------------------------M---------------------------- B3KU25_HUMAN B3KU25_HUMAN -------------------------------M---------------------------- A4D1H4_HUMAN A4D1H4_HUMAN -------------------------------MKAARFVLRSAGSLNGAGL---------- PDK4_HUMAN PDK4_HUMAN -------------------------------MKAARFVLRSAGSLNGAGL---------- Q53FG1_HUMAN Q53FG1_HUMAN -------------------------------MKAARFVLRSAGSLNGAGL---------- Q20AM2_ICTPU Q20AM2_ICTPU ------------------------------------------------------------ A0T2S7_9NEOB A0T2S7_9NEOB ------------------------------------------------------------ Q6DFQ9_XENTR Q6DFQ9_XENTR -------------------------------MKFARFLLKNAALAN-------------- Q6PB12_XENLA Q6PB12_XENLA -------------------------------MKFARFLLKNAALAN-------------- Q7ZXU6_XENLA Q7ZXU6_XENLA -------------------------------MKFARFLLKNAALAN-------------- Q4RNN6_TETNG Q4RNN6_TETNG -------------------------------MKLVRFIARSAALAS-------------- Q9JID3_RAT Q9JID3_RAT -------------------------------MRWFRALLKNASLAG-------------- B3DIT9_DANRE B3DIT9_DANRE -------------------------------MKFAQIMLKNSSKLN-------------- Q1LX05_DANRE Q1LX05_DANRE ------------------------------------------------------------ Q99P94_PHOSU Q99P94_PHOSU -------------------------------R----ALLKNASLAG-------------- PDK2_RAT PDK2_RAT -------------------------------MRWFRALLKNASLAG-------------- PDK2_MOUSE PDK2_MOUSE -------------------------------MRWVRALLKNASLAG-------------- Q8VC63_MOUSE Q8VC63_MOUSE -------------------------------MRWVRALLKNASLAG-------------- Q1JPJ6_BOVIN Q1JPJ6_BOVIN ------------------------------------------------------------ Q29RH8_BOVIN Q29RH8_BOVIN RRGTGPDWAEQSASAARAGSRTRVLEVVAIAMRWVRALLKNASLAG-------------- Q5NVN2_PONAB Q5NVN2_PONAB -------------------------------MRWVWALLKNASLAG-------------- B3KNW0_HUMAN B3KNW0_HUMAN ------------------------------------------------------------ Q6P515_HUMAN Q6P515_HUMAN -------------------------------MRWVWALLKNASLAG-------------- B4DLP2_HUMAN B4DLP2_HUMAN -------------------------------MRWVWALLKNASLAG-------------- PDK2_HUMAN PDK2_HUMAN -------------------------------MRWVWALLKNASLAG-------------- Q4R567_MACFA Q4R567_MACFA -------------------------------MRWVWALLKNASLAG-------------- Q63ZR8_XENLA Q63ZR8_XENLA -------------------------------MRLLRALMKSAPLSSSS------------ Q6IR88_XENLA Q6IR88_XENLA -------------------------------MRLLRALMRSAPLSSRN------------ Q5ZLT4_CHICK Q5ZLT4_CHICK -------------------------------MRLLRALLRCASPGS-------------- PDK1_RAT PDK1_RAT -------------------------------MRLARLLRGGTSVRPLCAVPCASRSLASD Q5FVT5_RAT Q5FVT5_RAT -------------------------------MRLARLLRGGTSVRPLCAVPCASRSLASD Q99P95_PHOSU Q99P95_PHOSU ------------------------------------------------------------ PDK1_MOUSE PDK1_MOUSE -------------------------------MRLARLLRGGTSVRPLCAVPCASRSLASA Q8R2U8_MOUSE Q8R2U8_MOUSE -------------------------------MRLARLLRGGTSVRPLCAVPCASRSL--A Q3U5E5_MOUSE Q3U5E5_MOUSE -------------------------------MRLARLLRGGTSVRPLCAVPCASRSLASA Q8BFP4_MOUSE Q8BFP4_MOUSE ------------------------------------------------------------ Q308M4_HUMAN Q308M4_HUMAN -------------------------------MRLARLLLGAALAGPGPGLRAAGFSRSFS B7Z7N6_HUMAN B7Z7N6_HUMAN ------------------------------------------------------------ PDK1_HUMAN PDK1_HUMAN -------------------------------MRLARLLRGAALAGPGPGLRAAGFSRSFS Q53R49_HUMAN Q53R49_HUMAN -------------------------------MRLARLLRGAALAGPGPGLRAAGFSRSFS B7Z937_HUMAN B7Z937_HUMAN -------------------------------MRLARLLRGAALAGPGPGLRAAGFSRSFS B7Z207_HUMAN B7Z207_HUMAN ------------------------------------------------------------ B5DGI3_SALSA B5DGI3_SALSA -------------------------------MRLFNFLLKD------------------- Q4SMY8_TETNG Q4SMY8_TETNG -------------------------------MRIFTFLLKNS------------------ B5XFN4_SALSA B5XFN4_SALSA -------------------------------MRLFAVLLKNT------------------ A9ULF7_XENTR A9ULF7_XENTR -------------------------------MRLCRFLLKNT------------------ Q5ZLT2_CHICK Q5ZLT2_CHICK -------------------------------MRLCGALLKSP------------------ Q3V250_MOUSE Q3V250_MOUSE -------------------------------MRLFYRLLKQP------------------ B5DFI9_RAT B5DFI9_RAT -------------------------------MRLFYRLLKQP------------------ PDK3_MOUSE PDK3_MOUSE -------------------------------MRLFYRLLKQP------------------ Q4FJR4_MOUSE Q4FJR4_MOUSE -------------------------------MRLFYRLLKQP------------------ A6QLG3_BOVIN A6QLG3_BOVIN -------------------------------MRLFRLLLKQP------------------ B4DXG6_HUMAN B4DXG6_HUMAN -------------------------------MRLFRWLLKQP------------------ PDK3_HUMAN PDK3_HUMAN -------------------------------MRLFRWLLKQP------------------ MATCH CONSENSUS ???????????????????????????????M????????????????????????????

Q7ZV57_DANRE Q7ZV57_DANRE ------------APKHIDYYAKFSPLPLSMKQFLDFGTTNACEKTSFAFLRQELPVRMSN Q4T5D1_TETNG Q4T5D1_TETNG ------------VPKHIEHFSKFSPSPLSMKQFLDFGTINACERTSFVFLRQELPVRLSN A6QR49_BOVIN A6QR49_BOVIN ------------IPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLAN PDK4_SPETR PDK4_SPETR ------------VPREVELFSRYSPSPLSMKQLLDFGSDNACERTSFSFLRQELPVRLAN PDK4_MOUSE PDK4_MOUSE ------------VPREVELFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLAN Q544J2_MOUSE Q544J2_MOUSE ------------VPREVELFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLAN PDK4_RAT PDK4_RAT ------------VPREVELFSRYSPSPLSMKQLLDFGSENACERTSFSFLRQELPVRLAN PDK4_RHIFE PDK4_RHIFE ------------VPREVEHFSRYSPSPLSMKQLLDFGSENACERTSSAFLRQELPVRLAN B3KUX1_HUMAN B3KUX1_HUMAN ------------------------------------------------------------ B3KU25_HUMAN B3KU25_HUMAN ------------------------------KQLLDFGSENACERTSFAFLRQELPVRLAN A4D1H4_HUMAN A4D1H4_HUMAN ------------VPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLAN PDK4_HUMAN PDK4_HUMAN ------------VPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLAN Q53FG1_HUMAN Q53FG1_HUMAN ------------VPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLAN Q20AM2_ICTPU Q20AM2_ICTPU ------------------------------------------------------------ A0T2S7_9NEOB A0T2S7_9NEOB -----------------------------MKQFIDFGSANGCEKTSFVFLRQELPVRLAN Q6DFQ9_XENTR Q6DFQ9_XENTR ------------APKQIERFSRFSPSPLSMKQFIDFGSANGCEKTSFAFLRQELPVRLAN Q6PB12_XENLA Q6PB12_XENLA ------------APKQIERFSRFSPSPLSMKQFIDFGSANGCEKISFAFLRQELPVRLAN Q7ZXU6_XENLA Q7ZXU6_XENLA ------------APKQIERFSRFSPSPLSMKQFIDFGSANGCEKTSFGFLRQELPVRLAN Q4RNN6_TETNG Q4RNN6_TETNG ------------APTHIEHFSKFSPSPLSMKQFLDFGSINACEKTSFVFLRQELPVRLSN Q9JID3_RAT Q9JID3_RAT ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN B3DIT9_DANRE B3DIT9_DANRE ------------IPKQVDRFSKFSPSPLSMKQFIDFGSANACEKTSFMFLRQELPVRLAN Q1LX05_DANRE Q1LX05_DANRE ------------------------------------------------------------ Q99P94_PHOSU Q99P94_PHOSU ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN PDK2_RAT PDK2_RAT ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN PDK2_MOUSE PDK2_MOUSE ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN Q8VC63_MOUSE Q8VC63_MOUSE ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN Q1JPJ6_BOVIN Q1JPJ6_BOVIN ------------------------------------------------------------ Q29RH8_BOVIN Q29RH8_BOVIN ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN Q5NVN2_PONAB Q5NVN2_PONAB ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN B3KNW0_HUMAN B3KNW0_HUMAN ------------------------------------------------------------ Q6P515_HUMAN Q6P515_HUMAN ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN B4DLP2_HUMAN B4DLP2_HUMAN ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN PDK2_HUMAN PDK2_HUMAN ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN Q4R567_MACFA Q4R567_MACFA ------------APKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLAN Q63ZR8_XENLA Q63ZR8_XENLA ------------TTSQVDFYSKFSPSPLSMKQFLDFGSVNACEKTSFIFLRHELPVRLAN Q6IR88_XENLA Q6IR88_XENLA ------------TPSLVDFYSKFSPSPLSMKQFLDFGSVNACEKTSFIFLRHELPVRLAN Q5ZLT4_CHICK Q5ZLT4_CHICK ------------IPQQVDFYSRFSPSPLSMKQFLDFGSENACEKTSFMFLRQELPVRLAN