Alignment of the gene Family HBG001989 of HOVERGEN

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Threshold: 50% 80% 100%
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Isoforms are ON
Q6GR44_XENLA Q6GR44_XENLA --------------------------------MALCWCLDNGLVRTPPMGWMTWQRYRCN Q6GQ17_XENLA Q6GQ17_XENLA LKPRHRRCLYKELLLQRGYKMHLTSLCLLLTLMGLCWCLDNGLVRTPPMGWMTWQRYRCN A8WGV2_XENTR A8WGV2_XENTR -----------------------------MTLLALCWCLDNGLVRTPPMGWMTWQRYRCN Q0P4I8_XENTR Q0P4I8_XENTR FLLLVLCNGRQIHSQLFTNRMHFTSLCILMTLLALCWCLDNGLVRTPPMGWMTWQRYRCN A4QP41_DANRE A4QP41_DANRE -------------------------------------------MRTPPMGWLAWERFRCD Q4STX0_TETNG Q4STX0_TETNG --------------------MHLALLLLASVLSLGTLALDNGLMRTPPMGWLAWERFRCD NAGAB_CHICK NAGAB_CHICK --------------------------------------LENGLARTPPMGWLAWERFRCN NAGAB_RAT NAGAB_RAT ---------------------MLQKTVLLLALVAQVLMLENGLLRTPPMGWLAWERFRCN NAGAB_MOUSE NAGAB_MOUSE ---------------------MLQKTVLLLALVAQVLMLENGLLRTPPMGWLAWERFRCN Q3U6T2_MOUSE Q3U6T2_MOUSE ---------------------MLQKTVLLLALVAQVLMLENGLLRTPPMGWLAWERFRCN B1PK16_PIG B1PK16_PIG ---------------------MLLKTVLLLALVAHVLMLENGLLRKPPMGWLGWERFRCN NAGAB_HUMAN NAGAB_HUMAN ---------------------MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCN B8ZZ35_HUMAN B8ZZ35_HUMAN ------------------------------------------------------------ B8ZZ36_HUMAN B8ZZ36_HUMAN ------------------------------------------------------------ B2LSM7_SHEEP B2LSM7_SHEEP ---------------------MLLKTVLLLALVAQVLVLENGLLRKPPMGWLAWERFRCN NAGAB_BOVIN NAGAB_BOVIN ---------------------MLLKTVLLLALASQVLVLENGLLRKPPMGWLAWERFRCN Q1RMM9_BOVIN Q1RMM9_BOVIN ---------------------MLLKTVLLLALASQVLVLENGLLRKPPMGWLAWERFRCN Q5XJT6_DANRE Q5XJT6_DANRE ------------------------------------------------------------ B1WBF4_XENTR B1WBF4_XENTR -----MDYAWLS-----------VLLGTVLW-PQGAQSLQNGLALTPPMGWLHWERFLCE Q3KQ87_XENLA Q3KQ87_XENLA -----MTFAWLS-----------VLLGSVVW-LPGARSLQNGLALTPPMGWLHWERFLCE Q53HF3_HUMAN Q53HF3_HUMAN -------MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCN AGAL_HUMAN AGAL_HUMAN -------MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCN Q53Y83_HUMAN Q53Y83_HUMAN -------MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCN Q6LER7_HUMAN Q6LER7_HUMAN ---------------------------------PGARALDNGLARTPTMGWLHWERFMCN Q3TLY5_MOUSE Q3TLY5_MOUSE -----MAMKLLSGDTRLVCELALCPLALVFWSILGVRALDNGLARTPTMGWLHWERFMCN Q3UM38_MOUSE Q3UM38_MOUSE -----MAMKLLSGDTRLVCELALCPLALVFWSILGVRALDNGLARTPTMGWLHWERFMCN AGAL_MOUSE AGAL_MOUSE -------MKLLSRDTRLVCELALCPLALVFWSILGVRALDNGLARTPTMGWLHWERFMCN Q8BGZ6_MOUSE Q8BGZ6_MOUSE -----MAMKLLSRDTRLVCELALCPLALVFWSILGVRALDNGLARTPTMGWLHWERFMCN MATCH CONSENSUS ??????????????????????????????????????L?NGL???P?MGW??W?R??C?

