Alignment of the gene Family HBG001960 of HOVERGEN

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Isoforms are ON
GYS1_MOUSE GYS1_MOUSE PLSRSLSVSSLPG-LEDWEDE-FDPENAVLFEVAWEVANK-------------------- GYS1_RAT GYS1_RAT PLSRSLSMSSLPG-LEDWEDE-FDPENAVLFEVAWEVANK-------------------- B7Z806_HUMAN B7Z806_HUMAN ------------------------------MNSTWR------------------------ GYS1_RABIT GYS1_RABIT PLSRTLSVSSLPG-LEDWEDE-FDLENSVLFEVAWEVANK-------------------- Q4VK70_PIG Q4VK70_PIG ------------------------------------------------------------ B2L109_HORSE B2L109_HORSE PLNRTLSMSSLPG-LDDWEDE-FDLENTVLFEVAWEVANK-------------------- B2L110_HORSE B2L110_HORSE PLNRTLSMSSLPG-LDDWEDE-FDLENTVLFEVAWEVANK-------------------- GYS1_BOVIN GYS1_BOVIN PLNRTLSMSSLPG-LEDWEDE-FDLENTVLFEVAWEVANK-------------------- Q58CX0_BOVIN Q58CX0_BOVIN PLNRTLSMSSLPG-LEDWEDE-FDLENTVLFEVAWEVANK-------------------- GYS1_MACMU GYS1_MACMU PLNRTLSMSSLPG-LEDWEDE-FDLENTVLFEVAWEVANK-------------------- GYS1_PONAB GYS1_PONAB PLNRTLSMSSLPG-LEDWEDE-FDLENAVLFEVAWEVANK-------------------- A8K6K7_HUMAN A8K6K7_HUMAN PLNRTLSMSSLPG-LEDWEDE-FDLENAVLFEVAWEVANK-------------------- Q53ER0_HUMAN Q53ER0_HUMAN PLNRTLSMSSLPG-LEDWEDE-FDLENAVLFEVAWEVANK-------------------- Q9BTT9_HUMAN Q9BTT9_HUMAN PLNRTLSMSSLPG-LEDWEDE-FDLENAVLFEVAWEVANK-------------------- B7Z6I6_HUMAN B7Z6I6_HUMAN PLNRTLSMSSLPG-LEDWEDE-FDL----------------------------------- GYS1_HUMAN GYS1_HUMAN PLNRTLSMSSLPG-LEDWEDE-FDLENAVLFEVAWEVANK-------------------- A8JYA3_OREMO A8JYA3_OREMO PLARSLSVTSLSG-LEEWDEE-FDLEDAVLFEIAWEVANK-------------------- Q4S9G6_TETNG Q4S9G6_TETNG PLARSLSVTSLSG-LEEWDEE-FDLEDAVLFEIAWEVANKGKSPFGLSELGSYWNRRSKP Q7SYB8_DANRE Q7SYB8_DANRE PLARSLSVTSLSG-LDDWDEE-FDREDAVLFEIAWEVANK-------------------- Q4SRH4_TETNG Q4SRH4_TETNG PLSRSLSMTSLSGLLPAWEEDQLPVEELLLFEVAWEVTNK-------------------- Q5RGX8_DANRE Q5RGX8_DANRE RLSRSLSITSLSG-LPLFEEESLPVEDLLLFEVAWEVTNK-------------------- GYS2_HUMAN GYS2_HUMAN LRGRSLSVTSLGG-LPQWEVEELPVEELLLFEVAWEVTNK-------------------- Q9N0W0_CANFA Q9N0W0_CANFA ------------------------------------------------------------ GYS2_RAT GYS2_RAT LRGRSLSVTSLGG-LPAWEAERLPVEDLLLFEVSWEVTNK-------------------- GYS2_MOUSE GYS2_MOUSE LRGRSLSVTSLGG-LPVWEAERLPVEDLLLFEVSWEVTNK-------------------- Q3UTY0_MOUSE Q3UTY0_MOUSE LRGRSLSVTSLGG-LPVWEAERLPVEDLLLFEVSWEVTNK-------------------- Q5FVV6_XENTR Q5FVV6_XENTR PLSRSLSVSSLNG-LPQWQDEDLPLQDLLLFEVAWEVTNK-------------------- Q6NRR2_XENLA Q6NRR2_XENLA PLSRSLSVSSLNG-LPLWQDEDLPLQDLLLFEVAWEVTNK-------------------- MATCH CONSENSUS ???R?LS??SL?G?L??W??E????????LFE??WEV?NK????????????????????