PDK1_RAT PDK1_RAT SASGSGPASESGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLAN Q5FVT5_RAT Q5FVT5_RAT SASGSGPASESGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLAN Q99P95_PHOSU Q99P95_PHOSU -------------PGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRRELPVRLAN PDK1_MOUSE PDK1_MOUSE SASGSGPASELGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLAN Q8R2U8_MOUSE Q8R2U8_MOUSE SASGSGPASELGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLAN Q3U5E5_MOUSE Q3U5E5_MOUSE SASGSGPASELGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLAN Q8BFP4_MOUSE Q8BFP4_MOUSE ------------------------------------------------------------ Q308M4_HUMAN Q308M4_HUMAN SDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLAN B7Z7N6_HUMAN B7Z7N6_HUMAN -----------------------------------------------MFLRQELPVRLAN PDK1_HUMAN PDK1_HUMAN SDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLAN Q53R49_HUMAN Q53R49_HUMAN SDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLAN B7Z937_HUMAN B7Z937_HUMAN SDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLAN B7Z207_HUMAN B7Z207_HUMAN ------------------------------------------------------------ B5DGI3_SALSA B5DGI3_SALSA ------------VTSKIEYYSRFSPSPMSIKQFLDFGRENACEKTSYVFLRKELAVRGAN Q4SMY8_TETNG Q4SMY8_TETNG ------------NPK-IEYYSKFSPSPLSIKQFLDFGRENACEKTSYMFLRKELPVRLAN B5XFN4_SALSA B5XFN4_SALSA --------------KKIEYYSRFSPSPLSIKQFLEFGRDNACEKTSFMFLRKELPVRLVN A9ULF7_XENTR A9ULF7_XENTR ------------VPSQIEYYSKFSPSPLSIKQFLDFGRNNACEKTSYLFLRKELPVRIAN Q5ZLT2_CHICK Q5ZLT2_CHICK ------------IPKQIEYYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLAN Q3V250_MOUSE Q3V250_MOUSE ------------VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLAN B5DFI9_RAT B5DFI9_RAT ------------VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLAN PDK3_MOUSE PDK3_MOUSE ------------VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLAN Q4FJR4_MOUSE Q4FJR4_MOUSE ------------VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLAN A6QLG3_BOVIN A6QLG3_BOVIN ------------VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLAN B4DXG6_HUMAN B4DXG6_HUMAN ------------VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLAN PDK3_HUMAN PDK3_HUMAN ------------VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLAN MATCH CONSENSUS ???????????????????????SPSPLS?KQ??DFG??NACE?TS??FLR?ELPVRLAN

Q7ZV57_DANRE Q7ZV57_DANRE SLKEISLLPDQLIETQSVQLVHSWF-----VQSLMDILEFQDKCPDDPRVLAE------- Q4T5D1_TETNG Q4T5D1_TETNG IMKEINLLPDRLLGTPSVQLVQSWY-----IQSLMEILEFLDKNPDDQSVLET------- A6QR49_BOVIN A6QR49_BOVIN ILKEIYILPDRLVNTSSVQLVKSWY-----MQSLMELVEFHEKSPEDQKALSD------- PDK4_SPETR PDK4_SPETR ILKEIDVLPDRLTNTSSVQLVKSWY-----IQSLMELVEFHEKSPEDQKNLSD------- PDK4_MOUSE PDK4_MOUSE ILKEIDILPDRLVNTPSVQLVKSWY-----IQSLMDLVEFHEKSPEDQKALSE------- Q544J2_MOUSE Q544J2_MOUSE ILKEIDILPDRLVNTPSVQLVKSWY-----IQSLMDLVEFHEKSPEDQKALSE------- PDK4_RAT PDK4_RAT ILKEIDILPEHLVNTPSVQLVKSWY-----IQSLMDLVEFHEKSPEDQKVLSD------- PDK4_RHIFE PDK4_RHIFE ILKEIDILPDRLVNTSSVQLVKSWY-----IQSLMELVEFHERSPDDQKVLSD------- B3KUX1_HUMAN B3KUX1_HUMAN ------------------------------------------------------------ B3KU25_HUMAN B3KU25_HUMAN ILKEIDILPTQLVNTSSVQLVKSWY-----IQSLMDLVEFHEKSPDDQKALSD------- A4D1H4_HUMAN A4D1H4_HUMAN ILKEIDILPTQLVNTSSVQLVKSWY-----IQSLMDLVEFHEKSPDDQKALSD------- PDK4_HUMAN PDK4_HUMAN ILKEIDILPTQLVNTSSVQLVKSWY-----IQSLMDLVEFHEKSPDDQKALSD------- Q53FG1_HUMAN Q53FG1_HUMAN ILKEIDILPTQLVNTSSVQLVKSWY-----IQSLMDLVEFHEKSPDDQKALSD------- Q20AM2_ICTPU Q20AM2_ICTPU ------------------------------------------------------------ A0T2S7_9NEOB A0T2S7_9NEOB IMREIYILPDPLLGTPSVQLVQSWY-----IQSLMELIEFVEMNPEDQRVLSD------- Q6DFQ9_XENTR Q6DFQ9_XENTR IMRELYILPDQLLGTPSVQLVQSWY-----IQSLMELIEFVERNPEDQRVLSD------- Q6PB12_XENLA Q6PB12_XENLA IMRELYILPDQLLGTPSVQLVQSWY-----IQSLMELIEFVEKDPEEQRVLSD------- Q7ZXU6_XENLA Q7ZXU6_XENLA IMRELYILPDQLLGTPSVQLVQSWY-----IQSLMELIEFVERDPEDQRVLSD------- Q4RNN6_TETNG Q4RNN6_TETNG IMKEINLLPGRLLTTPSVQMVQSW------------------------------------ Q9JID3_RAT Q9JID3_RAT IMKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- B3DIT9_DANRE B3DIT9_DANRE IMKEIDFLPDKLLGTPSLKLLQSWY-----AQSLMELVDFLEKDPDDKKILTK------- Q1LX05_DANRE Q1LX05_DANRE ------------------------------------------------------------ Q99P94_PHOSU Q99P94_PHOSU IMKEINLLPDRVLGTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- PDK2_RAT PDK2_RAT IMKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- PDK2_MOUSE PDK2_MOUSE IMKEINLLPDRVLGTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- Q8VC63_MOUSE Q8VC63_MOUSE IMKEINLLPDRVLGTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- Q1JPJ6_BOVIN Q1JPJ6_BOVIN -MKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- Q29RH8_BOVIN Q29RH8_BOVIN IMKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- Q5NVN2_PONAB Q5NVN2_PONAB IMKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDVMEFLDKDPEDHRTLSQ------- B3KNW0_HUMAN B3KNW0_HUMAN -MKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- Q6P515_HUMAN Q6P515_HUMAN IMKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- B4DLP2_HUMAN B4DLP2_HUMAN IMKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDIME--------------------- PDK2_HUMAN PDK2_HUMAN IMKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- Q4R567_MACFA Q4R567_MACFA IMKEINLLPDRVLSTPSVQLVQSWY-----VQSLLDIMEFLDKDPEDHRTLSQ------- Q63ZR8_XENLA Q63ZR8_XENLA IMKEINLLPDNLLKMPSIRLVQSWY-----VQSFQEIIDFKDTNTEDPNTVRK------- Q6IR88_XENLA Q6IR88_XENLA IMKEINLLPDNLLKMPSIKLVQSWY-----VQSFQEIIDFKDTNAEDLNTVQK------- Q5ZLT4_CHICK Q5ZLT4_CHICK IMKEISLLPDNLLRTPSVQLVQSWY-----VQSLQEILDFKDKSSEDSGAIHS------- PDK1_RAT PDK1_RAT IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKTIYE------- Q5FVT5_RAT Q5FVT5_RAT IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKTIYE------- Q99P95_PHOSU Q99P95_PHOSU IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKTIYE------- PDK1_MOUSE PDK1_MOUSE IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKTIYE------- Q8R2U8_MOUSE Q8R2U8_MOUSE IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKTIYE------- Q3U5E5_MOUSE Q3U5E5_MOUSE IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKTIYE------- Q8BFP4_MOUSE Q8BFP4_MOUSE ------------------------------------------------------------ Q308M4_HUMAN Q308M4_HUMAN IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKAIYERPRRTWL B7Z7N6_HUMAN B7Z7N6_HUMAN IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKAIYD------- PDK1_HUMAN PDK1_HUMAN IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKAIYD------- Q53R49_HUMAN Q53R49_HUMAN IMKEISLLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKAIYD------- B7Z937_HUMAN B7Z937_HUMAN IMKEISRLPDNLLRTPSVQLVQSWY-----IQSLQELLDFKDKSAEDAKAIYERPRRTWL B7Z207_HUMAN B7Z207_HUMAN ------------------------------------------------------------ B5DGI3_SALSA B5DGI3_SALSA TMKEINLLPSDLRTQPSVKLVHSWY-----IQSFEELLNYEHRGPEDSRTLND------- Q4SMY8_TETNG Q4SMY8_TETNG TMKEVNLLPDKLLGQPSVRLVQKWLQVSPPLLAVPQLPGAPDRDPQPPQ----------- B5XFN4_SALSA B5XFN4_SALSA TMREVNLLPDNLLSQPSIKLVQKWY-----MQSFVELLGYENRKPEDPQALND------- A9ULF7_XENTR A9ULF7_XENTR SLKEVNLLPESLLQRPSVKLVRSWY-----LQSFLELLEYENKSPEDSDVLYD------- Q5ZLT2_CHICK Q5ZLT2_CHICK TMREVNLLPDNLLNRPSVGLVQSWY-----MQSFLELLEYENKSPEDPHVLDD------- Q3V250_MOUSE Q3V250_MOUSE TMREVNLLPDNLLNRPSVGLVQSWY-----MQSFLELLEYENKSPEDPRVLDN------- B5DFI9_RAT B5DFI9_RAT TMREVNLLPDNLLNRPSVGLVQSWY-----MQSFLELLEYENKSPEDPRVLDN------- PDK3_MOUSE PDK3_MOUSE TMREVNLLPDNLLNRPSVGLVQSWY-----MQSFLELLEYENKSPEDPRVLDN------- Q4FJR4_MOUSE Q4FJR4_MOUSE TMREVNLLPDNLLNRPSVGLVQSWY-----MQSFLELLEYENKSPEDPRVLDN------- A6QLG3_BOVIN A6QLG3_BOVIN TMREVNLLPENLLNRPSVGLVQSWY-----MQSFLELLEYENKSPEDPQVLDN------- B4DXG6_HUMAN B4DXG6_HUMAN TMREVNLLPDNLLNRPSVGLVQSWY-----MQSFLELLEYENKSPEDPQVLDN------- PDK3_HUMAN PDK3_HUMAN TMREVNLLPDNLLNRPSVGLVQSWY-----MQSFLELLEYENKSPEDPQVLDN------- MATCH CONSENSUS ???E???LP???????SV?LV?SWY??????QS?????????????D?????????????