Q6GR44_XENLA Q6GR44_XENLA IDCKSDPDNCISENLIKSMADKMADSGWRDVGYTYISIDDCWSQKQRDSNGRLQPDLERF Q6GQ17_XENLA Q6GQ17_XENLA IDCKSDPDNCISENLIKIMADEMADSGWRDLGYVYVCIDDCWSQKQRDSNGRLQPDPERF A8WGV2_XENTR A8WGV2_XENTR IDCKSDPDNCIGENLIKSMADKMADSGWRDLGYVYVCIDDCWSRKQRDSNGRLEPDPERF Q0P4I8_XENTR Q0P4I8_XENTR IDCKSDPDNCIGENLIKSMADKMADSGWRDLGYVYVCIDDCWSRKQRDSNGRLEPDPERF A4QP41_DANRE A4QP41_DANRE IDCQNDPYNCISEQLFMDMADRLSEDGWKELGYVYVNIDDCWSSKDRDAQGRLQPDPKRF Q4STX0_TETNG Q4STX0_TETNG IDCDQDPKNCISENLFTDMADRLSQDGWKDLGYVYVNIDDCWSSKERDKKGRLQPDPKRF NAGAB_CHICK NAGAB_CHICK VNCREDPRQCISEMLFMEMADRIAEDGWRELGYKYINIDDCWAAKQRDAEGRLVPDPERF NAGAB_RAT NAGAB_RAT INCEEDPKNCISERLFMEMADRLAQDGWRDLGYVYLNIDDCWIG-GRDATGRLIPDPKRF NAGAB_MOUSE NAGAB_MOUSE IDCVEDPKNCISERLFMEMADRLAQDGWRDLGYVYLNIDDCWIG-GRDASGRLIPDPKRF Q3U6T2_MOUSE Q3U6T2_MOUSE IDCVEDPKNCISERLFMEMADRLAQDGWRDLGYVYLNIDDCWIG-GRDASGRLIPDPKRF B1PK16_PIG B1PK16_PIG IDCDEDPKNCISERLFMEMADRLAQDGWRDLGYVYLNIDDCWIG-GRDAKGNLMPDPKRF NAGAB_HUMAN NAGAB_HUMAN INCDEDPKNCISEQLFMEMADRMAQDGWRDMGYTYLNIDDCWIG-GRDASGRLMPDPKRF B8ZZ35_HUMAN B8ZZ35_HUMAN ------------------------------------------------------------ B8ZZ36_HUMAN B8ZZ36_HUMAN ------------------------------------------------------------ B2LSM7_SHEEP B2LSM7_SHEEP IDCNEDPKSCISEELFMEMADRLAQDGWRELGYVYLNIDDCWIG-GRDAKGNLVPDRKRF NAGAB_BOVIN NAGAB_BOVIN IDCSEDPKNCISEQLFMEMADRLAQDGWRDLGYVYLNIDDCWIG-GRDAKGNLVPDRKRF Q1RMM9_BOVIN Q1RMM9_BOVIN IDCSEDPKNCISEQLFMEMADRLAQDGWRDLGYVYLNIDDCWIG-GRDAKGNLVPDRKRF Q5XJT6_DANRE Q5XJT6_DANRE -------------MLDMSLCALMIA-GLRNKG---------------THRGACRQTPKGF B1WBF4_XENTR B1WBF4_XENTR TNCERNPKNCISEQLFMDMADKMVSEGWLDAGYQYLCIDDCWLAPERDEKNRLQADPVRF Q3KQ87_XENLA Q3KQ87_XENLA TNCERNPKNCISERLFMDMADQMVSEGWLDAGYRYLCIDDCWLDRERDENNRLQADPVRF Q53HF3_HUMAN Q53HF3_HUMAN LDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRF AGAL_HUMAN AGAL_HUMAN LDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRF Q53Y83_HUMAN Q53Y83_HUMAN LDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRF Q6LER7_HUMAN Q6LER7_HUMAN LDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRF Q3TLY5_MOUSE Q3TLY5_MOUSE LDCQEEPDACISEQLFMQMAELMVSDGWRDAGYDYLCIDDCWMAPERDSKGRLQADPQRF Q3UM38_MOUSE Q3UM38_MOUSE LDCQEEPGACISEQLFMQMAELMVSDGWRDAGYDYLCIDDCWMAPERDSKGRLQADPQRF AGAL_MOUSE AGAL_MOUSE LDCQEEPDACISEQLFMQMAELMVSDGWRDAGYDYLCIDDCWMAPERDSKGRLQADPQRF Q8BGZ6_MOUSE Q8BGZ6_MOUSE LDCQEEPDACISEQLFMQMAELMVSDGWRDAGYDYLCIDDCWMAPERDSKGRLQADPQRF MATCH CONSENSUS ??C???P??CISE?L???MA??????GW???GY?Y??IDDCW????RD??G?L??D??RF