GYS1_MOUSE GYS1_MOUSE -------------VGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPE GYS1_RAT GYS1_RAT -------------VGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPE B7Z806_HUMAN B7Z806_HUMAN -------------------------TQCSSKWPGRWL----------------------- GYS1_RABIT GYS1_RABIT -------------VGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEPPTPA Q4VK70_PIG Q4VK70_PIG ------------------------------------------------------------ B2L109_HORSE B2L109_HORSE -------------VGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPA B2L110_HORSE B2L110_HORSE -------------VGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPA GYS1_BOVIN GYS1_BOVIN -------------VGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPA Q58CX0_BOVIN Q58CX0_BOVIN -------------VGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTHVELLEPPTPA GYS1_MACMU GYS1_MACMU -------------VGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEAPTPA GYS1_PONAB GYS1_PONAB -------------VGGIYTVLQTKAKVTGDEWGANYFLVGPYTEQGVRTQVELLEAPTPA A8K6K7_HUMAN A8K6K7_HUMAN -------------VGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPA Q53ER0_HUMAN Q53ER0_HUMAN -------------VGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPA Q9BTT9_HUMAN Q9BTT9_HUMAN -------------VGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPA B7Z6I6_HUMAN B7Z6I6_HUMAN ------------------------------------------------------EAPTPA GYS1_HUMAN GYS1_HUMAN -------------VGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPA A8JYA3_OREMO A8JYA3_OREMO -------------VGGIYTVIQTKARLTSEEWGENYFLVGPYVESNVRTQVELIEPTNPA Q4S9G6_TETNG Q4S9G6_TETNG VFHFCRVCVCVCVVGGIYTVIQTKARLTAEEWGENYFLVGPYVESNVRTQVELIEPPTPV Q7SYB8_DANRE Q7SYB8_DANRE -------------VGGIYTVIQTKARLTCEEWGENYFLVGPYMESNVRTQVELIEPCNAA Q4SRH4_TETNG Q4SRH4_TETNG -------------VGGIYTVIQTKAKVTVDEWGENYFMMGPYFEHNFKTQVEACEPPNPA Q5RGX8_DANRE Q5RGX8_DANRE -------------VGGIYTVIQTKAKITVDEWGENYFMMGPYYEHNFKTQVEKCEPPNQA GYS2_HUMAN GYS2_HUMAN -------------VGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDA Q9N0W0_CANFA Q9N0W0_CANFA ------------------------------------------------------------ GYS2_RAT GYS2_RAT -------------VGGICTVIQSKAKTTANEWGENYFLIGPYFEHNVKTQVEPCEPANDA GYS2_MOUSE GYS2_MOUSE -------------VGGICTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPTNDA Q3UTY0_MOUSE Q3UTY0_MOUSE -------------VGGICTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPTNDA Q5FVV6_XENTR Q5FVV6_XENTR -------------VGGIYTVIQTKAKVTADEWGDNYFLMGPYMEQNVRTQVEICDPPSPQ Q6NRR2_XENLA Q6NRR2_XENLA -------------VGGIYTVIQTKAKVTADEWGDNYFLMGPYMEHNVRTQVEICDPPNGH MATCH CONSENSUS ?????????????VGGI?TV?QTKA??T??EWG?NY???GPY?E????TQVE??E?????

GYS1_MOUSE GYS1_MOUSE LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR GYS1_RAT GYS1_RAT LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR B7Z806_HUMAN B7Z806_HUMAN ------------TRVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR GYS1_RABIT GYS1_RABIT LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR Q4VK70_PIG Q4VK70_PIG ------------------------------------------------------------ B2L109_HORSE B2L109_HORSE LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR B2L110_HORSE B2L110_HORSE LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR GYS1_BOVIN GYS1_BOVIN LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR Q58CX0_BOVIN Q58CX0_BOVIN LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR GYS1_MACMU GYS1_MACMU LKKTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR GYS1_PONAB GYS1_PONAB LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR A8K6K7_HUMAN A8K6K7_HUMAN LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR Q53ER0_HUMAN Q53ER0_HUMAN LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR Q9BTT9_HUMAN Q9BTT9_HUMAN LKRTLDSMNSKGCK---------------------------------------------- B7Z6I6_HUMAN B7Z6I6_HUMAN LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR GYS1_HUMAN GYS1_HUMAN LKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDR A8JYA3_OREMO A8JYA3_OREMO LKRTIDKMNSSGCKVYFGRWLIEGSPYVVLIDIGFTAWSLDSGRA----SCGSFVPLVCR Q4S9G6_TETNG Q4S9G6_TETNG LRRTIDKMNSRGCKIYFGRWLIEGSPYVILIDVGFTAWSLDTWKSELWDISGIGVPWFDR Q7SYB8_DANRE Q7SYB8_DANRE LRRTIDKMNSSGCKVYFGRWLIEGSPYVVLLDVGFTAWSLDRWKSELWEKCNIGVPWFDR Q4SRH4_TETNG Q4SRH4_TETNG IRKAMDALLHNGCQVHFGRWLIEGSPYVILFDIGSAAWNLDRWKGDLWQTCSIGLPYHDR Q5RGX8_DANRE Q5RGX8_DANRE IRAAMDSLINNGCQVHFGRWLIEGSPYVILFDIGAAAWNLDRWKGDLWSACGIGLPYHDR GYS2_HUMAN GYS2_HUMAN VRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDR Q9N0W0_CANFA Q9N0W0_CANFA -----------------GRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDR GYS2_RAT GYS2_RAT VRKAVDAMNKHGCQVHFGRWLIEGSPYVVLFDISSSVWNLDRWKGDFWEACGVGIPHDDR GYS2_MOUSE GYS2_MOUSE VRKAVDAMNKHGCQVHFGRWLIEGSPYVVLFDISSSAWNLDRWKGDFWEACGVGIPHHDR Q3UTY0_MOUSE Q3UTY0_MOUSE VRKAVDAMNKHGCQVHFGRWLIEGSPYVVLFDISSSAWNLDRWKGDFWEACGVGIPHHDR Q5FVV6_XENTR Q5FVV6_XENTR IRKAIDLLQSQGCQVYFGRWLIEGNPYVVLFDIGSAAWNLDRWKGEFWECCSVGIPYNDR Q6NRR2_XENLA Q6NRR2_XENLA IRKAIDVLQSQGCQVYFGRWLIEGNPYVVLFDIGSAAWNLDRWKGEFWDCCTVGIPYNDR MATCH CONSENSUS ?????D?????GC?V?FGRWLIEG?P?VVL?D?G??AW?L?RWKG??W??C??G?P??DR