Q7ZV57_DANRE Q7ZV57_DANRE -------------FVETLVTIRNRHNDVVATMAQGVIEYRDT-FGADPVTSQNIQYFLDR Q4T5D1_TETNG Q4T5D1_TETNG -------------FVEVLETIRNRHNEVVPTMAQGVIEYKDAFCQQDPVTDHNIQYFLDR A6QR49_BOVIN A6QR49_BOVIN -------------FVDTLIKVRNRHHDVIPTMAQGILEYKDA-CTVDPVTNQNLQYFLDR PDK4_SPETR PDK4_SPETR -------------FVDTLIKVRNRHHNVVPTMAQGILEYKDT-CTVDPVTNQSLQYFLDR PDK4_MOUSE PDK4_MOUSE -------------FVDTLVKVRNRHHNVVPTMAQGILEYKDT-CTVDPVTNQNLQYFLDR Q544J2_MOUSE Q544J2_MOUSE -------------FVDTLVKVRNRHHNVVPTMAQGILEYKDT-CTVDPVTNQNLQYFLDR PDK4_RAT PDK4_RAT -------------FVDTLVKVRNRHHNVVPTMAQGILEYKDN-CTVDPVTNQNLQYFLDR PDK4_RHIFE PDK4_RHIFE -------------FVDTLITVRNRHHNVVPTMAQGIIEYKDS-CTVDPVTNQNLQYFLDR B3KUX1_HUMAN B3KUX1_HUMAN ------------------------------------------------------------ B3KU25_HUMAN B3KU25_HUMAN -------------FVDTLIKVRNRHHNVVPTMAQGIIEYKDA-CTVDPVTNQNLQYFLDR A4D1H4_HUMAN A4D1H4_HUMAN -------------FVDTLIKVRNRHHNVVPTMAQGIIEYKDA-CTVDPVTNQNLQYFLDR PDK4_HUMAN PDK4_HUMAN -------------FVDTLIKVRNRHHNVVPTMAQGIIEYKDA-CTVDPVTNQNLQYFLDR Q53FG1_HUMAN Q53FG1_HUMAN -------------FVDTLIKVRNRHHNVVPTMAQGIIEYKDA-CTVDPVTNQNLQYFLDR Q20AM2_ICTPU Q20AM2_ICTPU ------------------------------------------------------------ A0T2S7_9NEOB A0T2S7_9NEOB -------------FTETLVNIRNRHNNVVPTMAQGVIEYKEA-FGVDPVTNQNVQYFLDR Q6DFQ9_XENTR Q6DFQ9_XENTR -------------FTEALVTIRNRHNNVVPTMAQGVIEYKEA-FGVDPVTNQNVQYFLDR Q6PB12_XENLA Q6PB12_XENLA -------------FTEALVTIRNRHNNVVPTMAQGVIEYKEA-FGVDPVTNQNVQYFLDR Q7ZXU6_XENLA Q7ZXU6_XENLA -------------FTEALVTIRNRHNDVVPTMAQGVIEYKEA-FGVDPVTNQNVQYFLDR Q4RNN6_TETNG Q4RNN6_TETNG -------------FVDALVTIRNRHNDVVPTMAQGILEYKEA-FPQDPVTNQNIQYFLDR Q9JID3_RAT Q9JID3_RAT -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR B3DIT9_DANRE B3DIT9_DANRE -------------FTETLINVRNRHNNVVPTMAQGVLEYKEA-FGVDPVTNQNVQYFLDR Q1LX05_DANRE Q1LX05_DANRE ------------------------------------------------------------ Q99P94_PHOSU Q99P94_PHOSU -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR PDK2_RAT PDK2_RAT -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR PDK2_MOUSE PDK2_MOUSE -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR Q8VC63_MOUSE Q8VC63_MOUSE -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR Q1JPJ6_BOVIN Q1JPJ6_BOVIN -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR Q29RH8_BOVIN Q29RH8_BOVIN -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR Q5NVN2_PONAB Q5NVN2_PONAB -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR B3KNW0_HUMAN B3KNW0_HUMAN -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR Q6P515_HUMAN Q6P515_HUMAN -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR B4DLP2_HUMAN B4DLP2_HUMAN --------------------------------------------------------FLDR PDK2_HUMAN PDK2_HUMAN -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR Q4R567_MACFA Q4R567_MACFA -------------FTDALVTIRNRHNDVVPTMAQGVLEYKDT-YGDDPVSNQNIQYFLDR Q63ZR8_XENLA Q63ZR8_XENLA -------------FSDTVITIRNRHNDVIPTMAQGVVEYKDS-FGVDPVTSQNVQYFLDR Q6IR88_XENLA Q6IR88_XENLA -------------FTDTVITIRNRHNDVIPTMAQGVVEFKDS-FGVDPVTSQNVQYFLDR Q5ZLT4_CHICK Q5ZLT4_CHICK -------------FTDTVIKIRNRHNDVIPTMAQGVIEYKES-FGIDPVTSQNVQYFLDC PDK1_RAT PDK1_RAT -------------FTDTVIRIRNRHNDVIPTMAQGVTEYKES-FGVDPVTSQNVQYFLDR Q5FVT5_RAT Q5FVT5_RAT -------------FTDTVIRIRNRHNDVIPTMAQGVTEYKES-FGVDPVTSQNVQYFLDR Q99P95_PHOSU Q99P95_PHOSU -------------FTDTVIRIRNRHNDVIPTMAQGVTEYKES-FGVDPVTSQNVQYFLDR PDK1_MOUSE PDK1_MOUSE -------------FTDTVIRIRNRHNDVIPTMAQGVTEYKES-FGVDPVTSQNVQYFLDR Q8R2U8_MOUSE Q8R2U8_MOUSE -------------FTDTVIRIRNRHNDVIPTMAQGVTEYKES-FGVDPVTSQNVQYFLDR Q3U5E5_MOUSE Q3U5E5_MOUSE -------------FTDTVIRIRNRHNDVIPTMAQGVTEYKES-FGVDPVTSQNVQYFLDR Q8BFP4_MOUSE Q8BFP4_MOUSE ------------------------------------------------------------ Q308M4_HUMAN Q308M4_HUMAN QVSSLCCMACKMIFTDTVIRIRNRHNDVIPTMAQGVIEYKES-FGVDPVTSQNVQYFLDR B7Z7N6_HUMAN B7Z7N6_HUMAN -------------FTDTVIRIRNRHNDVIPTMAQGVIEYKES-FGVDPVTSQNVQYFLDR PDK1_HUMAN PDK1_HUMAN -------------FTDTVIRIRNRHNDVIPTMAQGVIEYKES-FGVDPVTSQNVQYFLDR Q53R49_HUMAN Q53R49_HUMAN -------------FTDTVIRIRNRHNDVIPTMAQGVIEYKES-FGVDPVTSQNVQYFLDR B7Z937_HUMAN B7Z937_HUMAN QVSSLCCMACKMIFTDTVIRIRNRHNDVIPTMAQGVIEYKES-FGVDPVTSQNVQYFLDR B7Z207_HUMAN B7Z207_HUMAN -------------------------------MAQGVIEYKES-FGVDPVTSQNVQYFLDR B5DGI3_SALSA B5DGI3_SALSA -------------FLDTLVKIRNRHNEVVPTMAQGVIEYKQK-FGFDPFISSNVQYFLDR Q4SMY8_TETNG Q4SMY8_TETNG --------------------------RRVPTMAQGVIEYREK-FGFDPFISSNVQYFLDR B5XFN4_SALSA B5XFN4_SALSA -------------FLELLIEIRNRHNDVVPTMAQGVIEYKEK-FGFDPFISSNIQYFLDR A9ULF7_XENTR A9ULF7_XENTR -------------FLNVLIQVRNRHNDVVPTMAQGVIEYKEK-YGFDPFVSSNIQYFLDR Q5ZLT2_CHICK Q5ZLT2_CHICK -------------FLDVLIKVRNRHNDVVPTMAQGVIEYKEK-YGFDPFVSSNIQYFLDR Q3V250_MOUSE Q3V250_MOUSE -------------FLNVLINIRNRHNDVVPTMAQGVIEYKEK-FGFDPFISSNIQYFLDR B5DFI9_RAT B5DFI9_RAT -------------FLHVLINIRNRHNDVVPTMAQGVIEYKEK-FGFDPFISSNIQYFLDR PDK3_MOUSE PDK3_MOUSE -------------FLNVLINIRNRHNDVVPTMAQGVIEYKEK-FGFDPFISSNIQYFLDR Q4FJR4_MOUSE Q4FJR4_MOUSE -------------FLNVLINIRNRHNDVVPTMAQGVIEYKEK-FGFDPFISSNIQYFLDR A6QLG3_BOVIN A6QLG3_BOVIN -------------FLQVLIKVRNRHNDVVPTMAQGVIEYKEK-FGFDPFISSNIQYFLDR B4DXG6_HUMAN B4DXG6_HUMAN -------------FLQVLIKVRNRHNDVVPTMAQGVIEYKEK-FGFDPFISTNIQYFLDR PDK3_HUMAN PDK3_HUMAN -------------FLQVLIKVRNRHNDVVPTMAQGVIEYKEK-FGFDPFISTNIQYFLDR MATCH CONSENSUS ?????????????F???????RNRH??V?PTMAQG??EYK??????DP????N?QYFLDR

