Alignment of the gene Family HBG001886 of HOVERGEN

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Threshold: 50% 80% 100%
Size: Bigger Smaller Normal
Isoforms are ON
Q4H2W3_CIOIN Q4H2W3_CIOIN --------------------------------------------MAKNDGHNGNDNKRID ARAF_MOUSE ARAF_MOUSE ------------------------------------------------------------ ARAF_RAT ARAF_RAT ------------------------------------------------------------ ARAF_PIG ARAF_PIG ------------------------------------------------------------ Q2KJA0_BOVIN Q2KJA0_BOVIN ------------------------------------------------------------ Q5BIM4_BOVIN Q5BIM4_BOVIN ------------------------------------------------------------ B4DV85_HUMAN B4DV85_HUMAN ------------------------------------------------------------ ARAF_HUMAN ARAF_HUMAN ------------------------------------------------------------ Q96II5_HUMAN Q96II5_HUMAN ------------------------------------------------------------ Q4SDH1_TETNG Q4SDH1_TETNG ------------------------------------------------------------ Q75W79_DANRE Q75W79_DANRE ------------------------------------------------------------ Q5FBD1_DANRE Q5FBD1_DANRE ------------------------------------------------------------ Q75Y03_DANRE Q75Y03_DANRE ------------------------------------------------------------ Q5M7Y2_DANRE Q5M7Y2_DANRE ------------------------------------------------------------ Q4R1J4_ONCKE Q4R1J4_ONCKE ------------------------------------------------------------ Q0D2E4_XENTR Q0D2E4_XENTR ------------------------------TEGPSLLNGDLLESETGGLGGAGEMCASG- Q68FI8_XENLA Q68FI8_XENLA AALSGG-----------------------SAEGPSLLNGDLLESETGGLGGAGEMSVSG- Q4F9K6_XENLA Q4F9K6_XENLA AALSGG-----------------------SAEGPSLLNGDLLESETGGLGGAGEMSVSG- Q643Z8_XENLA Q643Z8_XENLA AALSGG-----------------------SAEGPSLLNGDLLESETGGLGGAGEMSVSG- B7ZRT9_XENLA B7ZRT9_XENLA AALSGG-----------------------SAEGLSLLNGDLLESDTGGLGGAGEMSVSG- Q767H5_XENLA Q767H5_XENLA AALSGG-----------------------SAEGLSLLN------------GAGEMSVSG- BRAF1_CHICK BRAF1_CHICK AALSSG----------------------SSAEGASLFNGDMEPEPPPPVLGACYAGSGGG BRAF1_COTJA BRAF1_COTJA AALSSG----------------------SSAEGASLFNGDMEPEPPPPVLGACYAGSGGG Q4R345_MACFA Q4R345_MACFA AALSGG-------------------GGGGAEPGQALFNGDMEPE-------AGAAASSAA BRAF1_MOUSE BRAF1_MOUSE AALSGGGGRRSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPE--A---GAGAAASSAA Q9JJU6_MOUSE Q9JJU6_MOUSE ------------------------------------------------------------ A4D1T4_HUMAN A4D1T4_HUMAN AALSGG-------------------GGGGAEPGQALFNGDMEPEAGA---GAGAAASSAA BRAF1_HUMAN BRAF1_HUMAN AALSGG-------------------GGGGAEPGQALFNGDMEPEAGA---GAGAAASSAA Q698R1_CANFA Q698R1_CANFA ---------------------------------QALFNGDMEPEA-----GAGAAASSAA Q75V92_DANRE Q75V92_DANRE AALSSA------ESPPPVFNGDTMNRDPERDPGLDELGAGLEPA------CPGEAAIPEC Q761X4_DANRE Q761X4_DANRE AALSSA------ESPPPVFNGDTMNRDPERDPGLDELGAGLEPA------CPGEAAIPEC Q767H4_DANRE Q767H4_DANRE AALSSA------ESPPPVFNGDTMNRDPERDPGLDELGAGLEPA------CPGEAAIPEC Q75V91_DANRE Q75V91_DANRE AALSSA------ESPPPVFNGDTMNRDPERDPGLDELGAGLEPA------CPGEAAIPEC B3DFX5_DANRE B3DFX5_DANRE AALSSA------ESPPPVFNGDTMNRDPERDPGLDELGAGLEPA------CPGEAAIPEC Q1LYG2_DANRE Q1LYG2_DANRE AALSSA------ESPPPVFNGDTMNRDPERDPGLDELGAGLEPA------CPGEAAIPEC Q4SRI2_TETNG Q4SRI2_TETNG ------------------------------------------------------------ Q6L8Q6_SERQU Q6L8Q6_SERQU ------------------------------------------------------------ Q6PA51_XENLA Q6PA51_XENLA ------------------------------------------------------------ Q6INV2_XENLA Q6INV2_XENLA ------------------------------------------------------------ Q767H6_XENLA Q767H6_XENLA ------------------------------------------------------------ Q4V900_DANRE Q4V900_DANRE ------------------------------------------------------------ Q2V2G8_SALSA Q2V2G8_SALSA ------------------------------------------------------------ Q28GW9_XENTR Q28GW9_XENTR ------------------------------------------------------------ Q6GQJ4_XENLA Q6GQJ4_XENLA ------------------------------------------------------------ RAF1_XENLA RAF1_XENLA ------------------------------------------------------------ RAF1_CHICK RAF1_CHICK ------------------------------------------------------------ Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE ------------------------------------------------------------ RAF1_RAT RAF1_RAT ------------------------------------------------------------ RAF1_BOVIN RAF1_BOVIN ------------------------------------------------------------ B4E0X2_HUMAN B4E0X2_HUMAN ------------------------------------------------------------ B4E1N6_HUMAN B4E1N6_HUMAN ------------------------------------------------------------ RAF1_PONAB RAF1_PONAB ------------------------------------------------------------ RAF1_HUMAN RAF1_HUMAN ------------------------------------------------------------ O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ------------------------------------------------------------ Q76FQ3_DANRE Q76FQ3_DANRE ------------------------------------------------------------ Q6BE22_DANRE Q6BE22_DANRE ------------------------------------------------------------ Q7ZTR8_DANRE Q7ZTR8_DANRE ------------------------------------------------------------ Q4S5I4_TETNG Q4S5I4_TETNG ------------------------------------------------------------ Q98TC3_SERQU Q98TC3_SERQU ------------------------------------------------------------ Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H2W3_CIOIN Q4H2W3_CIOIN KKKLEEDILNLEHVINLTKDSITRLNQEFGGKSHPPSIYL-------QEYRELTDRLD-D ARAF_MOUSE ARAF_MOUSE ------------------------------------------------------------ ARAF_RAT ARAF_RAT ------------------------------------------------------------ ARAF_PIG ARAF_PIG ------------------------------------------------------------ Q2KJA0_BOVIN Q2KJA0_BOVIN ------------------------------------------------------------ Q5BIM4_BOVIN Q5BIM4_BOVIN ------------------------------------------------------------ B4DV85_HUMAN B4DV85_HUMAN ------------------------------------------------------------ ARAF_HUMAN ARAF_HUMAN ------------------------------------------------------------ Q96II5_HUMAN Q96II5_HUMAN ------------------------------------------------------------ Q4SDH1_TETNG Q4SDH1_TETNG ------------------------------------------------------------ Q75W79_DANRE Q75W79_DANRE ------------------------------------------------------------ Q5FBD1_DANRE Q5FBD1_DANRE ------------------------------------------------------------ Q75Y03_DANRE Q75Y03_DANRE ------------------------------------------------------------ Q5M7Y2_DANRE Q5M7Y2_DANRE ------------------------------------------------------------ Q4R1J4_ONCKE Q4R1J4_ONCKE ------------------------------------------------------------ Q0D2E4_XENTR Q0D2E4_XENTR --GYPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYV-------EAYEEYTSKLD-L Q68FI8_XENLA Q68FI8_XENLA --GYPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-L Q4F9K6_XENLA Q4F9K6_XENLA --GYPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-L Q643Z8_XENLA Q643Z8_XENLA --GYPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-L B7ZRT9_XENLA B7ZRT9_XENLA --GFPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-L Q767H5_XENLA Q767H5_XENLA --GFPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-L BRAF1_CHICK BRAF1_CHICK DPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A BRAF1_COTJA BRAF1_COTJA DPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A Q4R345_MACFA Q4R345_MACFA DPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A BRAF1_MOUSE BRAF1_MOUSE DPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A Q9JJU6_MOUSE Q9JJU6_MOUSE ---------------------------KFGGEHNPPSIYL-------EAYEEYTSKLD-A A4D1T4_HUMAN A4D1T4_HUMAN DPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A BRAF1_HUMAN BRAF1_HUMAN DPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A Q698R1_CANFA Q698R1_CANFA DPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A Q75V92_DANRE Q75V92_DANRE QQGIPEEIWNIKQMIKLTQEHLEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A Q761X4_DANRE Q761X4_DANRE QQGIPEEIRNIKQMIKLTQEHLEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A Q767H4_DANRE Q767H4_DANRE QQGIPEEIWNIKQMIKLTQEHLEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A Q75V91_DANRE Q75V91_DANRE QQGIPEEIRNIKQMIKLTQEHLEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A B3DFX5_DANRE B3DFX5_DANRE QQGIPEEIWNIKQMIKLTQEHLEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A Q1LYG2_DANRE Q1LYG2_DANRE QQGIPEEIWNIKQMIKLTQEHLEALLDKFGGEHNPPSIYL-------EAYEEYTSKLD-A Q4SRI2_TETNG Q4SRI2_TETNG ------QIWNIKQMIKLTQEHLEALLDKFGGEHNPPTIYLESASAPRQAYEEYTSKLD-A Q6L8Q6_SERQU Q6L8Q6_SERQU -----------------------------------------------EAYEEYTSKLD-A Q6PA51_XENLA Q6PA51_XENLA -------------------------------------------------MKRSHTPPGAL Q6INV2_XENLA Q6INV2_XENLA ------------------------------------------------------------ Q767H6_XENLA Q767H6_XENLA ------------------------------------------------------------ Q4V900_DANRE Q4V900_DANRE ------------------MEHFQG---------------------------AWKSVSSHG Q2V2G8_SALSA Q2V2G8_SALSA ------------------MEHIQG---------------------------AWKTLSN-G Q28GW9_XENTR Q28GW9_XENTR ------------------MEHIQG---------------------------AWKTISN-G Q6GQJ4_XENLA Q6GQJ4_XENLA ------------------MEHIQG---------------------------AWKTLSN-G RAF1_XENLA RAF1_XENLA ------------------MEHIQG---------------------------AWKTLSN-G RAF1_CHICK RAF1_CHICK ------------------MEHIQG---------------------------AWKTISN-G Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE ------------------MEHIQG---------------------------AWKTISN-G RAF1_RAT RAF1_RAT ------------------MEHIQG---------------------------AWKTISN-G RAF1_BOVIN RAF1_BOVIN ------------------MEHIQG---------------------------AWKTISN-G B4E0X2_HUMAN B4E0X2_HUMAN ------------------------------------------------------------ B4E1N6_HUMAN B4E1N6_HUMAN ------------------------------------------------------------ RAF1_PONAB RAF1_PONAB ------------------MEHIQG---------------------------AWKTISN-G RAF1_HUMAN RAF1_HUMAN ------------------MEHIQG---------------------------AWKTISN-G O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ------------------------------------------------------------ Q76FQ3_DANRE Q76FQ3_DANRE ------------------MEQLQG---------------------------AWRTVTN-G Q6BE22_DANRE Q6BE22_DANRE ------------------MEQLQG---------------------------AWRTVTN-G Q7ZTR8_DANRE Q7ZTR8_DANRE ------------------MEQLQG---------------------------AWRTVTN-G Q4S5I4_TETNG Q4S5I4_TETNG ------------------PLQAQGFTNG-------------------TPARAWKTLSN-G Q98TC3_SERQU Q98TC3_SERQU ------------------MEHLQG---------------------------AWKTLSN-G Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H2W3_CIOIN Q4H2W3_CIOIN HQKRLENLYDVREQEQSNSNNDTEVQPSYSPQSNQYPHTGTSYGRHVCQSHDQHFFPTPL ARAF_MOUSE ARAF_MOUSE ------------------------------------------------------------ ARAF_RAT ARAF_RAT ------------------------------------------------------------ ARAF_PIG ARAF_PIG ------------------------------------------------------------ Q2KJA0_BOVIN Q2KJA0_BOVIN ------------------------------------------------------------ Q5BIM4_BOVIN Q5BIM4_BOVIN ------------------------------------------------------------ B4DV85_HUMAN B4DV85_HUMAN ------------------------------------------------------------ ARAF_HUMAN ARAF_HUMAN ------------------------------------------------------------ Q96II5_HUMAN Q96II5_HUMAN ------------------------------------------------------------ Q4SDH1_TETNG Q4SDH1_TETNG ------------------------------------------------------------ Q75W79_DANRE Q75W79_DANRE ------------------------------------------------------------ Q5FBD1_DANRE Q5FBD1_DANRE ------------------------------------------------------------ Q75Y03_DANRE Q75Y03_DANRE ------------------------------------------------------------ Q5M7Y2_DANRE Q5M7Y2_DANRE ------------------------------------------------------------ Q4R1J4_ONCKE Q4R1J4_ONCKE ------------------------------------------------------------ Q0D2E4_XENTR Q0D2E4_XENTR LQQREQQLLESMGNGTDSTSLPSELTL-----------SSVPS----------------- Q68FI8_XENLA Q68FI8_XENLA LQQREQQLLESMGNGSDSSSLSSELTL-----------SSVPS----------------- Q4F9K6_XENLA Q4F9K6_XENLA LQQREQQLLESMGNGSDSSSLSSELTI-----------SSVPS----------------- Q643Z8_XENLA Q643Z8_XENLA LQQREQQLLESMGNGSDSSSLSSELTI-----------SSVPS----------------- B7ZRT9_XENLA B7ZRT9_XENLA LQQREQQLLESMGNGTDSSSLSSELTL-----------SSVPS----------------- Q767H5_XENLA Q767H5_XENLA LQQREQQLLESMGNGTDSSSLSSELTL-----------SSVPS----------------- BRAF1_CHICK BRAF1_CHICK LQQREQQLLESMGNGTDFSVSSSASTDTVA--------SSSSS----------------- BRAF1_COTJA BRAF1_COTJA LQQREQQLLESMGNGTDFSVSSSASTDTVA--------SSSSS----------------- Q4R345_MACFA Q4R345_MACFA LQQREQQLLEYLGNGTDFSVSSSASMDTVT--------SSSSS----------------- BRAF1_MOUSE BRAF1_MOUSE LQQREQQLLESL------------------------------------------------ Q9JJU6_MOUSE Q9JJU6_MOUSE LQQREQQLLESLGNGAYFSVSSSASMDTVT--------SSSSS----------------- A4D1T4_HUMAN A4D1T4_HUMAN LQQREQQLLESLGNGTDFSVSSSASMDTVT--------SSSSS----------------- BRAF1_HUMAN BRAF1_HUMAN LQQREQQLLESLGNGTDFSVSSSASMDTVT--------SSSSS----------------- Q698R1_CANFA Q698R1_CANFA LQQREQQLLESLGNGTDFSVSSSASTDTVT--------SSSSS----------------- Q75V92_DANRE Q75V92_DANRE LQQREQQLLEAIGNGTEF-CS-SPTPTLLDVK------GQGIQ----------------- Q761X4_DANRE Q761X4_DANRE LQQREQQLLEAIGNGTEF-CS-SPTPTLLDVK------GQGIQ----------------- Q767H4_DANRE Q767H4_DANRE LQQREQQLLEAIGNGTEF-CS-SPTPTLLDVK------GQGIQ----------------- Q75V91_DANRE Q75V91_DANRE LQQREQQLLEAIGNGTEF-CS-SPTPTLLDVK------GQGIQ----------------- B3DFX5_DANRE B3DFX5_DANRE LQQREQQLLEAIGNGTEF-CS-SPTPTLLDVK------GQGIQ----------------- Q1LYG2_DANRE Q1LYG2_DANRE LQQREQQLLEAIGNGTEF-CS-SPTPTLLDVK------GQGIQ----------------- Q4SRI2_TETNG Q4SRI2_TETNG LQQREQQLLEAMGNGADFPCSPSPMPALLEVKMGGCGIGGGAQ----------------- Q6L8Q6_SERQU Q6L8Q6_SERQU LQQREQQLLEAMGNGTDFSCSPSPMPALLEVKMGGCGVGXGAQ----------------- Q6PA51_XENLA Q6PA51_XENLA VNGALHSLSRELGKGSAVMLSAAVLELPN------------------------------- Q6INV2_XENLA Q6INV2_XENLA ------------------------------------------------------------ Q767H6_XENLA Q767H6_XENLA ------------------------------------------------------------ Q4V900_DANRE Q4V900_DANRE FGCKDSVFEDSC------------------------------------------------ Q2V2G8_SALSA Q2V2G8_SALSA LGLKDSGFDDSC------------------------------------------------ Q28GW9_XENTR Q28GW9_XENTR FSFKDSVF------------------------------DGSSC----------------- Q6GQJ4_XENLA Q6GQJ4_XENLA FGFKESVF------------------------------EGSSC----------------- RAF1_XENLA RAF1_XENLA FGFKESVF------------------------------EGSSC----------------- RAF1_CHICK RAF1_CHICK FGLKDSVF------------------------------DGPNC----------------- Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE FGLKDAVF------------------------------DGSSC----------------- RAF1_RAT RAF1_RAT FGLKDAVF------------------------------DGSSC----------------- RAF1_BOVIN RAF1_BOVIN FGFKDTVF------------------------------DGTSC----------------- B4E0X2_HUMAN B4E0X2_HUMAN ------------------------------------------------------------ B4E1N6_HUMAN B4E1N6_HUMAN ------------------------------------------------------------ RAF1_PONAB RAF1_PONAB FGFKDAVF------------------------------DGSSC----------------- RAF1_HUMAN RAF1_HUMAN FGFKDAVF------------------------------DGSSC----------------- O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ------------------------------------------------------------ Q76FQ3_DANRE Q76FQ3_DANRE LLTKDSVFESSY------------------------------------------------ Q6BE22_DANRE Q6BE22_DANRE LLTKDSVFESSY------------------------------------------------ Q7ZTR8_DANRE Q7ZTR8_DANRE LLTKDSVFESSY------------------------------------------------ Q4S5I4_TETNG Q4S5I4_TETNG FGMKETEF-------------------------------DSPC----------------- Q98TC3_SERQU Q98TC3_SERQU FGMKDSAF-------------------------------EGPC----------------- Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H2W3_CIOIN Q4H2W3_CIOIN AQQTNGQKTHSSRLLSAGGSASSDSPHSPIQQNTTASKPGSE-KAIGVIRIYLPNG-KTT ARAF_MOUSE ARAF_MOUSE -------------------------MEPPRGPPVSGAEPS---RAVGTVKVYLPNKQRTV ARAF_RAT ARAF_RAT -------------------------MEPPRGPPASGAEPS---RAVGTVKVYLPNKQRTV ARAF_PIG ARAF_PIG -------------------------MEPPRGPPANGAEPS---RAVGTVKVYLPNKQRTV Q2KJA0_BOVIN Q2KJA0_BOVIN -------------------------MEPPRGPPANGAEPS---RSVGTVKVYLPNKQRTV Q5BIM4_BOVIN Q5BIM4_BOVIN -------------------------MEPPRGPPANGAEPS---RSVGTVKVYLPNKQRTV B4DV85_HUMAN B4DV85_HUMAN --------------------------------MASVAKP-------------VATSSTSI ARAF_HUMAN ARAF_HUMAN -------------------------MEPPRGPPANGAEPS---RAVGTVKVYLPNKQRTV Q96II5_HUMAN Q96II5_HUMAN -------------------------MEPPRGPPANGAEPS---RAVGTVKVYLPNKQRTV Q4SDH1_TETNG Q4SDH1_TETNG ------------------------MSSTSSYSSSGETSPEDIPRGGGTIRVYLPNKQRTV Q75W79_DANRE Q75W79_DANRE ------------------------MSNTSSCSSSGETSPDDTPRGGGTIRVYLPNKQRTV Q5FBD1_DANRE Q5FBD1_DANRE ------------------------MSNTSSCSSSGETSPDDTPRGGGTIRVYLPNKQRTV Q75Y03_DANRE Q75Y03_DANRE ------------------------MSNTSSCSSSGETSPDDTPRGGGTIRVYLPNKQRTV Q5M7Y2_DANRE Q5M7Y2_DANRE ------------------------MSNTSSCSSSGETSPDDTPRGGGTIRVYLPNKQRTV Q4R1J4_ONCKE Q4R1J4_ONCKE --------------------------------------------------SYPPNKQRTV Q0D2E4_XENTR Q0D2E4_XENTR ------------------NLSLAPSALSALRTPSDPSRINPKSPQKPIVRVFLPNKQRTV Q68FI8_XENLA Q68FI8_XENLA ------------------NLSLAPSTLSALHTPSDPSRINPRSPQKPIVRVFLPNKQRTV Q4F9K6_XENLA Q4F9K6_XENLA ------------------NLSLAPSTLSALHTPSDPSRINPRSPQKPIVRVFLPNKQRTV Q643Z8_XENLA Q643Z8_XENLA ------------------NLSLAPSTLSALHTPSDPSRINPRSPQKPIVRVFLPNKQRTV B7ZRT9_XENLA B7ZRT9_XENLA ------------------NLSLAPSTLSALGTPSDPSRINPKSPQKPIVRVFLPNKQRTV Q767H5_XENLA Q767H5_XENLA ------------------NLSLAPSTLSALGTPSDPSRINPKSPQKPIVRVFLPNKQRTV BRAF1_CHICK BRAF1_CHICK ------------------SLSVAPSSLSVYQNPTDMSRNNPKSPQKPIVRVFLPNKQRTV BRAF1_COTJA BRAF1_COTJA ------------------SLSVAPSSLSVYQNPTDMSRNNPKSPQKPIVRVFLPNKQRTV Q4R345_MACFA Q4R345_MACFA ------------------SLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTV BRAF1_MOUSE BRAF1_MOUSE ----------------------------VFQTPTDASRNNPKSPQKPIVRVFLPNKQRTV Q9JJU6_MOUSE Q9JJU6_MOUSE ------------------SLSVLPSSLSVFQTPTDASRNNPKSPQKPIVRVFLPNKQRTV A4D1T4_HUMAN A4D1T4_HUMAN ------------------SLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTV BRAF1_HUMAN BRAF1_HUMAN ------------------SLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTV Q698R1_CANFA Q698R1_CANFA ------------------SLSVLPSSLSVFQNPTDISRSNPKSPQKPIVRVFLPNKQRTV Q75V92_DANRE Q75V92_DANRE ------------------SAPTAPNTLAVLQTPTDATRGNPRSSQKPIVRVFLPNKQRTV Q761X4_DANRE Q761X4_DANRE ------------------SAPTAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTV Q767H4_DANRE Q767H4_DANRE ------------------SAPTAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTV Q75V91_DANRE Q75V91_DANRE ------------------SAPTAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTV B3DFX5_DANRE