GYS1_MOUSE GYS1_MOUSE ----EANDAVLFGFLTTWFLGEFL-AQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATI GYS1_RAT GYS1_RAT ----EANDAVLFGFLTTWFLGEFL-AQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATI B7Z806_HUMAN B7Z806_HUMAN ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATI GYS1_RABIT GYS1_RABIT ----EANDAVLFGFLTTWFLGEFL-AQNEEKPHVVAHFHEWLAGIGLCLCRARRLPVATI Q4VK70_PIG Q4VK70_PIG ------------------------------------------------------------ B2L109_HORSE B2L109_HORSE ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGIGLCLCRARRLPVATI B2L110_HORSE B2L110_HORSE ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGIGLCLCRARRLPVATI GYS1_BOVIN GYS1_BOVIN ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATI Q58CX0_BOVIN Q58CX0_BOVIN ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATI GYS1_MACMU GYS1_MACMU ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGIGLCLCRARRLPVATI GYS1_PONAB GYS1_PONAB ----EANDAVLFGFLTTWFLGEFL-AQSEEKLHVVAHFHEWLAGIGLCLCRARRLPVATI A8K6K7_HUMAN A8K6K7_HUMAN ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATI Q53ER0_HUMAN Q53ER0_HUMAN ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATI Q9BTT9_HUMAN Q9BTT9_HUMAN ----------------------FL-AQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATI B7Z6I6_HUMAN B7Z6I6_HUMAN ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATI GYS1_HUMAN GYS1_HUMAN ----EANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATI A8JYA3_OREMO A8JYA3_OREMO GLTVRPTMRVLFGFLTAWLLGEFA-AQCEQPAHIVAHFHEWLAGLGLMLCRQRQLPVATI Q4S9G6_TETNG Q4S9G6_TETNG ----EANDSVLFGFLTAWLLGEYA-AQSEDPPHIVAHFHEWLAGLGLVLCRQRQLPVATI Q7SYB8_DANRE Q7SYB8_DANRE ----EANDAVLFGFLTAWLLGEYA-AQCDEPPHIVAHFHEWLAGLGLVLCRQRQLPVSTI Q4SRH4_TETNG Q4SRH4_TETNG ----EANDALILGSLIAWFFKEVSRHQLGDKPNVIGHFHEWQAGPGLILSRSRKIPLATV Q5RGX8_DANRE Q5RGX8_DANRE ----EANDSLILGSLVAWFFKELT-DQLQDKLNVVAHFHEWQAGTGLVLSRSRNLPLATI GYS2_HUMAN GYS2_HUMAN ----EANDMLIFGSLTAWFLKEVT-DH-ADGKYVVAQFHEWQAGIGLILSRARKLPIATI Q9N0W0_CANFA Q9N0W0_CANFA ----EANDMLIFGSLTAWFLKEVT-DH-ADGKHVIAQFHEWQAGTGLILSRARKLPIATI GYS2_RAT GYS2_RAT ----EANDMLIFGSLTAWFLKEVT-DH-ADGKHVIAQFHEWQAGTGLILSRARKLPIATI GYS2_MOUSE GYS2_MOUSE ----EANDMLIFGSLTAWFLKEVT-DH-ADGKHVIAQFHEWQAGTGLILSRARKLPIATV Q3UTY0_MOUSE Q3UTY0_MOUSE ----EANDMLIFGSLTAWFLKEVT-DH-ADGKHVIAQFHEWQAGTGLILSRARKLPIATV Q5FVV6_XENTR Q5FVV6_XENTR ----EANDALIFGSLTAWFLKELT-DQFQDKPNLIAHFHEWQAGAGLILCRNQKLPVATI Q6NRR2_XENLA Q6NRR2_XENLA ----EANDALIFGSLTAWFLKELT-DQFQDKPGVIAHFHEWQAGAGLVLCRNQKLPVATI MATCH CONSENSUS ????EAND???FG?LT?WFL?E???????????V?A?FHEW?AG?GL?L?R?R?LP?ATI

GYS1_MOUSE GYS1_MOUSE FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI GYS1_RAT GYS1_RAT FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI B7Z806_HUMAN B7Z806_HUMAN FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI GYS1_RABIT GYS1_RABIT FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI Q4VK70_PIG Q4VK70_PIG ------------------------------------------------------------ B2L109_HORSE B2L109_HORSE FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCTHVFTTVSQI B2L110_HORSE B2L110_HORSE FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCTHVFTTVSQI GYS1_BOVIN GYS1_BOVIN FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI Q58CX0_BOVIN Q58CX0_BOVIN FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI GYS1_MACMU GYS1_MACMU FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI GYS1_PONAB GYS1_PONAB FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI A8K6K7_HUMAN A8K6K7_HUMAN FTTHATLLGRYLCAGVVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI Q53ER0_HUMAN Q53ER0_HUMAN FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI Q9BTT9_HUMAN Q9BTT9_HUMAN FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI B7Z6I6_HUMAN B7Z6I6_HUMAN FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI GYS1_HUMAN GYS1_HUMAN FTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQI A8JYA3_OREMO A8JYA3_OREMO FTTHATLLGRYLCAGNVDFYNNLAEFNVDKEAGDRQIYHRYCLERAAAHCAHVFTTVSQI Q4S9G6_TETNG Q4S9G6_TETNG FTTHATLLGRYLCAGNVDFYNKLSEFNVDKEAGDRQIYHRYCIERAAAHCAHVFTTVSKI Q7SYB8_DANRE Q7SYB8_DANRE FTTHATLLGRYLCAGNVDFYNNLAEFNVDKEAGDRQIYHRYCLERAACRCAHVFTTVSQI Q4SRH4_TETNG Q4SRH4_TETNG FTTHATLLGRYLCAGNADFYNNLDKFNIDREAGERQIYHRYCLERAAVHCAHVFTTVSQI Q5RGX8_DANRE Q5RGX8_DANRE FTTHATLLGRYLCAGNADFYNNLDKFDIDREAGERQIYHRYCLERAAVHCAHVFTTVSQI GYS2_HUMAN GYS2_HUMAN FTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEI Q9N0W0_CANFA Q9N0W0_CANFA FTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVLTTVSEI GYS2_RAT GYS2_RAT FTTHATLLGRYLCAANIDFYNQLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEI GYS2_MOUSE GYS2_MOUSE FTTHATLLGRYLCAANIDFYNQLDKFDIDKEAGERQIYHRYCMERASVHCAHVFTTVSEI Q3UTY0_MOUSE Q3UTY0_MOUSE FTTHATLLGRYLCAANIDFYNQLDKFDIDKEAGERQIYHRYCMERASVHCAHVFTTVSEI Q5FVV6_XENTR Q5FVV6_XENTR FTTHATLLGRYLCAANEDFYNRLDQFDIDREAGDRQIYHRYCMERAAVHCAHVFTTVSQI Q6NRR2_XENLA Q6NRR2_XENLA FTTHATLLGRYLCAANVDFYNQLDQFDIDREAGDREIYHRYCMERAAVHCAHVFTTVSQI MATCH CONSENSUS FTTHATLLGRYLCA???DFYN?L??F??DKEAG?RQIYHRYC?ERA??HCAHVFTTVS?I