Q6GR44_XENLA Q6GR44_XENLA PSGMKALADYVHAKGLKLGIYSDMGTYTCGGYPGTTLDTIKIDAETFASWEVDMLKFDGC Q6GQ17_XENLA Q6GQ17_XENLA PSGMKALADYVHAKGLKLGIYSDMGNYTCGGYPGTTLDTIKTDAETFASWEVDMLKFDGC A8WGV2_XENTR A8WGV2_XENTR PSGMKALADYVHAKGLKLGIYSDMGNYTCGGYPGTTLDTIKIDADTFASWEVDMLKFDGC Q0P4I8_XENTR Q0P4I8_XENTR PSGMKALADYVHAKGLKLGIYSDMGNYTCGGYPGTTLDTIKIDADTFASWEVDMLKFDGC A4QP41_DANRE A4QP41_DANRE PRGIPHLAQYVHDRGLKLGIYGDMGTLTCGGYPGTTLDKIETDAQTFADWGIDMLKLDGC Q4STX0_TETNG Q4STX0_TETNG PGGIPKLARYMHDRGLKLGIYGDMGTLTCGGYPGTPLDKIDIDAKTFAEWEVDMLKFDGC NAGAB_CHICK NAGAB_CHICK PRGIKALADYVHARGLKLDIYGDLGRLTCGGYPGTTLDRVEQDAQTFAEWGVDMLKLDGC NAGAB_RAT NAGAB_RAT PHGIAFLADYAHSLGLKLGIYEDMGKMTCMGYPGTTLDKVELDAATFAEWKVDMLKLDGC NAGAB_MOUSE NAGAB_MOUSE PHGIAFLADYAHSLGLKLGIYEDMGKMTCMGYPGTTLDKVELDAETFAEWKVDMLKLDGC Q3U6T2_MOUSE Q3U6T2_MOUSE PHGIAFLADYAHSLGLKLGIYEDMGKMTCMGYPGTTLDKVELDAETFAEWKVDMLKLDGC B1PK16_PIG B1PK16_PIG PHGIAFLADYAHSLGLKLGIYDDLGSFTCMGYPGTTLDKVVHDAHTFAEWKVDMLNLDGC NAGAB_HUMAN NAGAB_HUMAN PHGIPFLADYVHSLGLKLGIYADMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGC B8ZZ35_HUMAN B8ZZ35_HUMAN -------------------------NFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGC B8ZZ36_HUMAN B8ZZ36_HUMAN -------------------------NFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGC B2LSM7_SHEEP B2LSM7_SHEEP PHGIAFLADYAHSLGLKLGIYEDLGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGC NAGAB_BOVIN NAGAB_BOVIN PHGIAFLADYAHSLGLKLGIYEDLGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGC Q1RMM9_BOVIN Q1RMM9_BOVIN PHGIAFLADYAHSLGLKLGIYEDLGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGC Q5XJT6_DANRE Q5XJT6_DANRE PVASKKLADYVHSKGLKLGIYADVGTKTCAGYPGS-LGYYDIDAKTFADWGVDLLKFDGC B1WBF4_XENTR B1WBF4_XENTR PGGIKKLADYVHSRGLLLGIYEDVGSKTCEGFPGS-QGYYDIDAQTFAEWGVDLLKFDGC Q3KQ87_XENLA Q3KQ87_XENLA PGGIKKLADYVHSRGLLLGIYQDVGTKTCEGFPGS-QGYYDLDAQTFAEWEVDLLKFDGC Q53HF3_HUMAN Q53HF3_HUMAN PHGVRQLANYVHSKGLKLGIYADVGNKTCAGFPGS-FGYYDIDAQTFADWGVDLLKFDGC AGAL_HUMAN AGAL_HUMAN PHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGS-FGYYDIDAQTFADWGVDLLKFDGC Q53Y83_HUMAN Q53Y83_HUMAN PHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGS-FGYYDIDAQTFADWGVDLLKFDGC Q6LER7_HUMAN Q6LER7_HUMAN PHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGS-FGYYDIDAQTFADWGVDLLKFDGC Q3TLY5_MOUSE Q3TLY5_MOUSE PSGIKHLANYVHSKGLKLGIYADVGNKTCAGFPGS-FGSYDIDAQTFADWGVDLLKFDGC Q3UM38_MOUSE Q3UM38_MOUSE PSGIKHLANYVHSKGLKLGIYADVGNKTCAGFPGS-FGSYDIDAQTFADWGVDLLKFDGC AGAL_MOUSE AGAL_MOUSE PSGIKHLANYVHSKGLKLGIYADVGNKTCAGFPGS-FGSYDIDAQTFADWGVDLLKFDGC Q8BGZ6_MOUSE Q8BGZ6_MOUSE PSGIKHLANYVHSKGLKLGIYADVGNKTCAGFPGS-FGSYDIDAQTFADWGVDLLKFDGC MATCH ** *:**: . ** ***.* :*:*::*** CONSENSUS P?G???LA?Y?H??GLKLGIY?D?G??TC?G?PG????????DA?TFA?W?VD?LK?DGC