Q7ZV57_DANRE Q7ZV57_DANRE FYMSRVSIRMLINQHT------------------------LIFD--GSTNPGHPSSIGCI Q4T5D1_TETNG Q4T5D1_TETNG FYTSRISIRMLINQHT------------------------LVFS--GNINPAHPNTIGCI A6QR49_BOVIN A6QR49_BOVIN FYMNRISTRMLMNQHI------------------------LIF---GDLQTGNPSLIGSI PDK4_SPETR PDK4_SPETR FYMNRISTRMLMNQHI------------------------LIF---SDSQTGNPSHIGSI PDK4_MOUSE PDK4_MOUSE FYMNRISTRMLMNQHI------------------------LIF---SDSKTGNPSHIGSI Q544J2_MOUSE Q544J2_MOUSE FYMNRISTRMLMNQHI------------------------LIF---SDSKTGNPSHIGSI PDK4_RAT PDK4_RAT FYMNRISTRMLMNQHI------------------------LIF---SDSKTGNPSHIGSI PDK4_RHIFE PDK4_RHIFE FYMNRISTRMLMNQHI------------------------LIF---SDSQTGNPSHIGSI B3KUX1_HUMAN B3KUX1_HUMAN ------------------------------------------------------------ B3KU25_HUMAN B3KU25_HUMAN FYMNRISTRMLMNQHI------------------------LIF---SDSQTGNPSHIGSI A4D1H4_HUMAN A4D1H4_HUMAN FYMNRISTRMLMNQHI------------------------LIF---SDSQTGNPSHIGSI PDK4_HUMAN PDK4_HUMAN FYMNRISTRMLMNQHI------------------------LIF---SDSQTGNPSHIGSI Q53FG1_HUMAN Q53FG1_HUMAN FYMNRISTRMLMNQHI------------------------LIF---SDSQTGNPSHIGSI Q20AM2_ICTPU Q20AM2_ICTPU --TSGIWTRMFMNQHT------------------------VMFS--VSTNPAHPKHIGSF A0T2S7_9NEOB A0T2S7_9NEOB FYMSRISIRMLINQHT------------------------LLFD--GGTNPAHPKHIGGI Q6DFQ9_XENTR Q6DFQ9_XENTR FYMSRISIRMLINQHT------------------------LLFD--GGTNPAHPKHIGSI Q6PB12_XENLA Q6PB12_XENLA FYMSRISIRMLINQHT------------------------LLFD--GGTNPAHPKHIGSI Q7ZXU6_XENLA Q7ZXU6_XENLA FYMSRISIRMLINQHT------------------------LLFD--GGTNPAHPKHIGSI Q4RNN6_TETNG Q4RNN6_TETNG FYTSRISIRMLINQHT------------------------LIFD--GSANPVHPNTIGSI Q9JID3_RAT Q9JID3_RAT FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI B3DIT9_DANRE B3DIT9_DANRE FYMSRISTRMLMNQHT------------------------LIFD--GSTNPAHPKHIGSI Q1LX05_DANRE Q1LX05_DANRE ----------------------------------------LIFD--GSTNPAHPKHIGSI Q99P94_PHOSU Q99P94_PHOSU FYLSRISIRKLINQHT------------------------LIFD--GSTNPAHP------ PDK2_RAT PDK2_RAT FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI PDK2_MOUSE PDK2_MOUSE FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI Q8VC63_MOUSE Q8VC63_MOUSE FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI Q1JPJ6_BOVIN Q1JPJ6_BOVIN FYLSRISIRMLINQHT------------------------LLFD--GRTNPAHPKHIGSI Q29RH8_BOVIN Q29RH8_BOVIN FYLSRISIRMLINQHT------------------------LLFD--GRTNPAHPKHIGSI Q5NVN2_PONAB Q5NVN2_PONAB FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI B3KNW0_HUMAN B3KNW0_HUMAN FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI Q6P515_HUMAN Q6P515_HUMAN FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI B4DLP2_HUMAN B4DLP2_HUMAN FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI PDK2_HUMAN PDK2_HUMAN FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI Q4R567_MACFA Q4R567_MACFA FYLSRISIRMLINQHT------------------------LIFD--GSTNPAHPKHIGSI Q63ZR8_XENLA Q63ZR8_XENLA FYMSRISIRMLLNQHT------------------------LLFGGKVKVNPAHPKHIGSI Q6IR88_XENLA Q6IR88_XENLA FYMSRISIRMLLNQHT------------------------LLFGGEVKVNPAHPKHIGSI Q5ZLT4_CHICK Q5ZLT4_CHICK FYMSRISIRMLLNQHS------------------------LLFG--GKINPAHPKHIGSI PDK1_RAT PDK1_RAT FYMSRISIRMLLNQHS------------------------LLFG--GKGSPSHRKHIGSI Q5FVT5_RAT Q5FVT5_RAT FYMSRISIRMLLNQHS------------------------LLFG--GKGSPSHRKHIGSI Q99P95_PHOSU Q99P95_PHOSU FYMSRISIRMLLNQHS------------------------LLFG--GKGSPSYRKHIGSI PDK1_MOUSE PDK1_MOUSE FYMSRISIRMLLNQHS------------------------LLFG--GKGSPSHRKHIGSI Q8R2U8_MOUSE Q8R2U8_MOUSE FYMSRISIRMLLNQHS------------------------LLFG--GKGSPSHRKHIGSI Q3U5E5_MOUSE Q3U5E5_MOUSE FYMSRISIRMLLNQHS------------------------LLFG--GKGSPSHRKHIGSI Q8BFP4_MOUSE Q8BFP4_MOUSE ------------------------------------------------------------ Q308M4_HUMAN Q308M4_HUMAN FYMSRISIRMLLNQHS------------------------LLFGGKGKGSPSHRKHIGSI B7Z7N6_HUMAN B7Z7N6_HUMAN FYMSRISIRMLLNQHS------------------------LLFGGKGKGSPSHRKHIGSI PDK1_HUMAN PDK1_HUMAN FYMSRISIRMLLNQHS------------------------LLFGGKGKGSPSHRKHIGSI Q53R49_HUMAN Q53R49_HUMAN FYMSRISIRMLLNQHS------------------------LLFGGKGKGSPSHRKHIGSI B7Z937_HUMAN B7Z937_HUMAN FYMSRISIRMLLNQHS------------------------LLFGGKGKGSPSHRKHIGSI B7Z207_HUMAN B7Z207_HUMAN FYMSRISIRMLLNQHS------------------------LLFGGKGKGSPSHRKHIGSI B5DGI3_SALSA B5DGI3_SALSA FYTNRISFRMLINQHT------------------------LLFG--DDRTTSHPKHIGGI Q4SMY8_TETNG Q4SMY8_TETNG FYTNRISFRMLINQHSEPPPPPLPPSVLCCPQPLLFVLSALLFG--NDTNPAHPKHIGSI B5XFN4_SALSA B5XFN4_SALSA FYTNRISFRMLINQHT------------------------LLFG--NDTNPAHPKHIGSI A9ULF7_XENTR A9ULF7_XENTR FYMNRISFRMLINQHT------------------------LLFG--GDINPAHPKHIGSI Q5ZLT2_CHICK Q5ZLT2_CHICK FYTNRISFRMLINQHT------------------------LLFG--GDINPAHPKHIGSI Q3V250_MOUSE Q3V250_MOUSE FYTNRISFRMLINQHT------------------------LLFG--GDTNPAHPKHIGSI B5DFI9_RAT B5DFI9_RAT FYTNRISFRMLINQHT------------------------LLFG--GDTNPAHPKHIGSI PDK3_MOUSE PDK3_MOUSE FYTNRISFRMLINQHT------------------------LLFG--GDTNPAHPKHIGSI Q4FJR4_MOUSE Q4FJR4_MOUSE FYTNRISFRMLINQHT------------------------LLFG--GDTNPAHPKHIGSI A6QLG3_BOVIN A6QLG3_BOVIN FYTNRISFRMLINQHT------------------------LLFG--GDTNPVHPKHIGSI B4DXG6_HUMAN B4DXG6_HUMAN FYTNRISFRMLINQHT------------------------LLFG--GDTNPVHPKHIGSI PDK3_HUMAN PDK3_HUMAN FYTNRISFRMLINQHT------------------------LLFG--GDTNPVHPKHIGSI MATCH CONSENSUS FY??RIS?RML?NQH?????????????????????????L?F????????????HIGSI

Q7ZV57_DANRE Q7ZV57_DANRE DSCCDVTDVIRDAYESAKMLCEQNYLGSPELELREINAK-NKSKPIEISYVPSHLYHMVF Q4T5D1_TETNG Q4T5D1_TETNG DSMCDVTEVTRDAYESAKLLCEQYYLGAPELELSQMNAN-KDRGPIQISYVPSHLYHMLF A6QR49_BOVIN A6QR49_BOVIN DPNCDVAAVVQDAFECSKMLCDQYYLTSPELNLTQVNVK-FPGQPIHIVYVPSHLHHMLF PDK4_SPETR PDK4_SPETR DPKCDVVAVIQDAFESSKMLCDQYYLTSPELKLTQVNGK-FPGQPIHIVYVPSHLHHMLF PDK4_MOUSE PDK4_MOUSE DPNCDVVAVVQDAFECAKMLCDQYYLTSPELNLTQVNGK-FPGQPIHIVYVPSHLHHMLF Q544J2_MOUSE Q544J2_MOUSE DPNCDVVAVVQDAFECAKMLCDQYYLTSPELNLTQVNGK-FPGQPIHIVYVPSHLHHMLF PDK4_RAT PDK4_RAT DPNCDVVAVVEDAFECAKMLCDQYYLTSPELKLTQVNGK-FPGQPIHIVYVPSHLHHMLF PDK4_RHIFE PDK4_RHIFE DPNCNVAAVVQDAFECSRMLCDQYYLTSPELKLTQVNGK-FPGEPIHIVYVPSHLHHMLF B3KUX1_HUMAN B3KUX1_HUMAN -------------------LCDQYYLSSPELKLTQVNGK-FPDQPIHIVYVPSHLHHMLF B3KU25_HUMAN B3KU25_HUMAN DPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGK-FPDQPIHIVYVPSHLHHMLF A4D1H4_HUMAN A4D1H4_HUMAN DPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGK-FPDQPIHIVYVPSHLHHMLF PDK4_HUMAN PDK4_HUMAN DPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGK-FPDQPIHIVYVPSHLHHMLF Q53FG1_HUMAN Q53FG1_HUMAN DPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGK-FPDQPIHIVYVPSHLHHMLF Q20AM2_ICTPU Q20AM2_ICTPU DPNCDVVEVVKDAYESSRMLRDQYYPMSPEVEIEQVNYK-NPNEPVNIVYVPSHLYHMFY A0T2S7_9NEOB A0T2S7_9NEOB DPNCDVVEVVHDAFENAKMLCEQ------------------------------------- Q6DFQ9_XENTR Q6DFQ9_XENTR DPNCDVVEVVHDAFDTAKMLCEQYYLASPKLIIRQANGK-DPTQPIHIVYVPSHLYHMLF Q6PB12_XENLA Q6PB12_XENLA DPNCDVVEVVHDAFDTAKMLCEQYYLASPELRIKQTNGN-DPSQPIHIVYVPSHLYHMLF Q7ZXU6_XENLA Q7ZXU6_XENLA DPNSDVVEVVHDAFDTAKMLCEQYYLASPELRIKQANGK-DPSQPIHIVYVPSHLYHMLF Q4RNN6_TETNG