GYS1_MOUSE GYS1_MOUSE TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD GYS1_RAT GYS1_RAT TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD B7Z806_HUMAN B7Z806_HUMAN TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD GYS1_RABIT GYS1_RABIT TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD Q4VK70_PIG Q4VK70_PIG -----------------------------------------RIQEFVRGHFY----GHLD B2L109_HORSE B2L109_HORSE TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD B2L110_HORSE B2L110_HORSE TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVHGHFY----GHLD GYS1_BOVIN GYS1_BOVIN TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD Q58CX0_BOVIN Q58CX0_BOVIN TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD GYS1_MACMU GYS1_MACMU TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD GYS1_PONAB GYS1_PONAB TAIEAQYLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD A8K6K7_HUMAN A8K6K7_HUMAN TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD Q53ER0_HUMAN Q53ER0_HUMAN TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD Q9BTT9_HUMAN Q9BTT9_HUMAN TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD B7Z6I6_HUMAN B7Z6I6_HUMAN TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD GYS1_HUMAN GYS1_HUMAN TAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD A8JYA3_OREMO A8JYA3_OREMO TAIEAEHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKSRIQEFVRGHFY----GHLD Q4S9G6_TETNG Q4S9G6_TETNG TAIEAEHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKNRIQEFIRGHFY----GHLD Q7SYB8_DANRE Q7SYB8_DANRE TAIEAEHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY----GHLD Q4SRH4_TETNG Q4SRH4_TETNG TAVEANHMLHRKPDVVTPNGLNVKKFSAMHEFQNLHSTNKGRIQEF---SFYILSDSHLD Q5RGX8_DANRE Q5RGX8_DANRE TAVEADHMLHRNPDVVTPNGLNVRKFSAMHEFQNLHSMNKSKIQEFVRGHFY----GHLD GYS2_HUMAN GYS2_HUMAN TAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFY----GHLD Q9N0W0_CANFA Q9N0W0_CANFA TAIEAEHMLKRKPDVVTPNGLSVKKFSAVHEFQNLHAMYKARIQDFVRGHFY----GHLD GYS2_RAT GYS2_RAT TAIEADHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHATYKARIQDFVRGHFY----GHLD GYS2_MOUSE GYS2_MOUSE TAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFY----GHLD Q3UTY0_MOUSE Q3UTY0_MOUSE TAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFY----GHLD Q5FVV6_XENTR Q5FVV6_XENTR TGIEAENMLKRKPDVITPNGLNIKKFSATHEFQNLHAMYKAQIQEFVRGHFY----GHLD Q6NRR2_XENLA Q6NRR2_XENLA TGIEAEHMLKRKPDVITPNGLNIKKFSATHEFQNLHAMYKAQIQEFVRGHFY----GHLD MATCH :**:* ** .*** CONSENSUS TAIEA?H?LKRKPD?VTPNGLNVKKFSA?HEFQNLHA??KARIQEFVRGHFY????GHLD