Q6GR44_XENLA Q6GR44_XENLA YSNSTEKAL-GYPKMSEALNGTGRPILYSCSWPAYEGGLPPKVNYTQLGSICNMWRNYGD Q6GQ17_XENLA Q6GQ17_XENLA YSNSTEKAL-GYPKMSEALNATGRPILYSCSWPAYEGGLPPKVNYTQLGSICNMWRNYDD A8WGV2_XENTR A8WGV2_XENTR YSNSTEKAL-GYPKMSEALNATGRPILYSCSWPAYEGGLPPKVNYTQLGSICNMWRNYGD Q0P4I8_XENTR Q0P4I8_XENTR YSNSTEKAL-GYPKMSEALNATGRPILYSCSWPAYEGGLPPKVNYTQLGSICNMWRNYGD A4QP41_DANRE A4QP41_DANRE YSNSSYQEQ-GYPMMSKALNATGRPIGYSCSWPAYQGGLPPKVNYTLLGQICNLWRNYDD Q4STX0_TETNG Q4STX0_TETNG YSNEVEQQQ-GYPLMSKALNATGRPIAYSCSWPAYSGGLPPKVNYTQLGEICNLWRNYDD NAGAB_CHICK NAGAB_CHICK YSSGKEQAQ-GYPQMARALNSTGRPIVYSCSWPAYQGGLPPKVNYTLLGEICNLWRNYDD NAGAB_RAT NAGAB_RAT YSTPKERAE-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTEVAGTCNLWRNYKD NAGAB_MOUSE NAGAB_MOUSE FSSSRERAE-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTEVSRVCNLWRNYKD Q3U6T2_MOUSE Q3U6T2_MOUSE FSSSRERAE-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTEVSRVCNLWRNYKD B1PK16_PIG B1PK16_PIG FSTHKERAD-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDD NAGAB_HUMAN NAGAB_HUMAN FSTPEERAQ-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDD B8ZZ35_HUMAN B8ZZ35_HUMAN FSTPEERAQ-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDD B8ZZ36_HUMAN B8ZZ36_HUMAN FSTPEERAQ-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDD B2LSM7_SHEEP B2LSM7_SHEEP YSSPQERAE-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTLLADICNLWRNFDD NAGAB_BOVIN NAGAB_BOVIN YSTPQERAE-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTLLADICNLWRNFDD Q1RMM9_BOVIN Q1RMM9_BOVIN YSTPQERAE-GYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTLLADICNLWRNFDD Q5XJT6_DANRE Q5XJT6_DANRE FMPDWHQLGEGYINMSSALNQTGRSIVYSCEWPLYEWQH-QQPDYEAIRKTCNHWRNYGD B1WBF4_XENTR B1WBF4_XENTR YYGTLDKLEDGYRQMSMALNRTGRKIVLSCEWPLYERGI-KKINYSEVAEYCNSWRNFGD Q3KQ87_XENLA Q3KQ87_XENLA NYGTLDQLEDGYRQMSVALNRTGRKIVFSCEWPLYERGI-KKINYTEVAEYCNSWRNFGD Q53HF3_HUMAN Q53HF3_HUMAN YCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPF-QKPNYTEIRQYCNHWRNFAD AGAL_HUMAN AGAL_HUMAN YCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPF-QKPNYTEIRQYCNHWRNFAD Q53Y83_HUMAN Q53Y83_HUMAN YCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPF-QKPNYTEIRQYCNHWRNFAD Q6LER7_HUMAN Q6LER7_HUMAN YCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPF-QKPNYTEIRQYCNHWRNFAD Q3TLY5_MOUSE Q3TLY5_MOUSE HCDSVVSLENGYKYMALALNRTGRSIVYSCEWPLYLRPF-HKPNYTDIQYYCNHWRNFDD Q3UM38_MOUSE Q3UM38_MOUSE HCDSVVSLENGYKYMALALNRTGRSIVYSCEWPLYLRPF-HKPNYTDIQYYCNHWRNFDD AGAL_MOUSE AGAL_MOUSE HCDSVVSLENGYKYMALALNRTGRSIVYSCEWPLYLRPF-HKPNYTDIQYYCNHWRNFDD Q8BGZ6_MOUSE Q8BGZ6_MOUSE HCDSVVSLENGYKYMALALNRTGRSIVYSCEWPLYLRPF-HKPNYTDIQYYCNHWRNFDD MATCH ** *: *** *** * **.** * : :* : ** ***: * CONSENSUS ??????????GY??M??ALN?TGR?I??SC?WP?Y??????K?NY??????CN?WRN??D