Q4RNN6_TETNG APHCQVGDVVQDAFHSAKMLCDQYYLCSPDLVLQEMSGE--KKPPISIVYVPSHLYHMLF Q9JID3_RAT Q9JID3_RAT DPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNAT-NATQPIHMVYVPSHLYHMLF B3DIT9_DANRE B3DIT9_DANRE DPNCDVVEVVRDAYESSKMLCDQYYLTSPEVEIKQVNIK-GPSDPIHIVYVPSHLYHMLF Q1LX05_DANRE Q1LX05_DANRE DPNCDVVEVVRDAYESSKMLCDQYYLTSPEVEIKQVNR---PSDPIHIVYVPSHLYHMLF Q99P94_PHOSU Q99P94_PHOSU ------------------------------------------------------------ PDK2_RAT PDK2_RAT DPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNAT-NATQPIHMVYVPSHLYHMLF PDK2_MOUSE PDK2_MOUSE DPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNAT-NANQPIHMVYVPSHLYHMLF Q8VC63_MOUSE Q8VC63_MOUSE DPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNAT-NANQPIHMVYVPSHLYHMLF Q1JPJ6_BOVIN Q1JPJ6_BOVIN DPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAS-NSKQPIHMVYVPSHLYHMLF Q29RH8_BOVIN Q29RH8_BOVIN DPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAS-NSKQPIHMVYVPSHLYHMLF Q5NVN2_PONAB Q5NVN2_PONAB DPNCNVSEVVKGAYDMAKLLCDKYYMASPDLEIQEINAA-NSKQPIHMVYVPSHLYHMLF B3KNW0_HUMAN B3KNW0_HUMAN DPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAA-NSKQPIHMVYVPSHLYHMLF Q6P515_HUMAN Q6P515_HUMAN DPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAA-NSKQPIHMVYVPSHLYHMLF B4DLP2_HUMAN B4DLP2_HUMAN DPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAA-NSKQPIHMVYVPSHLYHMLF PDK2_HUMAN PDK2_HUMAN DPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAA-NSKQPIHMVYVPSHLYHMLF Q4R567_MACFA Q4R567_MACFA DPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAA-NSKQPIHMVYVPSHLYHMLF Q63ZR8_XENLA Q63ZR8_XENLA DPTCNVVDVVKDGYENAKHLCDLYYMSSPELELTEFNAK-SQGQPIQVVYVPSHLYHMVF Q6IR88_XENLA Q6IR88_XENLA DPACNVVDVVKDGYENAKHLCDLYYMSSPELELTEFNAK-SPGQPIQVVYVPSHLYHMVF Q5ZLT4_CHICK Q5ZLT4_CHICK DPSCNVVGVIRDGYESAKSLCDLYYMSSPELVLEELNIK-SPGQPMQVVYVPSHLYHMVF PDK1_RAT PDK1_RAT NPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAK-SPGQPIQVVYVPSHLYHMVF Q5FVT5_RAT Q5FVT5_RAT NPNCDVVEVIKDGYENARRLCDLYYINSPELELEELNAK-SPGQPIQVVYVPSHLYHMVF Q99P95_PHOSU Q99P95_PHOSU NPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAV-SPGQTIQVVYVPSHLYHMVF PDK1_MOUSE PDK1_MOUSE NPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAK-SPGQTIQVVYVPSHLYHMVF Q8R2U8_MOUSE Q8R2U8_MOUSE NPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAK-SPGQTIQVVYVPSHLYHMVF Q3U5E5_MOUSE Q3U5E5_MOUSE NPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAK-SPGQTIQVVYVPSHLYHMVF Q8BFP4_MOUSE Q8BFP4_MOUSE ------------------------------------------------------------ Q308M4_HUMAN Q308M4_HUMAN NPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAK-SPGQPIQVVYVPSHLYHMVF B7Z7N6_HUMAN B7Z7N6_HUMAN NPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAK-SPGQPIQVVYVPSHLYHMVF PDK1_HUMAN PDK1_HUMAN NPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAK-SPGQPIQVVYVPSHLYHMVF Q53R49_HUMAN Q53R49_HUMAN NPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAK-SPGQPIQVVYVPSHLYHMVF B7Z937_HUMAN B7Z937_HUMAN NPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAK-SPGQPIQVVYVPSHLYHMVF B7Z207_HUMAN B7Z207_HUMAN NPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAK-SPGQPIQVVYVPSHLYHMVF B5DGI3_SALSA B5DGI3_SALSA DPSCNVPEVVKDAYETAKMLCEQYYMVAPELNIEEYNSK-APSKAIQVVYVPSHLFHMLF Q4SMY8_TETNG Q4SMY8_TETNG DPTCSVAEVVNDAYDTAKMLCEKYYLAAPELSIQEFNTK-AAGKPIQVVYVPSHLFHMLF B5XFN4_SALSA B5XFN4_SALSA DPTCNVAEVVKDAYETAKMLCEQYYLAAPALQIQEFNMKQDKDKSIQAVYVPSHLFHMLF A9ULF7_XENTR A9ULF7_XENTR DPTCNVPEVVKDAYETAKMLCEQYYMAAPELKIEEFNAK-APGRPLHVVYVPSHLFHMLF Q5ZLT2_CHICK Q5ZLT2_CHICK DPNCNVAEVVKDAYETAKMLCEQYYLVAPDLEVEEFNAK-APNKPIQVVYVPSHLFHMLF Q3V250_MOUSE Q3V250_MOUSE DPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAK-APNKPIQVVYVPSHLFHMLF B5DFI9_RAT B5DFI9_RAT DPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAK-APNKPIQVVYVPSHLFHMLF PDK3_MOUSE PDK3_MOUSE DPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAK-APNKPIQVVYVPSHLFHMLF Q4FJR4_MOUSE Q4FJR4_MOUSE DPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAK-APNKPIQVVYVPSHLFHMLF A6QLG3_BOVIN A6QLG3_BOVIN DPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAK-APNKPIQVVYVPSHLFHMLF B4DXG6_HUMAN B4DXG6_HUMAN DPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAK-APDKPIQVVYVPSHLFHMLF PDK3_HUMAN PDK3_HUMAN DPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAK-APDKPIQVVYVPSHLFHMLF MATCH CONSENSUS ?P?C?V??V??D???????LC??YY???P?L?????N???????PI??VYVPSHL?HM?F

Q7ZV57_DANRE Q7ZV57_DANRE ELFK-NAMRATIENHETSST-LPPIKVMVALGGEDLSIK----ISDRGGGVPFRKIERLF Q4T5D1_TETNG Q4T5D1_TETNG ELFK-NAMRATIETHESSRT-LPPVKIMIALGGEDLSIK----MSDRGGGVPFRRTERLF A6QR49_BOVIN A6QR49_BOVIN ELFK-NAMRATVEHQQNWPS-LTPIQVIVVLGKEDLTIK----ISDRGGGVPLRVIDRLF PDK4_SPETR PDK4_SPETR ELFK-NAMRATVERQESWPS-LTPVEVIVVLGKEDLTIK----ISDRGGGVPLRITDRLF PDK4_MOUSE PDK4_MOUSE ELFK-NAMRATVEHQENRPS-LTPVEATVVLGKEDLTIK----ISDRGGGVPLRITDRLF Q544J2_MOUSE Q544J2_MOUSE ELFK-NAMRATVEHQENRPS-LTPVEATVVLGKEDLTIK----ISDRGGGVPLRITDRLF PDK4_RAT PDK4_RAT ELFK-NAMRATVEHQENRPF-LTPVEATVVLGKEDLTIK----ISDRGGGVPLRITDRLF PDK4_RHIFE PDK4_RHIFE ELFK-NAMRATVEHQENEPS-LTPVEVTVVLGKEDLTIK----ISDRGGGVPLRITDRLF B3KUX1_HUMAN B3KUX1_HUMAN ELFK-NAMRATVEHQENQPS-LTPIEVIVVLGKEDLTIK----ISDRGGGVPLRIIDRLF B3KU25_HUMAN B3KU25_HUMAN ELFK-NAMRATVEHQENQPS-LTPIEVIVVLGKEDLTIK----ISDRGGGVPLRIIDRLF A4D1H4_HUMAN A4D1H4_HUMAN ELFK-NAMRATVEHQENQPS-LTPIEVIVVLGKEDLTIK----ISDRGGGVPLRIIDRLF PDK4_HUMAN PDK4_HUMAN ELFK-NAMRATVEHQENQPS-LTPIEVIVVLGKEDLTIK----ISDRGGGVPLRIIDRLF Q53FG1_HUMAN Q53FG1_HUMAN ELFK-NAMRATVEHQENQPS-LTPIEVIVVLGKEDLTIK----ISDRGGGVPLRIIDRLF Q20AM2_ICTPU Q20AM2_ICTPU EFFK-NAMRATVETHENSKY-LPPIKVRVSLGHEDLTIK----MSDRGGGVPLRKIERLF A0T2S7_9NEOB A0T2S7_9NEOB ------------------------------------------------------------ Q6DFQ9_XENTR Q6DFQ9_XENTR ELFK-NAMRATIENHETSSH-LPPVEVNVVLGNEDLTIK----ISDNGGGVPLRKIERLF Q6PB12_XENLA Q6PB12_XENLA ELFK-NAMRATVESHETSPR-LPPIKVNVVLGNEDVTIK----ISDNGGGVPLRKIERLF Q7ZXU6_XENLA Q7ZXU6_XENLA ELFK-NAMRATIENHETSPR-LPPIKVNVVLGSEDLTIK----ISDNGGGVPLRKIERLF Q4RNN6_TETNG Q4RNN6_TETNG ELFK-NAMRATIETHENSDQ-LPPVHVMVALGDEDVSIK----VSDTGGGVPFRKIENLF Q9JID3_RAT Q9JID3_RAT ELFK-NAMRATVESHESSLT-LPPIKIMVALGEEDLSIK----MSDRGGGVPLRKIERLF B3DIT9_DANRE B3DIT9_DANRE ELFK-NAMRATVETHETSLH-LPPIKVRVSLGTEDLTIK----MSDRGSGVPLRKIERLF