B3DFX5_DANRE ------------------SAPTAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTV Q1LYG2_DANRE Q1LYG2_DANRE ------------------SAPTAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTV Q4SRI2_TETNG Q4SRI2_TETNG ----------------------TPSSLAVLQTPIDGNRINPRSPQKPIVRVFLPNKQRTV Q6L8Q6_SERQU Q6L8Q6_SERQU ------------------AFPSAPNTLAVLQTPTDASRANPRSPQKPIVRVFLPNKQRTV Q6PA51_XENLA Q6PA51_XENLA ------------------PGARMPTQQVSSRGASVSEYPHTDGKSGGTVKVYLPNQQRTV Q6INV2_XENLA Q6INV2_XENLA ---------------------MMPTQQESSRGASVSEYPYAEGKSGGTVKVYLPHQQWTV Q767H6_XENLA Q767H6_XENLA ----------------------MPTQQESSRGASVSEYPYAEGKSGGTVKVYLPHQQWTV Q4V900_DANRE Q4V900_DANRE ------------------MSPSILKTFPYRRLSDDGRIPD--SKTSSTIRVFLPNKQRTV Q2V2G8_SALSA Q2V2G8_SALSA ------------------MSPTIMKGFPYQRRSSDDGKMAD-PKTSSTIRVFLPNKQCTV Q28GW9_XENTR Q28GW9_XENTR ------------------MSPTIGHQFGYQRRASDDGKLSDTSKTGSTMRVYLPNKQRTV Q6GQJ4_XENLA Q6GQJ4_XENLA ------------------MSPTIGHQFGYQRRASDDGKLSDTSKTSSTMRVYLPNKQRTV RAF1_XENLA RAF1_XENLA ------------------MSPTIVHQFGYQRRASDDGKLSDTSKTSSTMRVYLPNKQRTV RAF1_CHICK RAF1_CHICK ------------------ISPTIVQQFGYQRRASDDGKISDTSKTSNTIRVFLPNKQRTV Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE ------------------ISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV RAF1_RAT RAF1_RAT ------------------ISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV RAF1_BOVIN RAF1_BOVIN ------------------ISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV B4E0X2_HUMAN B4E0X2_HUMAN ---------------------------------------------------MMANSQ--- B4E1N6_HUMAN B4E1N6_HUMAN ------------------------------------------------------------ RAF1_PONAB RAF1_PONAB ------------------ISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV RAF1_HUMAN RAF1_HUMAN ------------------ISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ------------------------------------------------------------ Q76FQ3_DANRE Q76FQ3_DANRE ------------------------VSPVIKSPAPCQSRSSDDSKTSRTIRVFLPNQQRTV Q6BE22_DANRE Q6BE22_DANRE ------------------------VSPVIKSPAPCQSRSSDDSKTSRTIRVFLPNQQRTV Q7ZTR8_DANRE Q7ZTR8_DANRE ------------------------VSPVIKSPAPCQSRSSDDSKTSRTIRVFLPNQQRTV Q4S5I4_TETNG Q4S5I4_TETNG ------------------LSPTMVQGFPCQRRSSDDGKMPDS-KTSSTIRVYLPNQQRTV Q98TC3_SERQU Q98TC3_SERQU ------------------LSPTMVQGFPCQRRSSDDSKMPDS-KTSSTIRVYLPNQQRTV Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS ??????????????????????????????????????????????????V?LPN?QRTV

Q4H2W3_CIOIN Q4H2W3_CIOIN VGAIPGKRLKEVLLKSARLKSLRDKLDQCSVYRF-----GTDDHVDWNSDSGILAGVQLE ARAF_MOUSE ARAF_MOUSE VTVREGMSVYDSLDKALKVRGLNQ--DCCVVYRLIK---GRKTVTAWDTAIAPLDGEELI ARAF_RAT ARAF_RAT VTVRDGMSVYDSLDKALKVRGLNQ--DCCVVYRLIK---GRKTVTAWDTAIAPLDGEELI ARAF_PIG ARAF_PIG VTVRDGMSVYDSLDKALKVRGLNQ--DCCVVYRLIK---GRKTVTAWDTAIAPLDGEELI Q2KJA0_BOVIN Q2KJA0_BOVIN VTVRDGMSVYDSLDKALKVRGLNQ--DCCVVYRLIK---GRKTVTAWDTAIAPLDGEELI Q5BIM4_BOVIN Q5BIM4_BOVIN VTVRDGMSVYDSLDKALKVRGLNQ--DCCVVYRLIK---GRKTVTAWDTAIAPLDGEELI B4DV85_HUMAN B4DV85_HUMAN VPPR-------------------------------------------------------- ARAF_HUMAN ARAF_HUMAN VTVRDGMSVYDSLDKALKVRGLNQ--DCCVVYRLIK---GRKTVTAWDTAIAPLDGEELI Q96II5_HUMAN Q96II5_HUMAN VTVRDGMSVYDSLDKALKVRGLNQ--DCCVVYRLIK---GRKTVTAWDTAIAPLDGEELI Q4SDH1_TETNG Q4SDH1_TETNG VNVRQGQTVHESLDKALKVRGLSQ--ECCAVFRLLE---GRKRLTDWDTDITPLVGEELL Q75W79_DANRE Q75W79_DANRE VNVRPGQTVYDSLDKALKVRGLSQ--DCCAVFRLLE---GRKRLTEWDTDITPLVGEELL Q5FBD1_DANRE Q5FBD1_DANRE VNVRPGQTVYDSLDKALKVRGLSQ--DCCAVFRLLE---GRKRLTEWDTDITPLVGEELL Q75Y03_DANRE Q75Y03_DANRE VNVRPGQTVYDSLDKALKVRGLSQ--DCCAVFRLLE---GRKRLTEWDTDITPLVGEELL Q5M7Y2_DANRE Q5M7Y2_DANRE VNVRPGQTVYDSLDKALKVRGLSQ--DCCAVFRLLE---GRKRLTEWDTDITPLVGEELL Q4R1J4_ONCKE Q4R1J4_ONCKE VNVRPGQTVYDSLDKALKVRGLSQ--DCCAVFRLLE---GRKRLTEWDTDITPLVGEELL Q0D2E4_XENTR Q0D2E4_XENTR VPARSGVTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWITGEELH Q68FI8_XENLA Q68FI8_XENLA VPARSGVTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWITGEELH Q4F9K6_XENLA Q4F9K6_XENLA VPARSGVTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWITGEELH Q643Z8_XENLA Q643Z8_XENLA VPARSGVTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWITGEELH B7ZRT9_XENLA B7ZRT9_XENLA VPARSGVTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWITGEELH Q767H5_XENLA Q767H5_XENLA VPARSGVTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWITGEELH BRAF1_CHICK BRAF1_CHICK VPARCGVTVRDSLKKALMMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTGEELH BRAF1_COTJA BRAF1_COTJA VPARCGVTVRDSLKKALMMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTGEELH Q4R345_MACFA Q4R345_MACFA VPARCGVTVRDSLKKALMMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTGEELH BRAF1_MOUSE BRAF1_MOUSE VPARCGVTVRDSLKKALMMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTGEELH Q9JJU6_MOUSE Q9JJU6_MOUSE VPARCGVTVRDSLKKALMMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTGEELH A4D1T4_HUMAN A4D1T4_HUMAN VPARCGVTVRDSLKKALMMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTGEELH BRAF1_HUMAN BRAF1_HUMAN VPARCGVTVRDSLKKALMMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTGEELH Q698R1_CANFA Q698R1_CANFA VPARCGVTVRDSLKKALMMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTGEELH Q75V92_DANRE Q75V92_DANRE VPARCGMTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWLTGEELH Q761X4_DANRE Q761X4_DANRE VPARCGMTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWLTGEELH Q767H4_DANRE Q767H4_DANRE VPARCGMTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWLTGEELH Q75V91_DANRE Q75V91_DANRE VPARCGMTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWLTGEELH B3DFX5_DANRE B3DFX5_DANRE VPARCGMTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWLTGEELH Q1LYG2_DANRE Q1LYG2_DANRE VPARCGMTVRDSLKKALMMRGLIP--ECCAVYRVQD---GEKKPIGWDTDISWLTGEELH Q4SRI2_TETNG Q4SRI2_TETNG VSARCGMTVRDSLKKALTMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTLEELH Q6L8Q6_SERQU Q6L8Q6_SERQU VPARCGMTVRDSLKKALMMRGLIP--ECCAVYRIQD---GEKKPIGWDTDISWLTGEELH Q6PA51_XENLA Q6PA51_XENLA VNVRPGMTVYDSLDKALKVRGLSQ--ECCAVYRLIQ---GRKALTDWETDITPLVGEELM Q6INV2_XENLA Q6INV2_XENLA VNVRPGMTVYDSLDKALKMRGLSQ--ECCAVYRLIQ---GRKALTDWETDITPLVGEELM Q767H6_XENLA Q767H6_XENLA VNVRPGMTVYDSLDKALKMRGLSQ--ECCAVYRLIQ---GRKALTDWETDITPLVGEELM Q4V900_DANRE Q4V900_DANRE VNVRAGMTLRNCLIKALKVRGLQP--ECCAVFKLQREHSAKKLRMDWSTDSTSLVGEELL Q2V2G8_SALSA Q2V2G8_SALSA VNARPGMTLHNCLIKAMKVXGLQP--ECCAVFRLHSAQ-SRKSRMDWNTDATSLIGEELL Q28GW9_XENTR Q28GW9_XENTR VNVRSGMSLHDCLMKALKVRGLQP--ECCAVFRLIQDPKG-KLRLDWNTDAMSLVGAELQ Q6GQJ4_XENLA Q6GQJ4_XENLA VNVRSGMSLHDCLMKSLKVRGLQP--ECCAVFRLIQDPKG-KLRLDWNTDAMSLVGAELQ RAF1_XENLA RAF1_XENLA VNVRSGMSLHDCLMKSLKVRGLQP--ECCAVFRLIQDPKG-KLRLDWNTDAMSLVGAELQ RAF1_CHICK RAF1_CHICK VNVRNGMTLHDCLMKALKVRGLQP--ECCAVFRLVTEPKGKKVRLDWNTDAASLIGEELQ Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE VNVRNGMSLHDCLMKALKVRGLQP--ECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQ RAF1_RAT RAF1_RAT VNVRNGMSLHDCLMKALKVRGLQP--ECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQ RAF1_BOVIN RAF1_BOVIN VNVRNGMSLHDCLMKALKVRGLQP--ECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQ B4E0X2_HUMAN B4E0X2_HUMAN ------ILLRQATLSVFSCRTSKE--QC------------KKARLDWNTDAASLIGEELQ B4E1N6_HUMAN B4E1N6_HUMAN ------------------------------------------------------------ RAF1_PONAB RAF1_PONAB VNVRNGMSLHDCLMKALKVRGLQP--ECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQ RAF1_HUMAN RAF1_HUMAN VNVRNGMSLHDCLMKALKVRGLQP--ECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQ O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ------------------------------------------------------------ Q76FQ3_DANRE Q76FQ3_DANRE VNVRPGMTLHSCLIKALKVRGLQP--ECCAVFSLHPGQRSKKSRMEWSTDSTSLIGEELL Q6BE22_DANRE Q6BE22_DANRE VNVRPGMTLHSCLIKALKVRGLQP--ECCAVFSLHPGQRSKKSRMEWSTDSTSLIGEELL Q7ZTR8_DANRE Q7ZTR8_DANRE VNVRPGMTLHSCLIKALKVRGLQP--ECCAVFSLHPGQRSKKSRMEWSTDSTSLIGEELL Q4S5I4_TETNG Q4S5I4_TETNG VNVRPGMTLHSCLIKALKVRGLQP--QCCAVFRLHPGQSSKKLRMDWNTDSTSLIGQELL Q98TC3_SERQU Q98TC3_SERQU VNVRPGMTLHNCLIKALKVRGLQP--QCCAVFRLHPGQRSKKLRMDWNTDSTSLIGQELL Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS V??R?G??????L?KAL??RGL?????CC?V?R????????K????W?T????L?GEEL?