Q6GR44_XENLA Q6GR44_XENLA IQDSWDSVLDIIEWYAKNQDVLQPAAGPGRWNDPDMLITGDFGLSYEQSKSQLAIWAILA Q6GQ17_XENLA Q6GQ17_XENLA IDDSWDSVLDIIEWYAKNQDVLQPAAGPGRWNDPDMLITGDFGLSYEQSKSQLAIWAILA A8WGV2_XENTR A8WGV2_XENTR IQDSWDSVLDIIEWYAKNQDVLQPAAGPGRWNDPDMLITGDFGLSYEQSKSQLAIWAILA Q0P4I8_XENTR Q0P4I8_XENTR IQDSWDSVLDIIEWYAKNQDVLQPAAGPGRWNDPDMLITGDFGLSYEQSKSQLAIWAILA A4QP41_DANRE A4QP41_DANRE IQDSWDSVMGIVDWFFDNQDALQPAAAPGQWNDPDMLIIGDFSLSLDQSRAQMALWSIMA Q4STX0_TETNG Q4STX0_TETNG IQDSWDSVLNIIDWFFDNQDVIAPAAGPGRWNDPDMLIVGDFGLSLEQSRTQMALWAIMA NAGAB_CHICK NAGAB_CHICK IQDSWDSVLSIVDWFFTNQDVLQPFAGPGHWNDPDMLIIGNFGLSYEQSRSQMALWTIMA NAGAB_RAT NAGAB_RAT IQDSWKSVLSILDWFVKHQDILQPVSGPGHWNDPDMLLIGNFGLSFDESRAQMALWTVLA NAGAB_MOUSE NAGAB_MOUSE IQDSWKSVLSILDWFVRHQDVLQPVAGPGHWNDPDMLLIGNFGLSFDESRAQMALWTVLA Q3U6T2_MOUSE Q3U6T2_MOUSE IQDSWKSVLSILDWFVRHQDVLQPVAGPGHWNDPDMLLIGNFGLSYDESRAQMALWTVLA B1PK16_PIG B1PK16_PIG IQDSWWSVLSILDWFVAHQDILQPVAGPGHWNDPDMLLIGNFGLSFEQAQSQMALWTVLA NAGAB_HUMAN NAGAB_HUMAN IQDSWWSVLSILNWFVEHQDILQPVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLA B8ZZ35_HUMAN B8ZZ35_HUMAN IQDSWWSVLSILNWFVEHQDILQPVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLA B8ZZ36_HUMAN B8ZZ36_HUMAN IQDSWWSVLSILNWFVEHQDILQPVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLA B2LSM7_SHEEP B2LSM7_SHEEP IQDSWRSVLSILDWFVAHQDVLQPVAGPGHWNDPDVLLIGNFGLSFEQARAQMALWTVLA NAGAB_BOVIN NAGAB_BOVIN IQDSWRSVLSVLDWFVTHQDVLQPIAGPGHWNDPDMLLIGNFGLSFEQAQAQMALWTVLA Q1RMM9_BOVIN Q1RMM9_BOVIN IQDSWRSVLSVLDWFVTHQDVLQPIAGPGHWNDPDMLLIGNFGLSFEQARAQMALWTVLA Q5XJT6_DANRE Q5XJT6_DANRE VYDQWTSVKSILDWTAEKQKIVVPVAGPGGWNDPDMLIIGNFGLSRDQQQTQMALWAIMA B1WBF4_XENTR B1WBF4_XENTR ITDSWGSVKAVMDLSSAVQEEIVPVAGPGSWNDPDMLVIGNFGLSWNQQVTQMALWSIMA Q3KQ87_XENLA Q3KQ87_XENLA ISDSWGSVKAVMTLSSAVQEELVPVAGPGSWNDPDMLVIGNFGLSWNQQVTQMALWAIMA Q53HF3_HUMAN Q53HF3_HUMAN IDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMA AGAL_HUMAN AGAL_HUMAN IDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMA Q53Y83_HUMAN Q53Y83_HUMAN IDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMA Q6LER7_HUMAN Q6LER7_HUMAN IDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMA Q3TLY5_MOUSE Q3TLY5_MOUSE VYDSWESIKNILSWTVVYQKEIVEVAGPGSWNDPDMLVIGNFGLSWDQQVTQMALWAIMA Q3UM38_MOUSE Q3UM38_MOUSE VYDSWESIKNILSWTVVYQKEIVEVAGPGSWNDPDMLVIGNFGLSWDQQVTQMALWAIMA AGAL_MOUSE AGAL_MOUSE VYDSWESIKNILSWTVVYQKEIVEVAGPGSWNDPDMLVIGNFGLSWDQQVTQMALWAIMA Q8BGZ6_MOUSE Q8BGZ6_MOUSE VYDSWESIKNILSWTVVYQKEIVEVAGPGSWNDPDMLVIGNFGLSWDQQVTQMALWAIMA MATCH : *.* *: :: *. : :.** *****:*: *:*.** :: :*:*:*:::* CONSENSUS I?DSW?S???I??W????Q??????AGPG?WNDPDML?IG?FGLS??Q???QMALW???A