Q1LX05_DANRE Q1LX05_DANRE ELFKQNAMRATVETHETSLH-LPPIKVRVSLGTEDLTIKVTINMSDRGSGVPLRKIERLF Q99P94_PHOSU Q99P94_PHOSU ------------------------------------------------------------ PDK2_RAT PDK2_RAT ELFK-NAMRATVESHESSLT-LPPIKIMVALGEEDLSIK----MSDRGGGVPLRKIERLF PDK2_MOUSE PDK2_MOUSE ELFK-NAMRATVESHESSLT-LPPIKIMVALGEEDLSIK----MSDRGGGVPLRRIERLF Q8VC63_MOUSE Q8VC63_MOUSE ELFK-NAMRATVESHESSLT-LPPIKIMVALGEEDLSIK----MSDRGGGVPLRKIERLF Q1JPJ6_BOVIN Q1JPJ6_BOVIN ELFK-NAMRATVESHESSVT-LPPVKVMVALGEEDLSIK----MSDRGGGVPLRKIDRLF Q29RH8_BOVIN Q29RH8_BOVIN ELFK-NAMRATVESHESSVT-LPPVKVMVALGEEDLSIK----MSDRGGGVPLRKIDRLF Q5NVN2_PONAB Q5NVN2_PONAB ELFK-NAMRATVESHESSLI-LPPIKVMVALGEEDLSIK----MSDRGGGVPLRKIERLF B3KNW0_HUMAN B3KNW0_HUMAN ELFK-NAMRATVESHESSLI-LPPIKVMVALGEEDLSIK----MSDRGGGVPLRKIERLF Q6P515_HUMAN Q6P515_HUMAN ELFK-NAMRATVESHESSLI-LPPIKVMVALGEEDLSIK----MSDRGGGVPLRKIERLF B4DLP2_HUMAN B4DLP2_HUMAN ELFK-NAMRATVESHESSLI-LPPIKVMVALGEEDLSIK----MSDRGGGVPLRKIERLF PDK2_HUMAN PDK2_HUMAN ELFK-NAMRATVESHESSLI-LPPIKVMVALGEEDLSIK----MSDRGGGVPLRKIERLF Q4R567_MACFA Q4R567_MACFA ELFK-NAMRATVESHESSLI-LPPIKVMVALGEEDLSIK----MSDRGGGVPLRKIERLF Q63ZR8_XENLA Q63ZR8_XENLA ELFK-NAMRATMEFQADKGV-YPPIKVHVALGSEDLSVK----LSDRGGGVPLRKIERLF Q6IR88_XENLA Q6IR88_XENLA ELFK-NAMRATMEFQADKGV-YPPIKVHVVLGSEDLTVK----LSDRGGGVPLRKIERLF Q5ZLT4_CHICK Q5ZLT4_CHICK ELFK-NAMRATMEHNADRCI-YPPIHVHVTLGNEDLTVK----MSDRGGGVPMRKIDRLF PDK1_RAT PDK1_RAT ELFK-NAMRATMEHHADKGV-YPPIQVHVTLGEEDLTVK----MSDRGGGVPLRKIDRLF Q5FVT5_RAT Q5FVT5_RAT ELFK-NAMRATMEHHADKGV-YPPIQVHVTLGEEDLTVK----MSDRGGGVPLRKIDRLF Q99P95_PHOSU Q99P95_PHOSU ELFK-NAMRAT------------------------------------------------- PDK1_MOUSE PDK1_MOUSE ELFK-NAMRATMEHHADKGV-YPPIQVHVTLGEEDLTVK----MSDRGGGVPLSKIDRLF Q8R2U8_MOUSE Q8R2U8_MOUSE ELFK-NAMRATMEHHADKGV-YPPIQVHVTLGEEDLTVK----MSDRGGGVPLRKIDRLF Q3U5E5_MOUSE Q3U5E5_MOUSE ELFK-NAMRATMEHHADKGV-YPPIQVHVTLGEEDLTVK----MSDRGGGVPLRKIDRLF Q8BFP4_MOUSE Q8BFP4_MOUSE -------------------------------------------------GVPLRKIDRLF Q308M4_HUMAN Q308M4_HUMAN ELFK-NAMRATMEHHANRGV-YPPIQVHVTLGNEDLTVK----MSDRGGGVPLRKIDRLF B7Z7N6_HUMAN B7Z7N6_HUMAN ELFK-NAMRATMEHHANRGV-YPPIQVHVTLGNEDLTVK----MSDRGGGVPLRKIDRLF PDK1_HUMAN PDK1_HUMAN ELFK-NAMRATMEHHANRGV-YPPIQVHVTLGNEDLTVK----MSDRGGGVPLRKIDRLF Q53R49_HUMAN Q53R49_HUMAN ELFK-NAMRATMEHHANRGV-YPPIQVHVTLGNEDLTVK----MSDRGGGVPLRKIDRLF B7Z937_HUMAN B7Z937_HUMAN ELFK-NAMRATMEHHANRGV-YPPIQVHVTLGNEDLTVK----MSDRGGGVPLRKIDRLF B7Z207_HUMAN B7Z207_HUMAN ELFK-NAMRATMEHHANRGV-YPPIQVHVTLGNEDLTVK----MSDRGGGVPLRKIDRLF B5DGI3_SALSA B5DGI3_SALSA ELFK-NSMRAIVELHENSSAGLPPVKAMVTLGKEDLSIK----ISDRGGGVPLRKIDKLF Q4SMY8_TETNG Q4SMY8_TETNG ELFK-NSMRATVELHQTSGEGLPPVKAKVTLGKEDLSIK----ISDRGGGVPLRKIDRLF B5XFN4_SALSA B5XFN4_SALSA ELFK-NSMRASVELHEDSKEGLPPVKAKVTLGKEDLSIK----ISDRGGGVPLRKIDRLF A9ULF7_XENTR A9ULF7_XENTR ELFK-NSMRATVELHEGKTDALPPVKALVTLGKEDLSIR----ISDKGGGVPLRKIDRLF Q5ZLT2_CHICK Q5ZLT2_CHICK ELFK-NSMRATVELHEGKREGYPSIKTLVTLGKEDLSIK----ISDQGGGVPLRKIDRLF Q3V250_MOUSE Q3V250_MOUSE ELFK-NSMRATVELHEDKKEGYPAVKTLVTLGKEDLSIK----ISDLGGGVPLRKIDRLF B5DFI9_RAT B5DFI9_RAT ELFK-NSMRATVELYEDKKEGYPAVKTLVTLGKEDLSIK----ISDLGGGVPLRKIDRLF PDK3_MOUSE PDK3_MOUSE ELFK-NSMRATVELHEDKKEGYPAVKTLVTLGKEDLSIK----ISDLGGGVPLRKIDRLF Q4FJR4_MOUSE Q4FJR4_MOUSE ELFK-NSMRATVELHEDKKEGYPAVKTLVTLGKEDLSIK----ISDLGGGVPLRKIDRLF A6QLG3_BOVIN A6QLG3_BOVIN ELFK-NSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK----ISDLGGGVPLRKIDRLF B4DXG6_HUMAN B4DXG6_HUMAN ELFK-NSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK----ISDLGGGVPLRKIDRLF PDK3_HUMAN PDK3_HUMAN ELFK-NSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIK----ISDLGGGVPLRKIDRLF MATCH CONSENSUS ELFK?N?MRAT?E??????????P????V?LG?EDL??K?????SD?GGGVPLR?I?RLF

Q7ZV57_DANRE Q7ZV57_DANRE SYMYSTAPRPTIGD---HQRTPMAGFGYGLPISRLYARYFQGDLQLYPMEGYGTDAVIQL Q4T5D1_TETNG Q4T5D1_TETNG SYMYSTAPRPCIED---KHRAPLAGFGYGLPISRLYARYFQGDLQLYSMEGSGTDAIIHL A6QR49_BOVIN A6QR49_BOVIN SYTYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLPGYGTDAIIYL PDK4_SPETR PDK4_SPETR SYMYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYL PDK4_MOUSE PDK4_MOUSE SYTYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYL Q544J2_MOUSE Q544J2_MOUSE SYTYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYL PDK4_RAT PDK4_RAT SYTYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYL PDK4_RHIFE PDK4_RHIFE SYMYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLHLYSLSGYGTDAIIYL B3KUX1_HUMAN B3KUX1_HUMAN SYTYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYL B3KU25_HUMAN B3KU25_HUMAN SYTYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYL A4D1H4_HUMAN A4D1H4_HUMAN SYTYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYL PDK4_HUMAN PDK4_HUMAN SYTYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYL Q53FG1_HUMAN Q53FG1_HUMAN SYTYSTAPTPVMDN---SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYL Q20AM2_ICTPU Q20AM2_ICTPU SYMYSTAPSPVIDN---ARNAPPAGFGL-------------------------------- A0T2S7_9NEOB A0T2S7_9NEOB ------------------------------------------------------------ Q6DFQ9_XENTR Q6DFQ9_XENTR SYMYSTAPRPLMDN---SRNAPLAGFGYGLPISRLYARYFQGDLMLQSMEGFGTDAVIYL Q6PB12_XENLA Q6PB12_XENLA SYMYSTAPRPLMDN---SRNAPLAGFGYGLPISRLYARYFQGDLMLHSMEGFGTDAVIYL Q7ZXU6_XENLA Q7ZXU6_XENLA SYMYSTAPRPLMDN---SRNAPLAGFGYGLPISRLYARYFQGDLMLHSMEGFGTDAVIYL Q4RNN6_TETNG Q4RNN6_TETNG SYMYSTAPAPQIGQ---HARTPLAGFGYGLPISRLYAKYFQGDLQLYSMEGHGTDAVIYL Q9JID3_RAT Q9JID3_RAT SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL B3DIT9_DANRE B3DIT9_DANRE SYMYSTAPSPVAED---TRNAPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYL Q1LX05_DANRE Q1LX05_DANRE SYMYSTAPSPVAED---TRNAPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYL Q99P94_PHOSU Q99P94_PHOSU ------------------------------------------------------------ PDK2_RAT PDK2_RAT SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL PDK2_MOUSE PDK2_MOUSE SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL Q8VC63_MOUSE Q8VC63_MOUSE SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL Q1JPJ6_BOVIN Q1JPJ6_BOVIN SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL Q29RH8_BOVIN Q29RH8_BOVIN SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL Q5NVN2_PONAB Q5NVN2_PONAB