Q4H2W3_CIOIN Q4H2W3_CIOIN LRTEDKSFTKSTRILKANHNFARKTFFSLSYCDWCRKILFQGVTCKMCGFKLHQKCINEV ARAF_MOUSE ARAF_MOUSE VEVLED-------VPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV ARAF_RAT ARAF_RAT VEVLED-------VPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV ARAF_PIG ARAF_PIG VEVLED-------VPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV Q2KJA0_BOVIN Q2KJA0_BOVIN VEVLED-------VPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV Q5BIM4_BOVIN Q5BIM4_BOVIN VEVLED-------VPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV B4DV85_HUMAN B4DV85_HUMAN ------------------------------------------------------------ ARAF_HUMAN ARAF_HUMAN VEVLED-------VPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV Q96II5_HUMAN Q96II5_HUMAN VEVLED-------VPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV Q4SDH1_TETNG Q4SDH1_TETNG VEVLDD-------IPLTMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKV Q75W79_DANRE Q75W79_DANRE VEVLDD-------VPLTMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKV Q5FBD1_DANRE Q5FBD1_DANRE VEVLDD-------VPLTMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKV Q75Y03_DANRE Q75Y03_DANRE VEVLDD-------VPLTMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKV Q5M7Y2_DANRE Q5M7Y2_DANRE VEVLDD-------VPLTMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKV Q4R1J4_ONCKE Q4R1J4_ONCKE VEVLDD-------VPLTMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKV Q0D2E4_XENTR Q0D2E4_XENTR VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q68FI8_XENLA Q68FI8_XENLA VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q4F9K6_XENLA Q4F9K6_XENLA VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q643Z8_XENLA Q643Z8_XENLA VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV B7ZRT9_XENLA B7ZRT9_XENLA VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCCYKFHQRCSTEV Q767H5_XENLA Q767H5_XENLA VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCCYKFHQRCSTEV BRAF1_CHICK BRAF1_CHICK VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV BRAF1_COTJA BRAF1_COTJA VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q4R345_MACFA Q4R345_MACFA VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV BRAF1_MOUSE BRAF1_MOUSE VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q9JJU6_MOUSE Q9JJU6_MOUSE VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV A4D1T4_HUMAN A4D1T4_HUMAN VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV BRAF1_HUMAN BRAF1_HUMAN VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q698R1_CANFA Q698R1_CANFA VEVLEN-------VPLTTRNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q75V92_DANRE Q75V92_DANRE VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFRQRCSTEV Q761X4_DANRE Q761X4_DANRE VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q767H4_DANRE Q767H4_DANRE VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q75V91_DANRE Q75V91_DANRE VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV B3DFX5_DANRE B3DFX5_DANRE VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q1LYG2_DANRE Q1LYG2_DANRE VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q4SRI2_TETNG Q4SRI2_TETNG VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q6L8Q6_SERQU Q6L8Q6_SERQU VEVLEN-------VPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEV Q6PA51_XENLA Q6PA51_XENLA VEVLAD-------VPLSMHNFVRKTHFNLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV Q6INV2_XENLA Q6INV2_XENLA VEVLAD-------VPLSMHNFVRKTHFNLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV Q767H6_XENLA Q767H6_XENLA VEVLAD-------VPLSMYNFVRKTHFNLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKV Q4V900_DANRE Q4V900_DANRE VEVLDH-------VPLTTHNFVRKTFLKLAFCDICQKFLLHGFRCQTCGYKFHEHCSTKV Q2V2G8_SALSA Q2V2G8_SALSA VDVLDH-------VPLTTHNFVRNTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV Q28GW9_XENTR Q28GW9_XENTR VDFLDH-------VPLTTHNFVRKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV Q6GQJ4_XENLA Q6GQJ4_XENLA VDFLDH-------VPLTTHNFVRKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV RAF1_XENLA RAF1_XENLA VDFLDH-------VPLTTHNFVRKTFLKLAFCDICQKFLLNAFRCQTCGYKFHEHCSTKV RAF1_CHICK RAF1_CHICK VDFLDH-------VPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE VDFLDH-------VPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV RAF1_RAT RAF1_RAT VDFLDH-------VPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV RAF1_BOVIN RAF1_BOVIN VDFLDH-------VPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV B4E0X2_HUMAN B4E0X2_HUMAN VDFLDH-------VPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV B4E1N6_HUMAN B4E1N6_HUMAN ------------------------------------------------------------ RAF1_PONAB RAF1_PONAB VDFLDH-------VPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV RAF1_HUMAN RAF1_HUMAN VDFLDH-------VPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ------------------------------------------------------------ Q76FQ3_DANRE Q76FQ3_DANRE VEVLDH-------VPLTTHNFVRKTFLKLAFCDICQKFLLNGFRCQRCGYKFHEHCSTKV Q6BE22_DANRE Q6BE22_DANRE VEVLDH-------VPLTTHNFVRKTFLKLAFCDICQKFLLNGFRCQRCGYKFHEHCSTKV Q7ZTR8_DANRE Q7ZTR8_DANRE VEVLDH-------VPLTTHNFVRKTFLKLAFCDICQKFLLNGFRCQRCGYKFHEHCSTKV Q4S5I4_TETNG Q4S5I4_TETNG VEVLDH-------VPLTTHNFVRKTYLKLAFCDICQKFLLNGFRCQTCCYKFHEHCSTKV Q98TC3_SERQU Q98TC3_SERQU VEVLDH-------VPLTTHNFVRKTYLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS V??L?????????VPLT?HNF?RKTF??LA?CD?C?K?L??GFRCQTCGYKFH??CS??V

Q4H2W3_CIOIN Q4H2W3_CIOIN PDYCITQIQILEL-----------------------EKK--IRPQTP---------SPDS ARAF_MOUSE ARAF_MOUSE PTVCVDMSTNRRQ-----FYHSIQDLSGGSRQQEAPSNL--SVNE--LLTPQGP--SPFT ARAF_RAT ARAF_RAT PTVCVDMSTNRRQ-----FYHSIQDLSGGSRQQEVPSNL--SVNE--LLTPQGP--SPFT ARAF_PIG ARAF_PIG PTVCVDMSTNRRQ-----FYHSVQDLSGGSRQHETPSNR----PLNEPLTPQGP--SSCT Q2KJA0_BOVIN Q2KJA0_BOVIN PTVCVDMSTNRRQ-----FYHSVQDLSGSSRQHEVPSNRPLNEPLTPQSPSLSPA-SSCT Q5BIM4_BOVIN Q5BIM4_BOVIN PTVCVDMSTNRRQ-----FYHSVQDLSGSSRQHEVPSNR----PLNEPLTPQSP--SSCT B4DV85_HUMAN B4DV85_HUMAN ------------------FYHSVQDLSGGSRQHEAPSNR----PLNELLTPQGP--SPRT ARAF_HUMAN ARAF_HUMAN PTVCVDMSTNRQQ-----FYHSVQDLSGGSRQHEAPSNR----PLNELLTPQGP--SPRT Q96II5_HUMAN Q96II5_HUMAN PTVCVDMSTNRQQPSR--FYHSVQDLSGGSRQHEAPSNR----PLNELLTPQGP--SPRT Q4SDH1_TETNG Q4SDH1_TETNG PTVCLDMDTVSKRCE---PSTCVDEYPQVLLSEHSPSQS--NLTPEPAGPVSGGFHGCRM Q75W79_DANRE Q75W79_DANRE PTVCVDMDTM--------TKRCVNNTEDCPAILIYPATN--SISQSD---------LPLT Q5FBD1_DANRE Q5FBD1_DANRE PTVCVDMDTM--------TKRCVNNTEDCPAILIYPATN--SISQSD---------LPLT Q75Y03_DANRE Q75Y03_DANRE PTVCVDMDTM--------TKRCVNNTEDCPAILIYPATN--SISQSD---------LPLT Q5M7Y2_DANRE Q5M7Y2_DANRE PTVCVDMDTM--------TKRCVNNTEDCPAILIYPATN--SISQSD---------LPLT Q4R1J4_ONCKE Q4R1J4_ONCKE PTVCVDMDTM--------TKRCVNNTEDCPAILIYPATN--SISQSD---------LPLT Q0D2E4_XENTR Q0D2E4_XENTR PLMCVNYDRLDLLFVSKFFEHHPISQEEAPFEEVAPAAE--SSTPPPPPDATGP--LCLP Q68FI8_XENLA Q68FI8_XENLA PLMCVNYDRLDLLFVSKFFEHHPISQEEAPFEEFVPAVE--SLTPPPPPDATGP--PSLP Q4F9K6_XENLA Q4F9K6_XENLA PLMCVNYDRLDLLFVSKFFEHHPISQEEAPFEEFVPAVE--SLTPPPPPDATGP--PSLP Q643Z8_XENLA Q643Z8_XENLA PLMCVNYDRLDLLFVSKFFEHHPISQEEAPFEEFVPAVE--SLTPPPPPDATGP--PSLP B7ZRT9_XENLA B7ZRT9_XENLA PLMCVNYDRLDLLFVSKFFEHHPISQEEAPFEEFVPAVE--SSTPPPPPDATGP--PSLL Q767H5_XENLA Q767H5_XENLA PLMCVNYDRLDLLFVSKFFEHHPISQEEAPFEEFVPLVE--SSTPPPPPDATGP--PSLP BRAF1_CHICK BRAF1_CHICK PLMCVNYDQLDLLFVSKFFEHHPISQEETTLGETTPASG--SYPSVPPSDSVGP--PILP BRAF1_COTJA BRAF1_COTJA PLMCVNYDQLDLLFVSKFFEHHPISQEETTLGETTPASG--SYPSVPPSDSVGP--PILP Q4R345_MACFA Q4R345_MACFA PLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSG--SSPSAPTSDSLGP--QILT BRAF1_MOUSE BRAF1_MOUSE PLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSG--SS-SAPPSDSTGP--QILT Q9JJU6_MOUSE Q9JJU6_MOUSE PLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSG--S-SSAPPSDSTGP--QILT A4D1T4_HUMAN A4D1T4_HUMAN PLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSG--SSPSAPASDSIGP--QILT BRAF1_HUMAN BRAF1_HUMAN PLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSG--SSPSAPASDSIGP--QILT Q698R1_CANFA Q698R1_CANFA PLMCVNYDQLDLLFVSKFFEHHPIPQEEASIAETALTSG--SSPSAPPSDSPGP--PILT Q75V92_DANRE Q75V92_DANRE PLMCVNYDQLDLLLASKFLVHHPITQEEVSSEGTTPISE--MCPSLPPSESTGS--LCHP Q761X4_DANRE Q761X4_DANRE PLMCVNYDQLDLLLASKFLVHHPITQEEVSSEGTTPISE--MCPSLPPSESTGS--LCHP Q767H4_DANRE Q767H4_DANRE PLMCVNYDQLDLLLASKFLVHHPITQEEVSSEGTTPISE--MCPSLPPSESTGS--LCHP Q75V91_DANRE Q75V91_DANRE PLMCVNYDQLDLLLASKFLVHHPITQEEVSSEGTTPISE--MCPSLPPSESTGS--LCHP B3DFX5_DANRE B3DFX5_DANRE PLMCVNYDQLDLLLASKFLVHHPITQEEVSSEGTTPISE--MCPSLPPSESTGS--LCHP Q1LYG2_DANRE Q1LYG2_DANRE PLMCVNYDQLDLLLASKFLVHHPITQEEVSSEGTTPISE--MCPSLPPSESTGS--LCHP Q4SRI2_TETNG Q4SRI2_TETNG PLMCVNYDQLDLLLVSKFFEHHPFTQEEVSSEGTTPVSE--VCPSLPPSDSIGS--ICHS Q6L8Q6_SERQU Q6L8Q6_SERQU PLMCVNYDQLDLLLVSKFFEHHPFTQEEVSSEGTTPVSE--ACPSLPPSDSTGS--ICHT Q6PA51_XENLA Q6PA51_XENLA PTACVDMAKL------------PKPLTPLSYQDFQSYYE--HPTVHTPLSPQPP--SPRT Q6INV2_XENLA Q6INV2_XENLA PTACVDMAKL------------PKPLTPLSYQDFQSYYD--HPPVHTPLSPQPP--SPRT Q767H6_XENLA Q767H6_XENLA PTACVDMAKL------------PKPLTPLSYQDFQSYYD--HPPVHTPLSPQPP--SPRT Q4V900_DANRE Q4V900_DANRE PTMCVDWSNIRQLLL---FPTP--GENGALTLPPLSSRR--MQNSRFSFSPY----HRYS Q2V2G8_SALSA Q2V2G8_SALSA PTMCVDWSNIRQLLL---FPTP--GETGGPSLPPLTSRR--LRDSLSRFPVRHS--TLHA Q28GW9_XENTR Q28GW9_XENTR PTMCVDWSNIRQLLL---FPNPNNMEGGSHTLPSLTVRR--MRESV-RIPISSQ--QRYS Q6GQJ4_XENLA Q6GQJ4_XENLA PTMCVDWSNIRQLLL---FPNPNNIEGGSHTLPSLTMRR--MRESV-RIPVSSQ--QRYS RAF1_XENLA RAF1_XENLA PTMCVDWSNIRQLLL---FPNPNNIEGGSHTLPSLTMRR--IGESV-RIPVSSQ--QRYS RAF1_CHICK RAF1_CHICK PTMCVDWSNIRQLLL---FPNSNISDSGVPALPPLTMRR--MRESVSRIPVSSQ--HRYS Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE PTMCVDWSNIRQLLL---FPNSTVGDSGVPAPPSFPMRR--MRESVSRMPASSQ--HRYS RAF1_RAT RAF1_RAT PTMCVDWSNIRQLLL---FPNSTASDSGVPAPPSFTMRR--MRESVSRMPASSQ--HRYS RAF1_BOVIN RAF1_BOVIN PTMCVDWSNIRQLLL---FPNSTVGDGGVPALPSLTMRR--MRESVSRIPPGSQ--HRYS B4E0X2_HUMAN B4E0X2_HUMAN PTMCVDWSNIRQLLL---FPNSTIGDSGVPALPSLTMRR--MRESVSRMPVSSQ--HRYS B4E1N6_HUMAN B4E1N6_HUMAN --MCVDWSNIRQLFSQ----------------------------------------HRYS RAF1_PONAB RAF1_PONAB PTMCVDWSNIRQLLL---FPNSTIGDSGVPALPSLTMRR--MRESVSRMPVSSQ--HRYS RAF1_HUMAN RAF1_HUMAN PTMCVDWSNIRQLLL---FPNSTIGDSGVPALPSLTMRR--MRESVSRMPVSSQ--HRYS O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ------------------------------------------------------------ Q76FQ3_DANRE Q76FQ3_DANRE PTMCVDWTNIRQLLL---FPTP--GESGAPSLPSLTSRR--MRESLTRIPSSSV--HRYS Q6BE22_DANRE Q6BE22_DANRE PTMCVDWTNIRQLLL---FPTP--GESGAPSLPSLTSRR--MRESLTRIP---------- Q7ZTR8_DANRE Q7ZTR8_DANRE PTMCVDWTNIRQLLL---FPTP--GESGAPSLPSLTSRR--MRESLTRIPSSSV--HRYS Q4S5I4_TETNG Q4S5I4_TETNG PTMCVDWSNIRQLLL---FPSP--GDSGAPSLPSLTSRR--MRDSLTRFPSSA---HRYS Q98TC3_SERQU Q98TC3_SERQU PTMCVDWSNIRQLLL-----CPTPGESGAPSLPPLTSRR--MRESLTRFPSSA---HRYS Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS P??CV???????????????????????????????????????????????????????