Q6GR44_XENLA Q6GR44_XENLA APLIMSNDLRTISQDAKDLLQNRLLIYINQDALGKQGSLISQVG-SLEVWKRELINGQYA Q6GQ17_XENLA Q6GQ17_XENLA APLIMSNDLRAISQDAKDLLQNRLLIYINQDSLGKQGSLISRIG-NLEVWKRELINGQYA A8WGV2_XENTR A8WGV2_XENTR APFIMSNDLRTISQDAKDLLQNRLLIYINQDSMGKQGNLILRFG-SLEVWKRELMNGQYA Q0P4I8_XENTR Q0P4I8_XENTR APFIMSNDLRTISQDAKDLLQNRLLIYINQDSMGKQGNLILRFG-SLEVWKRELMNGQYA A4QP41_DANRE A4QP41_DANRE APLFMSNDLRTISSAARSVLQNKAVISINQDPLGIQGRRLLKEKSGIQVFQRPLSKGASA Q4STX0_TETNG Q4STX0_TETNG APLFMSNDLRTISAEARSILQNKIAIGINQDPLGFQGRRLVKEKSGIEVFWRQLSNDTSA NAGAB_CHICK NAGAB_CHICK APLLMSTDLRTISPSAKKILQNRLMIQINQDPLGIQGRRIIKEGSHIEVFLRPLSQAASA NAGAB_RAT NAGAB_RAT APLFMSTDLRTISPQNIDILQNPLLIKINQDPLGIQGRLIFKSKSHIEVFKRNLSDDASA NAGAB_MOUSE NAGAB_MOUSE APLLMSTDLRTISPQNMDILQNPLMIKINQDPLGIQGRRILKSKSHIEVFKRYLSNQASA Q3U6T2_MOUSE Q3U6T2_MOUSE APLLMSTDLRTISPQNMDILQNPLMIKINQDPLGIQGRRILKSKSHIEVFKRYLSNQASA B1PK16_PIG B1PK16_PIG APLFMSTDLRTISAQNVDILQNTLMIKINQDPLGIQGRRVLKEKSFIDVFMRPLANEACA NAGAB_HUMAN NAGAB_HUMAN APLLMSTDLRTISAQNMDILQNPLMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASA B8ZZ35_HUMAN B8ZZ35_HUMAN APLLMSTDLRTISAQNMDILQNPLMIKINQDPLGIQGRRIHKEA---------------- B8ZZ36_HUMAN B8ZZ36_HUMAN APLLMSTDLRTISAQNMDILQNPLMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASA B2LSM7_SHEEP B2LSM7_SHEEP APLLMSTDLRTISAQNVDILQNPLMIKINQDPLGIQGRRILKEKSYIEVYLRPLVNEASA NAGAB_BOVIN NAGAB_BOVIN APLFMSTDLRTISAQNMDILQNPLMIKINQDPLGIQGRRILKEKSHIEVYLRPLASEASA Q1RMM9_BOVIN Q1RMM9_BOVIN APLFMSTDLRTISAQNMDILQNPLMIKINQDPLGIQGRRILKEKSHIEVYLRPLASEASA Q5XJT6_DANRE Q5XJT6_DANRE APLLMSNDLRDICPKAKELLQNKQIIAINQDPLGKQGYRILKAD-SFELWERPLSGNRLA B1WBF4_XENTR B1WBF4_XENTR APLMMSNDLRDIPAESKALLQDKNVISINQDPLGAQGYRVFKAD-YFEVWERPLIKGSLA Q3KQ87_XENLA Q3KQ87_XENLA APLMMSNDLRDISAESKALLQDKHVISINQDPLGAQGYRVFKAD-NFEVWEKPLIKGSLA Q53HF3_HUMAN Q53HF3_HUMAN APLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGD-NFEVWERPLSGLAWA AGAL_HUMAN AGAL_HUMAN APLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGD-NFEVWERPLSGLAWA Q53Y83_HUMAN Q53Y83_HUMAN APLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGD-NFEVWERPLSGLAWA Q6LER7_HUMAN Q6LER7_HUMAN APLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGD-NFEVWERPLSGLAWA Q3TLY5_MOUSE Q3TLY5_MOUSE APLLMSNDLRQISSQDKALLQNKDVIAINQDPLGKQGYCFRKEN-HIEVWERPLSNLAWA Q3UM38_MOUSE Q3UM38_MOUSE APLLMSNDLRQISSQDKALLQNKDVIAINQDPLGKQGYCFRKEN-HIEVWERPLSNLAWA AGAL_MOUSE AGAL_MOUSE APLLMSNDLRQISSQAKALLQNKDVIAINQDPLGKQGYCFRKEN-HIEVWERPLSNLAWA Q8BGZ6_MOUSE Q8BGZ6_MOUSE APLLMSNDLRQISSQAKALLQNKDVIAINQDPLGKQGYCFRKEN-HIEVWERPLSNLAWA MATCH **::**.