SYMYSTAPTP-QPG---TGGTPLTGFGYRLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL B3KNW0_HUMAN B3KNW0_HUMAN SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL Q6P515_HUMAN Q6P515_HUMAN SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQRDLQLFSMEGFGTDAVIYL B4DLP2_HUMAN B4DLP2_HUMAN SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL PDK2_HUMAN PDK2_HUMAN SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL Q4R567_MACFA Q4R567_MACFA SYMYSTAPTP-QPG---TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL Q63ZR8_XENLA Q63ZR8_XENLA NYMYSTAPLPRMET---SRATPLAGFGYGLPISRLYAKYFQGDLKLYSLEGYGTDAVIYF Q6IR88_XENLA Q6IR88_XENLA NYMYSTAPLPRMET---SRATPLAGFGYGLPISRLYAKYFQGDLKLYSLEGYGTDAVIYF Q5ZLT4_CHICK Q5ZLT4_CHICK NYMYSTAPRPRVET---SRATPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI PDK1_RAT PDK1_RAT NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI Q5FVT5_RAT Q5FVT5_RAT NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI Q99P95_PHOSU Q99P95_PHOSU ------------------------------------------------------------ PDK1_MOUSE PDK1_MOUSE NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI Q8R2U8_MOUSE Q8R2U8_MOUSE NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI Q3U5E5_MOUSE Q3U5E5_MOUSE NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI Q8BFP4_MOUSE Q8BFP4_MOUSE NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI Q308M4_HUMAN Q308M4_HUMAN NYMYSTAPRPRVET---SRAVPLAGFGYGLPISCLYAQYFQGDLKLYSLEGYGTDAVIYI B7Z7N6_HUMAN B7Z7N6_HUMAN NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI PDK1_HUMAN PDK1_HUMAN NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI Q53R49_HUMAN Q53R49_HUMAN NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI B7Z937_HUMAN B7Z937_HUMAN NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI B7Z207_HUMAN B7Z207_HUMAN NYMYSTAPRPRVET---SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI B5DGI3_SALSA B5DGI3_SALSA SYMYSTAPTPSLEPGNGTQAAPLAGFGYGLPISRLYARYFQGDLNLYSMEGVGTDAVIYL Q4SMY8_TETNG Q4SMY8_TETNG HYMYSTAPTPSLEQ---G-AVPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYL B5XFN4_SALSA B5XFN4_SALSA NYMYSTAPTPSLEP---SSTVPLAGFGYGLPISRLYARYFRET----------------- A9ULF7_XENTR A9ULF7_XENTR NYMYSTAPRPSLEP---SRAVPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYL Q5ZLT2_CHICK Q5ZLT2_CHICK NYMYSTAPRPSLEP---TRAVPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGSDAVIYL Q3V250_MOUSE Q3V250_MOUSE NYMYSTAPRPSLEP---TRAAPWLDLVMACQFGRLYARYFQGDLKLYSMEGVGTDAVIYL B5DFI9_RAT B5DFI9_RAT NYMYSTAPRPSLEP---TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYL PDK3_MOUSE PDK3_MOUSE NYMYSTAPRPSLEP---TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYL Q4FJR4_MOUSE Q4FJR4_MOUSE NYMYSTAPRPSLEP---TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYL A6QLG3_BOVIN A6QLG3_BOVIN NYMYSTAPRPSLEP---TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYL B4DXG6_HUMAN B4DXG6_HUMAN NYMYSTAPRPSLEP---TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYL PDK3_HUMAN PDK3_HUMAN NYMYSTAPRPSLEP---TRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYL MATCH CONSENSUS ?YMYSTAP?P???????????PLAGFGYGLPISRLYA?YFQGDL?L?S??G?GTDA?IY?

Q7ZV57_DANRE Q7ZV57_DANRE KALSTDS----------------------VEKLPVFNKTALRNYKVNQEADDWCVPSKEP Q4T5D1_TETNG Q4T5D1_TETNG KALSTDS----------------------VERLPVFNKSALRHYKLSLEADDWCVPSKEP A6QR49_BOVIN A6QR49_BOVIN KALSSES----------------------IEKLPVFNKSAFKHYQTSSEAGDWCIPSKEP PDK4_SPETR PDK4_SPETR KALSSES----------------------VEKLPVFNKSAFKHYQMSSEADDWCIPSREP PDK4_MOUSE PDK4_MOUSE KALSSES----------------------VEKLPVFNKSAFKHYQMSSEADDWCIPSREP Q544J2_MOUSE Q544J2_MOUSE KALSSES----------------------VEKLPVFNKSAFKHYQMSSEADDWCIPSREP PDK4_RAT PDK4_RAT KALSSES----------------------IEKLPVFNKSAFKHYQMSSEADDWCIPSKEP PDK4_RHIFE PDK4_RHIFE KALSSES----------------------VEKLPVFNKSAFKHYQMSIEADDWCIPSKEP B3KUX1_HUMAN B3KUX1_HUMAN KALSSES----------------------IEKLPVFNKSAFKHYQMSSEADDWCIPSREP B3KU25_HUMAN B3KU25_HUMAN KALSSES----------------------IEKLPVFNKSAFKHYQMSSEADDWCIPSREP A4D1H4_HUMAN A4D1H4_HUMAN KALSSES----------------------IEKLPVFNKSAFKHYQMSSEADDWCIPSREP PDK4_HUMAN PDK4_HUMAN KALSSES----------------------IEKLPVFNKSAFKHYQMSSEADDWCIPSREP Q53FG1_HUMAN Q53FG1_HUMAN KALSSES----------------------IEKLPVFNKSAFKHYQMSPEADDWCIPSREP Q20AM2_ICTPU Q20AM2_ICTPU ----------------------------------------------------W------P A0T2S7_9NEOB A0T2S7_9NEOB ------------------------------------------------------------ Q6DFQ9_XENTR Q6DFQ9_XENTR KALSTES----------------------VERLPVFNKSAWKHYKFCTEADDWCIPSSEP Q6PB12_XENLA Q6PB12_XENLA KALSSES----------------------VERLPVFNKSAWKHYKFSTEADDWCIPSSEP Q7ZXU6_XENLA Q7ZXU6_XENLA KALSSES----------------------VERLPVFNKSAWKHYKFCTEADDWCIPSSEP Q4RNN6_TETNG Q4RNN6_TETNG KALSTDS----------------------IERLPVYNKTALKNYRLRQEADDWCVPSKEP Q9JID3_RAT Q9JID3_RAT K----------------------------CSLGPVHGLSG-----APACLQQVCLAPLPD B3DIT9_DANRE B3DIT9_DANRE KALSTES----------------------IERLPVFNKSALRHYQTSTEADDWCIPSSEP Q1LX05_DANRE Q1LX05_DANRE KALSTES----------------------IERLPVFNKSALRHYQTSTEADDWCIPSSEP Q99P94_PHOSU Q99P94_PHOSU ------------------------------------------------------------ PDK2_RAT PDK2_RAT KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP PDK2_MOUSE PDK2_MOUSE KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP Q8VC63_MOUSE Q8VC63_MOUSE KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP Q1JPJ6_BOVIN Q1JPJ6_BOVIN KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP Q29RH8_BOVIN Q29RH8_BOVIN KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP Q5NVN2_PONAB Q5NVN2_PONAB KALSTDS----------------------VERLPVYNKSAWRHYLTIQEAGDWCVPSTEP B3KNW0_HUMAN B3KNW0_HUMAN KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP Q6P515_HUMAN Q6P515_HUMAN KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP B4DLP2_HUMAN B4DLP2_HUMAN KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP PDK2_HUMAN PDK2_HUMAN KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP Q4R567_MACFA Q4R567_MACFA KALSTDS----------------------VERLPVYNKSAWRHYQTIQEAGDWCVPSTEP Q63ZR8_XENLA Q63ZR8_XENLA KALSTES----------------------VERLPVYNKSAWKHYKTNHEADDWCVPSSEP Q6IR88_XENLA Q6IR88_XENLA KALSTES----------------------VERLPVYNKSAWKHYKTNHEADDWCVPSSEP Q5ZLT4_CHICK Q5ZLT4_CHICK