GYS1_MOUSE GYS1_MOUSE FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV GYS1_RAT GYS1_RAT FNLDKTLYFFIAGRYEFSNKGADIFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV B7Z806_HUMAN B7Z806_HUMAN FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV GYS1_RABIT GYS1_RABIT FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV Q4VK70_PIG Q4VK70_PIG FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV B2L109_HORSE B2L109_HORSE FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV B2L110_HORSE B2L110_HORSE FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV GYS1_BOVIN GYS1_BOVIN FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV Q58CX0_BOVIN Q58CX0_BOVIN FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV GYS1_MACMU GYS1_MACMU FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVALFIMPARTNNFNV GYS1_PONAB GYS1_PONAB FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV A8K6K7_HUMAN A8K6K7_HUMAN FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV Q53ER0_HUMAN Q53ER0_HUMAN FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV Q9BTT9_HUMAN Q9BTT9_HUMAN FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV B7Z6I6_HUMAN B7Z6I6_HUMAN FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV GYS1_HUMAN GYS1_HUMAN FNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNV A8JYA3_OREMO A8JYA3_OREMO FNLDKCLFLFIAGRYEFSNKGADIFLEALARLNYLLRVNHSDVTVIAFFFMPARTNNFNV Q4S9G6_TETNG Q4S9G6_TETNG FNLDKCLFLFIAGRYEFSNKGADLFLEALARLNYLLRVSHSDVTVIAFFIMPARTNNFNV Q7SYB8_DANRE Q7SYB8_DANRE FNLDKTVFLFIAGRYEFSNKGADIFLEALARLNYLLRVNHSEVTVIAFFIMPARTNNFNV Q4SRH4_TETNG Q4SRH4_TETNG FNLEKTLFFFIAGRYEFSNKGADLFIESLSRLNYLLRVHRNDMTVVVFFIMPAKTNNFNV Q5RGX8_DANRE Q5RGX8_DANRE FNLEKTLFFFIAGRYEFSNKGADLFLESLSRLNYLLRVHKSDVTVVVFFIMPAKTNNFNV GYS2_HUMAN GYS2_HUMAN FDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVVVFFIMPAKTNNFNV Q9N0W0_CANFA Q9N0W0_CANFA FDLEKTLFLFIAGRYEFSNKGADIFLESLSR----------------------------- GYS2_RAT GYS2_RAT FDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSNVTVVVFFIMPAKTNNFNV GYS2_MOUSE GYS2_MOUSE FDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSNVTVVVFFIMPAKTNNFNV Q3UTY0_MOUSE Q3UTY0_MOUSE FDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSNVTVVVFFIMPAKTNNFNV Q5FVV6_XENTR Q5FVV6_XENTR FSLEKTLFFFIAGRYEYTNKGADIFLEALSRLNFLLRVHRSDVTVVVFFIMPTKTNNFNV Q6NRR2_XENLA Q6NRR2_XENLA FSLEKTLFFFIAGRYEYTNKGADIFLEALSRLNFLLRVHRSDVTVVVFFIMPTKTNNFNV MATCH *.*:* :::*******::*****:*:*:*:* CONSENSUS F?L?KTL??FIAGRYEFSNKGAD?FLE?L?RLN?LLRV??S??TVV?FFIMPA?TNNFNV

GYS1_MOUSE GYS1_MOUSE ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR GYS1_RAT GYS1_RAT ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR B7Z806_HUMAN B7Z806_HUMAN ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR GYS1_RABIT GYS1_RABIT ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR Q4VK70_PIG Q4VK70_PIG ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR B2L109_HORSE B2L109_HORSE ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR B2L110_HORSE B2L110_HORSE ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR GYS1_BOVIN GYS1_BOVIN ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR Q58CX0_BOVIN Q58CX0_BOVIN ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR GYS1_MACMU GYS1_MACMU ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR GYS1_PONAB GYS1_PONAB ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR A8K6K7_HUMAN A8K6K7_HUMAN ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR Q53ER0_HUMAN Q53ER0_HUMAN ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVESLPDMNKMLDKEDFTMMKRAIFATQR Q9BTT9_HUMAN Q9BTT9_HUMAN ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR B7Z6I6_HUMAN B7Z6I6_HUMAN ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR GYS1_HUMAN GYS1_HUMAN ETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR A8JYA3_OREMO A8JYA3_OREMO ETLKGQAVRKQLWDTAQTVKERFGKKLYESLLVGQLPDVSKILDKEDFTIMKRAIFATQR Q4S9G6_TETNG Q4S9G6_TETNG ET---------------------------------------------------------- Q7SYB8_DANRE Q7SYB8_DANRE ETLKGQAVRKQLWDTAQSVKERFGKKLYESLLVGQLPDVSKMLDKEDFTMMKRAIFATQR Q4SRH4_TETNG Q4SRH4_TETNG ESLKGQAVRKQLWDTAHTVKEKFGKKLYDALLKGEIPDMNAILDRDDFTIMKRAIYATQR Q5RGX8_DANRE Q5RGX8_DANRE ESLKGQAVRKQLWDTAQSVKEKFGKKLYESLLRGEIPDMSKILDRDDFTIMKRAIYATQR GYS2_HUMAN GYS2_HUMAN ETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQR Q9N0W0_CANFA Q9N0W0_CANFA ------------------------------------------------------------ GYS2_RAT GYS2_RAT ETLKGQAVRKQLWDTVHCMKEKFGKKLYDGLLRGEIPDMNSILDRDDLTIMKRAIFSTQR GYS2_MOUSE GYS2_MOUSE ETLKGQAVRKQLWDTVHCLKEKFGKKLYDGLLRGEIPDMNSILDRDDLTIMKRAIFSTQR Q3UTY0_MOUSE Q3UTY0_MOUSE ETLKGQAVRKQLWDTVHCLKEKFGKKLYDGLLRGEIPDMNSILDRDDLTIMKRAIFSTQR Q5FVV6_XENTR Q5FVV6_XENTR ETLKGQAVRKQLWDTAHSVKEKFGKKLYDALLKGEIPDLNKILDRDDLTIMKRAIFATQR Q6NRR2_XENLA Q6NRR2_XENLA ETLKGQAVRKQLWDTAHSVKEKFGKKLYEALLKGEIPDLNKILDRDDVTIMKRAIFATQR MATCH CONSENSUS ETLKGQAVRKQLWDTA??VKEKFG?KLY??LL?G??PD?N??LD??D?T?MKRAIF?TQR