*** * :**: * ****.:* ** . : CONSENSUS APL?MS?DLR?IS??????LQ????I?INQDPLG?QG??????????EV??R?L?????A

Q6GR44_XENLA Q6GR44_XENLA VAVLNKGTDGLPRPYTTSLGLLN-ITQCTDG-YK--MYNVFEKEYIGMFKSGTPIDMRVN Q6GQ17_XENLA Q6GQ17_XENLA LAVLNKGTDGLPRPYSTNLGLLN-VTQCTDG-YK--LYNVFEKEYLGMFTSSTPIIIRVN A8WGV2_XENTR A8WGV2_XENTR VAVLNKGTDGLPKPYSTSLGLLN-VTQCTDG-YK--LYNVFEKEYLGIFKSSTGIDMRVN Q0P4I8_XENTR Q0P4I8_XENTR VAVLNKGTDGLPKPYSTSLGLLN-VTQCTDG-YK--LYNVFEKEYLGIFKSSTGIDMRVN A4QP41_DANRE A4QP41_DANRE LVFFSRRSD-MPYRYTTSLKTLG----YQPGVFE--VFDVFSEQRLPELKDSTQFTVSIN Q4STX0_TETNG Q4STX0_TETNG LVFFSRRTD-MPYRYKTSLSKLS----YPTGYYK--IVDVFTQKG-SSLKDSADFVVSVN NAGAB_CHICK NAGAB_CHICK LVFFSRRTD-MPFRYTTSLAKLG---FPMGAAYE--VQDVYSGKIISGLKTGDNFTVIIN NAGAB_RAT NAGAB_RAT LVFFSRRTD-MPYHFHCSLLELN---YPKGSVYE--GQNVFTGDIISGLHPETNFTVIIN NAGAB_MOUSE NAGAB_MOUSE LVFFSRRTD-MPFRFHCSLLELN---YPKGRVYE--GQNVFTGDIFSGLQTEVNFTVIIN Q3U6T2_MOUSE Q3U6T2_MOUSE LVFFSRRTD-MPFRFHCSLLELN---YPKGRVYE--GQNVFTGDIFSGLQTEVNFTVIIN B1PK16_PIG B1PK16_PIG LVFFSRRTD-MPYRYHCSLGRLN---FTGSRVYE--AQNVYTGDIISGLHVTTNFTVTVN NAGAB_HUMAN NAGAB_HUMAN LVFFSCRTD-MPYRYHSSLGQLN---FTGSVIYE--AQDVYSGDIISGLRDETNFTVIIN B8ZZ35_HUMAN B8ZZ35_HUMAN ------------------------------------SKKVYSLAVHGCL----------- B8ZZ36_HUMAN B8ZZ36_HUMAN LVFFSCRTD-MPYRYHSSLGQLN---FTGSVIYEEASKKVYSLAVHGCL----------- B2LSM7_SHEEP B2LSM7_SHEEP IVFFSRRTD-MPYHYHSSLARLN---FSSSVVYE--AQDVYTGEIISGLQDKTNFTVIIN NAGAB_BOVIN NAGAB_BOVIN IVFFSRRMD-MPYHYHSSLARLN---FSSSVVYE--AQDVYTGDIISGLQDKTNFTVIIN Q1RMM9_BOVIN Q1RMM9_BOVIN IVFFSRRMD-MPYHYHSSLARLN---FSSSVVYE--AQDVYTGDIISGLQDKTNFTVIIN Q5XJT6_DANRE Q5XJT6_DANRE VAVVNRQEIGGPRRFTISVAIMPSWKLCNPKCNV--TQILPTYKEMGVQNLLSEVVVQVN B1WBF4_XENTR B1WBF4_XENTR VAVTNRNEIGGPRNFLLSLSLLWEDRVCQNSCFI--TQLLPSFQKYGHLNDTSLLSLWIN Q3KQ87_XENLA Q3KQ87_XENLA VSVTNFYEIGSPRNFLLSLSLLWKKRVCRNSCFI--TRLLPSYHKYGHLNDNSLLSLWIN Q53HF3_HUMAN Q53HF3_HUMAN VAMINRQEIGGPRSYTIAVASLGKGVACNPACFI--TQLLPVKRKLGFYEWTSRLRSHIN AGAL_HUMAN AGAL_HUMAN VAMINRQEIGGPRSYTIAVASLGKGVACNPACFI--TQLLPVKRKLGFYEWTSRLRSHIN Q53Y83_HUMAN Q53Y83_HUMAN VAMINRQEIGGPRSYTIAVASLGKGVACNPACFI--TQLLPVKRKLGFYEWTSRLRSHIN Q6LER7_HUMAN Q6LER7_HUMAN VAMINRQEIGGPRSYTIAVASLGKGVACNPACFI--TQLLPVKRKLGFYEWTSRLRSHIN Q3TLY5_MOUSE Q3TLY5_MOUSE