Q4H2W3_CIOIN Q4H2W3_CIOIN PNTPTD-TWPVPGQ--------SGDFPLYRPRSTSQPSLFINSTAPLGQN---------- ARAF_MOUSE ARAF_MOUSE QQRDQE-HFSFPAP---------ANPPLQRIRSTSTPNVHMVSTT-APMD---------- ARAF_RAT ARAF_RAT QQRDQE-HFSFPAP---------ANPPLQRIRSTSTPNVHMVSTT-APMD---------- ARAF_PIG ARAF_PIG QHRDPE-HFPFPAP---------ANAPLQRIRSTSTPNVHMVSTT-APMD---------- Q2KJA0_BOVIN Q2KJA0_BOVIN QHRDPE-HFSFPAQ---------ANTPLQRIRSTSTPNVHMVSTT-APMD---------- Q5BIM4_BOVIN Q5BIM4_BOVIN QHRDPE-HFSFPAQ---------ANTPLQRIRSTSTPNVHMVSTT-APMD---------- B4DV85_HUMAN B4DV85_HUMAN QHCDPE-HFPFPAP---------ANAPLQRIRSTSTPNVHMVSTT-APMD---------- ARAF_HUMAN ARAF_HUMAN QHCDPE-HFPFPAP---------ANAPLQRIRSTSTPNVHMVSTT-APMD---------- Q96II5_HUMAN Q96II5_HUMAN QHCDPE-HFPFPAP---------ANAPLQRIRSTSTPNVHMVSTT-APMD---------- Q4SDH1_TETNG Q4SDH1_TETNG DLSPAP-AFHFPVP-------GGDGQSLQRHRSTSTPNVHMVSTVGVAGA---------- Q75W79_DANRE Q75W79_DANRE SDSPGG-ELPSSPSNFCLFIRGEDGQSLQRHRSTSTPNVHMVSTL-EPGA---------- Q5FBD1_DANRE Q5FBD1_DANRE SDSPGG-ELPSSPSNFCLFIRGEDGQSLQRHRSTSTPNVHMVSTL-EPGA---------- Q75Y03_DANRE Q75Y03_DANRE SDSPGG-ELPSSPSNFCLFIRGEDGQSLQRHRSTSTPNVHMVSTL-EPGA---------- Q5M7Y2_DANRE Q5M7Y2_DANRE SDSPGG-ELPSSPSNFCLFIRGEDGQSLQRHRSTSTPNVHMVSTL-EPGA---------- Q4R1J4_ONCKE Q4R1J4_ONCKE SDSPGG-ELPSSPSNFCLFIRGEDGQSLQRHRSTSTPNVHMVSTL-EPGA---------- Q0D2E4_XENTR Q0D2E4_XENTR STSPSK-SIPIPQP-FRP-DEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q68FI8_XENLA Q68FI8_XENLA SASPSK-SIPIPQP-FRP-DEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q4F9K6_XENLA Q4F9K6_XENLA SASPSK-SIPIPQP-FRP-DEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q643Z8_XENLA Q643Z8_XENLA SASPSK-SIPIPQP-FRP-DEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- B7ZRT9_XENLA B7ZRT9_XENLA STSPSK-SIPIPQP-LRP-DEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q767H5_XENLA Q767H5_XENLA STSPSK-SIPIPQP-LRP-DEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- BRAF1_CHICK BRAF1_CHICK SPSPSK-SIPIPQP-FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- BRAF1_COTJA BRAF1_COTJA SPSPSK-SIPIPQP-FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q4R345_MACFA Q4R345_MACFA SPSPSK-SIPIPQP-FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- BRAF1_MOUSE BRAF1_MOUSE SPSPSK-SIPIPQP-FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDEKFPEVELQD Q9JJU6_MOUSE Q9JJU6_MOUSE SPSPSK-SIPIPQP-FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- A4D1T4_HUMAN A4D1T4_HUMAN SPSPSK-SIPIPQP-FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- BRAF1_HUMAN BRAF1_HUMAN SPSPSK-SIPIPQP-FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q698R1_CANFA Q698R1_CANFA SPSPSK-SIPIPQP-FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q75V92_DANRE Q75V92_DANRE TVSPSK-SIPIPQS-FRPGEEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q761X4_DANRE Q761X4_DANRE TVSPSK-SIPIPQS-FRPGEEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q767H4_DANRE Q767H4_DANRE TVSPSK-SIPIPQS-FRPGEEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q75V91_DANRE Q75V91_DANRE TVSPSK-SIPIPQS-FRPGEEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- B3DFX5_DANRE B3DFX5_DANRE TVSPSK-SIPIPQS-FRPGEEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q1LYG2_DANRE Q1LYG2_DANRE TVSPSK-SIPIPQS-FRPGEEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q4SRI2_TETNG Q4SRI2_TETNG TVSPSK-SIPIPPS-FRSSEEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q6L8Q6_SERQU Q6L8Q6_SERQU TVSPSK-SIPIPPS-FRPNEEDHRNQFGQRDRSSSAPNVHINTIEPVNID---------- Q6PA51_XENLA Q6PA51_XENLA QHPGSA-SFSFPGE----------GQPLQRHRSTSTPNVHIDSTT-GPVD---------- Q6INV2_XENLA Q6INV2_XENLA QHPGSA-SFSFPVE----------GQPLQRHRSTSTPNVHIDSTT-GPVD---------- Q767H6_XENLA Q767H6_XENLA QHPGSA-SFSFPVE----------GQPLQRHRSTSTPNVHIDSTT-GPVD---------- Q4V900_DANRE Q4V900_DANRE TPNALNYITPLPSP---------GVSLGHKVLSTSTPNVHMVSTT-QPVD---------- Q2V2G8_SALSA Q2V2G8_SALSA FNQAPG-SVLGAGP----------AVLSHRLRSTSTPNVHMVSTT-LPLD---------- Q28GW9_XENTR Q28GW9_XENTR TPHPFSFSTPSAPS---------ECSLSQRQRSTSTPNVHMVSTT-MAVD---------- Q6GQJ4_XENLA Q6GQJ4_XENLA TPHPFSFSTPSPVS---------ECSLSQRQRSTSTPNVHMVSTT-MAVD---------- RAF1_XENLA RAF1_XENLA TPHPFSFSTPSPVS---------ECSLSQRQRSTSTPNVHMVSTT-MAVD---------- RAF1_CHICK RAF1_CHICK TPHVFTFNTSNPSS---------EGTLSQRQRSTSTPNVHMVSTT-MPVD---------- Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE TPHAFTFNTSSPSS---------EGSLSQRQRSTSTPNVHMVSTT-LHVD---------- RAF1_RAT RAF1_RAT TPHAFTFNTSSPSS---------EGSLSQRQRSTSTPNVHMVSTT-LPVD---------- RAF1_BOVIN RAF1_BOVIN TPHAFTFSASSPSS---------EGSLSQRQRSTSTPNVHMVSAT-LPVD---------- B4E0X2_HUMAN B4E0X2_HUMAN TPHAFTFNTSSPSS---------EGSLSQRQRSTSTPNVHMVSTT-LPVD---------- B4E1N6_HUMAN B4E1N6_HUMAN TPHAFTFNTSSPSS---------EGSLSQRQRSTSTPNVHMVSTT-LPVD---------- RAF1_PONAB RAF1_PONAB TPHAFTFNTSSPSS---------EGSLSQRQRSTSTPNVHMVSTT-LPVD---------- RAF1_HUMAN RAF1_HUMAN TPHAFTFNTSSPSS---------EGSLSQRQRSTSTPNVHMVSTT-LPVD---------- O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ----------------------------------------------ITGD---------- Q76FQ3_DANRE Q76FQ3_DANRE NPHVSNYTSPYPPS---------GAALTQRLRSTSTPNVTMLSTT-VPVD---------- Q6BE22_DANRE Q6BE22_DANRE -------SSPYPPS---------GAALTQRLRSTSTPNVTMLSTT-VPVD---------- Q7ZTR8_DANRE Q7ZTR8_DANRE NPHVSNYTSPYPPS---------GAALTQRLRSTSTPNVTMLSTT-VPVD---------- Q4S5I4_TETNG Q4S5I4_TETNG TPHAFNYNTSYAPT---------GGGLSQRQRSTSTPNVHMVSTT-LPVD---------- Q98TC3_SERQU Q98TC3_SERQU TPHAFNYTTPYPPT---------GGGLSQRQRSTSTPNVHMVSTT-LPVD---------- Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS ???????????P????????????????QR?RS?S?PNVH?????????D??????????

Q4H2W3_CIOIN Q4H2W3_CIOIN ------------------------------------------------------------ ARAF_MOUSE ARAF_MOUSE --SSLMQFTAQS--------FSTDAA---------------------------------- ARAF_RAT ARAF_RAT --SSLMQFTAQS--------FSTDAA---------------------------------- ARAF_PIG ARAF_PIG --SGLVQLTAQS--------FNTDAA---------------------------------- Q2KJA0_BOVIN Q2KJA0_BOVIN --SGLIQLTGQN--------FNTDAA---------------------------------- Q5BIM4_BOVIN Q5BIM4_BOVIN --SGLIQLTGQN--------FNTDAA---------------------------------- B4DV85_HUMAN B4DV85_HUMAN --SNLIQLTGQS--------FSTDAA---------------------------------- ARAF_HUMAN ARAF_HUMAN --SNLIQLTGQS--------FSTDAA---------------------------------- Q96II5_HUMAN Q96II5_HUMAN --SNLIQLTGQS--------FSTDAA---------------------------------- Q4SDH1_TETNG Q4SDH1_TETNG --SFIEVWTFHR--------FTNTVG-----------------------------QLLQT Q75W79_DANRE Q75W79_DANRE --AGLLE---EP--------FKISTV---------------------------------- Q5FBD1_DANRE Q5FBD1_DANRE --AGLLE---EP--------FKISTV---------------------------------- Q75Y03_DANRE Q75Y03_DANRE --AGLLE---EP--------FKISTV---------------------------------- Q5M7Y2_DANRE Q5M7Y2_DANRE --AGLLE---EP--------FKISTV---------------------------------- Q4R1J4_ONCKE Q4R1J4_ONCKE --AGLLE---EP--------FKISTV---------------------------------- Q0D2E4_XENTR Q0D2E4_XENTR --DLIRD---QG--------LQCSEGAPSVQPTRCHRKYHSRDPSPLLHTLPSEIVFDFE Q68FI8_XENLA Q68FI8_XENLA --DLIQD---PG--------LQRIEGAPSVQPTRCHRKYHSRDPSPLLHTLPSEIVFDFE Q4F9K6_XENLA Q4F9K6_XENLA --DLIQD---PG--------LQRIEGAPSVQPTRCHRKYHSRDPSPLLHTLPSEIVFDFE Q643Z8_XENLA Q643Z8_XENLA --DLIQD---PG--------LQRIEGAPSVQPTRCHRKYHSRDPSPLLHTLPSEIVFDFE B7ZRT9_XENLA B7ZRT9_XENLA --DLIRD---QG--------LQRSEGAPSVQPTRCHRKYHSRDPSPLLHTLPSEIVFDFE Q767H5_XENLA Q767H5_XENLA --DLIRD---QG--------LQRSEGAPSVQPTRCHRKYHSRDPSPLLHTLPSEIVFDFE BRAF1_CHICK BRAF1_CHICK --DLIRD---QG--------V-RGEGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFE BRAF1_COTJA BRAF1_COTJA --DLIRD---QG--------V-RGEGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFE Q4R345_MACFA Q4R345_MACFA --DLIRD---QG--------F-RGDG---------------------------------- BRAF1_MOUSE BRAF1_MOUSE QRDLIRD---QG--------F-RGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFE Q9JJU6_MOUSE Q9JJU6_MOUSE --DLIRD---QG--------F-RGDG---------------------------------- A4D1T4_HUMAN A4D1T4_HUMAN --DLIRD---QG--------F-RGDG---------------------------------- BRAF1_HUMAN BRAF1_HUMAN --DLIRD---QG--------F-RGDG---------------------------------- Q698R1_CANFA Q698R1_CANFA --DLIRD---QG--------F-RSDG---------------------------------- Q75V92_DANRE Q75V92_DANRE --DLIRD---QG--------LPRSDG---------------------------------- Q761X4_DANRE Q761X4_DANRE --DLIRD---QG--------LPRSDG---------------------------------- Q767H4_DANRE Q767H4_DANRE --DLIRD---QG--------LPRSDG---------------------------------- Q75V91_DANRE Q75V91_DANRE --DLIRD---QG--------LPRSDGAPSQHPARCLRKNRTRTSSPLLSSHPNDIVFDFE B3DFX5_DANRE B3DFX5_DANRE --DLIRD---QG--------LPRSDG---------------------------------- Q1LYG2_DANRE Q1LYG2_DANRE --DLIRD---QG--------LPRSDGAPSQHPARCLRKNRTRTSSPLLSSHPNDIVFDFE Q4SRI2_TETNG Q4SRI2_TETNG --DLIRD---QG--------LPRSDGAPLTHPARCLRKHRTRTSSPLLYSYPNDIVFDFE Q6L8Q6_SERQU Q6L8Q6_SERQU --GLIRD---QG--------LPRSDG---------------------------------- Q6PA51_XENLA Q6PA51_XENLA --NSIIE---EA--------LRSAAV---------------------------------- Q6INV2_XENLA Q6INV2_XENLA --NSIIE---EA--------LRSAAL---------------------------------- Q767H6_XENLA Q767H6_XENLA --NSIIE---EA--------LRSAAL---------------------------------- Q4V900_DANRE Q4V900_DANRE --EAAYQ---EA--------LRHDE----------------------------------- Q2V2G8_SALSA Q2V2G8_SALSA --STAFK---DA--------MRSHE----------------------------------- Q28GW9_XENTR Q28GW9_XENTR --SRLIE---DA--------VRSHSD---------------------------------- Q6GQJ4_XENLA Q6GQJ4_XENLA --SRVIE---DA--------LRSHSE---------------------------------- RAF1_XENLA RAF1_XENLA --SRVIE---DA--------LRSHSE---------------------------------- RAF1_CHICK RAF1_CHICK --SRIIE---DA--------IRNHSE---------------------------------- Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE --SRMIE---DA--------IRSHSE---------------------------------- RAF1_RAT RAF1_RAT --SRMIE---DA--------IRSHSE---------------------------------- RAF1_BOVIN RAF1_BOVIN --SRMIE---DA--------IRSHSE---------------------------------- B4E0X2_HUMAN B4E0X2_HUMAN --SRMIE---DA--------IRSHSE---------------------------------- B4E1N6_HUMAN B4E1N6_HUMAN --SRMIE---DA--------IRSHSE---------------------------------- RAF1_PONAB RAF1_PONAB --SRMIE---DA--------IRSHSE---------------------------------- RAF1_HUMAN RAF1_HUMAN --SRMIE---DA--------IRSHSE---------------------------------- O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ------------------------------------------------------------ Q76FQ3_DANRE Q76FQ3_DANRE --SSLIE---DA--------IRVHSS---------------------------------- Q6BE22_DANRE Q6BE22_DANRE --SSLIE---DA--------IRVHSS---------------------------------- Q7ZTR8_DANRE Q7ZTR8_DANRE --SSLIELDTSPSSWCQQFSLKRRDA---------------------------------- Q4S5I4_TETNG Q4S5I4_TETNG --SSMIE---DV--------MRDHDSGRCFSPVASLNSF--------------------- Q98TC3_SERQU Q98TC3_SERQU --SSVIE---DA--------MRDHDS---------------------------------- Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS ????????????????????????????????????????????????????????????