GYS1_MOUSE GYS1_MOUSE QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV GYS1_RAT GYS1_RAT QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV B7Z806_HUMAN B7Z806_HUMAN QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV GYS1_RABIT GYS1_RABIT QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV Q4VK70_PIG Q4VK70_PIG QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV B2L109_HORSE B2L109_HORSE QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV B2L110_HORSE B2L110_HORSE QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV GYS1_BOVIN GYS1_BOVIN QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV Q58CX0_BOVIN Q58CX0_BOVIN QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV GYS1_MACMU GYS1_MACMU QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV GYS1_PONAB GYS1_PONAB QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV A8K6K7_HUMAN A8K6K7_HUMAN QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV Q53ER0_HUMAN Q53ER0_HUMAN QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV Q9BTT9_HUMAN Q9BTT9_HUMAN QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV B7Z6I6_HUMAN B7Z6I6_HUMAN QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV GYS1_HUMAN GYS1_HUMAN QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFV A8JYA3_OREMO A8JYA3_OREMO QCQPPICTHNMLEDSSDPILNCVRRIGLFNSSADRVKIIFHPEFLSSTSPLLPMDYEEFV Q4S9G6_TETNG Q4S9G6_TETNG ------------------------------------------------------------ Q7SYB8_DANRE Q7SYB8_DANRE QCQPPVCTHNMLEDSSDPILNCIRRIGLFNSAQDRVKVIFHPEFLSSTSPLLPMDYEEFV Q4SRH4_TETNG Q4SRH4_TETNG HSLPPVTTHNMLDDSADPILSNIRRISLFNSRNDRVKIIFHPEFLSSTSPLLPMDYEDFV Q5RGX8_DANRE Q5RGX8_DANRE HSLPPVTTHNMLDDSTDPILGNIRRIGLFNGRNDRVKIVFHPEFLSSTSPLLPMDYEEFV GYS2_HUMAN GYS2_HUMAN QSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFV Q9N0W0_CANFA Q9N0W0_CANFA ------------------------------------------------------------ GYS2_RAT GYS2_RAT HSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFV GYS2_MOUSE GYS2_MOUSE QSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRADRVKVILHPEFLSSTSPLLPMDYEEFV Q3UTY0_MOUSE Q3UTY0_MOUSE QSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRADRVKVILHPEFLSSTSPLLPMDYEEFV Q5FVV6_XENTR Q5FVV6_XENTR QSLPPVTTHNMVDDSADPILNTIRRIGLFNSRTDRVKVIVHPEFLSSTSPLLPMDYEEFV Q6NRR2_XENLA Q6NRR2_XENLA QSLPPITTHNMVDDSTDPILNTVRRIGLFNSRTDRVKIIVHPEFLSSTSPLLPLDYEEFV MATCH CONSENSUS QS?PPV?THNM?DDS?DPIL??IRRIGLFN???DRVK?I?HPEFLSSTSPLLP?DYEEFV

GYS1_MOUSE GYS1_MOUSE RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF GYS1_RAT GYS1_RAT RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF B7Z806_HUMAN B7Z806_HUMAN RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF GYS1_RABIT GYS1_RABIT RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF Q4VK70_PIG Q4VK70_PIG RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF B2L109_HORSE B2L109_HORSE RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF B2L110_HORSE B2L110_HORSE RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF GYS1_BOVIN GYS1_BOVIN RGCHLGVFPSYYEPWGYTPAECTVMGIPSVSTNLSGFGCFMEEHIADPSAYGIYILDRRF Q58CX0_BOVIN Q58CX0_BOVIN RGCHLGVFPSYYEPWGYTPAECTVMGIPSVSTNLSGFGCFMEEHIADPSAYGIYILDRRF GYS1_MACMU GYS1_MACMU RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF GYS1_PONAB GYS1_PONAB RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF A8K6K7_HUMAN A8K6K7_HUMAN RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF Q53ER0_HUMAN Q53ER0_HUMAN RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF Q9BTT9_HUMAN Q9BTT9_HUMAN RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF B7Z6I6_HUMAN B7Z6I6_HUMAN RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF GYS1_HUMAN GYS1_HUMAN RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRF A8JYA3_OREMO A8JYA3_OREMO RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPTAYGIYILDRRC Q4S9G6_TETNG Q4S9G6_TETNG ------------------------------------------------------------ Q7SYB8_DANRE Q7SYB8_DANRE RGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRY Q4SRH4_TETNG Q4SRH4_TETNG RGCNLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMEEHVSDPTAYGIYIVDRRF Q5RGX8_DANRE Q5RGX8_DANRE RGCHLGVFPSYYEPWGYTPGECTVMGIPSVTTNLSGFGCFMEEHVSDPSEYGIYIVDRRF GYS2_HUMAN GYS2_HUMAN RGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRF Q9N0W0_CANFA Q9N0W0_CANFA ------------------------------------------------------------ GYS2_RAT GYS2_RAT RGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRF GYS2_MOUSE GYS2_MOUSE RGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFVQEHVADPTAYGIYIVDRRF Q3UTY0_MOUSE Q3UTY0_MOUSE RGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFVQEHVADPTAYGIYIVDRRF Q5FVV6_XENTR Q5FVV6_XENTR RGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPAAYGVYITDRRF Q6NRR2_XENLA Q6NRR2_XENLA RGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGVYITDRRF MATCH CONSENSUS RGCHLGVFPSYYEPWGYTPAECTVMGIPS??TNLSGFGCFM?EH?ADP?AYGIYI?DRRF