VAVRNLQEIGGPCPYTIQISSLGRGLACNPGCII--TQLLPEKVHLGFYEWTLTLKTRVN Q3UM38_MOUSE Q3UM38_MOUSE VAVRNLQEIGGPCPYTIQISSLGRGLACNPGCII--TQLLPEKVHLGFYEWTLTLKTRVN AGAL_MOUSE AGAL_MOUSE VAVRNLQEIGGPCPYTIQISSLGRGLACNPGCII--TQLLPEKVHLGFYEWTLTLKTRVN Q8BGZ6_MOUSE Q8BGZ6_MOUSE VAVRNLQEIGGPCPYTIQISSLGRGLACNPGCII--TQLLPEKVHLGFYEWTLTLKTRVN MATCH : CONSENSUS ???????????P?????????L?????????????????????????????????????N

Q6GR44_XENLA Q6GR44_XENLA PTGVIFLFISPVSRSYMP---------------------------- Q6GQ17_XENLA Q6GQ17_XENLA PTGVIFLFLRPVSYIP------------------------------ A8WGV2_XENTR A8WGV2_XENTR PTGVIFLFMRPVSTSYIP---------------------------- Q0P4I8_XENTR Q0P4I8_XENTR PTGVIFLFMRPVSTSYIP---------------------------- A4QP41_DANRE A4QP41_DANRE PSGVVMWYIYPAADRRKEAEFEGFSKKLIGPKFHRHANEVDAPLVL Q4STX0_TETNG Q4STX0_TETNG PTGVVMWYVSAPAKLDPNQ--------------------------- NAGAB_CHICK NAGAB_CHICK PSGVVMWYLCPKALLIQQQAPGGPSRLPLL---------------- NAGAB_RAT NAGAB_RAT PSGVVMWYLYPVKGLGIYTMMSQL---------------------- NAGAB_MOUSE NAGAB_MOUSE PSGVVMWYLYPIKDLGISTMMSHW---------------------- Q3U6T2_MOUSE Q3U6T2_MOUSE PSGVVMWYLYPIKDLGISTMMSHW---------------------- B1PK16_PIG B1PK16_PIG PSGVVMWYLYPIKTLGTPPQ-------------------------- NAGAB_HUMAN NAGAB_HUMAN PSGVVMWYLYPIKNLEMSQQ-------------------------- B8ZZ35_HUMAN B8ZZ35_HUMAN ---------------------------------------------- B8ZZ36_HUMAN B8ZZ36_HUMAN ---------------------------------------------- B2LSM7_SHEEP B2LSM7_SHEEP PSGVVMWYLYPISKLGIPQQ-------------------------- NAGAB_BOVIN NAGAB_BOVIN PSGVVMWYLYPIRKLEIPQQ-------------------------- Q1RMM9_BOVIN Q1RMM9_BOVIN PSGVVMWYLYPIRKLEIPQQ-------------------------- Q5XJT6_DANRE Q5XJT6_DANRE PTGTTLLTVNPL---------------------------------- B1WBF4_XENTR B1WBF4_XENTR PSGTILLRID------------------------------------ Q3KQ87_XENLA Q3KQ87_XENLA PSGTILLRMD------------------------------------ Q53HF3_HUMAN Q53HF3_HUMAN PTGTVLLQLENTMQMSLKDLL------------------------- AGAL_HUMAN AGAL_HUMAN PTGTVLLQLENTMQMSLKDLL------------------------- Q53Y83_HUMAN Q53Y83_HUMAN PTGTVLLQLENTMQMSLKDLL------------------------- Q6LER7_HUMAN Q6LER7_HUMAN PTGTVLLQLENTMQMSLKDLL------------------------- Q3TLY5_MOUSE Q3TLY5_MOUSE PSGTVLFRLER----------------------------------- Q3UM38_MOUSE Q3UM38_MOUSE PSGTVLFRLER----------------------------------- AGAL_MOUSE AGAL_MOUSE PSGTVLFRLER----------------------------------- Q8BGZ6_MOUSE Q8BGZ6_MOUSE PSGTVLFRLER----------------------------------- MATCH CONSENSUS P?G???????????????????????????????????????????


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