Q4H2W3_CIOIN Q4H2W3_CIOIN ------SRQPEY------NNYPPA-HGFPQGVGLAQNAAVASLPAPVVVHR-------DP ARAF_MOUSE ARAF_MOUSE ------GR--GG------DGAPRG-SPSPASVSSGRKSPHSKLPSEQRERK----SLADE ARAF_RAT ARAF_RAT ------GR--GG------DGAPRG-SPSPASVSSGRKSPHSKLPAEQRERK----SLADE ARAF_PIG ARAF_PIG ------GNRGGG------DGAPRG-SPSPASVSSGRKSPHSKSPSEQRERK----SLADD Q2KJA0_BOVIN Q2KJA0_BOVIN ------GNRGGG------DGAPRG-SPSPASVSSGRKSPHSKSPSEQRERK----SLADD Q5BIM4_BOVIN Q5BIM4_BOVIN ------GNRGGG------DGAPRG-SPSPASVSSGRKSPHSKSPSEQRERK----SLADD B4DV85_HUMAN B4DV85_HUMAN ------GSRGGS------DGTPRG-SPSPASVSSGRKSPHSKSPAEQRERK----SLADD ARAF_HUMAN ARAF_HUMAN ------GSRGGS------DGTPRG-SPSPASVSSGRKSPHSKSPAEQRERK----SLADD Q96II5_HUMAN Q96II5_HUMAN ------GSRGGS------DGTPRG-SPSPASVSSGRKSPHSKSPAEQRERK----SLADD Q4SDH1_TETNG Q4SDH1_TETNG CLILLFAPVSGS------PEPSPKLSTSPTSSLGSPGRRPIKSPSENKERK---PSSSDD Q75W79_DANRE Q75W79_DANRE ------ASYTGY------ESSPKPSTSPPHLGSPGRKPP--KSPSEPKERK---QSSSDD Q5FBD1_DANRE Q5FBD1_DANRE ------ASSTGY------ESSPKPSTSPPHLGSPGRKPP--KSPSEPKERK---QSSSDD Q75Y03_DANRE Q75Y03_DANRE ------ASYTGY------ESSPKPSTSPPHLGSPGRKPP--KSPSEPKERK---QSSSDD Q5M7Y2_DANRE Q5M7Y2_DANRE ----------GY------ESSPKPSTSPPHLGSPGRKPP--KSPSEPKERK---QSSSDD Q4R1J4_ONCKE Q4R1J4_ONCKE ----------GY------ESSPKPSTSPPHLGSPGRKPP--KSPSEPKERK---QSSSDD Q0D2E4_XENTR Q0D2E4_XENTR SDPVCRGSTPGL------SATPPA--SLPGSLTNVKALQ--KSPGQQRERK-SSSSSTED Q68FI8_XENLA Q68FI8_XENLA SDPVCRGSTPGL------SATPPA--SLPGSLANVKALQ--KSPGQQRERK-SSSSSMED Q4F9K6_XENLA Q4F9K6_XENLA SDPVCRGSTPGL------SATPPA--SLPGSLANVKALQ--KSPGQQRERK-SSSSSMED Q643Z8_XENLA Q643Z8_XENLA SDPVCRGSTPGL------SATPPA--SLPGSLANVKALQ--KSPGQQRERK-SSSSSMED B7ZRT9_XENLA B7ZRT9_XENLA SDPVCRGSTPGL------SATPPA--SLPGSLTNVKALQ--KSPGQQRERK-SSSSSSED Q767H5_XENLA Q767H5_XENLA SDPVCRGSTPGL------SATPPA--SLPGSLTNVKALQ--KSPGQQRERK-SSSSSSED BRAF1_CHICK BRAF1_CHICK PGPVFRGSTAGL------SATPPA--SLPGSLTNVKALQ--KSPGPQRERK--SSSSSED BRAF1_COTJA BRAF1_COTJA PGPVFRGSTAGL------SATPPA--SLPGSLTNVKALQ--KSPGPQRERK--SSSSSED Q4R345_MACFA Q4R345_MACFA ------GSTTGL------SATPPA--SLPGSLTNVKALQ--KSPGPQRERK--SSSSSED BRAF1_MOUSE BRAF1_MOUSE PGPVFRGSTTGL------SATPPA--SLPGSLTNVKALQ--KSPGPQRERKSSSSSSSED Q9JJU6_MOUSE Q9JJU6_MOUSE ------GSTTGL------SATPPA--SLPGSLTNVKALQ--KSPGPQRERKSSSSSSSED A4D1T4_HUMAN A4D1T4_HUMAN ------GSTTGL------SATPPA--SLPGSLTNVKALQ--KSPGPQRERK--SSSSSED BRAF1_HUMAN BRAF1_HUMAN ------GSTTGL------SATPPA--SLPGSLTNVKALQ--KSPGPQRERK--SSSSSED Q698R1_CANFA Q698R1_CANFA ------GSTTGL------SATPPA--SLPGSLTNVKALQ--KSPGPQRERK--SSSSSED Q75V92_DANRE Q75V92_DANRE ------GSTTGL------SATPPA--SLPGSLPNVKVS---KSPCQPRERK--PSSSSED Q761X4_DANRE Q761X4_DANRE ------GSTTGL------SATPPA--SLPGSLPNVKVS---KSPCQPRERK--PSSSSED Q767H4_DANRE Q767H4_DANRE ------GSTTGL------SATPPA--SLPGSLPNVKVS---KSPCQPRERK--PSSSSED Q75V91_DANRE Q75V91_DANRE PEPVFRGSTTGL------SATPPA--SLPGSLPNVKVS---KSPCQPRERK--PSSSSED B3DFX5_DANRE B3DFX5_DANRE ------GSTTGL------SATPPA--SLPGSLPNVKVS---KSPCQPRERK--PSSSSED Q1LYG2_DANRE Q1LYG2_DANRE PEPVFRGSTTGL------SATPPA--SLPGSLPNVKVS---KSPCQPRERK--PSSSSED Q4SRI2_TETNG Q4SRI2_TETNG PEPIFRGSTTGL------SATPPA--SLPGSLTNVKIPQ--KSPCQQRERK--SSSSSED Q6L8Q6_SERQU Q6L8Q6_SERQU ------GSTTGL------SATPPA--SLPGSLTNVKVPQ--KSPCQQRERK--SSSSSED Q6PA51_XENLA Q6PA51_XENLA ---------TPV------DGPPKS--AQPRGSKSPQTK---SPLEATRERK---TSASDE Q6INV2_XENLA Q6INV2_XENLA ---------TPV------DGPPKS--AQPLGSKSPQTK---SASEPARERK---ASASDE Q767H6_XENLA Q767H6_XENLA ---------TPV------DGPPKS--AQPLGSKSPQTK---SASEPARERK---ASASDE Q4V900_DANRE Q4V900_DANRE ------------------SGSPQN--LSPTEWSK-------TPAPAHREKA--PSSNTQE Q2V2G8_SALSA Q2V2G8_SALSA ------------------SESPSD--LSLTCWSQSVSSR--APAPMHKERA--GSSNTQV Q28GW9_XENTR Q28GW9_XENTR ------------------SGSPNN--LSPTGWSNTK-----TPAPTHREKA--ASSSGQE Q6GQJ4_XENLA Q6GQJ4_XENLA ------------------SGSPNN--LSPTGWSNAK-----APAPTHREKA--ASSTGQE RAF1_XENLA RAF1_XENLA ------------------SGSPNN--LSPTGWSNAK-----APAPTHREKA--ASSTGQE RAF1_CHICK RAF1_CHICK -----SASPSAL------SGSPNN--MSPTGWSQPK-----TPVPAQRERA--PGTNTQE Q9CU36_MOUSE Q9CU36_MOUSE ------------------------------------------------------------ RAF1_MOUSE RAF1_MOUSE -----SASPSAL------SSSPNN--LSPTGWSQPK-----TPVPAQRERA--PGSGTQE RAF1_RAT RAF1_RAT -----SASPSAL------SSSPNN--LSPTGWSQPK-----TPVPAQRERA--PGSGTQE RAF1_BOVIN RAF1_BOVIN -----SGSPSAL------SSSPNN--LSPTGWSQPK-----TPAPAQRERA--PGSSTQE B4E0X2_HUMAN B4E0X2_HUMAN -----SASPSAL------SSSPNN--LSPTGWSQPK-----TPVPAQRERA--PVSGTQE B4E1N6_HUMAN B4E1N6_HUMAN -----SASPSAL------SSSPNN--LSPTGWSQPK-----TPVPAQRERA--PVSGTQE RAF1_PONAB RAF1_PONAB -----SASPSAL------SSSPNN--LSPTGWSQPK-----TPVPAQRERA--PVSGTQE RAF1_HUMAN RAF1_HUMAN -----SASPSAL------SSSPNN--LSPTGWSQPK-----TPVPAQRERA--PVSGTQE O19055_PAPHA O19055_PAPHA ------------------------------------------------------------ Q90458_DANRE Q90458_DANRE ------------------------------------------------------------ Q76FQ3_DANRE Q76FQ3_DANRE ------------------AGSSPN--QSPTGWNQASS----HIPA--------SALNPQE Q6BE22_DANRE Q6BE22_DANRE ------------------AGSSPN--QSPTGWNQASA----HIPA--------SALNPQE Q7ZTR8_DANRE Q7ZTR8_DANRE ------IRVHSS------AGSSPN--QSPTGWNQASA----HIPA--------SALNPQE Q4S5I4_TETNG Q4S5I4_TETNG ------GRHQNLPLVWFLAGSSPN--QSPTGWSQSHSK---APAPSQRERA--TSFNTQG Q98TC3_SERQU Q98TC3_SERQU ------------------AGSSPS--QSPTGWSQSK-----APAPAQRERA--PSFNTHE Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS ?????????????????????P??????P???????????????????ER?????S????