GYS1_MOUSE GYS1_MOUSE RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAF GYS1_RAT GYS1_RAT RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAF B7Z806_HUMAN B7Z806_HUMAN RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAF GYS1_RABIT GYS1_RABIT RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAF Q4VK70_PIG Q4VK70_PIG RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAF B2L109_HORSE B2L109_HORSE RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAF B2L110_HORSE B2L110_HORSE RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAF GYS1_BOVIN GYS1_BOVIN RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAF Q58CX0_BOVIN Q58CX0_BOVIN RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLXRV------------- GYS1_MACMU GYS1_MACMU RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAF GYS1_PONAB GYS1_PONAB RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAF A8K6K7_HUMAN A8K6K7_HUMAN RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAF Q53ER0_HUMAN Q53ER0_HUMAN RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAF Q9BTT9_HUMAN Q9BTT9_HUMAN RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAF B7Z6I6_HUMAN B7Z6I6_HUMAN RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAF GYS1_HUMAN GYS1_HUMAN RSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAF A8JYA3_OREMO A8JYA3_OREMO RGVDESCNQLTSFLFQFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYIAARHMALAKAF Q4S9G6_TETNG Q4S9G6_TETNG ------------------------------------------------------------ Q7SYB8_DANRE Q7SYB8_DANRE RSVDESCNQLTSFLFQFCQQSRRQRIIQRNRTERLSDLLDWRYLGRYYVSARHLALAKAY Q4SRH4_TETNG Q4SRH4_TETNG RSAEESCNQLTQFMFSFCQQSRRQRIIQRNRTERLSDLLDWRYLGRFYVHARHLALSRTF Q5RGX8_DANRE Q5RGX8_DANRE RSADESCNQLTQFMFSFCQKSRRQRIIQRNRTERLSDLLDWRYLGRFYMHARHLALSRSF GYS2_HUMAN GYS2_HUMAN RSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAF Q9N0W0_CANFA Q9N0W0_CANFA ------------------------------------------------------------ GYS2_RAT GYS2_RAT RSPDDSCNQLTQFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAF GYS2_MOUSE GYS2_MOUSE RSPDDSCNQLTQFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAF Q3UTY0_MOUSE Q3UTY0_MOUSE RSPDDSCNQLTQFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAF Q5FVV6_XENTR Q5FVV6_XENTR RSPDESCNQLTQFLYGFCQQSRRQRIIQRNRTERLSDLLDWRYLGRFYTHARHLALSRMF Q6NRR2_XENLA Q6NRR2_XENLA RSPDESCNQLTQLLYGFCQQSRRQRIIQRNRTERLSDLLDWRYLGRFYKHARHLALCRMF MATCH CONSENSUS RS?D?SC?QLT?FL??FC?QSRRQRIIQRNRTERLSDLLDW?YLGR?Y??ARH??L???F

GYS1_MOUSE GYS1_MOUSE PDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLGEDSERYDE GYS1_RAT GYS1_RAT PDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLREDSERYDE B7Z806_HUMAN B7Z806_HUMAN PEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDE GYS1_RABIT GYS1_RABIT PDHFTYEPHEADATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGLPEEDGERYDE Q4VK70_PIG Q4VK70_PIG PEHFTYEPHEADATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPPDEDGERYDE B2L109_HORSE B2L109_HORSE PEHFTYEPREADATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDVPPDEDSERYDE B2L110_HORSE B2L110_HORSE PEHFTYEPREADATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDVPPDEDSERYDE GYS1_BOVIN GYS1_BOVIN PEYFTYEPHEADATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDLPPDEDDERYDE Q58CX0_BOVIN Q58CX0_BOVIN ------------------------------------------------------------ GYS1_MACMU GYS1_MACMU PEHFTYEPSEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDSERYDE GYS1_PONAB GYS1_PONAB PEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDE A8K6K7_HUMAN A8K6K7_HUMAN PEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDE Q53ER0_HUMAN Q53ER0_HUMAN PEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDE Q9BTT9_HUMAN Q9BTT9_HUMAN PEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDE B7Z6I6_HUMAN B7Z6I6_HUMAN PEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDE GYS1_HUMAN GYS1_HUMAN PEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDE A8JYA3_OREMO A8JYA3_OREMO PDTFIYEPQEASQTAGFRYPRPASVPPSPALSRHSSPHHSEAEDN-------EDDERYDE Q4S9G6_TETNG Q4S9G6_TETNG ------------------------------------------------------------ Q7SYB8_DANRE Q7SYB8_DANRE PDTYIYEPQEPSSAAGFRYPRPASVPPSPAHSLHSSPHHSEAEDEE---------EPYDE Q4SRH4_TETNG Q4SRH4_TETNG PDKFKMDQMASLKTEGFRYPRPYSVPPSPSASLHSTPHHSDVEDDDD----DNDGEPYNE Q5RGX8_DANRE Q5RGX8_DANRE PEKFRPEHLNLTSTQGFRYPRPSSVPPSPSASIHSTPHHSDEEDDDT----------YDE GYS2_HUMAN GYS2_HUMAN PDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDE-------VEDERYDE Q9N0W0_CANFA Q9N0W0_CANFA ------------------------------------------------------------ GYS2_RAT GYS2_RAT PDKFHLEPTSPPTTDGFKYPRPSSVPPSPSGSQTSSPQSSDVENE------GDEDERYDE GYS2_MOUSE GYS2_MOUSE PDKFHLEPTSPPMTDGFKYPRPSSVPPSPSGSQASSPQSSDAEDE------EDEDERYDE Q3UTY0_MOUSE Q3UTY0_MOUSE PDKFHLEPTSPPTTDGFKYPRPSSVPPSPSGSQASSPQCSDAEDE------EDEDERYDE Q5FVV6_XENTR Q5FVV6_XENTR PDKFHMEPSAPPKTEGFRYPRPSSVPPSPAVSQPSSPRDSEEEDE--------DEERYDE Q6NRR2_XENLA Q6NRR2_XENLA PDKFQMEPSAPPKTEGFRYPRPSSVPPSPAVSQPSSPHDSEEEDDE---------ERYDE MATCH CONSENSUS P??F??E????????G??YPRP?SVPPSP??S??SSP??S??E????????????E?YDE