KALSTES----------------------IERLPVYNKAAWKHYKANHEADDWCVPSSEP PDK1_RAT PDK1_RAT KALSTES----------------------IERLPVYNKAAWKHYRTNHEADDWCVPSREP Q5FVT5_RAT Q5FVT5_RAT KALSTES----------------------IERLPVYNKAAWKHYRTNHEADDWCVPSREP Q99P95_PHOSU Q99P95_PHOSU ------------------------------------------------------------ PDK1_MOUSE PDK1_MOUSE KALSTES----------------------VERLPVYNKAAWKHYKANHEADDWCVPSREP Q8R2U8_MOUSE Q8R2U8_MOUSE KALSTES----------------------VERLPVYNKAAWKHYKANHEADDWCVPSREP Q3U5E5_MOUSE Q3U5E5_MOUSE KALSTES----------------------VERLPVYNKAAWKHYKANHEADDWCVPSREP Q8BFP4_MOUSE Q8BFP4_MOUSE KALSTES----------------------VERLPVYNKAAWKHYKANHEADDWCVPSREP Q308M4_HUMAN Q308M4_HUMAN KALSTDS----------------------IERLPVYNKAAWKHYNTNHEADDWCVPSREP B7Z7N6_HUMAN B7Z7N6_HUMAN KALSTDS----------------------IERLPVYNKAAWKHYNTNHEADDWCVPSREP PDK1_HUMAN PDK1_HUMAN KALSTDS----------------------IERLPVYNKAAWKHYNTNHEADDWCVPSREP Q53R49_HUMAN Q53R49_HUMAN K----------------------------------------------------------- B7Z937_HUMAN B7Z937_HUMAN KALSTDS----------------------IERLPVYNKAAWKHYNTNHEADDWCVPSREP B7Z207_HUMAN B7Z207_HUMAN KALSTDS----------------------IERLPVYNKAAWKHYNTNHEADDWCVPSREP B5DGI3_SALSA B5DGI3_SALSA KALSSES----------------------FERLPVFNKSAWRHYQTGPEADDWSNPSSDP Q4SMY8_TETNG Q4SMY8_TETNG KVRRPPGSSLAPSPSDSSAPPPTGPVQRVLRAPPRLQQVGLAPLHHQPGGGRLEQPQQGA B5XFN4_SALSA B5XFN4_SALSA ------------------------------------------------------------ A9ULF7_XENTR A9ULF7_XENTR KAVSSES----------------------FERLPVFNKSAWRHYKNAAEADDWSNPSREP Q5ZLT2_CHICK Q5ZLT2_CHICK KALSSES----------------------FERLPVFNKSAWRHYKTTPEADDWSNPSSEP Q3V250_MOUSE Q3V250_MOUSE KALSSES----------------------FERLPVFNKSAWRHYKTTPEADDWSNPSSEP B5DFI9_RAT B5DFI9_RAT KALSSES----------------------FERLPVFNKSAWRHYKTTPEADDWSNPSSEP PDK3_MOUSE PDK3_MOUSE KALSSES----------------------FERLPVFNKSAWRHYKTTPEADDWSNPSSEP Q4FJR4_MOUSE Q4FJR4_MOUSE KALSSES----------------------FERLPVFNKSAWRHYKTTPEADDWSNPSSEP A6QLG3_BOVIN A6QLG3_BOVIN KALSSES----------------------FERLPVFNKSAWRHYKSTAEADDWSNPSSEP B4DXG6_HUMAN B4DXG6_HUMAN KALSSES----------------------FERLPVFNKSAWRHYKTTPEADDWSNPSSEP PDK3_HUMAN PDK3_HUMAN KALSSES----------------------FERLPVFNKSAWRHYKTTPEADDWSNPSSEP MATCH CONSENSUS KALS??S???????????????????????E?LPV?NK?A??HY????EA?DW??PS?EP

Q7ZV57_DANRE Q7ZV57_DANRE LNVAAYKAAK------------------------- Q4T5D1_TETNG Q4T5D1_TETNG LNLA------------------------------- A6QR49_BOVIN A6QR49_BOVIN KNLAKEKVAA------------------------- PDK4_SPETR PDK4_SPETR RNLSKEKMAM------------------------- PDK4_MOUSE PDK4_MOUSE KNLAKEKLAV------------------------- Q544J2_MOUSE Q544J2_MOUSE KNLAKEKLAV------------------------- PDK4_RAT PDK4_RAT KNLSKEKLAV------------------------- PDK4_RHIFE PDK4_RHIFE KNLAKEKVAV------------------------- B3KUX1_HUMAN B3KUX1_HUMAN KNLAKEVAM-------------------------- B3KU25_HUMAN B3KU25_HUMAN KNLAKEVAM-------------------------- A4D1H4_HUMAN A4D1H4_HUMAN KNLAKEVAM-------------------------- PDK4_HUMAN PDK4_HUMAN KNLAKEVAM-------------------------- Q53FG1_HUMAN Q53FG1_HUMAN KNLAKEVAM-------------------------- Q20AM2_ICTPU Q20AM2_ICTPU SHLTSVRQ--------------------------- A0T2S7_9NEOB A0T2S7_9NEOB ----------------------------------- Q6DFQ9_XENTR Q6DFQ9_XENTR KNLAR------------------------------ Q6PB12_XENLA Q6PB12_XENLA KNLAR------------------------------ Q7ZXU6_XENLA Q7ZXU6_XENLA KNLAR------------------------------ Q4RNN6_TETNG Q4RNN6_TETNG LDLSSYKVP-------------------------- Q9JID3_RAT Q9JID3_RAT HPGGR------------------------------ B3DIT9_DANRE B3DIT9_DANRE KKLGKYEFSV------------------------- Q1LX05_DANRE Q1LX05_DANRE KKLGKYEFSV------------------------- Q99P94_PHOSU Q99P94_PHOSU ----------------------------------- PDK2_RAT PDK2_RAT KNTSTYRVS-------------------------- PDK2_MOUSE PDK2_MOUSE KNTSTYRVS-------------------------- Q8VC63_MOUSE Q8VC63_MOUSE KNTSTYRVS-------------------------- Q1JPJ6_BOVIN Q1JPJ6_BOVIN KNTSTYRVS-------------------------- Q29RH8_BOVIN Q29RH8_BOVIN KNTSTYRVS-------------------------- Q5NVN2_PONAB Q5NVN2_PONAB KNTSTYRVS-------------------------- B3KNW0_HUMAN B3KNW0_HUMAN KNTSTYRVS-------------------------- Q6P515_HUMAN Q6P515_HUMAN KNTSTYRVS-------------------------- B4DLP2_HUMAN B4DLP2_HUMAN KNTSTYRVS-------------------------- PDK2_HUMAN PDK2_HUMAN KNTSTYRVS-------------------------- Q4R567_MACFA Q4R567_MACFA KNTSTYRVS-------------------------- Q63ZR8_XENLA Q63ZR8_XENLA KDMTTFRSN-------------------------- Q6IR88_XENLA Q6IR88_XENLA KDMTTFRSN-------------------------- Q5ZLT4_CHICK Q5ZLT4_CHICK KDMTTFRST-------------------------- PDK1_RAT PDK1_RAT KDMTTFRSS-------------------------- Q5FVT5_RAT Q5FVT5_RAT KDMTTFRSS-------------------------- Q99P95_PHOSU Q99P95_PHOSU ----------------------------------- PDK1_MOUSE PDK1_MOUSE KDMTTFRSS-------------------------- Q8R2U8_MOUSE Q8R2U8_MOUSE KDMTTFRSS-------------------------- Q3U5E5_MOUSE Q3U5E5_MOUSE KDMTTFRSS-------------------------- Q8BFP4_MOUSE Q8BFP4_MOUSE KDMTTFRSS-------------------------- Q308M4_HUMAN Q308M4_HUMAN KDMTTFRSA-------------------------- B7Z7N6_HUMAN B7Z7N6_HUMAN KDMTTFRSA-------------------------- PDK1_HUMAN PDK1_HUMAN KDMTTFRSA-------------------------- Q53R49_HUMAN Q53R49_HUMAN ----------------------------------- B7Z937_HUMAN B7Z937_HUMAN KDMTTFRSA-------------------------- B7Z207_HUMAN B7Z207_HUMAN KDMTTFRSA-------------------------- B5DGI3_SALSA B5DGI3_SALSA RDAAKYKIK-------------------------- Q4SMY8_TETNG Q4SMY8_TETNG ARRQQVQLQGQQITPQAPPLLLRSFVRLFVCLFVR B5XFN4_SALSA B5XFN4_SALSA ----------------------------------- A9ULF7_XENTR A9ULF7_XENTR RDASKYKSN-------------------------- Q5ZLT2_CHICK Q5ZLT2_CHICK RDASKYKANR------------------------- Q3V250_MOUSE Q3V250_MOUSE RDASKYKAKQDKIKSNRTF---------------- B5DFI9_RAT B5DFI9_RAT RDASKYKAKQDKIKSNKTF---------------- PDK3_MOUSE PDK3_MOUSE RDASKYKAKQDKIKSNRTF---------------- Q4FJR4_MOUSE Q4FJR4_MOUSE RDASKYKAKQDKIKSNRTF---------------- A6QLG3_BOVIN A6QLG3_BOVIN RDASKYKAKQDKMKTNRTL---------------- B4DXG6_HUMAN B4DXG6_HUMAN RDASKYKAKQDKIKTNRTF---------------- PDK3_HUMAN PDK3_HUMAN RDASKYKAKQ------------------------- MATCH CONSENSUS ???????????????????????????????????


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