Q4H2W3_CIOIN Q4H2W3_CIOIN SHRR------------------------SHSPRRDSNEDWEVPEEEIEWGDKIGSGSYGI ARAF_MOUSE ARAF_MOUSE KKKV------------------------KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGT ARAF_RAT ARAF_RAT KKKV------------------------KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGT ARAF_PIG ARAF_PIG KKKV------------------------KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGT Q2KJA0_BOVIN Q2KJA0_BOVIN KKKV------------------------KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGT Q5BIM4_BOVIN Q5BIM4_BOVIN KKKV------------------------KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGT B4DV85_HUMAN B4DV85_HUMAN KKKV------------------------KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGT ARAF_HUMAN ARAF_HUMAN KKKV------------------------KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGT Q96II5_HUMAN Q96II5_HUMAN KKKV------------------------KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGT Q4SDH1_TETNG Q4SDH1_TETNG KKKVVSGVPSLPLATADLLFDLDLDLFQHRGGYRDSSYYWEVHPREVAIQKRIGTGSFGT Q75W79_DANRE Q75W79_DANRE KKKV------------------------HRGGYRDSSYYWEVHPREVSMLKRIGAGSFGT Q5FBD1_DANRE Q5FBD1_DANRE KKKV------------------------HRGGYRDSSYYWEVHPREVSMLKRIGAGSFGT Q75Y03_DANRE Q75Y03_DANRE KKKV------------------------HRGGYRDSSYYWEVHPREVSMLKRIGAGSFGT Q5M7Y2_DANRE Q5M7Y2_DANRE KKKV------------------------HRGGYRDSSYYWEVHPREVSMLKRIGAGSFGT Q4R1J4_ONCKE Q4R1J4_ONCKE KKKV------------------------HRGGYRDSSYYWEVHPREVSMLKRIGAGSFGT Q0D2E4_XENTR Q0D2E4_XENTR RSRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT Q68FI8_XENLA Q68FI8_XENLA RSRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT Q4F9K6_XENLA Q4F9K6_XENLA RSRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT Q643Z8_XENLA Q643Z8_XENLA RSRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT B7ZRT9_XENLA B7ZRT9_XENLA RSRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT Q767H5_XENLA Q767H5_XENLA RSRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT BRAF1_CHICK BRAF1_CHICK RNRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT BRAF1_COTJA BRAF1_COTJA RNRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT Q4R345_MACFA Q4R345_MACFA RNRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT BRAF1_MOUSE BRAF1_MOUSE RSRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT Q9JJU6_MOUSE Q9JJU6_MOUSE RSRM-------------------------------------------------------- A4D1T4_HUMAN A4D1T4_HUMAN RNRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT BRAF1_HUMAN BRAF1_HUMAN RNRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT Q698R1_CANFA Q698R1_CANFA RNRM------------------------KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGT Q75V92_DANRE Q75V92_DANRE RNKM------------------------KTLGRRDSSDDWEIPEGQITLGQRIGSGSFGT Q761X4_DANRE Q761X4_DANRE RNKM------------------------KTLGRRDSSDDWEIPEGQITLGQRIGSGSFGT Q767H4_DANRE Q767H4_DANRE RNKM------------------------KTLGRRDSSDDWEIPEGQITLGQRIGSGSFGT Q75V91_DANRE Q75V91_DANRE RNKM------------------------KTLGRRDSSDDWEIPEGQITLGQRIGSGSFGT B3DFX5_DANRE B3DFX5_DANRE RNKM------------------------KTLGRRDSSDDWEIPEGQITLGQRIGSGSFGT Q1LYG2_DANRE Q1LYG2_DANRE RNKM------------------------KTLGRRDSSDDWEIPEGQITLGQRIGSGSFGT Q4SRI2_TETNG Q4SRI2_TETNG RSKM------------------------KTLGRRDSSDDWEIPEGQITLGQRIGSGSFGT Q6L8Q6_SERQU Q6L8Q6_SERQU RNKM------------------------KTLGRRDSSDDWEIPEGQITLGQRIGSGSFGT Q6PA51_XENLA Q6PA51_XENLA KKKV------------------------KQLGYRDSSYYWEVNSSEVIILKRIGTGSFGT Q6INV2_XENLA Q6INV2_XENLA KKKV------------------------KQLGYRDSSYYWEVNSSEVIILKRIGTGSFGT Q767H6_XENLA Q767H6_XENLA KKKV------------------------KQLGYRDSSYYWEVNSSEVIILKRIGTGSFGT Q4V900_DANRE Q4V900_DANRE K-RI------------------------RPREKRDSSYYWEIEATEVLLLSRIGSGSFGT Q2V2G8_SALSA Q2V2G8_SALSA KNRM------------------------RPRXKRASSYYWEIEASEVVLQNRIGSGSFGT Q28GW9_XENTR Q28GW9_XENTR KNKI------------------------RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGT Q6GQJ4_XENLA Q6GQJ4_XENLA KNKI------------------------RPRGQRDSSYYWEIEASEVMLSSRIGSGSFGT RAF1_XENLA RAF1_XENLA KNKI------------------------RARGQRDSSYYWEIIASEVMLSSRIGSGSFGT RAF1_CHICK RAF1_CHICK KNKI------------------------RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGT Q9CU36_MOUSE Q9CU36_MOUSE --------------------------------------YWEIEASEVMLSTRIGSGSFGT RAF1_MOUSE RAF1_MOUSE KNKI------------------------RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGT RAF1_RAT RAF1_RAT KNKI------------------------RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGT RAF1_BOVIN RAF1_BOVIN KNKI------------------------RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGT B4E0X2_HUMAN B4E0X2_HUMAN KNKI------------------------RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGT B4E1N6_HUMAN B4E1N6_HUMAN KNKI------------------------RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGT RAF1_PONAB RAF1_PONAB KNKI------------------------RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGT RAF1_HUMAN RAF1_HUMAN KNKI------------------------RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGT O19055_PAPHA O19055_PAPHA ---------------------------------------------EVMLSTRIGSGSFGT Q90458_DANRE Q90458_DANRE ----------------------------RT--------------NEVVLLSRIGSGSFGT Q76FQ3_DANRE Q76FQ3_DANRE KVKI------------------------RPRDKRDSSYYWEIEANEVVLLSRIGSGSFGT Q6BE22_DANRE Q6BE22_DANRE KVKI------------------------RPREKRDSSYYWEIEANEVVLLSRIGSGSFGT Q7ZTR8_DANRE Q7ZTR8_DANRE KVKI------------------------RPREKRDSSYYWEIEANEVVLLSRIGSGSFGT Q4S5I4_TETNG Q4S5I4_TETNG EHKI------------------------RPRDKRDSSYYWEIEASEVYLHSRIGSGSFGT Q98TC3_SERQU Q98TC3_SERQU KNKI------------------------RPRDKRDSSYYWEIEASEVYLNSRIGSGSFGT Q9DEB2_SERQU Q9DEB2_SERQU ------------------------------------------------------------ MATCH CONSENSUS ?????????????????????????????????RDS???WE??????????RIG?GSFGT

Q4H2W3_CIOIN Q4H2W3_CIOIN VYRCRWHGIVAVKVLNVSNPTPSQLQEFKNEVAVLRKTRHVNILLFMGYTIKNQLCIVTQ ARAF_MOUSE ARAF_MOUSE VFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQ ARAF_RAT ARAF_RAT VFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQ ARAF_PIG ARAF_PIG VFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQ Q2KJA0_BOVIN Q2KJA0_BOVIN VFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQ Q5BIM4_BOVIN Q5BIM4_BOVIN VFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQ B4DV85_HUMAN B4DV85_HUMAN VFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQ ARAF_HUMAN ARAF_HUMAN VFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQ Q96II5_HUMAN Q96II5_HUMAN VFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQ Q4SDH1_TETNG Q4SDH1_TETNG VFKGKWHGDVAVKILKVTEPTPEQLQAFKNEMQVLRKTRHVNILLFMGYMTKPNFAIITQ Q75W79_DANRE Q75W79_DANRE VFKGKWHGDVAIKILKVTEPTPEQLQAFKNEMQVLRKTRHVNILLFMGFMTRPNFAIITQ Q5FBD1_DANRE Q5FBD1_DANRE VFKGKWHGDVAIKILKVTEPTPEQLQAFKNEMQVLRKTRHVNILLFMGFMTRPNFAIITQ Q75Y03_DANRE Q75Y03_DANRE VFKGKWHGDVAIKILKVTEPTPEQLQAFKNEMQVLRKTRHVNILLFMGFMTRPNFAIITQ Q5M7Y2_DANRE Q5M7Y2_DANRE VFKGKWHGDVAIKILKVTEPTPEQLQAFKNEMQVLRKTRHVNILLFMGFMTRPNFAIITQ Q4R1J4_ONCKE Q4R1J4_ONCKE VFKGKWHGDVAIKILKVTEPTPEQLQAFKNEMQVFEKTRHVNILLFMGFMTRPNFAIITQ Q0D2E4_XENTR Q0D2E4_XENTR VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLRLVTQ Q68FI8_XENLA Q68FI8_XENLA VYKGKWHGDVAVKILNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQ Q4F9K6_XENLA Q4F9K6_XENLA VYKGKWHGDVAVKILNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQ Q643Z8_XENLA Q643Z8_XENLA VYKGKWHGDVAVKILNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIMTQ B7ZRT9_XENLA B7ZRT9_XENLA VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLVIVTQ Q767H5_XENLA Q767H5_XENLA VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLVIVTQ BRAF1_CHICK BRAF1_CHICK VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQ BRAF1_COTJA BRAF1_COTJA VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQ Q4R345_MACFA Q4R345_MACFA VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQ BRAF1_MOUSE BRAF1_MOUSE VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQ Q9JJU6_MOUSE Q9JJU6_MOUSE ------------------------------------------------------------ A4D1T4_HUMAN A4D1T4_HUMAN VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQ BRAF1_HUMAN BRAF1_HUMAN VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQ Q698R1_CANFA Q698R1_CANFA VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQ Q75V92_DANRE Q75V92_DANRE VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQ Q761X4_DANRE Q761X4_DANRE VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQ Q767H4_DANRE Q767H4_DANRE VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQ Q75V91_DANRE Q75V91_DANRE VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQ B3DFX5_DANRE B3DFX5_DANRE VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQ Q1LYG2_DANRE Q1LYG2_DANRE VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQ Q4SRI2_TETNG Q4SRI2_TETNG VFKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQ Q6L8Q6_SERQU Q6L8Q6_SERQU VFKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQ Q6PA51_XENLA Q6PA51_XENLA VYRGKWHGDVAVKILKVTNPTSEQIQAFKNEMQVLRKTRHVNILLFMGFMTRPQFAIITQ Q6INV2_XENLA Q6INV2_XENLA VYRGKWHGDVAVKILKVTNPTSEQIQAFKNEMQVLRKTRHVNILLFMGFMTRPQFAIITQ Q767H6_XENLA Q767H6_XENLA VYRGKWHGDVAVKILKVTNPTSEQIQAFKNEMQVLRKTRHVNILLFMGFMTRPQFAIITQ Q4V900_DANRE Q4V900_DANRE VYKGKWHGDVAVKILKVINPTPEQLQAFRNEVAVLRKTRHVNIVLFMGYMTKVKLAIVTQ Q2V2G8_SALSA Q2V2G8_SALSA VYKGKWHGDVAVKILXVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTEDNLAIVTQ Q28GW9_XENTR Q28GW9_XENTR VYKGKWHGDVAVKILKVTNPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKENLAIVTQ Q6GQJ4_XENLA Q6GQJ4_XENLA VYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ RAF1_XENLA RAF1_XENLA VYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ RAF1_CHICK RAF1_CHICK VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ Q9CU36_MOUSE Q9CU36_MOUSE VYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ RAF1_MOUSE RAF1_MOUSE VYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ RAF1_RAT RAF1_RAT VYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ RAF1_BOVIN RAF1_BOVIN VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ B4E0X2_HUMAN B4E0X2_HUMAN VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ B4E1N6_HUMAN B4E1N6_HUMAN VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ RAF1_PONAB RAF1_PONAB VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ RAF1_HUMAN RAF1_HUMAN VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ O19055_PAPHA O19055_PAPHA VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ Q90458_DANRE Q90458_DANRE VHKGKWHGDVAVKVLKVTNPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKGNLAIVTQ Q76FQ3_DANRE Q76FQ3_DANRE VHKGKRHGDVAVKVLKVTNPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKGNLAIVTQ Q6BE22_DANRE Q6BE22_DANRE VHKGKWHGDVAVKVLKVTNPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKGNLAIVTQ Q7ZTR8_DANRE Q7ZTR8_DANRE VHKGKWHGDVAVKVLKVTNPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKGNLAIVTQ Q4S5I4_TETNG Q4S5I4_TETNG VYKGKWHGDVAVKILKVTNPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ Q98TC3_SERQU Q98TC3_SERQU VYKGKWHGDVAVKILKVTDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ Q9DEB2_SERQU Q9DEB2_SERQU VYKGKWHGDVAVKILKVTDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQ MATCH CONSENSUS V??GKWHGDVAVK?L?V??PTP?Q?QAF?NE??VLRKTRHVNILLFMG??T????AI?TQ

Q4H2W3_CIOIN Q4H2W3_CIOIN WCDGSSLYRHLHMIDTKFDMLQTINIARQTAQGMEYLHAKNIIHRDMKSN---------- ARAF_MOUSE ARAF_MOUSE WCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSN---------- ARAF_RAT ARAF_RAT WCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSN---------- ARAF_PIG ARAF_PIG WCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSN---------- Q2KJA0_BOVIN Q2KJA0_BOVIN WCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSN---------- Q5BIM4_BOVIN Q5BIM4_BOVIN WCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSN---------- B4DV85_HUMAN B4DV85_HUMAN WCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSN---------- ARAF_HUMAN ARAF_HUMAN WCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSN---------- Q96II5_HUMAN Q96II5_HUMAN WCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSN---------- Q4SDH1_TETNG Q4SDH1_TETNG WCEGSSLYRHLHVTETKFDTMRRIDVARQTSQGMDYLHAKNIIHRDLKSN---------- Q75W79_DANRE Q75W79_DANRE WCEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYLHAKNIIHRDLKSN---------- Q5FBD1_DANRE Q5FBD1_DANRE WCEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYLHAKNIIHRDLKSN---------- Q75Y03_DANRE Q75Y03_DANRE WCEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYLHAKNIIHRDLKSN---------- Q5M7Y2_DANRE Q5M7Y2_DANRE WCEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYLHAKNIIHRDLKSN---------- Q4R1J4_ONCKE Q4R1J4_ONCKE WCEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYLHAKNIIHRDLKSN---------- Q0D2E4_XENTR Q0D2E4_XENTR WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q68FI8_XENLA Q68FI8_XENLA WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q4F9K6_XENLA Q4F9K6_XENLA WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q643Z8_XENLA Q643Z8_XENLA WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- B7ZRT9_XENLA B7ZRT9_XENLA WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q767H5_XENLA Q767H5_XENLA WCEGSSLYHHLHIIETKFEMIKLIDIARQAAQGMDYLHAKSIIHRDLKSN---------- BRAF1_CHICK BRAF1_CHICK WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- BRAF1_COTJA BRAF1_COTJA WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q4R345_MACFA Q4R345_MACFA WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGME------------------------- BRAF1_MOUSE BRAF1_MOUSE WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q9JJU6_MOUSE Q9JJU6_MOUSE ------------------------------------------------------------ A4D1T4_HUMAN A4D1T4_HUMAN WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- BRAF1_HUMAN BRAF1_HUMAN WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q698R1_CANFA Q698R1_CANFA WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q75V92_DANRE Q75V92_DANRE WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q761X4_DANRE Q761X4_DANRE WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGME------------------------- Q767H4_DANRE Q767H4_DANRE WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q75V91_DANRE Q75V91_DANRE WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- B3DFX5_DANRE B3DFX5_DANRE WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q1LYG2_DANRE Q1LYG2_DANRE WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q4SRI2_TETNG Q4SRI2_TETNG WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q6L8Q6_SERQU Q6L8Q6_SERQU WCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSN---------- Q6PA51_XENLA Q6PA51_XENLA WCEGSSLYRHLHVIETRFDIFQLIDIARQTAQGMDYLHAKNIIHRDLKSN---------- Q6INV2_XENLA Q6INV2_XENLA WCEGSSLYRHLHVIETRFDIFQLIDIARQTAQGMDYLHAKNIIHRDLKSN---------- Q767H6_XENLA Q767H6_XENLA WCEGSSLYRHLHVIETRFDIFQLIDIARQTAQGMDYLHAKNIIHRDLKSN---------- Q4V900_DANRE Q4V900_DANRE WCEGSSLYKHLHVQETNFQMFQLMDIARQTAQGMDYLHAKNIIHRDMKSN---------- Q2V2G8_SALSA Q2V2G8_SALSA WCDGSSLYHHLHIQETNLQMFQLMDIARQTAQGMNYLHAKNIIHRDMKSN---------- Q28GW9_XENTR Q28GW9_XENTR WCEGSSLYKHLHVLETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- Q6GQJ4_XENLA Q6GQJ4_XENLA WCEGSSLYYHLHVLDTKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- RAF1_XENLA RAF1_XENLA WCEGSSLYYHLHVLDTKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- RAF1_CHICK RAF1_CHICK WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- Q9CU36_MOUSE Q9CU36_MOUSE WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- RAF1_MOUSE RAF1_MOUSE WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- RAF1_RAT RAF1_RAT WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- RAF1_BOVIN RAF1_BOVIN WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- B4E0X2_HUMAN B4E0X2_HUMAN WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- B4E1N6_HUMAN B4E1N6_HUMAN WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- RAF1_PONAB RAF1_PONAB WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- RAF1_HUMAN RAF1_HUMAN WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- O19055_PAPHA O19055_PAPHA WCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- Q90458_DANRE Q90458_DANRE WCEGSSLYKHLHVLETNFQMFQLIDIARQTAQGMDYLYMRKHIHRDMKSN---------- Q76FQ3_DANRE Q76FQ3_DANRE WCEGSSLYKHLHVLETNFQMFQLIDIARQTAQGMDYLYMRKHIHRDMKSN---------- Q6BE22_DANRE Q6BE22_DANRE WCEGSSLYKHLHVLETNFQMFQLIDIARQTAQGMDYLYMRKHIHRDMKSN---------- Q7ZTR8_DANRE Q7ZTR8_DANRE WCEGSSLYKHLHVLETNFQMFQLIDIARQTAQGMDYLYMRKHIHRDMKSN---------- Q4S5I4_TETNG Q4S5I4_TETNG WCEGSSLYKHIHVLETNFKIIQLIDIARQTAQGMDYLHAKNIIHRDMKSNSILSTLLFEE Q98TC3_SERQU Q98TC3_SERQU WCEGSSLYKHIHVLETNFKMIQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- Q9DEB2_SERQU Q9DEB2_SERQU WCEGSSLYKHIHVLETNFKMIQLIDIARQTAQGMDYLHAKNIIHRDMKSN---------- MATCH CONSENSUS WCEGSSLY?HLH??ET?F?M??LID?ARQTAQGMDYLHAK?IIHRD?KSN??????????