GYS1_MOUSE GYS1_MOUSE EEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPL--------SP GYS1_RAT GYS1_RAT EEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPL--------SP B7Z806_HUMAN B7Z806_HUMAN DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-NSVDTATSSSLSTPSEPL--------SP GYS1_RABIT GYS1_RABIT DEEAAKDRRNIRAPEWPRRASCTSSSGGSKRSNSVDTSS---LSTPSEPL--------SP Q4VK70_PIG Q4VK70_PIG DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-GSVDTGPSSSLSTPSEPL--------SP B2L109_HORSE B2L109_HORSE DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-GSVDTGPSSSLSTPSEPL--------SP B2L110_HORSE B2L110_HORSE DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-GSVDTGPSSSLSTPSEPL--------SP GYS1_BOVIN GYS1_BOVIN DEEAAKDRRNIRAPEWPRRASCTSST-GSKR-GSVDTAPSSSVSTPSEPL--------SP Q58CX0_BOVIN Q58CX0_BOVIN ------------------------------------------------------------ GYS1_MACMU GYS1_MACMU DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-NSVDTATSSSLSTPSEPL--------SP GYS1_PONAB GYS1_PONAB DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-NSVDTATSSSLSTPSEPL--------SP A8K6K7_HUMAN A8K6K7_HUMAN DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-NSVDTATSSSLSTPSEPL--------SP Q53ER0_HUMAN Q53ER0_HUMAN DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-NSVDTATSSSLSTPSEPL--------SP Q9BTT9_HUMAN Q9BTT9_HUMAN DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-NSVDTATSSSLSTPSEPL--------SP B7Z6I6_HUMAN B7Z6I6_HUMAN DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-NSVDTATSSSLSTPSEPL--------SP GYS1_HUMAN GYS1_HUMAN DEEAAKDRRNIRAPEWPRRASCTSSTSGSKR-NSVDTATSSSLSTPSEPL--------SP A8JYA3_OREMO A8JYA3_OREMO DLEAEKDKVNIRQP----------------------------YTLPMKNKSIAIIGANGN Q4S9G6_TETNG Q4S9G6_TETNG ------------------------------------------------------------ Q7SYB8_DANRE Q7SYB8_DANRE DLEAEKDRVNIRQP----------------------------YNLPNRNK--------NQ Q4SRH4_TETNG Q4SRH4_TETNG EEEAERDRLNIKAP----------------------------FVLGAVPE--------GK Q5RGX8_DANRE Q5RGX8_DANRE EEEAERDRLNIKAP----------------------------FSVGADTD--------GK GYS2_HUMAN GYS2_HUMAN EEEAERDRLNIKSP----------------------------FSLSHVPH--------GK Q9N0W0_CANFA Q9N0W0_CANFA ------------------------------------------------------------ GYS2_RAT GYS2_RAT EEEAERDRLNIKSP----------------------------FSLNHIPK--------GK GYS2_MOUSE GYS2_MOUSE EEEAERDRLNIKSP----------------------------FSLNHFPK--------GK Q3UTY0_MOUSE Q3UTY0_MOUSE EEEAERDRLNIKSP----------------------------FSLNHFPK--------GK Q5FVV6_XENTR Q5FVV6_XENTR DEEAERDRQNIKSD----------------------------FSLGPVSR--------GK Q6NRR2_XENLA Q6NRR2_XENLA DEEAERDRQNIKST----------------------------FSFGPVSR--------GK MATCH CONSENSUS ?EEA??DR?NI??P??????????????????????????????????????????????

GYS1_MOUSE GYS1_MOUSE TSSLGEERN GYS1_RAT GYS1_RAT TSSLGEERN B7Z806_HUMAN B7Z806_HUMAN TSSLGEERN GYS1_RABIT GYS1_RABIT ASSLGEERN Q4VK70_PIG Q4VK70_PIG ASSLGEERN B2L109_HORSE B2L109_HORSE ASSLGEERN B2L110_HORSE B2L110_HORSE ASSLGEERN GYS1_BOVIN GYS1_BOVIN ASSLGEERN Q58CX0_BOVIN Q58CX0_BOVIN --------- GYS1_MACMU GYS1_MACMU TSSLGEERN GYS1_PONAB GYS1_PONAB TSSLGEERN A8K6K7_HUMAN A8K6K7_HUMAN TSSLGEERN Q53ER0_HUMAN Q53ER0_HUMAN TSSLGEERN Q9BTT9_HUMAN Q9BTT9_HUMAN TSSLGEERN B7Z6I6_HUMAN B7Z6I6_HUMAN TSSLGEERN GYS1_HUMAN GYS1_HUMAN TSSLGEERN A8JYA3_OREMO A8JYA3_OREMO GDKVTSEKN Q4S9G6_TETNG Q4S9G6_TETNG --------- Q7SYB8_DANRE Q7SYB8_DANRE TVGLPEKN- Q4SRH4_TETNG Q4SRH4_TETNG KKQPGESGN Q5RGX8_DANRE Q5RGX8_DANRE RTQPVENGN GYS2_HUMAN GYS2_HUMAN KKLHGEYKN Q9N0W0_CANFA Q9N0W0_CANFA --------- GYS2_RAT GYS2_RAT KKLHGEYKN GYS2_MOUSE GYS2_MOUSE KKLHGEYKN Q3UTY0_MOUSE Q3UTY0_MOUSE KKLHGEYKN Q5FVV6_XENTR Q5FVV6_XENTR KKKHGEFRN Q6NRR2_XENLA Q6NRR2_XENLA KKKHGENRN MATCH CONSENSUS ?????E??N


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