Q4H2W3_CIOIN Q4H2W3_CIOIN ------------------------NIFLLEDYTVKIGDFGLATVKSRWSGSEQLMQP-TG ARAF_MOUSE ARAF_MOUSE ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP-SG ARAF_RAT ARAF_RAT ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP-SG ARAF_PIG ARAF_PIG ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP-SG Q2KJA0_BOVIN Q2KJA0_BOVIN ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP-SG Q5BIM4_BOVIN Q5BIM4_BOVIN ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP-SG B4DV85_HUMAN B4DV85_HUMAN ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP-SG ARAF_HUMAN ARAF_HUMAN ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP-SG Q96II5_HUMAN Q96II5_HUMAN ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP-SG Q4SDH1_TETNG Q4SDH1_TETNG ------------------------NIFLHEGWTVKIGDFGLATVKSRWSGSKQVEQP-SG Q75W79_DANRE Q75W79_DANRE ------------------------NIFLHEGWTVKIGDFGLATVKSRWSGYSRSNSPVAP Q5FBD1_DANRE Q5FBD1_DANRE ------------------------NIFLHEGWTVKIGDFGLATVKSRWSGSQQVEQP-SG Q75Y03_DANRE Q75Y03_DANRE ------------------------NIFLHEGWTVKIGDFGLATVKSRWSGSQQVEQP-SG Q5M7Y2_DANRE Q5M7Y2_DANRE ------------------------NIFLHEGWTVKIGDFGLATVKSRWSGSQQVEQP-SG Q4R1J4_ONCKE Q4R1J4_ONCKE ------------------------NIFLHEGWTVKIGDFGLATVKSRWSGSQQVEQP-SG Q0D2E4_XENTR Q0D2E4_XENTR ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q68FI8_XENLA Q68FI8_XENLA ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q4F9K6_XENLA Q4F9K6_XENLA ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q643Z8_XENLA Q643Z8_XENLA ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG B7ZRT9_XENLA B7ZRT9_XENLA ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q767H5_XENLA Q767H5_XENLA ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG BRAF1_CHICK BRAF1_CHICK ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG BRAF1_COTJA BRAF1_COTJA ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q4R345_MACFA Q4R345_MACFA ----------------------------------------------------RFEES--- BRAF1_MOUSE BRAF1_MOUSE ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q9JJU6_MOUSE Q9JJU6_MOUSE ------------------------------------------------------------ A4D1T4_HUMAN A4D1T4_HUMAN ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG BRAF1_HUMAN BRAF1_HUMAN ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q698R1_CANFA Q698R1_CANFA ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q75V92_DANRE Q75V92_DANRE ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q761X4_DANRE Q761X4_DANRE ------------------------------------------------------------ Q767H4_DANRE Q767H4_DANRE ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q75V91_DANRE Q75V91_DANRE ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG B3DFX5_DANRE B3DFX5_DANRE ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q1LYG2_DANRE Q1LYG2_DANRE ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q4SRI2_TETNG Q4SRI2_TETNG ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q6L8Q6_SERQU Q6L8Q6_SERQU ------------------------NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SG Q6PA51_XENLA Q6PA51_XENLA ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQP-SG Q6INV2_XENLA Q6INV2_XENLA ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-SG Q767H6_XENLA Q767H6_XENLA ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQHVEQP-SG Q4V900_DANRE Q4V900_DANRE ------------------------NIFLHEGLTVKIGDFGLATVKARWSGSHRVEQP-SG Q2V2G8_SALSA Q2V2G8_SALSA ------------------------NIFLHEGLTVKIGDFGLATVKARWSGSYQVEQP-SG Q28GW9_XENTR Q28GW9_XENTR ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG Q6GQJ4_XENLA Q6GQJ4_XENLA ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQL-TG RAF1_XENLA RAF1_XENLA ------------------------NIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQL-TG RAF1_CHICK RAF1_CHICK ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG Q9CU36_MOUSE Q9CU36_MOUSE ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG RAF1_MOUSE RAF1_MOUSE ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG RAF1_RAT RAF1_RAT ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG RAF1_BOVIN RAF1_BOVIN ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG B4E0X2_HUMAN B4E0X2_HUMAN ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG B4E1N6_HUMAN B4E1N6_HUMAN ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG RAF1_PONAB RAF1_PONAB ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG RAF1_HUMAN RAF1_HUMAN ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG O19055_PAPHA O19055_PAPHA ------------------------NIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TG Q90458_DANRE Q90458_DANRE ------------------------NIFLHEGLTVKIGDFGLATVKARWSGSQQVEQP-SG Q76FQ3_DANRE Q76FQ3_DANRE ------------------------NIFLHEGLTVKIGDFGLATVKARWSGSQQVEQP-SG Q6BE22_DANRE Q6BE22_DANRE ------------------------NIFLHEGLTVKIGDFGLATVKARWSGSQQVEQP-SG Q7ZTR8_DANRE Q7ZTR8_DANRE ------------------------NIFLHEGLTVKIGDFGLATVKARWSGSQQVEQP-SG Q4S5I4_TETNG Q4S5I4_TETNG SRRSRQWRGTLVSASESYPFNGRTDIFLHEGLTVKIGDFGLATVKSRWSGSHQVEQP-SG Q98TC3_SERQU Q98TC3_SERQU ------------------------NIFLHEGLTVKIGDFGLATVKARWSGSHQVEQP-SG Q9DEB2_SERQU Q9DEB2_SERQU ------------------------NIFLHEGLTVKIGDFGLATVKARWSGSHQVEQP-SG MATCH CONSENSUS ????????????????????????NIFLHE?LTVKIGDFGLATVK?RWSGS???EQ???G

Q4H2W3_CIOIN Q4H2W3_CIOIN SILWMAPEVIRMIDGNPYTFQSDVYAFGVVLYEMTSNTLPYSHIGNRDMILFQVGRGYLS ARAF_MOUSE ARAF_MOUSE SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLS ARAF_RAT ARAF_RAT SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLS ARAF_PIG ARAF_PIG SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLS Q2KJA0_BOVIN Q2KJA0_BOVIN SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLS Q5BIM4_BOVIN Q5BIM4_BOVIN SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLS B4DV85_HUMAN B4DV85_HUMAN SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLS ARAF_HUMAN ARAF_HUMAN SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLS Q96II5_HUMAN Q96II5_HUMAN SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLS Q4SDH1_TETNG Q4SDH1_TETNG SILWMAPEVIRMQDSNPYTFQSDVYAYGVVLFELMSGSLPYSNINNRDQIIFMVGRGYLS Q75W79_DANRE Q75W79_DANRE SCGWLLRD--QMQDTNPYTFQSDVYGYGVVLYELMSGTLPYSNINNRDQIIFMVGRGYLS Q5FBD1_DANRE Q5FBD1_DANRE SILWMAPEVIRMQDTNPYTFQSDVYGYGVVLYELMSGTLPYSNINNRDQIIFMVGRGYLS Q75Y03_DANRE Q75Y03_DANRE SILWMAPEVIRMQDTNPYTFQSDVYGYGVVLYELMSGTLPYSNINNRDQIIFMVGRGYLS Q5M7Y2_DANRE Q5M7Y2_DANRE SILWMAPEVIRMQDTNPYTFQSDVYGYGVVLYELMSGTLPYSNINNRDQIIFMVGRGYLS Q4R1J4_ONCKE Q4R1J4_ONCKE SILWMAPEVIRMQDTNPYTFQSDVYGYGVVLYELMSGTLPYSNINNRDQIIFMVGRGYLS Q0D2E4_XENTR Q0D2E4_XENTR SILWMAPEVIRMQDNNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS Q68FI8_XENLA Q68FI8_XENLA SILWMAPEVIRMQDNNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS Q4F9K6_XENLA Q4F9K6_XENLA SILWMAPEVIRMQDNNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS Q643Z8_XENLA Q643Z8_XENLA SILWMAPEVIRMQDNNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS B7ZRT9_XENLA B7ZRT9_XENLA SILWMAPEVIRMQDNNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLA Q767H5_XENLA Q767H5_XENLA SILWMAPEVIRMQDNNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLA BRAF1_CHICK BRAF1_CHICK SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS BRAF1_COTJA BRAF1_COTJA SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS Q4R345_MACFA Q4R345_MACFA ---WVN---------------------------------------------FTSSRG--- BRAF1_MOUSE BRAF1_MOUSE SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS Q9JJU6_MOUSE Q9JJU6_MOUSE ------------------------------------------------------------ A4D1T4_HUMAN A4D1T4_HUMAN SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS BRAF1_HUMAN BRAF1_HUMAN SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS Q698R1_CANFA Q698R1_CANFA SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS Q75V92_DANRE Q75V92_DANRE SILWMAPEVIRLQDKNPYSFQSDVYAFGIVLYELMSGALPYSNINNRDQIIFMVGRGYLS Q761X4_DANRE Q761X4_DANRE ------------------------------------------------------------ Q767H4_DANRE Q767H4_DANRE STLWMAPEVIRLQDKNPYSFQSDVYAFGIVLYELMSGALPYSNINNRDQIIFMVGRGYLS Q75V91_DANRE Q75V91_DANRE SILWMAPEVIRLQDKNPYSFQSDVYAFGIVLYELMSGALPYSNINNRDQIIFMVGRGYLS B3DFX5_DANRE B3DFX5_DANRE SILWMAPEVIRLQDKNPYSFQSDVYAFGIVLYELMSGALPYSNINNRDQIIFMVGRGYLS Q1LYG2_DANRE Q1LYG2_DANRE SILWMAPEVIRLQDKNPYSFQSDVYAFGIVLYELMSGALPYSNINNRDQIIFMVGRGYLS Q4SRI2_TETNG Q4SRI2_TETNG SILWMAPEVIRLQDKNPYSFQSDVYAFGIVLYELMSGVLPYSNINNRDQIIFMVGRGYLS Q6L8Q6_SERQU Q6L8Q6_SERQU SILWMAPEVIRLQDKNPYSFQSDVYAFGIVLYELMSGALPYSNINNRDQIIFMVGRGYLS Q6PA51_XENLA Q6PA51_XENLA SILWMAPEVIRMQENSPYSFQSDVYAYGVVLYELMAGLLPYANINNRDQIIFMVGRGYLT Q6INV2_XENLA Q6INV2_XENLA SILWMAPEVIRMQESSPYSFQSDVYAYGVVLYELMAAVLPY<